王怀民 - 西湖大学 - 浙江西湖高等研究院

个人简介

王怀民，2008年本科毕业于天津大学；2015年博士毕业于南开大学，随后在美国布兰迪斯大学化学系从事博士后研究。2019年9月加入西湖大学理学院任独立PI。自2022年1月起，任西湖大学工学院生物医学工程领域兼聘教授。

研究领域

课题组目前主要开发设计新型生物功能材料，化学生物学工具、活细胞原位标记探针和反应等。方向包括：生物功能材料、多肽水凝胶、多肽体内组装、免疫治疗、纳米医学、神经生物学材料、活性探针。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Yang, X.; Lu, H.; Tao, Y.; Zhang, H.; Wang, H.*, Controlling supramolecular filament chirality of hydrogel by co-assembly of enantiomeric aromatic peptides. Journal of Nanobiotechnology 2022, 20 (1), 1-12. Wu, B.; Zhao, S.; Yang, X.; Zhou, L.; Ma, Y.; Zhang, H.; Li, W.; Wang, H.*, Biomimetic Heterodimerization of Tetrapeptides to Generate Liquid Crystalline Hydrogel in A Two-Component System. ACS nano 2022, 16 (3), 4126-4138. Fang, Y.; Wang, H.*, Molecular Engineering of Peptide–Drug Conjugates for Therapeutics. Pharmaceutics 2022, 14 (1), 212. Wang, J., Hu, L., Zhang, H., Fang, Y., Wang, T., and Wang, H.* Intracellular Condensates of Oligopeptide for Targeting Lysosome and Addressing Multiple Drug Resistance of Cancer, Adv. Mater. 2022, 34 (1), 2104704. (Selected as frontispiece) Yang, X., Lu, H., Tao, Y., Zhou, L., and Wang, H.* Spatiotemporal Control over Chemical Assembly in Living Cells by Integration of Acid Catalyzed Hydrolysis and Enzymatic Reaction, Angew. Chem. Int. Ed. Engl. 2021, 60 (44), 23797-23804. (hot paper) Hu, L., Li, Y., Lin. X., Huo, X., Zhang, H., and Wang, H* Structure-Based Programming of Supramolecular Assemblies in Living Cells for Selective Cancer Cell Inhibition, Angew. Chem. Int. Ed. Engl., 2021, 60 (40), 21807-21816. (Selected as frontispiece and hot paper) Li, J.; Fang, Y.; Zhang, Y.; Wang, H.; Yang, Z.; Ding, D.*, Supramolecular Self‐Assembly‐Facilitated Aggregation of Tumor‐Specific Transmembrane Receptors for Signaling Activation and Converting Immunologically Cold to Hot Tumors. Adv. Mater. 2021, 33 (16), 2008518. Yang, X., Cao, Z., Lu, H., and Wang, H.* In Situ Construction of Functional Assemblies in Living Cells for Cancer Therapy, Adv. Healthcare Mater.., (2021): 2100381. Wang, H.#, Feng, Z.#, Xu, B.*, Intercellular Instructed-Assembly Mimics Protein Dynamics to Induce Cell Spheroids, J. Am. Chem. Soc., (2019). (# co-first authors) Wang, H., Feng, Z., Del Signore, S. J., Rodal, A. A., Xu, B.*, Active Probes for Imaging Membrane Dynamics of Live Cells with High Spatial and Temporal Resolution over Extended Time Scales and Areas, J. Am. Chem. Soc., 140 (2018) 3503-3509. Wang, H., Shi, J., Feng, Z., Zhou, R., Wang, S., Rodal, A. A., Xu, B.*, An in Situ Dynamic Continuum of Supramolecular Phosphoglycopeptides Enables Formation of 3d Cell Spheroids, Angew. Chem. Int. Ed. Engl., 56 (2017) 16297-16301. (VIP paper) Wang, H., Feng, Z., Xu, B.*, Bioinspired Assembly of Small Molecules in Cell Milieu, Chem. Soc. Rev., 46 (2017) 2421-2436. Wang, H, Feng, Z., Lu, A., Jiang, Y., Wu, H., Xu, B.*, Instant Hydrogelation Inspired by Inflammasomes, Angew. Chem. Int. Ed. Engl., 56 (2017) 7579-7583. Wang, H., Feng, Z., Wu, D., Fritzsching, K. J., Rigney, M., Zhou, J., Jiang, Y., Schmidt-Rohr, K., Xu, B.*, Enzyme-Regulated Supramolecular Assemblies of Cholesterol Conjugates against Drug-Resistant Ovarian Cancer Cells, J. Am. Chem. Soc., 138 (2016) 10758-10761. Wang, H., Feng, Z., Wang, Y., Zhou, R., Yang, Z., Xu, B.*, Integrating Enzymatic Self-Assembly and Mitochondria Targeting for Selectively Killing Cancer Cells without Acquired Drug Resistance, J. Am. Chem. Soc., 138 (2016) 16046-16055.