个人简介
EDUCATION
Postdoctoral work, Montana State University
Advisor: Gary A. Strobel (Professor of Plant Pathology)
Ph.D., Analytical Chemistry, University of Utah
Thesis advisor: David M. Grant (Distinguished Professor of Chemistry)
Dissertation: Analysis of Tensors in Solid-state Terpenes by Magic Angle Turning Nuclear Magnetic Resonance Methods
M. S., Physical Chemistry, Brigham Young University
Thesis advisor: Noel Owen (Professor of Chemistry)
Thesis: Isolation and Structure Elucidation of Indole Alkaloids from Aspidosperma Cruenta
B. S., Chemistry, Brigham Young University.
EMPLOYMENT
Associate Research Scientist, University of Utah, Department of Chemistry, D.M. Grant NMR Center (2002-2011)
Development of techniques for analyzing crystalline and amorphous biomaterials that defy traditional analysis. This work combines solid-state NMR techniques with ab initio computations, synchrotron data and chemical shift tensor analysis, and relies on traditional separation and crystallization methods to purify and prepare samples.
Visiting Scientist, Yale University, Department of Molecular Biophysics and Biochemistry (2006)
My time at Yale was a fast-paced tutorial in molecular biology. This work focused on learning RNA expression, purification, and modern nucleic acid analysis methods with specific emphasis on structural characterization of the guanosine riboswitch.
Postdoctoral work, Montana State University Department of Plant Pathology (2000-2002)
In Dr. Gary Strobel’s research laboratory, the emphasis was on diversifying my chemistry expertise by learning microbial growth techniques, isotopic labeling methods, natural products production and isolation. Two patents and eight publication resulted from this productive collaboration.
Graduate studies at the University of Utah, Department of Chemistry (1993-2000)
Graduate research with Dr. David Grant focused on developing methods for analyzing the structure of solids that are not suitable for study by traditional X-ray diffraction methods. Compounds that are amorphous or do not form suitable crystals or contain multiple crystalline forms are traditionally difficult to characterize. My work developed NMR methods to treat these challenging materials.
近期论文
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Valenti, D. J.; Arif, A. M.; Strobel, G. A.; Harper, J. K.* “6S*-(1'S*,2'R*-dihydroxypentyl)-4-methoxy-5,6-dihydropyran-2-one” Acta Crystallogr. 2013, In press.
Kalakewich, K.; Iuliucci, R. J.; Harper, J. K.* “Establishing accurate high-resolution crystal structures in the absence of diffraction structures and single crystals – an NMR approach” Cryst. Growth Des. 2013, In press.
Harper, J. K.*; Tishler, D.; Richardson, D.; Lokvam, J.; Pendrill, R.; Widmalm, G. “Solid-state NMR characterization of the molecular conformation in disordered methyl--L-rhamnofuranoside” J. Phys. Chem. A 2013, 117, 5534.
Harper, J. K.*; Iuliucci, R. J.; Grueber, M.; Kalakewich, K. “Refining crystal structures with experimental 13C NMR shift tensors and lattice-including electronic structure methods.” CrystEngComm, 2013, DOI: 10.1039/c3ce40108a.
Harper, J. K.*; Strobel, G. A.; Arif, A. “3-Carbamoylquinoxalin-1-ium chloride” Acta Crystallogr., 2012, E68, o79.
Harper, J. K.; Doebbler, J. A.; Jacques, E.; Grant, D. M.*; Von Dreele, R. “A combined solid-state NMR and synchrotron x-ray diffraction powder study on the structure of the antioxidant (+)-catechin 4.5 hydrate” J. Am. Chem. Soc. 2010, 132, 2928 (Cover).
Jiang, Y. J.*; Harper, J. K. “An explanation of magic angle spinning NMR experiments in the time domain” Concepts in Magn. Reson. A, 2009, 34A, 249.
Iuliucci, R.*; Hoop, C. L.; Arif, A. M.; Harper, J. K.; Pugmire, R. J.; Grant, D. M. “Redetermination of 1,4-dimethoxybenzene” Acta Crystallogr., 2009, E65, o251.
Kharwar, R. N.; Verma, V. C.; Kumar, A.; Gond, S. K.; Harper, J. K.; Hess, W. M.; Lobkovosky, E.; Ma, C.; Ren, Y.; Strobel, G. A.* “Javinicin, an antibacterial naphthaquinone from an endophytic fungus of Neem, Chloridium sp.” Curr. Microbiol. 2008, 58, 233.
Hoffman, A. M.*; Mayer, S. G.; Strobel, G. A.; Hess, W. M.; Sovocool, G. W.; Grange, A. H.; Harper, J. K.; Arif, A. M.; Grant, D. M. “Purification, identification and activity of phomodione, a furandione from an endophytic Phoma species” Phytochem. 2008, 69, 1049.
Heider, E. M.; Harper, J. K.; Grant, D. M.* “Structural characterization of an anhydrous polymorph of paclitaxel by solid-state NMR” Phys. Chem. Chem. Phys. 2007, 9, 1 (Cover).
Harper, J. K.; Strohmeier, M.; Grant, D. M.* “Pursuing structure in microcrystalline solids with independent molecules in the unit cell using 1H-13C correlation data” J. Magn. Reson. 2007, 189, 20.
Ma, Z.; Halling, M. D.; Solum, M. S.; Harper, J. K.; Orendt, A. M.; Facelli, J. C.; Pugmire, R. J.; Grant, D. M.*; Amick, A. W.; Scott, L. T. “Ring current effects in crystals. Evidence from 13C chemical shift tensors for intermolecular shielding in 4,7-di-t-butylacenaphthene versus 4,7-di-t-butylnaphthylene” J. Phys. Chem. A, 2007, 111, 2020.
Harper, J. K.; Grant, D. M.* “Enhancing crystal structure prediction with NMR tensor data” Crystal Growth & Design, 2006, 6, 2315.
Harper, J. K.; Grant, D. M.*; Zhang, Y.; Lee, P. L.; Von Dreele, R. B.* “Characterizing challenging microcrystalline solids with solid-state NMR shift tensor and synchrotron x-ray powder diffraction data: structural analysis of ambuic acid” J. Am. Chem. Soc. 2006, 128, 1547.
Heider, E. M.; Harper, J. K.; Grant, D. M.*; Hoffman, A.; Dugan, F.; Tomer, D. P.; O’Neill, K. L. “Exploring unusual antioxidant activity in a benzoic acid derivative: a proposed mechanism for citrinin” Tetrahedron, 2006, 62, 1199.
Harper, J. K.; Barich, D. H.; Heider, E. M.; Grant, D. M.*; Franke, R. R.; Johnson, J. H.; Zhang, Y.; Lee, P. L.; Von Dreele, R. B.*; Scott, B.; Williams, D.; Ansell, G. B. “A combined solid-state NMR and x-ray powder diffraction study of a stable polymorph of paclitaxel” Crystal Growth & Design, 2005, 5, 1737.
Strobel, G. A.*; Daisy, B.; Castillo, U. C.; Harper, J. K. “Natural products from endophytic microorganisms” J. Nat. Prod. 2004, 67, 257.
Harper, J. K.; Barich, D. H.; Hu, J. Z.; Strobel, G. A.; Grant, D. M.* “Stereochemical analysis by solid-state NMR: structural predictions in ambuic acid” J. Org. Chem. 2003, 68, 4609 (Cover).
Castillo, U.; Harper, J. K.; Strobel, G. A.*; Sears, J.; Alesi, K.; Ford, E.; Sugawara, F.; Lin, J.; Hunter, M.; Yaver, D.; Jensen, J. B.; Porter, H.; Robison, R.; Hess, W. M.; Condron, M.; Teplow, D. “Kakadumycins, novel antibiotics from Streptomyces sp. NRRL 30566, an endophyte from grevillea pteridifolia” FEMS Micro. Lett. 2003, 224, 183.