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个人简介

2019.04-至今 厦门大学化学化工学院,教授、博士生导师 2014.12-2019.03 德国马普煤炭所,洪堡学者,博士后(导师:Prof. Alois Fürstner) 2014.07-2014.10 中国科学院上海有机化学研究所,研究助理(导师:游书力 研究员) 2009.09-2014.07中国科学院上海有机化学研究所,博士(导师:游书力 研究员) 2005.09-2009.07 湖南大学化学系,学士

研究领域

有机合成方法学;不对称催化;活性天然产物及药物分子的合成

近期论文

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Yu, Y.-Z.; Su, H.-Y.; Zhuo, C.-X.* Anilines formation via molybdenum-catalyzed intermolecular reaction of ynones with allylic amines. Angew. Chem. Int. Ed. 2024, e202412299. Wang, J.-L.#; Li, J.-T.#; Wu, G.-Y.; Zhuo, C.-X.* Recent advances in molybdenum catalyzed asymmetric organic transformations. Trends Chem. 2024, 6, 487−501. Wang, J.-L.#; Wu, G.-Y. #; Luo, J.-N.; Liu, J.-L.; Zhuo, C.-X.*Catalytic intermolecular deoxygenative coupling of carbonyl compounds with alkynes by a Cp*Mo(II)-catalyst. J. Am. Chem. Soc. 2024, 146, 5605−5613. (# Equal contribution) Li, J.-T.; Fang, G.; Wu, G.-Y.;Zhuo, C.-X.* Modular access to diverse amphoteric α-boryl aldehydes or borylated heterocycles via photoredox catalysis. ACS Catal. 2023, 13, 12648−12655. Dong, Y.-Q.#; Shi, X.-N.#; Cao, L.-Y.#; Bai, J.; Zhuo, C.-X.* Molybdenum-catalyzed carbonyl-carbonyl olefination reaction for heterocycle syntheses. Org. Chem. Front. 2023, 10, 3544−3552 Modular access to meta-substituted benzenes via Mo-catalyzed intermolecular deoxygenative benzene formation.Yu, Y.-Z.; Bai, J.; Peng, J.-M.; Yao, J.-S.; Zhuo, C.-X.*J. Am. Chem. Soc. 2023, 145, ASAP Synthesis of 2-boryl allylboronates by a bimetallic platinum/zinc-promoted diborylation of propargylic amines.Shi, X.-N.; Wang, J.-L.; Wu, J.-B.; Zhuo, C.-X.*Synlett 2023, 34, doi:10.1055/a-2030-6797. Cao, L.-Y.; Wang, J.-L.; Wang, K.; Wu, J.-B.; Wang, D.-K.; Peng, J.-M.; Bai, J.; Zhuo, C.-X.* Catalytic asymmetric deoxygenative cyclopropanation reactions by a chiral salen-Mo catalyst. J. Am. Chem. Soc. 2023, 145, doi: 10.1021/jacs.2c12225. Dong, Y.-Q.#; Wang, K.#; Zhuo, C.-X.* Molybdenum-catalyzed intermolecular deoxygenative cross coupling reactions of 1,2-diketones with ɑ-ketoamides. ACS Catal. 2022, 12, 11428–11435. (# Equal contribution) Top 20 most downloaded articles in October 2022. Li, J.-T.; Luo, J.-N.; Wang, J.-L.; Wang, D.-K.; Yu, Y.-Z.; Zhuo, C.-X.* Stereoselective intermolecular radical cascade reactions of tryptophans or ɤ-alkenyl-α-amino acids with acrylamides via photoredox catalysis. Nat. commun. 2022, 13, 1778. DOI: 10.1038/s41467-022-29464-5. Wang, J.-L.; Zhuo, C.-X.* Catalytic deoxygenative cyclopropanation of 1,2-dicarbonyl or monocarbonyl compounds via molybdenum catalysis. Synlett 2021, DOI: 10.1055/a-1696-4553. (Invited Synpacts) Cao, L.-Y.; Luo, J.-N.; Yao, J.-S.; Wang, D.-K.; Dong, Y.-Q.; Zheng, C.; Zhuo, C.-X.* Molybdenum-catalyzed deoxygenative cyclopropanation of 1,2-dicarbonyl or mono-carbonyl compounds. Angew. Chem. Int. Ed. 2021, 60, 15254–15259. Zhuo, C.-X.; Fürstner, A.* Catalysis-based total syntheses of pateamine A and DMDA-Pat A. J. Am. Chem. Soc. 2018, 140, 10514–10523. Zhuo, C.-X.; Fürstner, A.* Concise synthesis of a pateamine A analogue with in vivo anticancer activity based on an iron catalyzed pyrone ring-opening/cross coupling. Angew. Chem. Int. Ed. 2016, 55, 6051-6056. Zhuo, C.-X.; Zhang, X.; You, S.-L.* Enantioselective synthesis of pyrrole fused piperazine and piperazinone derivatives via Ir-catalyzed asymmetric allylic amination. ACS Catal. 2016, 6, 5307−5310. Zhuo, C.-X.; Zhou, Y.; Cheng, Q.; Huang, L.; You, S.-L.* Enantioselective construction of spiroindolines with three contiguous stereogenic centers and chiral tryptamine derivative via the reactive spiroindolenine intermediates. Angew. Chem. Int. Ed. 2015, 54, 14146-14149. Zhuo, C.-X.; Cheng, Q.; Liu, W.-B.; Zhao, Q.; You, S.-L.* Enantioselective synthesis of pyrrole based spiro- and polycyclic derivatives via Ir-catalyzed asymmetric allylic dearomatization and controllable migration reactions. Angew. Chem. Int. Ed. 2015, 54, 8475-8479. Zhuo, C.-X.; Zhou, Y.; You, S.-L.* Highly regio- and enantioselective synthesis of poly-substituted 2H-pyrroles via Pd-catalyzed intermolecular asymmetric allylic dearomatization of pyrroles. J. Am. Chem. Soc. 2014, 136, 6590-6593. Zhuo, C.-X.; Zheng, C.; You, S.-L.* Transition-metal catalyzed asymmetric allylic dearomatization reactions. Acc. Chem. Res. 2014, 47, 2558-2573. Zhuo, C.-X.; You, S.-L.* Palladium-catalyzed intermolecular allylic dearomatization reaction of a-substituted-β-naphthol derivatives: scope and mechanistic investigation. Adv. Synth. Catal. 2014, 356, 2020-2028. Zhuo, C.-X.; You, S.-L.* Palladium-catalyzed intermolecular asymmetric allylic dearomatization reaction of naphthol derivatives. Angew. Chem. Int. Ed. 2013, 52, 10056-10059. Zhuo, C.-X.; Wu, Q.-F; Zhao, Q.; Xu, Q.-L.; You, S.-L.* Enantioselective functionalization of indoles and pyrroles via an in-situ formed spiro-intermediate. J. Am. Chem. Soc. 2013, 135, 8169-8172. Zheng, C.*; Zhuo, C.-X.; You, S.-L.* Mechanistic insights into the Pd-catalyzed intermolecular asymmetric allylic dearomatization of multisubstituted pyrroles: understanding the remarkable regio- and enantioselectivity. J. Am. Chem. Soc. 2014, 136, 16251-16259. Ye, K.-Y.; Cheng, Q.; Zhuo, C.-X.; You, S.-L.* An iridium(I) N-heterocyclic carbene complex catalyzes asymmetric intramolecular allylic amination reactions. Angew. Chem. Int. Ed. 2016, 55, 8113-8116. Wu, Q.-F; Zheng, C.*; Zhuo, C.-X.; You, S.-L.* Highly efficient synthesis and stereoselective migration reactions of chiral five-membered aza-spiroindolenines: scope and mechanistic understanding. Chem. Sci. 2016, 7, 4453-4459.

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