Perez, Manuel - University of Central Florida

个人简介

Ph.D. Degree: Boston University, Boston, MA M.S. Degree: University of Puerto Rico, Mayaguez, PR Chemistry, 1990. B.S. Degree: University of Puerto Rico, Mayaguez, PR Chemistry, 1986. Awards and Honors: 2004 Outstanding Presentation, AACR Conference on The Role of Telomeres and Telomerase in Cancer, San Francisco, CA. 2003 NCI-Career Development Award (KO1) 2002 Magnetic Microsphere Society Travel Award (4th International Conference on the Scientific and Clinical Application of Magnetic Carriers, Tallahassee Fl.) 2002 AACR Minority Scholar in Cancer Research Travel Award (Molecular Imaging in Cancer; Linking Biology, Function and Clinical Application) 2001-03 NCI-Postdoctoral Grant Supplement Recipient 1994-97 NIH Molecular Biophysics Training Fellow (Predoctoral) 1984 Puerto Rico Board of Chemists Award February, 2010: Dr. Perez’s Ceria Nanoparticle research highlighted in C&EN and appears as a cover in Angewandte Chemie Int’l Edition Congratulations to Dr. J. Manuel Perez and his group for their recent paper in Angewandte Chemie titled “Oxidase-like activity of polymer coated cerium oxide nanoparticles.” In this paper, the authors report the use of cerium oxide nanoparticles as a versatile aqueous redox catalyst that can oxidize a series of compounds without the need of hydrogen peroxide. This finding can be used in the design of simpler and less expensive immunoassays to detect cancer cells and potentially bacteria. This work is featured in the Communication’s cover of the journal and also in the Science and Technology Concentrate section of the February 16 edition of Chemical and Engineering News (C&EN). February, 2010: Congratulations to Dr. J. Manuel Perez (joint Chemistry appointment) who just received word that his National Institute of Health (NIH) R01 project titled An integrated NMR/magnetic nanosensor system for detection of bacteria and toxins will be awarded. This NIH/NIGMS R01 will provide over $800,000 over the four years of this project to address this crucial topic. This project will address the need for point-of-care, field-based analysis for water- and food-borne toxins and bacteria that cause diseases.

研究领域

In my laboratory, graduate students will be exposed to a cutting-edge multidisciplinary experience that will involve chemistry, material sciences, nanotechnology, biochemistry and biomedical research. Upon completing training in my laboratory, the doctoral candidate will be an individual with an excellent knowledge in one of the above areas and a good general knowledge in the others. This combination will result in well-rounded scientist that will be well-equipped to perform independent research in the future.

近期论文

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Kaittanis C., Santra, S., Perez J.M. Role of Nanoparticle Valency in the Nondestructive Magnetic-Relaxation-Mediated Detection and Magnetic Isolation of Cells in Complex Media, J. Am. Chem. Soc. 2009, 131, 12780-12791 Ma, L., Hong, Y., Ma, Z., Kaittanis, C., Perez, J. M. Su, M. Multiplexed highly sensitive detections of cancer biomarkers in thermal space using encapsulated phase change nanoparticles, Appl. Phys.Lett. 2009, 95, 043701, online. Banerjee, S., Kar, S., Perez, J. M., Santra, S. Quantum Dot-Based OFF/ON Probe for Detection of Glutathione, J. Phys. Chem. C. 2009, 113, 9659-9663 Santra, S., Kaittanis C., Grimm J. and Perez J.M. Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/MR-Imaging, Small 2009, 5, 1862-1868 Nath, S., Kaittanis, C., Ramachandran V., Dalal. N.S., Perez, J.M. Synthesis, magnetic characterization and sensing applications of novel dextran-coated iron oxide nanorods. Chem. Mat. 2009, 21, 1761-1767 Asati, A., Santra S., Kaittanis, C, Nath S. Perez, J.M. Oxidase-like activity of polymer-coated cerium oxide nanoparticles, Angew.Chem.Int.Ed. 2009, 48, 2308-2312 Kaittanis, C., Nath, S., Perez J.M. Rapid nanoparticle-mediated monitoring of bacterial metabolic activity and assessment of antimicrobial susceptibility in blood with magnetic relaxation, PLOS One 2008, 3(9), e3253 Perez J.M. Grimm, J, Josephson, L, Weissleder, R. Integrated nanosensors to determine levels and functional activity of human telomerase, Neoplasia 2008, 10, 1066-1072 Perez, J.M., Asati, A., Nath, S., Kaittanis, A. Synthesis of biocompatible dextran-coated nanoceria with pH-dependent antioxidant properties, Small 2008, 4, 552-556 Nath, S., Kaittanis, C., Tinkham, A., Perez J.M. Dextran coated gold nanoparticles for the assessment of antimicrobial susceptibility, Anal. Chem 2008, 80, 1033-1038 Kaittanis, C., Saleh, A. N., Perez J.M. One-step, nanoparticle-mediated Bacterial Detection with Magnetic Relaxation, NanoLetters 2007, 7, 380-383 Rabin, O*., Perez, J.M*., Grimm, J., Wojtkiewicz, G., Weissleder, R. An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles, Nature Mat.2006, 5, 118-122 J. Manuel Perez - page 6 McCarthy, J.R.*, Perez, J.M. *, Bruckner C, Weissleder, R. Polymeric Nanoparticle Preparation that Erradicate Tumors, NanoLetters 2005, 5, 2552-2556 * Contributed equally Tsorkas, A., Newton, G., Perez, J.M., Basilion, J.P., Weissleder, R. Detection of Peroxidase/H2O2-Mediated Oxidation with Enhanced Yellow Fluorescenct Protein, Anal. Chem. 2005, 77, 2862-2867. Perez, J.M., Simeone, F.J., Tsourkas, A., Josephson, L, Weissleder, R. Peroxidase substrate nanosensors for MR imaging, NanoLetters, 2004, 4, 119-122. Grimm, J., Perez, J.M., Josephson, L; Weissleder, R. Novel nanosensor for rapid analysis of telomerase activity, Cancer Research 2004; 64, 639-643. Perez, J.M., Simeone, F.J., Josephson, L; Weissleder, R. Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media, J. Amer. Chem. Soc., 2003; 125:10192-10193. Perez, J.M., Josephson, L, O’Loughin,T., Hogemann, D., Weissleder, R. Magnetic relaxation switches capable of sensing molecular interactions, Nature Biotech., 2002; 20:816-820. Perez, J.M., O’Loughin,T., Simeone, F.J., Weissleder, R., Josephson, L. DNA-based Magnetic Nanoparticle Assembly Acts as Magnetic relaxation Nanoswitch Allowing Screening of DNA Cleaving Agents, J. Amer. Chem. Soc., 2002; 124:2856-2857. Perez, J.M., Josephson, L, Weissleder. Magnetic Nanosensors for DNA Analysis, Eur. Cells and Mater., 2002, 3 (suppl. 2):181-182.