Cai, Jason - Yale University - School of Medicine

个人简介

Dr. Jason Cai is an Assistant Professor of Radiology and Biomedical Imaging with expertise in medicinal chemistry and PET imaging probe development. After studying at the University of Missouri-Columbia, Dr. Cai joined Carolyn Anderson’s lab at the University of Pittsburgh as a postdoctoral associate, focusing on radiopharmaceutical development and preclinical PET imaging in oncology. In 2015, he joint Yale PET Center as an Associate Research Scientist to expand his research portfolio to brain PET imaging and became an Assistant Professor in 2018. His research group is currently focusing on the development and translation of novel PET imaging probes for drug PK/PD study and the investigation of CNS disorders and Oncology. He is the recipient of the Berson-Yalow Award in 2018, and Archer Foundation Research Award in 2019. University of Pittsburgh (2015) University of Missouri-Columbia, Chemistry (2011)

研究领域

Alzheimer Disease; Chemistry, Pharmaceutical; Pharmacokinetics; Pharmacology; Biomarkers; Neurodegenerative Diseases; Positron-Emission Tomography; Drug Discovery; Drug Development

近期论文

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Li S, Cai Z, Zhang W, Holden D, Lin SF, Finnema SJ, Shirali A, Ropchan J, Carre S, Mercier J, Carson RE, Nabulsi N, Huang Y: Synthesis and in vivo evaluation of [18F]UCB-J for PET imaging of synaptic vesicle glycoprotein 2A (SV2A). Eur J Nucl Med Mol Imaging. 2019 Jun 7; 2019 Jun 7. PMID: 31175396 Toyonaga T, Smith LM, Finnema SJ, Gallezot JD, Naganawa M, Bini J, Mulnix T, Cai Z, Ropchan J, Huang Y, Strittmatter SM, Carson RE: In vivo synaptic density imaging with 11C-UCB-J detects treatment effects of saracatinib (AZD0530) in a mouse model of Alzheimer's disease. J Nucl Med. 2019 May 17; 2019 May 17. PMID: 31101744 Baum E, Zhang W, Li S, Cai Z, Holden D, Huang Y: A Novel 18F-Labeled Radioligand for Positron Emission Tomography Imaging of 11β-Hydroxysteroid Dehydrogenase (11β-HSD1): Synthesis and Preliminary Evaluation in Nonhuman Primates. ACS Chem Neurosci. 2019 May 15; 2019 Feb 19. PMID: 30689943 Bhatt S, Nabulsi NB, Li S, Cai Z, Matuskey D, Bini J, Najafzadeh S, Kapinos M, Ropchan JR, Carson RE, Cosgrove KP, Huang Y, Hillmer AT: First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1. J Cereb Blood Flow Metab. 2019 Mar 21; 2019 Mar 21. PMID: 30895878 Li S, Cai Z, Wu X, Holden D, Pracitto R, Kapinos M, Gao H, Labaree D, Nabulsi N, Carson RE, Huang Y: Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates. ACS Chem Neurosci. 2019 Mar 20; 2018 Nov 16. PMID: 30396272 Cai Z, Li S, Matuskey D, Nabulsi N, Huang Y: PET imaging of synaptic density: A new tool for investigation of neuropsychiatric diseases. Neurosci Lett. 2019 Jan 19; 2018 Jul 31. PMID: 30075287 Wu X, Cai H, Pan L, Cui G, Qin F, Li Y, Cai Z: Small Molecule Natural Products and Alzheimer's Disease. Curr Top Med Chem. 2019. PMID: 30714527 Kranz M, Bergmann R, Kniess T, Belter B, Neuber C, Cai Z, Deng G, Fischer S, Zhou J, Huang Y, Brust P, Deuther-Conrad W, Pietzsch J: Bridging from Brain to Tumor Imaging: (S)-(-)- and (R)-(+)-[18F]Fluspidine for Investigation of Sigma-1 Receptors in Tumor-Bearing Mice. Molecules. 2018 Mar 20; 2018 Mar 20. PMID: 29558382 Ocak M, Beaino W, White A, Zeng D, Cai Z, Anderson CJ: 64Cu-Labeled Phosphonate Cross-Bridged Chelator Conjugates of c(RGDyK) for PET/CT Imaging of Osteolytic Bone Metastases. Cancer Biother Radiopharm. 2018 Mar. PMID: 29634417 Li S, Cai Z, Zheng MQ, Holden D, Naganawa M, Lin SF, Ropchan J, Labaree D, Kapinos M, Lara-Jaime T, Navarro A, Huang Y: Novel 18F-Labeled κ-Opioid Receptor Antagonist as PET Radiotracer: Synthesis and In Vivo Evaluation of 18F-LY2459989 in Nonhuman Primates. J Nucl Med. 2018 Jan; 2017 Jul 26. PMID: 28747521 Bao W, Jia H, Finnema S, Cai Z, Carson RE, Huang YH: PET Imaging for Early Detection of Alzheimer's Disease: From Pathologic to Physiologic Biomarkers. PET Clin. 2017 Jul; 2017 May 2. PMID: 28576171 Baum E, Cai Z, Bois F, Holden D, Lin SF, Lara-Jaime T, Kapinos M, Chen Y, Deuther-Conrad W, Fischer S, Dukic-Stefanovic S, Bunse P, Wünsch B, Brust P, Jia H, Huang Y: PET Imaging Evaluation of Four σ1 Radiotracers in Nonhuman Primates. J Nucl Med. 2017 Jun; 2017 Feb 23. PMID: 28232607 Cai Z, Li S, Pracitto R, Navarro A, Shirali A, Ropchan J, Huang Y: Fluorine-18-Labeled Antagonist for PET Imaging of Kappa Opioid Receptors. ACS Chem Neurosci. 2017 Jan 18; 2016 Oct 20. PMID: 27741398 Zhang W, Cai Z, Li L, Ropchan J, Lim K, Boutagy NE, Wu J, Stendahl JC, Chu W, Gropler R, Sinusas AJ, Liu C, Huang Y: Optimized and Automated Radiosynthesis of [18F]DHMT for Translational Imaging of Reactive Oxygen Species with Positron Emission Tomography. Molecules. 2016 Dec 9; 2016 Dec 9. PMID: 27941676 Cai Z, Mason NS, Anderson CJ, Edwards WB: Synthesis and preliminary evaluation of an ¹⁸F-labeled oleic acid analog for PET imaging of fatty acid uptake and metabolism. Nucl Med Biol. 2016 Jan; 2015 Sep 2. PMID: 26602329 Song J, Cai Z, White AG, Jin T, Wang X, Kadayakkara D, Anderson CJ, Ambrose Z, Young WB: Visualization and quantification of simian immunodeficiency virus-infected cells using non-invasive molecular imaging. J Gen Virol. 2015 Oct; 2015 Jul 14. PMID: 26297664 Cai Z, Li BT, Wong EH, Weisman GR, Anderson CJ: Cu(I)-assisted click chemistry strategy for conjugation of non-protected cross-bridged macrocyclic chelators to tumour-targeting peptides. Dalton Trans. 2015 Mar 7. PMID: 25645688 Zeng D, Guo Y, White AG, Cai Z, Modi J, Ferdani R, Anderson CJ: Comparison of conjugation strategies of cross-bridged macrocyclic chelators with cetuximab for copper-64 radiolabeling and PET imaging of EGFR in colorectal tumor-bearing mice. Mol Pharm. 2014 Nov 3; 2014 Apr 25. PMID: 24720806 Cai Z, Ouyang Q, Zeng D, Nguyen KN, Modi J, Wang L, White AG, Rogers BE, Xie XQ, Anderson CJ: 64Cu-labeled somatostatin analogues conjugated with cross-bridged phosphonate-based chelators via strain-promoted click chemistry for PET imaging: in silico through in vivo studies. J Med Chem. 2014 Jul 24; 2014 Jul 11. PMID: 24983404 Cai Z, Anderson CJ: Chelators for copper radionuclides in positron emission tomography radiopharmaceuticals. J Labelled Comp Radiopharm. 2014 Apr; 2013 Dec 18. PMID: 24347474 Zeng D, Ouyang Q, Cai Z, Xie XQ, Anderson CJ: New cross-bridged cyclam derivative CB-TE1K1P, an improved bifunctional chelator for copper radionuclides. Chem Commun (Camb). 2014 Jan 4. PMID: 24141371 Gao X, Gaddam V, Altenhofer E, Tata RR, Cai Z, Yongpruksa N, Garimallaprabhakaran AK, Harmata M: C-H activation in S-alkenyl sulfoximines: an endo 1,5-hydrogen migration. Angew Chem Int Ed Engl. 2012 Jul 9; 2012 Jun 22. PMID: 22730316 Cai Z, Yongpruksa N, Harmata M: Total synthesis of the terpenoid buddledone A: 11-membered ring-closing metathesis. Org Lett. 2012 Apr 6; 2012 Mar 20. PMID: 22432972 Cai Z, Harmata M: Studies directed toward the synthesis of hamigeran B: a catalytic oxidative cyclization. Org Lett. 2010 Dec 17; 2010 Nov 16. PMID: 21080691 Harmata M, Cai Z, Chen Y: Benzothiazines in synthesis. A formal total synthesis of pseudopteroxazole. J Org Chem. 2009 Aug 7. PMID: 19537725