代云路 - 澳门大学 - 健康科学学院

个人简介

Education Ph.D. Inorganic Chemistry, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), China (2014) B.Sc. Chemical Engineering and Technology, Harbin Engineering University, China (2009) Academic and Professional Experience 08/2022 – Present Associate Professor, Faculty of Health Sciences, University of Macau 08/2018 – 08/2022 Assistant Professor, Faculty of Health Sciences, University of Macau 09/2016 – 07/2018 Postdoc Fellow, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), USA 10/2014 – 09/2016 Research Fellow, The University of Melbourne, Australia

研究领域

Our group research interest mainly focuses on the nanomaterials for targeted delivery of anticancer therapeutics and multimodal biological imaging (X-ray computed tomography, optical imaging, magnetic resonance imaging and photoacoustic imaging, etc). We aim to develop inorganic nanomaterials and nanoscale coordination materials for gene and drug delivery, immunotherapy and biological imaging. In particular, we are working on designing and preparing multi-functional nanomaterials for enhanced anticancer therapy by exploiting the tumor microenvironment. We are also developing promising nanodrugs for clinical translation.

近期论文

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Metal–Phenolic Nanomaterial with Organelle-Level Precision Primes Antitumor Immunity via mtDNA-dependent cGAS-STING Activation. Angew. Chem. Int. Ed., 2024, e202411498. Hao Tian, Wenxi Li, Guohao Wang, Ye Tian, Jie Yan, Xinying Yu, Ziliang Yan, Yuzhao Feng, Yunlu Dai* Cuproptotic nanoinducer-driven proteotoxic stress potentiates cancer immunotherapy by activating the mtDNA–cGAS–STING signaling. Biomaterials, 2024, 122512. Xinying Yu, Bei Li*, Jie Yan, Wenxi Li, Hao Tian, Guohao Wang, Songtao Zhou, Yunlu Dai* Dual-Epigenetically Relieving the MYC-Correlated Immunosuppression via an Advanced Nano-Radiosensitizer Potentiates Cancer Immuno-Radiotherapy. Adv. Mater., 2024, 2312588. Guohao Wang, Jie Yan, Hao Tian, Bei Li*, Xinying Yu, Yuzhao Feng, Wenxi Li, Songtao Zhou, Yunlu Dai* An Ultrasound-Triggered STING Pathway Nanoagonist for Enhanced Chemotherapy-Induced Immunogenic Cell Death. Small, 2024, 2309850. Ye Tian, Hao Tian, Bei Li, Chuanliang Feng, Yunlu Dai* Radiotherapy-activated tumor immune microenvironment: Realizing radiotherapy-immunity combination therapy strategies. Nano Today, 2023, 53, 102042. Haifen Luo, Wen Ma, Qi Chen*, Zhen Yang*, Yunlu Dai* PhotoPyro-Induced cGAS-STING Pathway Activation Enhanced Anti-Melanoma Immunotherapy via a Manganese-Coordinated Nanomedicine. Adv. Healthc. Mater., 2023, 2302811. Yuzhao Feng, Guohao Wang, Wenxi Li, Jie Yan, Xinying Yu, Hao Tian, Bei Li, Yunlu Dai* Lipid bilayer-based biological nanoplatforms for sonodynamic cancer therapy. Adv. Drug Deliv. Rev., 2023, 202, 115110. Songhao Li, Greta S.P. Mok, Yunlu Dai* Nanoghosts: Harnessing Mesenchymal Stem Cell Membrane for Construction of Drug Delivery Platforms Via Optimized Biomimetics. Small, 2023, 20, 2304824. Yuan Xiao, Ren-He Xu*, Yunlu Dai* Advanced Metallized Nanofibers for Biomedical Applications. Adv. Sci., 2023, 10, 2302044. Wei Sang, Ruiping Zhang*, Xiangyang Shi*, Yunlu Dai* Metal-Phenolic Nanomedicines Regulate T-Cell Antitumor Function for Sono-Metabolic Cancer Therapy. ACS Nano, 2023, 17, 14667. Jie Yan, Wenxi Li, Hao Tian, Bei Li*, Xinying Yu, Guohao Wang, Wei Sang, and Yunlu Dai* Gel/hydrogel-based in situ biomaterial platforms for cancer postoperative treatment and recovery. Exploration, 2023, 3, 20220173. Yuzhao Feng, Zhan Zhang, Wei Tang, Yunlu Dai* Self-Degradable Nanogels Reshape Immunosuppressive Tumor Microenvironment via Drug Repurposing Strategy to Reactivate Cytotoxic CD8+ T Cells. Adv. Sci., 2023, 10, 2301661. Hao Tian, Wenxi Li, Guohao Wang, Ye Tian, Jie Yan, Songtao Zhou, Xinying Yu, Bei Li, Yunlu Dai* Fueling sentinel node via reshaping cytotoxic T lymphocytes with a ﬂex-patch for postoperative immuno-adjuvant therapy. Nat. Commun., 2023, 14, 2518. Bei Li, Guohao Wang, Kai Miao, Aiping Zhang, Liangyu Sun, Xinwang Yu, Josh Haipeng Lei, Lisi Xie, Jie Yan, Wenxi Li, Chu-Xia Deng, Yunlu Dai* A Metal–Phenolic Nanocoordinator Launches Radiotherapeutic Cancer Pyroptosis Through an Epigenetic Mechanism. Adv. Funct. Mater., 2023, 33, 2213425. Guohao Wang, Bei Li, Hao Tian, Lisi Xie, Jie Yan, Wei Sang, Jie Li, Zhan Zhang, Wenxi Li, Yunlu Dai* IR780/Gemcitabine-conjugated metal-phenolic network enhanced photodynamic cancer therapy. Chinese Chem. Lett., 2023, 35, 108312. Songtao Zhou, Hao Tian, Jie Yan, Zhan Zhang, Guohao Wang, Xinying Yu, Wei Sang, Bei Li, Greta S.P. Mok, Jie Song, Yunlu Dai* APOL3-LDHA axis related immunity activation and cancer ferroptosis induction. Int. J. Biol. Sci., 2023, 19, 1401. Yuzhao Feng, Yunlu Dai* Wenxi Li, Jie Yan, Hao Tian, Bei Li, Guohao Wang, Wei Sang, Zhan Zhang, Xuanjun Zhang, Yunlu Dai*(corresponding author), A platinum@ polymer-catechol nanobraker enables radio-immunotherapy for crippling melanoma tumorigenesis, angiogenesis, and radioresistance, Bioactive Materials, 2023, 22, 34. (IF 16.874) Lisi Xie, Jie Li, Leyu Wang, Yunlu Dai*(corresponding author), Engineering metal‐phenolic networks for enhancing cancer therapy by tumor microenvironment modulation, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2022, DOI: 10.1002/wnan.1864. (IF 9.423) Chang Lu, Ye Tian, Hao Tian, Bei Li, Bo Peng, Jun Zheng*, Yunlu Dai*(corresponding author). An ultrasound activable metal-phenolic network nano-antibiotics for in vivo on-site infection therapy, Science China Materials, 2022, DOI: 10.1007/s40843-022-2125-1. (IF 8.64) Zhan Zhang, Rinkoo Dalan, Zhenyu Hu, Jiong‐Wei Wang, Nicholas WS Chew, Kian‐Keong Poh, Ru‐San Tan, Tuck Wah Soong, Yunlu Dai*(corresponding author), Lei Ye*, Xiaoyuan Chen*, Reactive Oxygen Species Scavenging Nanomedicine for The Treatment of Ischemic Heart Disease, Advanced Materials, 2022, 34, 2202169. (IF 32.086) Ye Tian, Wei Sang, Hao Tian, Lisi Xie, Guohao Wang, Zhan Zhang, Wenxi Li, Yunlu Dai*(Corresponding author). A Two-Step Flexible Ultrasound Strategy to Enhance the Tumor Radiotherapy via Metal-Phenolic Network Nanoplatform, Advanced Functional Materials, 2022, 32, 2205690. (IF 19.924) Chang Lu, Nian Zhang, Sihoi Kou, Liangliang Gao, Bo Peng, Yunlu Dai*(Corresponding author), Jun Zheng*, Sanguinarine synergistically potentiates aminoglycoside-mediated bacterial killing, Microbial Biotechnology, 2022, 15, 2055. (IF 6.575) Jie Li, Lisi Xie, Wei Sang, Wenxi Li, Guohao Wang, Jie Yan, Zhan Zhang, Hao Tian, Quli Fan, Yunlu Dai*(Corresponding author). A Metal-Phenolic Nanosensitizer Performs Hydrogen Sulfide-Reprogrammed Oxygen Metabolism for Cancer Radiotherapy Intensification and Immunogenicity, Angewandte Chemie International Edition, 2022, 61, e202200830. (IF 16.823) Wei Sang, Zhan Zhang, Guohao Wang, Lisi Xie, Jie Li, Wenxi Li, Hao Tian,, and Yunlu Dai*(corresponding author), A triple-kill strategy for tumor eradication reinforced by metal-phenolic network nanopumps, Advanced Functional Materials, 2022, 32, 2113168. (IF 19.924) Hao Tian, Guohao Wang, Wei Sang, Lisi Xie, Zhan Zhang, Wenxi Li, Jie Yan, Ye Tian, Jie Li, Bei Li, Yunlu Dai*(Corresponding author). Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy, Nano Today, 2022, 43, 101405. (IF 18.962) Lisi Xie, Jie Li, Guohao Wang, Wei Sang, Mengze Xu, Wenxi Li, Jie Yan, Bei Li, Zhan Zhang, Qi Zhao, Zhen Yuan, Quli Fan, and Yunlu Dai*(corresponding author), Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy, Journal of The American Chemical Society, 2022, 144, 787. (IF 16.383) Jie Yan, Guohao Wang, Lisi Xie, Hao Tian, Jie Li, Bei Li, Wei Sang, Wenxi Li, Zhan Zhang, Yunlu Dai*(corresponding author), Engineering radiosensitizer-based metal-phenolic networks potentiate STING pathway activation for advanced radiotherapy, Advanced Materials, 2022, 34, 2105783. (IF 32.086) Wenxi Li, Lisi Xie, Yi Ju, Zhan Zhang, Bei Li, Jie Li, Wei Sang, Guohao Wang, Hao Tian, Yunlu Dai*(corresponding author), A “three musketeers” tactic for inclining interferon-γ as a comrade-in-arm to reinforce the synergistic-tumoricidal therapy, Nano Research, 2022, 15, 3458. (IF 10.269) Jie Li, Lisi Xie, Wei Sang, Guohao Wang, Hao Tian, Zhan, Zhang, Jianhua Liu, Quli Fan, Yunlu Dai*(corresponding author), NIR-II-absorbing conjugated polymer-based theranostic agent for NIR-II fluorescence imaging-guided photothermal therapy acting synergistically with tumor microenvironment-responsive nitric oxide therapy, ChemPhysMater, 2022, 1, 51. (NEW JOURNAL) Guohao Wang, Lisi Xie, Bei Li, Wei Sang, Jie Yan, Jie Li, Hao Tian, Wenxi Li, Zhan Zhang, Ye Tian, Yunlu Dai*(corresponding author), A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis, Nature Communications, 2021, 12, 5733. (IF 17.694) Zhan Zhang, Bei Li, Lisi Xie, Wei Sang, Hao Tian, Jie Li, Guohao Wang, Yunlu Dai*(corresponding author), Metal-Phenolic Network-Enabled Lactic Acid Consumption Reverses Immunosuppressive Tumor Microenvironment for Sonodynamic Therapy, ACS Nano., 2021, 15, 16934. (IF 18.027) Jie Li, Wenxi Li, Lisi Xie, Wei Sang, Guohao Wang, Zhan Zhang, Bei Li, Hao Tian, Jie Yan, Ye Tian, Zhenhua Li, Quli Fan, Lin Yu, Yunlu Dai*(corresponding author), A metal–polyphenolic nanosystem with NIR-II fluorescence-guided combined photothermal therapy and radiotherapy, Chemical Communications, 2021, 57, 11473. (IF 6.065) Jie Yan, Bei Li, Piaoping Yang*, Jun Lin*, Yunlu Dai*(corresponding author), Progress in Light-Responsive Lanthanide Nanoparticles towards Deep Tumor Theranostics, Advanced Functional Materials, 2021, 31, 2104325. (IF 19.924) Boshi Tian, Shikai Liu, Lili Feng, Shaohua Liu, Shili Gai, Yunlu Dai*(corresponding author), Lisi Xie, Bin Liu, Piaoping Yang*, Yanli Zhao*, Renal‐Clearable Nickel‐Doped Carbon Dots with Boosted Photothermal Conversion Efficiency for Multimodal Imaging‐Guided Cancer Therapy in the Second Near‐Infrared Biowindow, Advanced Functional Materials, 2021, 31, 2100549. (IF 19.924) Jie Li, Lisi Xie, Bei Li†, Chao Yin, Guohao Wang, Wei Sang, Wenxi Li, Hao Tian, Zhan Zhang, Xuanjun Zhang, Quli Fan*, Yunlu Dai*(corresponding author), Engineering a Hydrogen Sulfide-based Nanomodulator to Normalize Hyperactive Photothermal Immunogenicity for Combination Cancer Therapy, Advanced Materials, 2021, 33, 2008481. (IF 32.086) Zhan Zhang, Lisi Xie, Yi Ju, Yunlu Dai*(corresponding author), Recent Advances in Metal-Phenolic Networks for Cancer Theranostics. Small, 2021, 17, 2100314. (IF 15.153) Yuxin Guo, Qing Sun, Fu-Gen Wu*, Yunlu Dai*(corresponding author), Xiaoyuan Chen*, Polyphenol-Containing Nanomaterials: Synthesis, Properties, and Biomedical Applications. Advanced Materials, 2021, 33, 2007356. (IF 32.086) Lisi Xie, Guohao Wang, Wei Sang, Jie Li, Zhan Zhang, Wenxi Li, Jie Yan, Qi Zhao, Yunlu Dai*(corresponding author), Phenolic immunogenic cell death nanoinducer for sensitizing tumor to PD-1 checkpoint blockade immunotherapy. Biomaterials, 2021, 269, 120638. (IF 15.304) Zhan Zhang†, Wei Sang†, Lisi Xie†, Wenxi Li, Bei Li, Jie Li, Hao Tian, Zhen Yuan, Qi Zhao, and Yunlu Dai*(corresponding author), Polyphenol-based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment. Angewandte Chemie International Edition, 2021, 60, 1967. (IF 16.823) Wei Sang, Lisi Xie, Guohao Wang, Jie Li, Zhan Zhang, Bei Li, Sen Guo, Chu-Xia Deng, Yunlu Dai*(corresponding author), Oxygen Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy. Advanced Science, 2021, 8, 2003338. (IF 17.521) Liwen Zhang, Lisi Xie, Sihao Xu, Rhiannon P Kuchel, Yunlu Dai*(corresponding author), Kenward Jung*, Cyrille Boyer* Dual Role of Doxorubicin for Photopolymerization and Therapy. Biomacromolecules, 2020, 21, 3887. (IF 6.979) Jingjing Wang, Wei Sang, Zhen Yang, Zheyu Shen, Zhantong Wang, Orit Jacobson, Yundai Chen, Yong Wang, Mingyan Shao, Gang Niu, Yunlu Dai*(corresponding author), and Xiaoyuan Chen* Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy. Journal of Materials Chemistry B, 2019, 7, 5688. (IF 7.571) Zhan Zhang, Wei Sang, Lisi Xie, Yunlu Dai*(corresponding author), Metal-organic frameworks for multimodal bioimaging and synergistic cancer chemotherapy. Coordination Chemistry Reviews, 2019, 399, 213022. (IF 24.833) Wei Sang, Zhan Zhang, Yunlu Dai*(corresponding author), Xiaoyuan Chen* Recent Advances in Nanomaterials-based Synergistic Combination Cancer Immunotherapy. Chemical Society Reviews, 2019, 48, 3771. (IF 60.615) (Back Cover Paper) Zhimei He, Xiaolin Huang, Chen Wang, Xiangli Li, Yijing Liu, Zijian Zhou, Sheng Wang, Fuwu Zhang, Zhantong Wang, Orit Jacobson, Jun-Jie Zhu,* Guocan Yu,* Yunlu Dai*(corresponding author), Xiaoyuan Chen* A Catalase-Like Metal-Organic Framework Nanohybrid for O2-Evolving Synergistic Chemoradiotherapy, Angewandte Chemie International Edition, 2019, 58, 8752. (IF 16.823) Lingling Shan, Guizhen Gao, Weiwei Wang, Wei Tang, Zhantong Wang, Zhen Yang, Wenpei Fan, Guizhi Zhu, Kefeng Zhai, Orit Jacobson, Yunlu Dai*(corresponding author), Xiaoyuan Chen,* Self-assembled Green Tea Polyphenol-based Coordination Nanomaterials to Improve Chemotherapy Efficacy by Inhibition of Carbonyl Reductase 1. Biomaterials, 2019, 210, 62. (IF 15.304) Yuan Liu, Christina S. Gong, Lisen Lin, Zijian Zhou, Yijing Liu, Zhen Yang, Zheyu Shen, Guocan Yu, Zhantong Wang, Sheng Wang, Ying Ma, Wenpei Fan, Liangcan He, Gang Niu, Yunlu Dai*(corresponding author), Xiaoyuan Chen* Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy. Theranostics 2019, 9, 2791. (IF 11.6) Zhimei He†, Yunlu Dai†(co-first author), Xiangli Li, Dan Guo, Yijing Liu, Xiaolin Huang, Jingjing Jiang, Sheng Wang, Guizhi Zhu, Fuwu Zhang, Lisen Lin, Jun-Jie Zhu,* Guocan Yu,* Xiaoyuan Chen* Hybrid Nanomedicine Fabricated from Photosensitizer-Terminated Metal-Organic Framework Nanoparticles for Photodynamic Therapy and Hypoxia-Activated Cascade Chemotherapy. Small, 2019, 15, 1804131. (IF 15.153) Zhen Yang, Yunlu Dai*(corresponding author), Lingling Shan, Zheyu Shen, Zhantong Wang, Bryant C Yung, Orit Jacobson, Yijing Liu, Wei Tang, Sheng Wang, Lisen Lin, Gang Niu, Pintong Huang*, Xiaoyuan Chen* Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics, Nanoscale Horizons, 2019, 4, 426. (IF 11.684)