研究领域

Application of organic chemistry to problems in biology. The chemistry of bacterial signaling. Isolation and structure determination of new signaling molecules/synthesis of the signals and analog structures/and evaluation of their biological activity.

Application of organic chemistry to problems in biology. The chemistry of bacterial signaling. Isolation and structure determination of new signaling molecules, synthesis of the signals and analog structures, and evaluation of their biological activity.

近期论文

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M. F. Semmelhack, in "The Encyclopedia of Inorganic Chemistry," Organometallic Section, Chapter 31., C. M. Lukehart, ed., John Wiley, New York, 1996. "Organic Synthesis: Transition Metal Complexes Containing Pi-Bonded Ligands." M. F. Semmelhack and H.-G. Schmalz, Tetrahedron Lett., 37, 3089 (1996); "Asymmetric Induction in The Nucleophiile Addition to h 6-Arene-Tricarbonyl-Chromium(0) Complexes." M. F. Semmelhack, Yansong Gu, and D. M. Ho, Tetrahedron Lett., 38, 5583 (1997). "A New Framework for the Cycloaromatization of Enediynes Under Mild Conditions." M. F. Semmelhack, G. Hilt, and J. H. Colley, Tetrahedron Lett., 39, 7683 (1998). "S NAr Reactions with Fluoroarene-Cr(CO) 2L Complexes, where L is a Potential Linker Ligand for Solid Phase Synthesis." M. F. Semmelhack and P. Shanmugam, Tetrahedron Lett., 41, 3567 (2000). "Development of an Approach to the Synthesis of the Plakortones." Semmelhack, M. F.; Sarpong, R. Abs. Am. Chem. Soc., 2000, 219, p 76-MEDI. "Kinetics of Rearrangment of a Model Enediyne." Semmelhack, M. F.; Hilt, G. Syn. Lett., 2000, 1127. "Selective Functionalization of an Isodurene-Cr(CO) 3 Complex. Semmelhack, M. F.; Jiang, Yu; and Ho, Douglas , Org. Lett. 2001, 3, 2403. "Synthesis of the Amino Sugar from C-1027" Semmelhack, M. F.; Chlenov, A.; Wu, Lingyun, J. Am Chem. Soc., 2001, 123, 8438. "Accelerated Arene Ligand Exchange in AreneCr(CO) 3 Complexes." Semmelhack, M. F.; Lindenschmidt, A.; Ho, D. M. Organometallics, 2001, 20, 4114. "Preparation and Structure of Chiral Carbene Complexes of manganese and Iron from Terminal alkynes." Semmelhack, M. F.; Sarpong, R.; Bergman, J. Ho, D. M. Tetrahedron Lett., 2002, 43, 541. "Evaluation of Alkene isomerization as a Trigger for enediyne Activation." Kipp, R. A.; Case, M. A.; Wist, A. D.; Cresson, C. M.; Carrel, M.; Griner, E.; Wiita, A.; Albiniak, P. A.; Chai, J.; Shi, Y.; Semmelhack, M. F.; McLendon, G. L. Biochem. 2002, 41, 7344-7349. "Molecular Targeting of Inhibitor of Apoptosis Proteins Based on Small Molecule Mimics of Natural Binding Partners." Semmelhack, M. F.; Jaskowski, M.; Sarpong, R.; Ho, D. M. Tetrahedron Lett. 2002, 43, 4947-4950. "A Simple Synthesis and Evaluation of the Bicyclo[8.3.0] Enediyne Framework." Semmelhack, M. F.; Hooley, R. J. Tetrahedon Lett.,2003, 44, 5737-5739. “Palladium-Catalyzed Hydrostannylations Of Highly Hindered Acetyolenes In Hexane.” Semmelhack, M. F.; Wu, Lingyun; Pascal, R. P.; Ho, Douglas M. J. Am. Chem. Soc., 2003, 125, 10496-10497 “Conformational Control in Activation of an Enediyne.” Semmelhack, M. F.; Campagna, S. r.; Hwa, C.; Federle, M. J.; Bassler, B. L. Org. Lett., 2004, 6, 2635-2637. “Boron Binding with the Quorum Sensing Signal AI-2 and Analogues.” Semmelhack, M. F.; Sarpong, R. J. Phys. Org. Chem., 2004, 17, 807-813. “Kinetic Analysis of a Reactive Model Enediyne.” Miller, S. T.; Xavier, K. B.; Campagna, S. R.; Taga, M. E.; Semmelhack, M. F.; Bassler, B., L.; Hughson, F. M. Molecular Cell, 2004, 15, 677-687. “Salmonella typhimurium Recognizes a Chemically Distinct Form of the Bacterial Quorum-Sensing Signal AI-2.” Semmelhack, M. F.; Chlenov, A. “AreneCr(CO) 3 Complexes: Arene Lithiation/Rea ction with Electrophiles.” in “Transition Metal Arene Pi Complexes in Organic Synthesis and Catalysis.” Kundig, E. P. ed.; Springer-Verlag, Berlin, 2004, pp 21-42. Semmelhack, M. F.; Chlenov, A. “AreneCr(CO) 3 ComplexesAromatic Nucleophilic Substitution.” in “Transition Metal Arene Pi Complexes in Organic Synthesis and Catalysis.” Kundig, E. P. ed.; Springer-Verlag, Berlin, 2004, pp 43-70.