Dutton, Rachel - University of California, San Diego

研究领域

Microbial communities play transformative roles in everything from Earth's geochemical cycles to the human body. However, the complexity and difficulty in manipulating microbial communities makes understanding the mechanisms involved in community formation incredibly challenging. One approach to understanding the basic principles of community formation is to use simplified model communities, in much the same way as model organisms such as E. coli have been used to elucidate basic principles of cellular metabolism, genetics, and biochemistry. Our lab has focused on the use of microbial communities from cheese as models due to their simplicity, culturability, and experimental tractability. These communities show reproducible and dynamic patterns of community formation which depend on widespread interactions between species. We are now developing genetic, cell biological, and chemical approaches to studying species interactions in this model microbial community. As with any model system, our goal is to gain insight into the workings of more complex systems.

近期论文

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Wolfe BE and Dutton RJ. Fermented Foods as Experimentally Tractable Microbial Ecosystems. Cell. Mar 26;161(1):49-55. (2015) Wolfe BE, Button JE, Santarelli M, Dutton RJ. Cheese rind communities provide tractable systems for in situ and in vitro studies of microbial diversity. Cell. July 17;158,422-33. (2014) David LA, Maurice CF, Gootenberg DB, Button JE, Ling A, Biddinger SB, Dutton RJ, Turnbaugh PJ. Diet rapidly and reproducibly alters the human gut microbiome. Nature. Jan 23;505(7484):559-63 (2014). Button JE and Dutton RJ. Quick Guide to Cheese Microbes. Current Biology. Aug 7; 22(15):587-9. (2012) Wolfe BE, Dutton RJ. Towards an ecosystems approach to cheese microbiology. Cheese and Microbes. ASM Press and Microbiology Spectrum (2014)