邹懿 - 西南大学

个人简介

2002-2009年于西南大学药学院，分别获制药工程学士和微生物与生化药学硕士学位。2013年于上海交通大学微生物代谢国家重点实验室获微生物学博士学位，研究方向为链霉菌来源的复杂结构天然产物生物合成，博士学位论文获上海市优秀博士学位论文奖。2014年-2017年，在美国加州大学洛杉矶分校（UCLA）从事博士后研究工作，研究方向为真菌来源的复杂结构天然产物酶学合成和催化机理。2017年7月，通过西南大学“聚贤工程”人才引进加入药学院任职。近几年来，以通讯作者或第一作者身份在包括Chem. Rev., Nat. Chem. Biol., Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., ACS Catal., Org. Lett., Acta. Pharm. Sin. B.等国际著名期刊上发表文章数篇，相关成果入选web of science高被引论文，被权威综述性杂志Nat. Prod. Rep.遴选为年度研究热点报道，同时被生物医学论文评价系统F1000 Prime评为杰出论文而被强烈推荐。教育与工作经历 2017. 07 - 至今西南大学，药学院，教授，博士生导师 2014. 01 - 2017. 01 加州大学洛杉矶分校，化学与分子生物工程学院，博士后 2009. 09 - 2013. 12 上海交通大学，微生物代谢国家重点实验室，微生物学，博士 2006. 09 - 2009. 07 西南大学，药学院，微生物与生化药学，硕士 2002. 09 - 2006. 07 西南大学，药学院，制药工程，学士

研究领域

1. 真菌天然药物生物合成与酶催化机理 2. 真菌天然药物合成生物学与绿色创制

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Chen, Q-B.*, Yuan, G-Y., Yuan, T., Zeng, H-T., Zou, Z-R., Tu, Z-C., Gao, J.*, Zou, Y.* Set of Cytochrome P450s Cooperatively Catalyzes the Synthesis of a Highly Oxidized and Rearranged Diterpene-Class Sordarinane Architecture. J. Am. Chem. Soc. 2022, DOI: 10.1021/jacs.1c12427. Zhang, J-M.#, Liu, X.#, Wei, Q., Ma, C-T., Li, D-H., Zou, Y.* Berberine Bridge Enzyme-like Oxidase-Catalysed Double Bond Isomerization Acts as the Pathway Switch in Cytochalasin Synthesis. Nat. Commun. 2022, 13: 225. (#co-first author) Cai, Y., Rao, L., Zou, Y.* Genome Mining Discovery of a C4‑Alkylated Dihydroisocoumarin Pathway in Fungi. Org. Lett. 2021, 23, 2337-2341. Wei, Q., Zeng, H-C., Zou, Y.* Divergent Biosynthesis of Fungal Dioxafenestrane Sesquiterpenes by the Cooperation of Distinctive Baeyer-Villiger Monooxygenases and α-Ketoglutarate-Dependent Dioxygenases. ACS Catal. 2021, 11, 948-957. Zhang, J-M., Wang, H-H., Liu, X., Hu, C-H., Zou, Y.* Heterologous and Engineered Biosynthesis of Nematocidal Polyketide-Nonribosomal Peptide Hybrid Macrolactone from Extreme Thermophilic Fungi. J. Am. Chem. Soc. 2020, 142, 1957-1965. Zeng, H-C., Yin, G-P., Wei, Q., Li, D-H., Wang, Y., Hu, Y-C., Hu, C-H.*, Zou, Y.* Unprecedented [5.5.5.6]Dioxafenestrane Ring Construction in Fungal Insecticidal Sesquiterpene Biosynthesis. Angew. Chem. Int. Ed. 2019, 58, 6569-6573. (Hot oﬀ the Press, Nat. Prod. Rep., 2019, 36, 1039-1043) Feng, C., Wei, Q., Hu, C-H.*, Zou, Y.* Biosynthesis of Diphenyl Ethers in Fungi. Org. Lett. 2019, 21, 3114-3118. Chen, X-W., Wang, L., Zhang, J-M., Jiang, T., Hu, C-H., Li, D-H.*, Zou, Y.* Immunosuppressant Mycophenolic Acid Biosynthesis Employs a New Globin-like Enzyme for Prenyl Side Chain Cleavage. Acta. Pharm. Sin. B. 2019, 9, 1253-1258. Zou, Y., Garcia-Borràs, M., Tang, M-C., Hirayama, Y., Li, D., Li, L., Watanabe, K., Houk, K. N.*, Tang, Y.* Enzyme-Catalyzed Cationic Epoxide Rearrangements in Quinolone Alkaloid Biosynthesis. Nat. Chem. Biol. 2017, 13, 325-332. (Recommended as the exceptional paper by F1000 Prime) Tang, M-C.#, Zou, Y.#, Watanabe, K., Walsh, C. T.*, Tang, Y.* Oxidative Cyclization in Natural Product Biosynthesis. Chem. Rev. 2017, 117, 5226-5333. (#co-first author, web of science, most-cited papers) Zou, Y., Zhan, Z., Li, D., Tang, M-C., Cacho, R., Watanabe, K., Tang, Y.* Tandem Prenyltransferases Catalyze Isoprenoid Elongation and Complexity Generation in Biosynthesis of Quinolone Alkaloids. J. Am. Chem. Soc. 2015, 137, 4980-4983. (Hot oﬀ the Press, Nat. Prod. Rep. 2015, 32, 1165-1169) Zou, Y.#, Xu, W.#, Tsunematsu, Y., Tang, M-C., Watanabe, K., Tang, Y.* Methylation-Dependent Acyl Transfer between Polyketide Synthase and Nonribosomal Peptide Synthetase Modules in Fungal Natural Product Biosynthesis. Org. Lett. 2014, 16, 6390-6393. (#co-first author) Zou, Y., Fang, Q., Yin, H., Liang, Z., Kong, D., Bai, L., Deng, Z., Lin, S.* Stereospecific Biosynthesis of β-Methyltryptophan from l-Tryptophan Features a Stereochemical Switch. Angew. Chem. Int. Ed. 2013, 52, 12951-12955. Zou, Y., Yin, H., Kong, D., Deng, Z., Lin, S.* A Trans-acting Ketoreductase in Biosynthesis of a Symmetric Polyketide Dimer SIA7248. ChemBioChem 2013, 14, 679-683. Tang, M-C.#, Zou, Y.#, Yee, D., Tang, Y.* Identification of the Pyranonigrin A Biosynthetic Gene Cluster by Genome Mining in Penicillium thymicola IBT 5891. AIChE Journal. 2018, 64, 4182-4186. (#co-first author) Yan, D-J., Chen, Q-B., Gao, J., Bai, J., Liu, B-Y., Zhang, Y-L., Zhang, L., Zhang, C., Zou, Y., Hu, Y-C.* Complexity and Diversity Generation in the Biosynthesis of Fumiquinazoline-Related Peptidyl Alkaloids. Org. Lett. 2019, 21, 1475-1479. Huang, T., Duan, Y., Zou, Y., Deng, Z., Lin, S.* NRPS Protein MarQ Catalyzes Flexible Adenylation and Specific S-Methylation. ACS Chem. Biol. 2018, 13, 2387-2391. Duan, Y., Liu, Y., Huang, T., Zou, Y., Huang, T., Hu, K., Deng, Z., Lin, S.* Divergent Biosynthesis of Indole Alkaloids FR900452 and Spiro-maremycins. Org. Biomol. Chem. 2018,16, 5446-5451. Bai, J., Yan, D., Zhang, T., Guo, Y, Liu, Y., Zou, Y., Tang, M-C., Liu, B., Wu, Q., Yu, S.*, Tang, Y.*, Hu, Y-C.* A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A. Angew. Chem. Int. Ed. 2017, 56, 4782-4786. Zhang, Y., Zou, Y., Brock, N. L., Huang, T., Lan, Y., Wang, X., Deng, Z., Tang, Y., Lin, S.* Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily. J. Am. Chem. Soc. 2017, 139, 11887-11894.