冯欣欣 - 湖南大学 - 化学化工学院

个人简介

教育背景 2005.9-2009.6 南京大学化学系，本科 2009.8-2010.12 美国伊利诺伊大学（香槟校区）化学系 (导师：Prof. Roman Boulatov) 2011.1-2014.5 美国伊利诺伊大学（香槟校区）化学系 (导师：Prof. Eric Oldfield) 工作履历 2014.5-2016.8 美国伊利诺伊大学（香槟校区）化学系，博士后 (导师：Prof. Eric Oldfield) 2014.5-2017.8 GlucoSentient, Inc.，研发科学家 2017.8-今湖南大学化学生物学与纳米医学研究所，化学生物传感与计量学国家重点实验室，湖南大学化学化工学院，副教授

研究领域

（1）抗菌肽模拟物：以细菌细胞膜靶向、DNA靶向、ROS激发等为主要机理，以组合化学的策略针对不同靶标进行抗菌药物的分子设计，将多重靶向能力集成在单个大分子中，合成大量结构多样化的、可同时靶向多个靶标的抗菌肽模拟物；（2）基于细胞膜靶向的药物联用：利用膜靶向分子增加革兰氏阴性菌外膜的渗透性，从而提高已有抗生素对其的抗菌活性，同时通过分子层面的机理研究，对药物联用协同的机理进行研究。（3）多靶向偶联抗菌化合物：利用分子建构的手段，将不同靶点的化合物通过连接体进行偶联，期望获得具有增强协同抗菌效果的复合体。

近期论文

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Lei, E.; Tao, H.; Jiao, S.; Yang, A.; Zhou, Y.; Wang, M.; Wen, K.; Wang, Y.; Chen, Z.; Chen, X.; Song, J.; Zhou, C.; Huang, W.; Xu, L.; Guan, D.; Tan, C.; Liu, H.; Cai, Q.; Zhou, K.; Modica, J.; Huang, S.-Y.*; Huang, W.*; Feng, X.*, Potentiation of Vancomycin: Creating Cooperative Membrane Lysis through a “Derivatization-for-Sensitization” Approach. Journal of the American Chemical Society 2022, 144 (23), 10622-10639. Chen, Z.; Zhou, C.; Xu, Y.; Wen, K.; Song, J.; Bai, S.; Wu, C.; Huang, W.; Cai, Q.; Zhou, K.; Wang, H.; Wang, Y.; Feng, X.*; Bai, Y.*, An alternatingly amphiphilic, resistance-resistant antimicrobial oligoguanidine with dual mechanisms of action. Biomaterials 2021, 275, 120858-120858. Chen, X.; Zhou, C.; Wang, J.; Wu, T.; Lei, E.; Wang, Y.; Huang, G.; Yu, Y.; Cai, Q.; Pu, H.; Feng, X.*; Bai, Y.*, Improving the Hemocompatibility of Antimicrobial Peptidomimetics through Amphiphilicity Masking Using a Secondary Amphiphilic Polymer. Advanced Healthcare Materials 2022, 11 (15). Wang, J.; Song, J.; Chen, X.; Guo, R.-T.; Wang, Y.; Huang, G.; Zheng, N.; Hu, P.; Feng, X.*; Bai, Y.*, Multivalent Display of Lipophilic DNA Binders for Dual-Selective Anti-Mycobacterium Peptidomimetics with Binary Mechanism of Action. CCS Chemistry 2022, 0 (0), 1-14. Chen, Z.; Zhou, C.; Xu, Y.; Wen, K.; Song, J.; Bai, S.; Wu, C.; Huang, W.; Cai, Q.; Zhou, K.; Wang, H.; Wang, Y.; Feng, X.*; Bai, Y.*, An alternatingly amphiphilic, resistance-resistant antimicrobial oligoguanidine with dual mechanisms of action. Biomaterials 2021, 275, 120858. Bai, S.; Wang, J.; Yang, K.; Zhou, C.; Xu, Y.; Song, J.; Gu, Y.; Chen, Z.; Wang, M.; Shoen, C.; Andrade, B.; Cynamon, M.; Zhou, K.; Wang, H.; Cai, Q.; Oldfield, E.; Zimmerman, S. C.; Bai, Y.*; Feng, X.*, A polymeric approach toward resistance-resistant antimicrobial agent with dual-selective mechanisms of action. Sci. Adv. 2021, 7, eabc9917. Wu, C.; Xia, L.; Huang, W.; Xu, Y.; Gu, Y.; Liu, C.; Ji, L.; Li, W.; Wu, Y.; Zhou, K.; Feng, X.*, Pentamidine sensitizes FDA-approved non-antibiotics for the inhibition of multidrug-resistant Gram-negative pathogens. Eur. J. Clin. Microbiol. 2020, 39, 1771. Song, J.; Malwal, S. R.; Baig, N.; Schurig-Briccio, L. A.; Gao, Z.; Vaidya, G. S.; Yang, K.; Abutaleb, N. S.; Seleem, M. N.; Gennis, R. B.; Pogorelov, T. V.; Oldfield, E.*; Feng, X.*, Discovery of Prenyltransferase Inhibitors with In Vitro and In Vivo Antibacterial Activity. ACS Infect. Dis. 2020, 6, 2979. Lu, Q.; Bai, S.; Chen, Z.; Zheng, N.; Feng, X.; Bai, Y.*, A Dense-Shell Macromolecular Scaffold for Catalyst- or Substrate-Guided Catalysis in a Cellular Environment. ACS Materials Lett. 2020, 2, 89. Song, J.; Shang, N.; Baig, N.; Yao, J.; Shin, C.; Kim, B. K.; Li, Q.; Malwal, S. R.; Oldfield, E.*; Feng, X.*; Guo, R.-T.*, Aspergillus flavus squalene synthase as an antifungal target: Expression, activity, and inhibition. Biochem. Biophys. Res. Commun. 2019, 512, 517. Malwal, S. R.; O’Dowd, B.; Feng, X.; Turhanen, P.; Shin, C.; Yao, J.; Kim, B. K.; Baig, N.; Zhou, T.; Bansal, S.; Khade, R. L.; Zhang, Y.; Oldfield, E., Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways. J. Am. Chem. Soc. 2018, 140, 7568. Bai, Y.; Feng, X.; Xing, H.; Kim, B. K.; Baig, N.; Zhou, T.; Gewirth, A.; Lu, Y.; Oldfield, E.; Zimmerman, S. C.; A Highly Efficient Single-chain Metal-organic Nanoparticle Catalyst for Alkyne-azide “Click” Reactions in Water and in Cells. J. Am. Chem. Soc. 2016, 138, 11077. Li, J.; Feng, X.; Zhu, W.; Oskolkov, N.; Zhou, T.; Kim, B. K.; Baig, N.; McMahon, M. T.; Oldfield, E.; Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI. Chem. Eur. J. 2016, 22, 264-271. Zhang, L.; Chen, C.-C.; Ko, T.-P.; Huang, J.-W.; Zheng, Y.; Liu, W.; Wang, I.; Malwal, S. R.; Feng, X.; Wang, K.; Huang, C.-H.; Hsu, S.-T. D.; Wang, A. H. J.; Oldfield, E.; Guo, R.-T.; Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5. Angew. Chem. Int. Ed. 2016, 55, 4716-4720. Liu, M.; Chen, C.-C.; Chen, L.; Xiao, X.; Zheng, Y.; Huang, J.-W.; Liu, W.; Ko, T.-P.; Cheng, Y.-S.; Feng, X.; Oldfield, E.; Guo, R.-T.; Ma, Y.; Structure and Function of a “Head-to-Middle” Prenyltransferase: Lavandulyl Diphosphate Synthase. Angew. Chem. Int. Ed. 2016, 55, 4721-4724. Feng, X.; Zhu, W.; Schurig-Briccio, L. A.; Lindert, S.; Shoen, C.; Hitchings, R.; Li, J.; Wang, Y.; Baig, N.; Zhou, T.; Kim, B. K.; Crick, D. C.; Cynamon, M.; McCammon, J. A.; Gennis, R. B.; Oldfield, E.; Antiinfectives Targeting Enzymes and the Proton Motive Force. Proc. Natl. Acad. Sci. USA 2015, 112, E7073-E7082. Hu, Y.; Liu, W.; Malwal, S. R.; Zheng, Y.; Feng, X.; Ko, T.-P.; Chen, C.-C.; Xu, Z.; Liu, M.; Han, X.; Gao, J.; Oldfield, E.; Guo, R.-T.; Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD+, NADPH, or NAD+/10-Oxogeranial: Reaction Mechanisms. Angew. Chem. Int. Ed. 2015, 54, 15478-15482. Bai, Y.; Xing, H.; Wu, P.; Feng, X.; Hwang, K.; Lee, J. M.; Phang, X. Y.; Lu, Y.; Zimmerman, S. C.; Chemical Control over Cellular Uptake of Organic Nanoparticles by Fine Tuning Surface Functional Groups. ACS Nano 2015, 9, 10227-10236. Kim, M. O.; Feng, X.; Feixas, F.; Zhu, W.; Lindert, S.; Bogue, S.; Sinko, W.; de Oliveira, C.; Rao, G.; Oldfield, E.; McCammon, J. A.; A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery. Chem. Biol. Drug Des. 2015, 85, 756-769. Han, X.; Chen, C.-C.; Kuo, C.-J.; Huang, C.-H.; Zheng, Y.; Ko, T.-P.; Zhu, Z.; Feng, X.; Wang, K.; Oldfield, E.; Wang, A. H. J.; Liang, P.-H.; Guo, R.-T.; Ma, Y.; Crystal Structures of Ligand-bound Octaprenyl Pyrophosphate Synthase from Escherichia coli Reveal the Catalytic and Chain-length Determining Mechanisms. Proteins 2015, 83, 37-45. Oldfield, E.; Feng, X.; Resistance-resistant Antibiotics. Trends Pharmacol. Sci. 2014, 35, 664-674. Feng, X.; Hu, Y.; Zheng, Y.; Zhu, W.; Li, K.; Huang, C.-H.; Ko, T.-P.; Ren, F.; Chan, H.-C.; Nega, M.; Bogue, S.; López, D.; Kolter, R.; Götz, F.; Guo, R.-T.; Oldfield, E.; Structural and Functional Analysis of Bacillus subtilis YisP Reveals a Role of Its Product in Biofilm Production. Chem. Biol. 2014, 21, 1557-1563. Liu, W.; Feng, X.; Zheng, Y.; Huang, C.-H.; Nakano, C.; Hoshino, T.; Bogue, S.; Ko, T.-P.; Chen, C.-C.; Cui, Y.; Li, J.; Wang, I.; Hsu, S.-T. D.; Oldfield, E.; Guo, R.-T.; Structure, Function and Inhibition of ent-kaurene Synthase from Bradyrhizobium japonicum. Sci. Rep. 2014, 4, 6214. Li, K.; Schurig-Briccio, L. A.; Feng, X.; Upadhyay, A.; Pujari, V.; Lechartier, B.; Fontes, F. L.; Yang, H.; Rao, G.; Zhu, W.; Gulati, A.; No, J. H.; Cintra, G.; Bogue, S.; Liu, Y.-L.; Molohon, K.; Orlean, P.; Mitchell, D. A.; Freitas-Junior, L.; Ren, F.; Sun, H.; Jiang, T.; Li, Y.; Guo, R.-T.; Cole, S. T.; Gennis, R. B.; Crick, D. C.; Oldfield, E.; Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases. J. Med. Chem. 2014, 57, 3126-3139. Chan, H.-C.; Feng, X.; Ko, T.-P.; Huang, C.-H.; Hu, Y.; Zheng, Y.; Bogue, S.; Nakano, C.; Hoshino, T.; Zhang, L.; Lv, P.; Liu, W.; Crick, D. C.; Liang, P.-H.; Wang, A. H. J.; Oldfield, E.; Guo, R.-T.; Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis. J. Am. Chem. Soc. 2014, 136, 2892-2896. Ren, F.; Feng, X.; Ko, T.-P.; Huang, C.-H.; Hu, Y.; Chan, H.-C.; Liu, Y.-L.; Wang, K.; Chen, C.-C.; Pang, X.; He, M.; Li, Y.; Oldfield, E.; Guo, R.-T.; Insights into TIM-Barrel Prenyl Transferase Mechanisms: Crystal Structures of PcrB from Bacillus subtilis and Staphylococcus aureus. ChemBioChem 2013, 14, 195-199. No, J. H.; de Macedo Dossin, F.; Zhang, Y.; Liu, Y.-L.; Zhu, W.; Feng, X.; Yoo, J. A.; Lee, E.; Wang, K.; Hui, R.; Freitas-Junior, L. H.; Oldfield, E.; Lipophilic Analogs of Zoledronate and Risedronate Inhibit Plasmodium Geranylgeranyl Diphosphate Synthase (GGPPS) and Exhibit Potent Antimalarial Activity. Proc. Natl. Acad. Sci. 2012, 109, 4058-4063. Ren, F.; Ko, T.-P.; Feng, X.; Huang, C.-H.; Chan, H.-C.; Hu, Y.; Wang, K.; Ma, Y.; Liang, P.-H.; Wang, A. H. J.; Oldfield, E.; Guo, R.-T.; Insights into the Mechanism of the Antibiotic-synthesizing Enzyme Moeo5 from Crystal Structures of Different Complexes. Angew. Chem. Int. Ed. 2012, 51, 4157-4160.