Zhao, Huimin - University of Illinois at Urbana-Champaign - Department of Chemical and Biomolecular Engineering

个人简介

Dr. Huimin Zhao is the Steven L. Miller Chair Professor of chemical and biomolecular engineering, and professor of chemistry, biochemistry, biophysics, and bioengineering at the University of Illinois at Urbana-Champaign (UIUC). He received his B.S. degree in Biology from the University of Science and Technology of China in 1992 and his Ph.D. degree in Chemistry from the California Institute of Technology in 1998 under the guidance of Nobel Laureate Dr. Frances Arnold. Prior to joining UIUC in 2000, he was a project leader at the Industrial Biotechnology Laboratory of the Dow Chemical Company. He was promoted to full professor in 2008. Dr. Zhao has authored and co-authored over 430 research articles and over 30 issued and pending patent applications. In addition, he has given over 490 plenary, keynote, or invited lectures. Thirty-seven (37) of his former graduate students and postdocs became professors or principal investigators around the world. Dr. Zhao received numerous research and teaching awards and honors such as AIChE Daniel I.C. Wang Award, AIChE FP&B Division Award, ECI Enzyme Engineering Award, ACS Marvin Johnson Award, and SIMB Charles Thom Award.His primary research interests are in the development and applications of synthetic biology, machine learning, and laboratory automation tools to address society’s most daunting challenges in health, energy, and sustainability. Research Interests

研究领域

Synthetic biology; AI/ML; automation; natural product biosynthesis; protein engineering; metabolic engineering; genome engineering; directed evolution

近期论文

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Amino acid based ionic liquids for revitalization of sulfated lead anodes Lu, J., Baby, A., Asserghine, A., Rodríguez-López, J. & Zhao, H., Jan 30 2024, In: Journal of Power Sources. 591, 233824. Chem-FINESE: Validating Fine-Grained Few-shot Entity Extraction through Text Reconstruction Wang, Q., Zhang, Z., Li, H., Liu, X., Han, J., Zhao, H. & Ji, H., 2024, EACL 2024 - 18th Conference of the European Chapter of the Association for Computational Linguistics, Findings of EACL 2024. Graham, Y., Purver, M. & Purver, M. (eds.). Association for Computational Linguistics (ACL), p. 1-16 16 p. (EACL 2024 - 18th Conference of the European Chapter of the Association for Computational Linguistics, Findings of EACL 2024). CRISPR-COPIES: an in silico platform for discovery of neutral integration sites for CRISPR/Cas-facilitated gene integration Boob, A. G., Zhu, Z., Intasian, P., Jain, M., Petrov, V., Lane, S. T., Tan, S.-I., Xun, G. & Zhao, H., Apr 12 2024, In: Nucleic acids research. 52, 6, gkae062. Enabling pathway design by multiplex experimentation and machine learning Boob, A. G., Chen, J. & Zhao, H., Jan 2024, In: Metabolic Engineering. 81, p. 70-87 18 p. Enterolyin S, a Polythiazole-containing Hemolytic Peptide from Enterococcus caccae Shi, C., Patel, V. A., Mitchell, D. A. & Zhao, H., Jun 17 2024, In: ChemBioChem. 25, 12, e202400212. Glycyl Radical Enzymes Catalyzing the Dehydration of Two Isomers of N-Methyl-4-hydroxyproline Jiang, L., Yang, Y., Huang, L., Zhou, Y., An, J., Zheng, Y., Chen, Y., Liu, Y., Huang, J., Ang, E. L., Zhao, S., Zhao, H., Liao, R., Wei, Y. & Zhang, Y., Apr 5 2024, In: ACS Catalysis. 14, 7, p. 4407-4422 16 p. Harnessing noncanonical crRNA for highly efficient genome editing Xun, G., Zhu, Z., Singh, N., Lu, J., Jain, P. K. & Zhao, H., Dec 2024, In: Nature communications. 15, 1, 3823. Inducing and real-time monitoring of lead (de)sulfation processes using scanning electrochemical microscopy for applications in the refurbishment of lead-acid batteries Asserghine, A., Baby, A., Gao, E., Zhao, H. & Rodríguez-López, J., Jan 20 2024, In: Electrochimica Acta. 475, 143620. Metabolic engineering of Saccharomyces cerevisiae for de novo production of odd-numbered medium-chain fatty acids Dong, G., Zhao, Y., Ding, W., Xu, S., Zhang, Q., Zhao, H. & Shi, S., Mar 2024, In: Metabolic Engineering. 82, p. 100-109 10 p. Mitochondrial ATP generation is more proteome efficient than glycolysis Shen, Y., Dinh, H. V., Cruz, E. R., Chen, Z., Bartman, C. R., Xiao, T., Call, C. M., Ryseck, R. P., Pratas, J., Weilandt, D., Baron, H., Subramanian, A., Fatma, Z., Wu, Z. Y., Dwaraknath, S., Hendry, J. I., Tran, V. G., Yang, L., Yoshikuni, Y. & Zhao, H. & 3 others, , 2024, (Accepted/In press) In: Nature chemical biology. Molecule Maker Lab Institute: Accelerating, advancing, and democratizing molecular innovation Burke, M. D., Denmark, S. E., Diao, Y., Han, J., Switzky, R. & Zhao, H., Mar 1 2024, In: AI Magazine. 45, 1, p. 117-123 7 p. Multifunctional Glucose Dehydrogenase Enabled Synthesis of Chiral-Bridged Bicyclic Nitrogen Heterocycles Jiang, G., Lu, J., Zhou, M., Harrison, W. & Zhao, H., May 3 2024, In: ACS Catalysis. 14, 9, p. 7074-7079 6 p. Nitrogen starvation causes lipid remodeling in Rhodotorula toruloides Mishra, S., Deewan, A., Zhao, H. & Rao, C. V., May 17 2024, In: Microbial cell factories. 23, 1, 141. Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptides Ren, H., Huang, C., Pan, Y., Dommaraju, S. R., Cui, H., Li, M., Gadgil, M. G., Mitchell, D. A. & Zhao, H., 2024, (Accepted/In press) In: Nature Chemistry. Photoenzymatic Asymmetric Hydroamination for Chiral Alkyl Amine Synthesis Harrison, W., Jiang, G., Zhang, Z., Li, M., Chen, H. & Zhao, H., Apr 17 2024, In: Journal of the American Chemical Society. 146, 15, p. 10716-10722 7 p. Portable, single nucleotide polymorphism-specific duplex assay for virus surveillance in wastewater Oh, C., Xun, G., Lane, S. T., Petrov, V. A., Zhao, H. & Nguyen, T. H., Feb 20 2024, In: Science of the Total Environment. 912, 168701. Remote stereocontrol with azaarenes via enzymatic hydrogen atom transfer Li, M., Harrison, W., Zhang, Z., Yuan, Y. & Zhao, H., Feb 2024, In: Nature Chemistry. 16, 2, p. 277-284 8 p. Self-Buffering system for Cost-Effective production of lactic acid from glucose and xylose using Acid-Tolerant Issatchenkia orientalis Lee, Y. G., Kang, N. K., Kim, C., Tran, V. G., Cao, M., Yoshikuni, Y., Zhao, H. & Jin, Y. S., May 2024, In: Bioresource Technology. 399, 130641. Site-selective chlorination of pyrrolic heterocycles by flavin dependent enzyme PrnC Peh, G. R., Tay, T., Tan, L. L., Tiong, E., Bi, J., Goh, Y. L., Ye, S., Lin, F., Tan, C. J. X., Tan, Y. Z., Wong, J., Zhao, H., Wong, F. T., Ang, E. L. & Lim, Y. H., Dec 2024, In: Communications Chemistry. 7, 1, 7. Special Issue on Artificial Intelligence for Synthetic Biology García Martín, H., Mazurenko, S. & Zhao, H., Feb 16 2024, In: ACS synthetic biology. 13, 2, p. 408-410 3 p. Synthetic Biology Continues to Grow Zhao, H., Jan 19 2024, In: ACS synthetic biology. 13, 1, p. 1-2 2 p. Adsorptive separation and recovery of triacetic acid lactone from fermentation broth Singh, R., Bhagwat, S. S., Viswanathan, M. B., Cortés‐Peña, Y. R., Eilts, K. K., Mcdonough, G., Cao, M., Guest, J. S., Zhao, H. & Singh, V., Jan 1 2023, In: Biofuels, Bioproducts and Biorefining. 17, 1, p. 109-120 12 p. A landing pad system for multicopy gene integration in Issatchenkia orientalis Fatma, Z., Tan, S. I., Boob, A. G. & Zhao, H., Jul 2023, In: Metabolic Engineering. 78, p. 200-208 9 p. An end-to-end pipeline for succinic acid production at an industrially relevant scale using Issatchenkia orientalis Tran, V. G., Mishra, S., Bhagwat, S. S., Shafaei, S., Shen, Y., Allen, J. L., Crosly, B. A., Tan, S. I., Fatma, Z., Rabinowitz, J. D., Guest, J. S., Singh, V. & Zhao, H., Dec 2023, In: Nature communications. 14, 1, 6152. A polycistronic system for multiplexed and precalibrated expression of multigene pathways in fungi Yue, Q., Meng, J., Qiu, Y., Yin, M., Zhang, L., Zhou, W., An, Z., Liu, Z., Yuan, Q., Sun, W., Li, C., Zhao, H., Molnár, I., Xu, Y. & Shi, S., Dec 2023, In: Nature communications. 14, 1, 4267. A Spirobicyclo[3.1.0]Terpene from the Investigation of Sesquiterpene Synthases from Lactarius deliciosus Cheong, C. B., Peh, G. R., Wei, Y., Rehka, T., Ang, E. L., Zhao, H., Zhang, C. & Lim, Y. H., Jan 20 2023, In: ACS chemical biology. 18, 1, p. 134-140 7 p. CMI: CRISPR/Cas9 Based Efficient Multiplexed Integration in Saccharomyces cerevisiae Meng, J., Qiu, Y., Zhang, Y., Zhao, H. & Shi, S., May 19 2023, In: ACS synthetic biology. 12, 5, p. 1408-1414 7 p. Comparative study of two Saccharomyces cerevisiae strains with kinetic models at genome-scale Hu, M., Dinh, H. V., Shen, Y., Suthers, P. F., Foster, C. J., Call, C. M., Ye, X., Pratas, J., Fatma, Z., Zhao, H., Rabinowitz, J. D. & Maranas, C. D., Mar 2023, In: Metabolic Engineering. 76, p. 1-17 17 p. Controlling circuitry underlies the growth optimization of Saccharomyces cerevisiae Nguyen, V., Xue, P., Li, Y., Zhao, H. & Lu, T., Nov 2023, In: Metabolic Engineering. 80, p. 173-183 11 p. Design and application of a kinetic model of lipid metabolism in Saccharomyces cerevisiae Mishra, S., Wang, Z., Volk, M. J. & Zhao, H., Jan 2023, In: Metabolic Engineering. 75, p. 12-18 7 p. Ene Reductase Enabled Intramolecular β-C−H Functionalization of Substituted Cyclohexanones for Efficient Synthesis of Bridged Bicyclic Nitrogen Scaffolds Jiang, G., Huang, C., Harrison, W., Li, H., Zhou, M. & Zhao, H., May 22 2023, In: Angewandte Chemie - International Edition. 62, 22, e202302125. Enzyme function prediction using contrastive learning Yu, T., Cui, H., Li, J. C., Luo, Y., Jiang, G. & Zhao, H., Mar 31 2023, In: Science. 379, 6639, p. 1358-1363 6 p. Further Characterization of Fungal Halogenase RadH and Its Homologs Peh, G., Gunawan, G. A., Tay, T., Tiong, E., Tan, L. L., Jiang, S., Goh, Y. L., Ye, S., Wong, J., Brown, C. J., Zhao, H., Ang, E. L., Wong, F. T. & Lim, Y. H., Jul 2023, In: Biomolecules. 13, 7, 1081. Genome mining unveils a class of ribosomal peptides with two amino termini Ren, H., Dommaraju, S. R., Huang, C., Cui, H., Pan, Y., Nesic, M., Zhu, L., Sarlah, D., Mitchell, D. A. & Zhao, H., Dec 2023, In: Nature communications. 14, 1, 1624. Imaging Method Using CRISPR/dCas9 and Engineered gRNA Scaffolds Can Perturb Replication Timing at the HSPA1 Locus Xiong, X., Tasan, I., Yang, C., Zhang, M., Hernandez Gonzalez, G. A., Liu, S., Chaturvedi, P., Belmont, A. S. & Zhao, H., May 19 2023, In: ACS synthetic biology. 12, 5, p. 1424-1436 13 p. Incorporation of noncanonical base Z yields modified mRNA with minimal immunogenicity and improved translational capacity in mammalian cells mZhang, M., Singh, N., Ehmann, M. E., Zheng, L. & Zhao, H., Oct 20 2023, In: iScience. 26, 10, 107739. In situ detection of reactive oxygen species spontaneously generated on lead acid battery anodes: a pathway for degradation and self-discharge at open circuit Asserghine, A., Baby, A., Putnam, S. T., Qian, P., Gao, E., Zhao, H. & Rodríguez-López, J., Oct 18 2023, In: Chemical Science. 14, 43, p. 12292-12298 7 p. Investigation of the Biosynthetic Mechanism of Bipentaromycin Featuring an Unprecedented Cyclic Head-to-Tail Dimeric Scaffold Huang, C., Cui, H., Ren, H. & Zhao, H., Jan 23 2023, In: JACS Au. 3, 1, p. 195-203 9 p. In vitro continuous protein evolution empowered by machine learning and automation Yu, T., Boob, A. G., Singh, N., Su, Y. & Zhao, H., Aug 16 2023, In: Cell Systems. 14, 8, p. 633-644 12 p. Machine Learning-Enabled Genome Mining and Bioactivity Prediction of Natural Products Yuan, Y., Shi, C. & Zhao, H., Sep 15 2023, In: ACS synthetic biology. 12, 9, p. 2650-2662 13 p. Machine learning-enabled retrobiosynthesis of molecules Yu, T., Boob, A. G., Volk, M. J., Liu, X., Cui, H. & Zhao, H., Feb 2023, In: Nature Catalysis. 6, 2, p. 137-151 15 p. Mass Spectrometry-Based High-Throughput Quantification of Bioproducts in Liquid Culture Zhou, S., Fatma, Z., Xue, P., Mishra, S., Cao, M., Zhao, H. & Sweedler, J. V., Feb 28 2023, In: Analytical Chemistry. 95, 8, p. 4067-4076 10 p. Metabolic Engineering: Methodologies and Applications Volk, M. J., Tran, V. G., Tan, S. I., Mishra, S., Fatma, Z., Boob, A., Li, H., Xue, P., Martin, T. A. & Zhao, H., May 10 2023, In: Chemical reviews. 123, 9, p. 5521-5570 50 p. Mining and application of constitutive promoters from Rhodosporidium toruloides Guo, X., Bai, Z., Zhang, Y., Zhao, H. & Shi, S., Dec 2023, In: AMB Express. 13, 1, 17. Multiplexed CRISPR-Based Nucleic Acid Detection Using a Single Cas Protein Fu, J., Zhang, L., Long, Y., Liu, Z., Meng, G., Zhao, H., Su, X. & Shi, S., Nov 7 2023, In: Analytical Chemistry. 95, 44, p. 16089-16097 9 p. Photoenzymatic enantioselective intermolecular radical hydroamination Zhang, Z., Feng, J., Yang, C., Cui, H., Harrison, W., Zhong, D., Wang, B. & Zhao, H., Aug 2023, In: Nature Catalysis. 6, 8, p. 687-694 8 p. REACTION MINER: An Integrated System for Chemical Reaction Extraction from Textual Data Zhong, M., Ouyang, S., Jiao, Y., Kargupta, P., Luo, L., Shen, Y., Zhou, B., Zhong, X., Liu, X., Li, H., Xiao, J., Jiang, M., Hu, V., Wang, X., Ji, H., Burke, M., Zhao, H. & Han, J., 2023, p. 389-402. 14 p. SHIELD: a platform for high-throughput screening of barrier-type DNA elements in human cells Zhang, M., Ehmann, M. E., Matukumalli, S., Boob, A. G., Gilbert, D. M. & Zhao, H., Dec 2023, In: Nature communications. 14, 1, 5616. To cut or not to cut: Next-generation genome editors for precision genome engineering Zhang, M., Zhu, Z., Xun, G. & Zhao, H., Dec 2023, In: Current Opinion in Biomedical Engineering. 28, 100489. Anaerobic Hydroxyproline Degradation Involving C-N Cleavage by a Glycyl Radical Enzyme Duan, Y., Wei, Y., Xing, M., Liu, J., Jiang, L., Lu, Q., Liu, X., Liu, Y., Ang, E. L., Liao, R. Z., Yuchi, Z., Zhao, H. & Zhang, Y., Jun 8 2022, In: Journal of the American Chemical Society. 144, 22, p. 9715-9722 8 p.