王良 - 南开大学

个人简介

2011.6 获山东大学理学学士学位 2011.9-2013.9 南开大学药学院药物化学专业硕转博（导师：陈悦） 2013.9-2016.7 南开大学化学学院有机化学专业博士（导师：汤平平） 2016.7-2018.12 南开大学药学院讲师 2018.12-2020.10 南开大学药学院副教授 2020.10-今南开大学化学学院副教授国家自然科学基金青年项目：低氧靶向的抗胰腺癌天然产物BE-43547A2的构效关系研究 2018.1-2020.12 主持国家自然科学基金面上项目：抗胰腺癌天然产物majusculamide D的构效关系研究2021.1-2024.12 主持

研究领域

1、复杂抗癌天然产物的全合成 2、基于复杂天然产物结构的药物化学 3、基于复杂天然产物靶点的药物化学

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Bolin Chen, Qianwei Wu, Dongdong Xu, Xijing Zhang, Yahui Ding, Shiqi Bao, Xuemei Zhang, Liang Wang,* Yue Chen.* A Two-phase Approach to Fusicoccane Synthesis to Uncover a Compound That Reduces Tumourigenesis in Pancreatic Cancer Cells. Angew. Chem. Int. Ed. 2022, 61, e202117476. Jianshuang Guo, Juanjuan Li, Zehan Wang, Yang Liu, Yuxin Yue, Huabin Li, Xiuhe Zhao, Yuanjun Sun, Yahui Ding, Fei Ding, Dongsheng Guo,* Liang Wang,* Yue Chen. Dual Hypoxia-Responsive Supramolecular Complex for Cancer Target Therapy. Nat. Comm. 2023, 5634. Sen Zhang, Songming Zhang, Yunlong Fan, Xuhan Zhang, Jing Chen, Chaofan Jin, Sisi Chen, Liang Wang,* Quan Zhang,* Yue Chen.* Total Synthesis of the Proposed Structure of Neaumycin B. Angew. Chem. Int. Ed. 2023, e202313186. Junhong Xiang, Yahui Ding,* Jiaxin Li, Xiuhe Zhao, Yuanjun Sun, Da Wang, Liang Wang,* Yue Chen.* Ovatodiolides: Scalable Protection-Free Syntheses, Configuration Determination and Biological Evaluation against Hepatic Cancer Stem Cells. Angew. Chem. Int. Ed. 2019, 58, 10587-10590. Can Liu, Liang Wang,* Yuanjun Sun, Xiuhe Zhao, Tianyang Chen, Xiuwen Su, Hui Guo, Qin Wang, Xiaonan Xi, Yahui Ding,* Yue Chen.* Probe Synthesis Reveals Eukaryotic Translation Elongation Factor 1 Alpha 1 as the Anti-Pancreatic Cancer Target of BE-43547A2. Angew. Chem. Int. Ed. 2022, 61, e202206953. Yuanjun Sun#, Yahui Ding#, Dongmei Li, Ruifei Zhou, Xiuwen Su, Juan Yang, Xiaoqian Guo, Chuanke Chong, Jinghan Wang, Weicheng Zhang, Cuigai Bai, Liang Wang,* Yue Chen.* Cyclic Depsipeptide BE-43547A2: Synthesis and Activity against Pancreatic Cancer Stem Cells. Angew. Chem. Int. Ed. 2017, 56, 14627-14631. Liang Wang, Hengtao Wang, Yi Hang Li, and Pingping Tang*, Total Synthesis of Schilancitrilactones B and C. Angew. Chem. Int. Ed. 2015, 54, 5732. Bolin Chen, Xijing Zhang, Yufen Yang, Dongdong Xu, Qianwei Wu, Shibo Wang, Shiqi Bao, Xuemei Zhang, Yahui Ding,* Liang Wang,* Yue Chen.* Hypocretenolides: Collective Total Syntheses and Activities toward Metastatic Colon Cancer, Chem. Sci. 2024, 15, 6397-6401. Yingjun Cui, Mengyi Zhang, Honglei Xu, Tingrong Zhang, Songming Zhang, Xiuhe Zhao, Peng Jiang, Jing Li,* Baijun Ye, Yuanjun Sun, Mukuo Wang, Yangping Deng, Qing Meng, Yang Liu, Qiang Fu, Liang Wang,* Yue Chen.* Elastase Inhibitor Cyclotheonellazole A: Total Synthesis and In Vivo Biological Evaluation for Acute Lung Injury. J. Med. Chem. 2022, 65, 2971-2987. Jinghan Wang, Beijia Kuang, Xiaoqian Guo, Jianwei Liu, Yahui Ding, Jiangnan Li, Shende Jiang, Ying Liu, Fang Bai, Luyuan Li, Quan Zhang, Xiao-Yu Zhu, Bo Xia, Chun-Qi Li, Liang Wang,* Guang Yang,* Yue Chen.* Total Syntheses and Biological Activities of Vinylamycin Analogs. J. Med. Chem. 2017, 60, 1189-1209.