李丹 - 湖南大学 - 生物学院

个人简介

2004年在中南大学湘雅医学院获博士学位。2009年-2010年在英国牛津大学Ludwig癌症研究所从事博士后研究。2004年-至今在湖南大学生物院从事科研与教学工作。近年来，在国内外学术刊物上发表研究论文30余篇，主持国家自然科学基金面上项目3项，以及省、校级项目多项。曾作为主要研究人员之一先后获2004 年国家科学技术进步二等奖（第7）和2008 年湖南省自然科学优秀学术论文二等奖（第1）；先后获湖南省普通高校青年骨干教师（2009）、湖南省优秀硕士学位论文指导教师（2014, 2015）、湖南大学优秀教师（2014）等奖励。学术兼职：国家自然科学基金通讯评审专家、教育部学位中心学位论文评阅通讯评审专家、湖南省神经科学学会理事等。教育背景 2004年在中南大学湘雅医学院获博士学位

研究领域

研究方向：医学遗传与发育分子生物学研究兴趣主要包括：（1）生殖疾病的分子机理研究；（2）细胞分化发育的表观遗传调控

近期论文

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1. Caihong Liu, Huan Yang, Zhijie Xu, Dan Li, Meiyu Zhou, Zhihui Shi, Lanyan, Zhu, Kui Xia, Lifang Yang* and Rui Zhou*. MicroRNA-548l is involved in the migration and invasion of non-small cell lung cancer by targeting the AKT1 signaling pathway. J Cancer Res Clin Oncol，2015;141(3):431-41. 2. Zhuoxian RONG, Dan LI*, Xiaowen LIU, Zhiyong LIU, Daobing WU, Xuanming LIU. Screening of miRNAs and their possible targets in response to TGF-β1 based on microRNA array and proteomics comparative analysis in mouse GC-1 spg cell line. Int J Mol Med, 2015, 35:821-828. 3. Lifang Yang, Weizhong Zeng, Dan Li, Rui Zhuo. Inhibition of cell proliferation, migration and invasion by DNAzyme targeting MMP-9 in A549 cell. Oncology Reports, 2009,22 (1):121-126 4. Yunsheng Zhang; Lifang Yang; Yiting Lin; Zhuoxian Rong; Xiaowen Liu; Dan Li*. SPATA12 and its possible role in DNA damage induced by ultraviolet-C. PLoS ONE, 2013, 8(10): e78201. 5. ZHENG YuanQing, TONG ChunYi, WANG Bei, XIE Ying, LIAO HongDong, LI Dan* & LIU XuanMing*.The Development and Application of Tumor-targeting Magetic Nanoparticles FA-StNP@Fe2O3 for Hyperthemia. Chin Sci Bull, 2009, 54(17):2998-3004. 6. LI Dan, YANG Lifang, LU Guangxiu*. Expression and possible functions of a novel gene SPATA12 in human testis. Journal of Andrology, 2007, 28(4):502-512 7. Ouyang Q, Zhao X, Feng H, Tian Y, Li D, Li M, Tan Z*. High GC content of simple sequence repeats in Herpes simplex virus type 1 genome. Gene, 2012;499 (1):37-40. 8. Dan LI*, Yiting LIN, Yunsheng ZHANG, Zhiwen LIU, Zhuoxian Rong, Xuanming LIU*.Transcriptional Regulation of Human Novel Gene SPATA12 Promoter by AP-1 and HSF. Gene,2012,511:18-25 9. Yiting LIN, Yunsheng ZHANG, Xuanming LIU，Zhiwen LIU, Zhuoxian Rong, Dan LI*. Microarray-based analysis of the gene expression profile in GC-1 spg cells transfected with spermatogenesis associated gene 12. International Journal of Molecular Medicine, 2013,31:459-466 10. LI Dan, LU Guangxiu*. Identification and expression of a novel human testis-specific gene by digital differential display. Chinese Medical Journal, 2004,117(12): 1791-1796. 11. Shihua ZHOU, Ziqian MIN, Kang SUN, Sijie QU, Jinrun ZHOU, Hongyan DUAN, Huawei LIU, Xiaowen LIU, Zhijun GONG, Dan LI*. miR-199a-3p/Sp1/LDHA axis controls aerobic glycolysis in testicular tumor cells. Int J Mol Med, 2018;42(4):2163-2174. 12. XIAOWEN LIU, HONGYAN DUAN, SHIHUA ZHOU, ZHIYONG LIU, DAOBING WU, TING ZHAO, SHAN XU, LIFANG YANG*, DAN LI*. microRNA-199a-3p functions as tumor suppressor by regulating glucose metabolism in testicular germ cell tumors. Molecular Medicine Reports,2016,14:2311-2320.