个人简介
EDUCATION
1999 Ph.D. Chemistry University of Miami, Coral Gables, Florida
1994 M.Sc. Chemistry Sun Yat-sen University, P.R. China
1991 B.Sc. Polymer Science University of Science and Technology of China, P.R. China
PROFESSIONAL EMPLOYMENT
2005-present Associate Professor University of Central Florida, Orlando, Florida
Joint appointments in: NanoScience Technology Center, Department of Chemistry,
Burnett School of Biomedical Sciences (School of Medicine), and Department of
Mechanics, Materials and Aerospace Engineering (College of Engineering)
2009-present President Nano Discovery Inc. Orlando, Florida
2001-2005 Assistant Professor North Dakota State University, Fargo, North Dakota
1999-2001 Postdoctoral Associate University of Miami, Coral Gables, Florida
HONORS AND AWARDS
2008-present National Institute of Health (NIH) panel review member
2010 Florida State University System, Scholar Boost Award
2010-present Associate Editor, Reviews in Nanoscience and Nanotechnology (RNN)
2008 Natural Science Foundation of China Oversea Young Investigator award
2006-present Associate Editor, Colloids and Surfaces B: Biointerfaces (Elsevier)
2006 US-Japan Young Researcher Exchange Program for Nanotechnology and
Nanomanufacturing delegation team (NSF and Japanese Ministry of Education,
Culture, Sports, Science, and Technology (total 14 members from USA, selected by
NSF program officers)
2005 National Science Foundation NIRT award (PI)
2003 National Science Foundation CAREER award (PI)
研究领域
We are a nanomaterial chemistry group who specializes in the synthesis, property studies and application development of nanoparticle materials. In the bottom-up approach towards nanomaterial development, there are two most important issues to be addressed: one is the synthesis of nanobuilding blocks and the other one is how to assemble the nanobuilding blocks together into materials or devices with expected structures, properties and functions. The property of a nanomaterial is not only dependent on nanobuilding blocks alone, but also determined by the architectural organization of nanobuilding blocks. Therefore, it is extremely important to achieve a precise control on both the chemical structures of individual nanoparticles and the architectural structures of the assembled nanoparticle materials.
Currently we have two major research projects: the first one is controlled chemical functionalization of nanoparticles and the second one is to study their applications in the development of nanoparticle/polymer hybrid materials with well-defined architectural structures and properties. Our group developed a solid phase chemistry method to prepare nanoparticles with single functional groups. Using these molecular nanobuilding blocks, we can synthesize sophisticated nanoparticle/polymer hybrid materials such as “nanonecklace”, “nanochains” and “nanoctopus”. These materials provide excellent opportunities for one to probe and study the inter-nanoparticle interactions in a highly controlled fashion from different dimensions. The long-term goal of these studies is aimed for the development nanomaterials with superior optical, electrical and thermal properties compared to conventional bulky materials.
Our group is the first one to report a unique solid phase approach to synthesize nanoparticles with a single functional group attached to the surface. Such nanoparticle materials are then used as molecular nanobuilding blocks to react with themselves or other chemicals to form sophisticated materials with predefined structures, just like the total chemical synthesis of natural product from small molecular units. This approach gives an unprecedented high level of control on the nanomaterial structures and properties. Our work published in Chemical Communications was listed as top ten most accessed articles in February 2004.
Using the molecular nanoparticles along with other nanomaterials developed in our research, we are developing polymer composite and hybrid materials with improved optical, thermal, electrical and mechanical properties. Our study addresses important problems and questions in composite field, such as the dispersion and adhesion of nanofillers with polymer matrix, interparticle interactions, and the long-term stability of the nanocomposites materials. As a material chemistry group, we use our expertise in synthetic chemistry and surface chemistry to modify both nanofillers and polymer matrix to develop systems with best performance and properties.
Currently our research is being supported by two National Science Foundation awards, CAREER award from DMR (0239424) and an NIRT award from DMI (0506531).
近期论文
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Huo, Q.; Litherland, S.A.; Sullivan, S.; Hallquist, H.; Decker, D.A.; Rivera-Ramirez, I. Developing a nanoparticle test for prostate cancer scoring. J. Translational Medicine, 2012, published online.
Jans, H.; Huo, Q. Gold nanoparticle-enabled biological and chemical detection and analysis. Chem. Soc. Rev. 2011, published online (DOI: 10.1039/C1CS15280G).
Huo, Q.; Cordero, A.; Bogdanovic, J.; Colon, J.; Baker, C.H.; Goodison, S.; Pensky, M. A facile nanoparticle immunoassay for cancer biomarker discovery. J. Nanobiotechnology, 2011, 9:20 (Open Access).
Jaganathan, S.; Yue, P.; Paladino, D.C.; Bogdanovic, J.; Huo, Q.; Turkson, J. A functional nuclear epidermal growth factor receptor, Src and Stat3 heteromeric complex in pancreatic cancer cells. PLoS One, 2011, 6(5):e19605 (Open Access).
Chen, H.; Chunder, A.; Liu, X.; Haque, F.; Zou, J.; Austin, L.; Knowles, G.; Zhai, L.; Huo, Q. A multifunctional gold nanoparticle/polyelectrolyte fibrous nanocomposite prepared from electrospinning process. Materials Express 2011, 1, 154-159.
Li, S.; Li, J.; Wang, K.; Wang, C.; Xu, J.; Chen, H.; Xia, X.; Huo, Q. A nanochannel array-based electrochemical device for quantitative label-free DNA analysis. ACS Nano 2010, 4, 6417-6424.
Jans, H.; Jans, K.; Lagae, L.; Borghs, G.; Maes, G.; Huo, Q. Poly(acrylic acid)-stabilized colloidal gold nanoparticles: synthesis and properties. Nanotechnology 2010, 21, 455702-455708.
Bogdanovic, J.; Colon, J.; Baker, C.; Huo, Q. A label-free nanoparticle aggregation assay for protein complex/aggregate detection and analysis. Anal. Biochem. 2010, 405, 96-102.
Huo, Q. Protein complexes/aggregates as potential cancer biomarker revealed by a nanoparticle aggregation immunoassay. Colloids Surf. B. 2010, 78, 259-265.
Bogdanovic, J.; Huo, Q. NanoDLSay: a new platform technology for biomolecular detection and analysis using gold nanoparticle probes coupled with dynamic light scattering. SPIE Proceedings, (2010), 7674 (Smart Biomedical and Physiological Sensor Technology), 767408/1-767408/9.
Austin, L.; Liu, X.; Huo, Q. An immunoassay for monoclonal antibody isotyping and quality analysis using gold nanoparticles and dynamic light scattering. 2010, American Biotechnology Laboratory, 2010, 22, No. 3, 8-12.
Jans, H.; Liu, X.; Austin, L.; Maes, G.; Huo, Q. Dynamic light scattering as a powerful tool for gold nanoparticle bioconjugation and biomolecular binding study. Anal. Chem. 2009, 81, 9425-9432.
Liu, X.; Huo, Q. A washing-free and amplification-free one-step homogeneous assay for protein detection using gold nanoparticle probes and dynamic light scattering. J. Immunol. Method 2009, 349, 38-44
Brennan, J.P.; Li, A.; Huo, Q. Advancing lattice path models for nanoparticle percolation of conductivity in a non-conductive matrix. J. Comput. Theor. Nanosci. 2009, 6, 519-524.
Stokes, P.; Liu, L.; Zou, J.; Zhai, L.; Huo, Q.; Khondaker, S. Photoresponse in large area multiwalled carbon nanotube/polymer composite films. Appl. Phys. Lett. 2009, 94, 042110/1-042110/3.
Zou, J.; Khondaker, S.; Huo, Q.; Zhai, L. A General Strategy to Disperse and Functionalize Carbon Nanotubes Using Conjugated Block Copolymers. Adv. Func. Mater. 2009, 19, 479-483.
Zou, J.; Tran, B.; Huo, Q.; Zhai, L. Transparent carbon nanotube/poly(3,4-ethylenediozythiophene) composite electrical conductors. Soft Materials 2009, 7, 355-365.
Ding, Y.; Gu, G.; Xia, X.; Huo, Q. Cysteine-grafted chitosan mediated gold nanoparticle assembly: from nanochains to microcubes. J. Mater. Chem. 2009, 19, 795-799.
Liu, X.; Lloyd, M.; Fedorenko, I.V.; Bapat, P.; Zhukov, T.; Huo, Q. Accelerated photothermalysis of A549 human lung cancer cells by gold nanospheres under laser irradiation. Nanomedicine, 2008, 3, 617-626.
Dai, Q.; Coutts, J.; Zou, J.; Huo, Q. Surface modification of gold nanorods through a place exchange reaction inside an anionic exchange resin. Chem. Comm. 2008, 2858-2860.
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