陈庭坚 - 华南理工大学 - 生物科学与工程学院

个人简介

教育与工作经历 2002-2006 清华大学化学工程系化学工程与工艺学士 2006-2011 清华大学化学工程系化学工程与技术（生物化工方向）博士工作经历 2011-2018 美国加州斯克里普斯研究所（The Scripps Research Institute）化学系博士后研究员 2018至今华南理工大学生物科学与工程学院教授（入选中组部第十四批“海外高层次人才引进计划”青年项目（重点资助），华南理工大学“兴华学者”精英学者）

研究领域

蛋白质工程、非天然核酸、合成生物学、化学生物学、生物材料、大分子药物、新型检测技术、人工生命

近期论文

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Evolution of thermophilic DNA polymerases for the synthesis and amplification of C2’-modified DNA. T. Chen, N. Hongdilokkul, Z. Liu, R. Adhikary, S. Tsuen, F.E. Romesberg, Nature Chemistry (2016) 8: 557-563. (Highlighted by Nature Chemical Biology (2016) 12: 387). Polymerase Chain Transcription: Exponential Synthesis of RNA and Modified RNA. T. Chen, FE Romesberg, Journal of the American Chemical Society (2017) 139 (29): 9949-9954. Enzymatic Synthesis, Amplification, and Application of DNA with a Functionalized Backbone. T. Chen, FE Romesberg, Angew. Chem. Int. Ed. (2017) 56. The expanding world of DNA and RNA. T. Chen, N. Hongdilokkul, Z. Liu, D. Thirunavukaras, F.E. Romesberg, Current Opinion in Chemical Biology (2016) 34: 80-87 Directed polymerase evolution. T. Chen, F.E. Romesberg, FEBS Letters (2014) 588:219-229. A Method for the Exponential Synthesis of RNA: Introducing the Polymerase Chain Transcription (PCT) Reaction.T. Chen, FE Romesberg, Biochemistry (2017) 56 (40): 5227-5228. A semi-synthetic organism with an expanded genetic alphabet. D.A. Malyshev, K. Dhami, T. Lavergne, T. Chen, N. Dai, J.M. Foster, I.R. Corrêa, F.E. Romesberg, Nature (2014) 509:385-388. Selection of 2′-Fluoro-Modified Aptamers with Optimized Properties. D Thirunavukarasu, T Chen, Z Liu, N Hongdilokkul, FE Romesberg, Journal of the American Chemical Society (2017) 139 (8), 2892-2895. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers. Z Liu, T Chen, FE Romesberg, Chemical Science (2017) (In press). Adaptive mutations alter antibody structure and dynamics during affinity maturation. R. Adhikary, W. Yu, M. Oda, R. Walker, T. Chen, R. Stanfield, I. Wilson, J. Zimmermann, F.E. Romesberg, Biochemistry (2015) 54:2085–2093. Significant rewiring of the transcriptome and proteome of an Escherichia coli strain harboring a tailored exogenous global regulator IrrE. T. Chen, J. Wang, L. Zeng, R. Li, J. Li, Y. Chen, Z. Lin, PloS one (2012) 7 (7): e37126. Laboratory-evolved mutants of an exogenous global regulator, IrrE from Deinococcus radiodurans, enhance stress tolerances of Escherichia coli. T. Chen, J. Wang, R. Yang, J. Li, M. Lin, Z. Lin. PloS one (2011) 6 (1): e16228. An in vivo, label-free quick assay for xylose transport in Escherichia coli. T. Chen, J. Zhang, L. Liang, R. Yang, Z. Lin. Analytical biochemistry (2009) 390 (1): 63-67. An evolved xylose transporter from Zymomonas mobilis enhances sugar transport in Escherichia coli. C. Ren, T. Chen, J. Zhang, L. Liang, Z. Lin. Microbial Cell Factories (2009) 8 (66): 1-9. Random dissection to select for protein split sites and its application in protein fragment complementation. Y Chen, S Li, T Chen, H. Hua, Z Lin. Protein Science (2009) 18 (2): 399-409.