张璨 - 湖南大学 - 生物学院

个人简介

2012年毕业于湖南师范大学，获得生物科学学士学位；同年保送至浙江大学基础医学院直接攻博，2017年获得干细胞和再生医学专业博士学位。2017年7月进入湖南大学生物学院生物纳米与组织工程学研究所任助理教授。获得第十七届国际肌腱韧带会议最佳研究者奖。教育背景 2012年毕业于湖南师范大学，获得生物科学学士学位； 2012年保送至浙江大学基础医学院直接攻博，2017年获得干细胞和再生医学专业博士学位工作履历 2017年7月进入湖南大学生物学院生物纳米与组织工程学研究所任助理教授

研究领域

从事肌腱组织损伤再生修复及肌腱病治疗的基础研究，研究方向为肌腱组织工程；表观遗传与干细胞定向分化；细胞与细胞外基质相互作用。研究兴趣主要包括：1. 具有生物活性的肌腱组织工程支架开发；2. 肌腱表型维持和分化的小分子筛选和功能验证；3. 大数据时代的肌腱组织发育和肌腱病发生的分析。

近期论文

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1. Can Zhang, Erchen Zhang, Long Yang, Wenjing Tu, Junxin Lin, Chunhui Yuan, Varisara Bunpetch, Xiao Chen*, Hongwei Ouyang*. Histone Deacetylase Inhibitor Treated Cell Sheet from Mouse Tendon Stem/Progenitor Cells Promotes Tendon Repair. Biomaterials, 172, 66-82. 2018 2. Can Zhang, Xianliu Wang, Erchen Zhang, Long Yang, Huihua Yuan, Wenjing Tu, Huilan Zhang, Zi Yin, Weiliang Shen, Xiao Chen*, Yanzhong Zhang*, Hongwei Ouyang*. An Epigenetic Bioactive Composite Scaffold with Well-aligned Nanoﬁbers for Functional Tendon Tissue Engineering. Acta Biomaterialia 66, 141-156. 2018 3. Can Zhang, Huihua Yuan, Liu Huanhuan, Chen Xiao, Lu Ping, Zhu Ting, Yang Long, Yin Zi, Boon Chin Heng, Zhang Yanzhong*, Ouyang HongWei*. Well-aligned Chitosan-based Ultrafine Fibers Committed Teno-lineage Differentiation of Human Induced Pluripotent Stem Cells for Achilles Tendon Regeneration. Biomaterials 53, 716-730. 2015 4. Huanhuan Liu, Can Zhang, Shouan Zhu, Ping Lu, Ting Zhu, Xiaolan Gong, Ziwang Zhang, Jiajie Hu, Zi Yin, Boon Chin Heng, Xiao Chen*, Hongwei Ouyang*. Mohawk Promotes The Tenogenesis of Mesenchymal Stem Cells Through Activation of The TGFβ Signaling Pathway, Stem Cells 33, 443-455. 2015 5. Mingying Yang#*, Yajun Shuai#, Can Zhang#, Yuyin Chen, Liangjun Zhu, Chuanbin Mao*, Hongwei Ouyang. Biomimetic Nucleation of Hydroxyapatite Crystals Mediated by Antheraea pernyi Silk Sericin Promotes Osteogenic Diﬀerentiation of Human Bone Marrow Derived Mesenchymal Stem Cells. Biomacromolecules 15, 1185-1193. 2014 6. Huanhuan Liu, Shouan Zhu, Can Zhang, Ping Lu, Jiajie Hu, Yue Ma, Xiao Chen, Hongwei Ouyang*. Crucial Transcription Factors in Tendon Development and Differentiation: Their Potential for Tendon Regeneration. Cell Tissue Research 356, 287-298. 2014 7. Huanhuan Liu, Hongju Peng, Yan Wu, Can Zhang, Youzhi Cai, Guowei Xu, Qin Li, Xiao Chen, Junfeng Ji, Yanzhong Zhang*, Hongwei Ouyang*. The Promotion of Bone Regeneration by Nanofibrous Hydroxyapatite/Chitosan Scaffolds by Effects on Integrin-BMP/Smad Signaling Pathway in BMSCs. Biomaterials 34, 4404-4417. 2013