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个人简介

李劼,教授,博士生导师 。1988年生于江苏泰兴;2010年本科毕业于武汉大学化学与分子科学学院,2015年毕业于北京大学化学院化学生物学系,获博士学位。2018年12月加入南京大学化学化工学院化学生物学学科,2019年加入南京大学化学和生物医药创新研究院,2019年入选江苏特聘教授,2020年入选国家级青年人才。目前在研项目有:国家自然科学基金面上项目,重大研究计划培育项目,科技部重点研发项目等。代表研究工作有“生物正交剪切反应”,“细胞-抗体偶联物”“细胞间邻近化学标记”等。课题组目前主要关注肿瘤化学免疫学前沿研究,致力于描绘肿瘤免疫微环境的细胞相互作用谱并开发新型的肿瘤免疫大分子药物。 工作经历 2015年到2018年在美国Scripps研究所(Scripps Research Institute)化学系及分子药学系从事博士后研究工作。

研究领域

免疫化学生物学:1)免疫识别的化学解码与重塑; 2)免疫微环境的化学单细胞组学; 3)金属元素的免疫功能;4)新型免疫药物或细胞疗法的开发

近期论文

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Liu Z†, Li J†*, Chen M†, Wu M, Shi Y, Li W, Teijaro J, Wu P*, “Detecting tumor antigen-specific T cells via interaction-dependent fucosyl-biotinylation”, Cell, 2020, 183, 1117–1133. Qiu S†, Li W†, Deng T†, Bi A, Yang Y, Jiang X, Li J*, “Ru(bpy)32+-Enabled Cell-Surface Photocatalytic Proximity Labeling toward More Efficient Capture of Physically Interacting Cells”, Angew. Chem. Int. Ed., 2023, https://doi.org/10.1002/anie.202303014. Yu W†, Zhao X†, Jalloh A†, Li Y, Zhao Y, Dinner B, Yang Y, Ouyang S, Tian T, Zhao Z, Yang R, Chen M, Lauvau G, Guo Z*, Wu P*, Li J*, J. Am. Chem. Soc., 2023, Accepted https://doi.org/10.1021/jacs.3c02602; see previous version in bioRxiv, 2022, DOI: 10.1101/2022.09.01.506123. Wu Q, Xue Q, Li J, Zheng Q, Zhao X, Li W, Sun S, Sha W, Yang Y, Yang Y, Li J*, “Identification of Styryl Sulfonyl Fluoride (SSF) as a Near Perfect Michael Acceptor for Diversified Protein Bioconjugations”, CCS Chem., 2023, https://doi.org/10.31635/ccschem.022.202202386. Qiu S†, Zhao Z†, Wu M†, Xue Q, Yang Y, Ouyang S, Li W, Zhong L, Wang W, Yang R, Wu P*, Li J*, “Use of Intercellular Proximity Labeling to Quantify and Decipher Cell-cell Interactions Directed by Diversified Molecular Pairs”, Sci. Adv., 2022, 8, eadd233. Zhao X†, Sun S†, Yu W†, Zhu W, Zhao Z, Zhou Y, Ding X, Fang N, Yang R, Li J*, “Improved ClickTags Enable Live-cell Barcoding for Highly Multiplexed Single-cell Sequencing”, RSC Chem. Biol., 2022, 3, 1052–1060. Liu H†, Luo H†, Xue Q, Qin S, Qiu S, Liu S, Lin J, Li J*, Chen P*, “Antigen-specific T cell detection via photocatalytic proximity cell labeling (PhoXCELL)”, J. Am. Chem. Soc., 2022, 144, 5517−5526. Kiessling L, Chen P, Wang J, Li J*, “Fighting the Coronavirus Outbreak”, ACS Chem. Biol.2020, 15, 4, 799–801. Li J†, Chen M†, Liu Z, Zhang L, Felding BH, Moremen KW, Lauvau G., Abadier M, Ley K, Wu P, “A Single-Step Chemoenzymatic Reaction for the Construction of Antibody–Cell Conjugates”, ACS Cent. Sci., 2018, 4, 1633–1641. Liu Z†, Li J†, Li S†, Li G, Sharpless KB, Wu P, “SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization”, J. Am. Chem. Soc., 2018, 140, 2919–2925. Li J, Chen P, “Development and Application of Bond Cleavage Reactions in Bioorthogonal Chemistry”, Nat. Chem. Biol., 2016, 12, 129-137. Zhang G†, Li J†, Xie R, Fan X, Liu Y, Zheng S, Ge Y, Chen P, “Bioorthogonal Chemical Activation of Kinases in Living Systems”, ACS Cent. Sci., 2016, 2, 325–331. Li J, Yu J, Zhao J, Wang J, Zheng S, Lin S, Chen L, Yang M, Jia S, Zhang X, Chen P, “Palladium-triggered Deprotection Chemistry for Protein Activation in Living Cells”, Nature Chem., 2014, 6, 352-361. Li J†, Jia S†, Chen P, “Diels–Alder Reaction-triggered Bioorthogonal Protein Decaging in Living Cells”, Nat. Chem. Biol., 2014, 10, 1003-1005. Zheng S, Zhang G, Li J, Chen P, “Monitoring Endocytic Trafficking of Anthrax Lethal Factor by Precise and Quantitative Protein Labeling”, Angew. Chem. Int. Ed., 2014, 53, 6449-6453. Li J, Lin S, Wang J, Ja S, Yang M, Hao Z, Zhang X, Chen P, “Ligand-free Palladium-mediated Site Specific Protein Labeling Inside Gram-negative Bacterial Pathogens”, J. Am. Chem. Soc., 2013, 135, 7330-7338.

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