邓力 - 西湖大学 - 浙江西湖高等研究院

个人简介

邓力，国际知名有机合成化学家，有机催化领域的创始者和引领者之一。现任西湖大学徐益明讲席教授、副校长、校学术委员会主任、理学院执行院长。邓力教授于清华大学获得理学学士学位（1987），威斯康星大学密尔沃基分校获得硕士学位（1990），在哈佛大学师从Eric. Jacobsen教授，获得博士学位（1995）。随后，获得美国癌症协会博士后奖学金，在哈佛大学George M. Whitesides和Gregory L. Verdine课题组从事博士后研究。1998年，受聘为美国布兰迪斯大学（Brandeis University）助理教授并开始独立研究。2003年，晋升为副教授并获得终身教职。2005年，晋升为教授和终身讲席教授（Orrie Friedman Distinguished Professor），曾在2011-2014年期间担任化学系主任。2018年7月，邓力教授全职加入西湖大学。

研究领域

邓力教授自1998年以来一直致力于有机小分子催化反应及机理研究，以及相关反应在有机合成中的应用，并取得了原创而系统性的重要学术成果。国际同行公认其为不对称有机催化领域的开创者和引领者之一。在该领域，邓力教授有关弱键有机催化的系统性研究产生了广泛影响。其建立的新概念和策略，被世界各地高校及实验室广泛应用到开发多种新型催化剂和新反应的过程中。邓力教授团队研究开发的众多新催化剂及反应大量应用于学术界及工业界的化学合成，并且已授权给知名试剂、制药和化学公司开发和使用。

近期论文

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Gao, Y.-H.; Zeng, Y.-Q.; Deng, T.-R.; Deng, Y.; .Cheng, C.; Luo,J.-S.; Deng, L.* "Catalytic Asymmetric Synthesis of Chiral α,α-Dialkyl Aminonitriles via Reaction of Cyanoketimines".J. Am. Chem. Soc. 2024, 146, 18, 12329–12337 Catalytic Asymmetric Construction of Chiral Amines with Three Nonadjacent Stereocenters via Trifunctional Catalysis Cheng Cheng, Yang Yu, Yuhong Gao, Yipan Li, Xianglei Han, Jisheng Luo, Li Deng.J.Am.Chem.Soc.2024, Doi.org/10.1021/jacs.4c01671 https://pubs.acs.org/doi/10.1021/jacs.4c01671 Deoxygenative Nucleophilic Phosphonation and Electrophilic Alkylation of Secondary Amides: A Facile Access to Quaternary α-Aminophosphonates Jiaxiang Lu, Zhenghua Li, Li Deng.J. Am. Chem. Soc.2024, 146, 7, 4357–4362 https://pubs.acs.org/doi/10.1021/jacs.3c14517?ref=PDF Organocatalytic Asymmetric α-C-H Functionalization of Alkyl Amines Tianran Dengǂ, Xianglei Hanǂ, Cheng Cheng, Xiangyuan Liu, Yang Yu, Yuhong Gao, Zhenghua Li, Jisheng Luo and Li Deng (ǂco-first author) Preprint available at 10.26434/chemrxiv-2023-flm08 https://chemrxiv.org/engage/chemrxiv/article-details/6528ee4945aaa5fdbbea9276 Chiral Betaine-Mediated Efficient Organocatalytic Asymmetric Isomerization of b,y-Unsaturated Butenolides Yiqun Zeng, Chao Fei, Xiao Zhou, Jisheng Luo and Li Deng. Syn. Lett. 2023（Special Issue Dedicated to Prof. Hisashi Yamamoto） https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0042-1751496 Ni, D.; Hu, S.; Tan, X.; Yu, Y.; Li, Z.; Deng, L.* "Intermolecular Formal Cycloaddition of Indoles with Bicyclo[1.1.0]butanes by Lewis Acid Catalysis". Angew. Chem. Int. Ed. 2023, DOI: 10.1002/anie.202308606. Liu, X.-Y.; D, K.; Luo, J.;Deng, L.* "Chiral Betaines Mediated Asymmetric Peroxidation-Kinetic Resolution Cascade for the Synthesis of Optically Pure Peroxides". CCS Chem. 2023，DOI: 10.31635/ccschem.023.202302759 Wang, L.; Yu, Y.; Deng, L.; Du, K.* "Photochemical and Atom-Economical Sulfonylimination of Alkenes with Bifunctional N-Sulfonyl Ketimine"Org. Lett. 2023, 25, 13, 2349–2354 Han, X.-L.; Hu, B.; Fei, C.; Li, Z.; Yu, Y.; Cheng C.; Foxman, B.; Luo, J.; Deng, L.* Catalytic Asymmetric Imine Cross-coupling Reaction J. Am. Chem. Soc. 2023, 145, 4400–4407. Luo, J.*; Deng, Y.; Deng, T.; Deng, L.* "Catalytic Enantioconvergent Conjugate Addition of Organosilanes via a Strategy of Fluorodesilylation" J. Am. Chem. Soc. 2022, 144, 23264–23270. Deng, Y.; Shi, X.; Shi, G.; Lu, X.; Luo, J.*; Deng, L.* "One-step Asymmetric Construction of 1,4-Stereocenters via Tandem Mannich-Isomerization Reactions Mediated by a Dual-functional Betaine Catalyst" JACS Au. 2022, 2, 2678–2685. Li, Z.; Hu, B.; Wu, Y.; Fei, C.; Deng, L.* "Control of Chemoselectivity in Asymmetric Tandem Reactions: Direct Synthesis of Chiral Amines Bearing Non-adjacent Stereocenters" PNAS, 2018, 115, 1730–1735. Zhou, X.; Wu, Y.; Deng, L.* "Cinchonium Betaines as Efficient Catalysts for Asymmetric Proton Transfer Catalysis: The Development of a Practical Enantioselective Isomerization of Trifluoromethyl Imines" J. Am. Chem. Soc. 2016, 138, 12297–12302. Wu. Y.; Hu, L.; Li, Z.; Deng, L.* "Catalytic Asymmetric Umpolung Reactions of Imines" Nature 2015, 523, 445–450. Wu Y.; Deng, L.* "Asymmetric Synthesis of Trifluoromethylated Amines via Catalytic Enantioselective Isomerization of Imines" J. Am. Chem. Soc. 2012, 134, 14334–14337. Wu, Y.; Singh, R.; Deng, L.* "Asymmetric Olefin Isomerization via Proton Transfer Catalysis with an Organic Molecule" J. Am. Chem. Soc. 2011, 133, 12458–12461. Lu, X.; Liu, Y.; Sun, B.; Cindric, B.; Deng, L.* "Catalytic Enantioselective Peroxidation of -Unsaturated Ketones" J. Am. Chem. Soc. 2008, 130, 8134–8135 (Selected by editors for a "JACS Select collection" focused on organocatalysis).　 Wang, Y.; Li, H.; Wang, Y.-Q.; Liu, Y.; Foxman, B. M.; Deng, L.* "Asymmetric Diels-Alder Reactions of 2-Pyrones with Bifunctional Organic Catalysts" J. Am. Chem. Soc. 2007, 129, 6364–6365. Wang, B.; Wu, F.; Wang, Y.; Liu, X.; Deng, L.* "Control of Diastereoselectivity in Tandem Asymmetric Reactions Generating Nonadjacent Stereocenters with Bifunctional Catalysis by Cinchona Alkaloids" J. Am. Chem. Soc. 2007, 129, 768–769. Song, J.; Wang, Y.; Deng, L.* "The Mannich Reaction of Malonates with Simple Imines Catalyzed by Bifunctional Cinchona Alkaloids: Enantioselective Synthesis of β-Amino Acids" J. Am. Chem. Soc. 2006, 128, 6048–6049. Wu, F.-H.; Li, H.; Hong, R.; Deng, L.* "Construction of Quaternary Stereocenters via Efficient and Practical Conjugate Additions to α,β-Unsaturated Ketones with a Chiral Organic Catalyst" Angew. Chem. Int. Ed. 2006, 45, 947–950. Wang, Y.; Liu, X.; Deng, L.* "Dual-Function Cinchona Alkaloid Catalysis: Catalytic Asymmetric Tandem Conjugate Addition-Protonation for the Direct Creation of Nonadjacent Stereocenters" J. Am. Chem. Soc. 2006, 128, 3928–3930. Li, H.; Wang, B.; Deng, L.* "Enantioselective Nitroaldol Reaction of α-Ketoesters Catalyzed by Cinchona Alkaloids" J. Am. Chem. Soc. 2005, 128, 732–733. Li, H.; Song, J.; Liu, X.; Deng, L.* "Catalytic Enantioselective Conjugate Additions with Vinyl Sulfones" J. Am. Chem. Soc. 2005, 127, 8948–8949.　 Li, H.; Wang, Y.; Tang, L.; Wu, F.; Liu, X.; Guo, C.; Foxman, B.; Deng, L.* "Stereocontrolled Creation of Adjacent Quaternary and Tertiary Stereocenters via a Catalytic, Diastereoselective and Enantioselective Conjugate Addition" Angew. Chem. Int. Ed. 2004, 44, 105–108 (designated as a "Very Important Paper (VIP)" paper). Li, H.; Wang, Y.; Tang, L.; Deng, L.* "Highly Enantioselective Conjugate Addition of Malonate and β-Ketoester to Nitroalkenes: Asymmetric C-C Bond Formation via New Bifunctional Organic Catalysts Based on Cinchona Alkaloids" J. Am. Chem. Soc. 2004, 126, 9906–9907. Tian, S.-K.; Chen, Y.; Hang, J.; Tang, L.; McDaid, P.; Deng, L.* "Asymmetric Organic Catalysis with Modified Cinchona Alkaloids" Acc. Chem. Res. 2004, 37, 621–631 (invited contribution for a special issue of asymmetric organic catalysis). Tian, S.-K.; Hong, R.; Deng, L.* "Catalytic Asymmetric Cyanosilylation of Ketones with Chiral Lewis Base" J. Am. Chem. Soc. 2003, 125, 9900–9901. McDaid, P.; Chen, Y.; Deng, L.* "A Highly Enantioselective and General Conjugate Addition of Thiols to Cyclic Enones with an Organic Catalyst" Angew. Chem. Int. Ed. 2002, 41, 338–340. (Designated as a "Hot Paper"). Tian, S.-K.; Deng, L.* "A Highly Enantioselective Chiral Lewis Base-Catalyzed Asymmetric Cyanation of Ketones" J. Am. Chem. Soc. 2001, 123, 6195–6196. Chen, Y.; Tian, S.-K.; Deng, L.* "A Highly Enantioselective Catalytic Desymmetrization of Cyclic Anhydrides with Modified Cinchona Alkaloids" J. Am. Chem. Soc. 2000, 122, 9542–9543.