Santra, Swadeshmukul - University of Central Florida

个人简介

1993 – 1998 Indian Institute of Technology (IIT) Kanpur, Kanpur, India PhD in Chemistry 1990 – 1992 University of Kalyani, West Bengal, India M. Sc. in Physical Chemistry 1987 – 1990 Vidyasagar University (Tamluk College), West Bengal, India B. Sc. in Chemistry D. AWARDS & PROFESSIONAL ACTIVITIES • Research Fellowship, Indian Institute of Technology Kanpur, India • Research Fellowship, Council of Scientific and Industrial Research, India • Member- American Chemical Society (ACS) • Member-American Vacuum Society (AVS) • Member- American Association for the Advancement of Science (AAAS)

研究领域

Research in nanobioimaging, cancer imaging and therapy, stroke biomarker detection, stem cell tracking, drug delivery, pathogen detection, nanotoxicity evaluation. To learn more, please visit the Group Webpage: http://www.nanoscience.ucf.edu/santra/ Real time noninvasive monitoring of biological processes such as stem cell tracking, cancer diagnosis, gene expression studies etc. requires highly sensitive probes, preferably with multimodal bioimaging capabilities. Conventional organic fluorescent dye or green fluorescent protein based labels are not suitable as they suffer from notorious shortcomings in photostability and lack of multimodal bioimaging capabilities. Therefore, there is certainly a need for developing engineered nanoparticle probes for real time, non-invasive and ultrasensitive bioimging. My primary goal is to develop an interdisciplinary research program on nanobioimaging and sensing at the University of Central Florida. Projects in my group will primarily be focused on the design and synthesis of various nanoparticle based contrast agents such as fluorescent nanoparticles, radio-opaque nanoparticles, magnetic nanoparticles, biocompatible and biodegradable multifunctional particles, nanoparticle sensors for probing gene expression, stem cell differentiation and other cellular functions both in vitro and in vivo. Recently we have developed multimodal quantum dots that are fluorescent, radio-opaque and paramagnetic (http://pubs3.acs.org/acs/journals/doilookup?in_doi=10.1021/ja0464140). With appropriate surface modification, we have successfully delivered them to rat brain tissue without compromising the blood-brain-barrier (http://www.rsc.org/publishing/journals/CC/article.asp?doi=b503234b). This research demonstrated our strength of making useful nanoparticles that have potential for pre-operative diagnosis of brain tumors by MR and/or CT scanning and intra-operative surgical guidance for tumor resection by direct visualization of nanoparticle fluorescence.

近期论文

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Banerjee S, Santra S*, “Remarkable catalytic activity of silica nanoparticle in the bis-Michael addition of active methylene compounds to conjugated alkenes”, Tetrahedron Letters, 2009, 50(18), 2037-2040. Banerjee S, Kar S*, Perez, J. M., Santra S*, “Quantum dot based OFF/ON probe for detection of glutathione”, Journal of Physical Chemistry C, 2009, 113 (22), 9659-9663. Kar S, Patel C, Santra S*, “Direct Room Temperature Synthesis of Valence State Engineered Ultra-Small Ceria Nanoparticles: Investigation on the Role of Ethylenediamine as a Capping Agent”, Journal of Physical Chemistry C, 2009, 113 (12), 4862-4867. Biswas S, Kar S, Santra S*, Jompol Y, Arif M, Khondaker SI, “Solvothermal synthesis of high-aspect ratio alloy semiconductor nanowires: Cd1-xZnxS, a case study, Journal of Physical Chemistry C, 2009, 113(9), 3617-3624. Tallury P, Kar S, Bamrungsap S, Huang YF, Tan WH, Santra S*, “Ultra-small water-dispersible fluorescent chitosan nanoparticles: synthesis, characterization and specific targeting”, Chemical Communications, 2009, (17), 2347-2349. Banerjee S, Das J, Santra S*, “Native silica nanoparticle catalyzed anti-Markovnikov addition of thiols to inactivated alkenes and alkynes: a new route to linear and vinyl thioethers”, Tetrahedron Letters, 50(1), 124-127, 2009. Banerjee S, Kar S, Santra S*, “A simple strategy for quantum dot assisted selective detection of cadmium ions” Chemical Communications, (26), 3037-3039, 2008. Sharma P, Brown SC, Bengtsson N, Zhang QZ, Walter GA, Grobmyer SR, Santra S, Jiang HB, Scott EW, Moudgil BM, “Gold-Speckled Multimodal Nanoparticles for Noninvasive Bioimaging”, Chemistry of Materials, 20(19), 6087-6094, 2008. Tallury P, Payton K and Santra S*, “Silica-based multimodal/multifunctional nanoparticles for bioimaging and biosensing applications” Nanomedicine, 3(4), 579-592, 2008. Kar S, Santra S*, Chaudhuri S, “Direct Synthesis of Indium Nanotubes from Indium Metal Source” Crystal Growth and Design, 8(1), 344-346, 2008. Santra, Swadeshmukul CV 4 4 Kar S, Santra S*, Chaudhuri S, “ZnO nanotube arrays and nanotube-based paint-brush structures: A simple methodology of fabricating hierarchical nanostructures with self-assembled junctions and branches” Journal of Physical Chemistry C, 112(22), 8144-8146, 2008. Kar, S., S. Santra*, and H. Heinrich, “Fabrication of high aspect ratio core-shell CdS-Mn/ZnS nanowires by a two step solvothermal process”, Journal of Physical Chemistry C, 112(11), 4036-4041, 2008. Kar S, Santra S*, Chaudhuri S, “Direct Synthesis of ZnS Nanoribbons, Micro-sheets and Tetrapods”, Journal of Nanoscience and Nanotechnology, 8(6), 3222-3227, 2008. Bera D, Qian L, Sabui S, Santra S, Holloway P. H., “Photoluminescence of ZnO quantum dots produced by a sol–gel process”, Optical Materials, 30(8), 1233-1239, 2008. Sharma P, Brown S. C., Walter G, Santra S, Scott E, Ichikawa H, Fukumori Y, Moudgil B. M., “Gd nanoparticulates: from magnetic resonance imaging to neutron capture therapy”, Advanced Powder Technology, 18 (6), 663-698, 2007. Yang H, Santra S*, Walter G. A. and Holloway P. H., “GdIII-functionalized fluorescent quantum dots for multimodal imaging probes”, Advanced Materials, 18, 2890-2894, 2006. Wang L. Wang K. Santra S., Zhao X., Hilliard L. R., Smith J., Tan W. “Watching Silica Nanoparticles Glow in the Biological World”, Analytical Chemistry, 78(3), 646-654, 2006 (featured article). Mericle RA, Richter EO, Eskioglu E, Watkins C, Prokai L, Batich CD and Santra S, “Preoperative endovascular brain mapping for intraoperative volumetric image guidance: preliminary concept and feasibility in animal models”, Journal of Neurosurgery, 104, 566-573, 2006. Mericle RA, Reig AS, Burry MV, Eskioglu E, Firment CS, Santra S, “Endovascular surgery for proximal PICA aneurysms combined with early and aggressive treatment of hydrocephalus: Many patients with poor Hunt-Hess grades can have good outcomes”, Neurosurgery, 58(4), 619-625, 2006. Sharma P, Brown S, Walter GA, Santra S. Moudgil BM, “Nanoparticles for bioimaging”, Advanced Colloid and Interface Sciences, 123-126, 471-485, 2006.