Jun, Suckjoon - University of California, San Diego

个人简介

Suckjoon Jun received his Ph.D. in theoretical physics from Simon Fraser University in Vancouver, Canada. He continued to work as a theorist for his post-doctoral training at the FOM-Institute AMOLF in Amsterdam and briefly at Necker Hospital in Paris with NSERC (Canada) and Marie Curie (Europe) post-doctoral fellowships. He was a Bauer Fellow at Harvard University between 2007-2012 before moving to UCSD, during which he completely switched to experimental physical and systems biology.

研究领域

The driving force of our lab is the curiosity and desire to understand why the biological systems are the way they are. We are often attracted to long-standing questions in biology, for which quantitative, inter- and multi-disciplinary approaches are essential. Some of these questions include: What is the driving force underlying chromosome segregation in bacteria? What is the relationship between growth and cell cycle? What is the origin of the plasticity of cell shape? While our research is naturally question-driven, we also develop tools when necessary. In doing so, we try to meet the highest standard in the relevant discipline (be it physics, biology, or engineering). We value both logic and intuition, but more of "night science" than "day science."

近期论文

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Fangwei Si, Guillaume Le Treut, John T Sauls, Stephen Vadia, Petra Anne Levin, Suckjoon Jun. “Mechanistic origin of cell-size control and homeostasis in bacteria” (Current Biology, under review) Fabai Wu, Pinaki Swain, Louis Kuijpers, Xuan Zheng, Kevin Felter, Margot Guurink, Jacopo Solari, Suckjoon Jun, Thomas S. Shimizu, Debasish Chaudhuri, Bela Mulder & Cees Dekker. “Cell boundary confinement sets the size and position of the E. coli chromosome”. (Cell, under review) K. Sekar, R. Ruscon, JT Sauls, T. Fuhrer, E. Noor, J. Nguyen, VI Fernandez, MF Buffing, M. Berney, S. Jun, R. Stocker, U. Sauer. "Synthesis and degradation of FtsZ quantitatively predicts the first cell division in starved bacteria". Mol. Sys. Biol., (2018) 14, e8623 Arshad Desai and Suckjoon Jun. Promoting an "Auteur Theory" for Young Scientists: Preserving Excitement and Creativity". BioEssays, 1800147 (2018) Suckjoon Jun, Fangwei Si, Rami Pugatch, Mathew Scott. Fundamental Principles in Bacterial Physiology - History, Recent progress, and the Future with Focus on Cell Size Control: A Review. Reports on Progress in Physics, 81 056601 (2018) Suckjoon Jun and Michael Rust. A fundamental unit of cell size in bacteria. TRENDS in Genetics 33(7), 433-435 (2017) Fangwei Si*, Dongyang Li*, Sarah E. Cox, John T. Sauls, Omid Azizi, Cindy Sou, Amy B. Schwartz, Michael J. Erickstad, Yonggun Jun, Xintian Li, Suckjoon Jun. Invariance of the initiation mass and predictability of cell size in Escherichia coli. Current Biology 27, 1278–1287 (2017) Xin-tian Li, Yonggun Jun, Michael J. Erickstad, Steven D. Brown, Adam Parks, Donald L. Court & Suckjoon Jun. tCRISPRi: tunable and reversible, one-step control of gene expression. Scientific Reports 6, 39076 (2016) John T Sauls, Dongyang Li, Suckjoon Jun Adder and quantitative, phenomenological approach to cell size homeostasis in bacteria. Current Opinion in Cell Biology, 38:38-44 (2016) Steven B. Brown and Suckjoon Jun. Complete Genome Sequence of Escherichia coli NCM3722. Genome Announcements, 3(4):e00879-15 (2015) Sattar Taheri-Araghi, Steven B. Brown, John T. Sauls, Dustin McIntosh, & Suckjoon Jun. Single-cell physiology. Annual Review of Biophysics 44:3.1-3.20 (2015) Suckjoon Jun. Chromosome, cell cycle, and entropy. Biophysical Journal 108, 785-786 (2015) Sattar Taheri-Araghi*, Serena Bradde*, Norbert Hill, Petra A. Levin, Johan Paulsson, Massimo Vergassola*, Suckjoon Jun*. Cell size control and homeostasis in bacteria. Current Biology 25, 385-391 (2015) Suckjoon Jun and Sattar Taheri-Araghi. Cell-size maintenance: universal strategy revealed. TRENDS in Microbiology 23, 4-6 (2015) Ariel Amir, Farinaz Babaeipour, Dustin McIntosh, David R. Nelson & Suckjoon Jun. Bending forces plastically deform growing bacterial cell walls. Proc. Nat. Acad. Sci. USA (2014) Brenda Youngren, Henrik J. Nielsen, Suckjoon Jun & Stuart Austin. The multi-fork Escherichia coli chromosome is a self-duplicating and self-segregating thermodynamic ring polymer. Genes & Development. 28, 71-84 (2014) James Pelletier and Suckjoon Jun. Isolation and characterization of bacterial nucleoids in microfluidic devices. The Bacterial Nucleoid. Methods in Molecular Biology, vol 1624. Humana Press, New York, NY Sattar Taheri & Suckjoon Jun. Single-cell cultivation in microfluidic devices. The Handbook of Hydrocarbon and Lipid Microbiology (Springer, 2016)