程靓 - 中国科学院化学研究所 -

个人简介

2000–2004北京师范大学，理学学士 2004–2009中国科学院化学研究所，理学博士 2009–2011合成研究员，凯美隆（北京）药业技术有限公司，北京赛林泰医药技术有限公司 2011–2014美国哥伦比亚大学，博士后（withProf.RonaldBreslow） 2015–至今中国科学院化学研究所，研究员

研究领域

1.RNA表观遗传的化学调控 2.生物活性分子的高效合成

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Cheng, H.-P.; Yang, X.-H.; Lan, L.; Xie, L.-J.; Chen, C.; Liu, C.; Chu, J.; Li, Z.-Y.; Zhang, T.-Q.;* Luo, D.-Q.;* Cheng, L.* "Artificial Deprenylation of N6‐isopentenyladenosine (i6A) RNA", Angew. Chem. Int. Ed. 2020, DOI: 10.1002/anie.202003360. Xie, L.-J.; Liu, L.; Cheng, L.* "Modifying Methionine on Proteins", ChemBioChem, 2020, 21, 461-463 (Invited review). Xie, L.-J.; Liu, L.; Cheng, L.* "Selective Inhibitors of AlkB Family of Nucleic Acid Demethylases", Biochemistry, 2020, 59, 230-239 (Invited review, Future of Biochemistry: The Asia-Pacific Issue). Wang, R. -L.; Lan, L.; Liu, L.; Cheng, L.* "Asymmetric Polymerase Chain Reaction and Loop-mediated Isothermal Amplification (AP-LAMP) for ultrasensitive detection of microRNAs", Chin. Chem. Lett. 2020, 31, 159-162. Wang, R.-L.#; Jin, X.-Y.#; Kong, D.-L.; Chen, Z.-G.; Liu, J.; Liu, L.; Cheng, L.* "Visible-Light Facilitated Fluorescence "Switch-On" Labelling of 5-Formylpyrimidine RNA", Adv. Synth. Catal. 2019, 361, 5406-5411. Wang, C.; Zou, P.; Yang, C.; Liu, L.; Cheng, L.; He, X.; Zhang, L.; Zhang, Y.; Jiang, H.*; Chen, P. R.* "Dynamic Modifications of Biomacromolecules: Mechanism and Chemical Interventions", Sci. China Life Sci. 2019, 62, 1459-1471. Li, X.-D.#; Gao, Y.-T.#; Sun, Y.-J.; Jin, X.-Y.; Wang, D.; Liu, L.; Cheng, L.* "A NaI/H2O2 Mediated Sulfenylation and Selenylation of Unprotected Uracil and its Derivatives", Org. Lett. 2019, 21, 6643-6647. Jin, X.-Y.; Wang, R.-L.; Xie, L.-J.; Kong, D.-L.; Liu, L.; Cheng, L.* "A chemical photo-oxidation of 5-methyl cytidines", Adv. Synth. Catal. 2019, 361, 4685-4690. (VIP Article) Lan, L.; Wang, R. L.; Liu , L.; Cheng, L.* "A Label-free Colorimetric Detection of microRNA via G-Quadruplex-based Signal Quenching Strategy", Anal. Chim. Acta. 2019, 1079, 207-211. Liu, T.; Zhu, J.; Sun, X.; Cheng, L.; Wu, L.* "I2/TBHP Mediated Divergent C(sp2)-P Cleavage of Allenylphosphine Oxides: Substituent-Controlled Regioselectivity", Adv. Synth. Catal. 2019, 361, 3532-3537. Xie, L.-J.#; Yang, X.-T.#; Wang, R.-L.; Cheng, H.-P.; Li, Z.-Y.; Liu, L.; Mao, L. Q.; Wang, M.*; Cheng, L.* "Identification of Flavin Mononucleotide as Cell-Active Artificial N6-Methyladenosine RNA Demethylase", Angew. Chem. Int. Ed. 2019, 58, 5028-5032. Liu, J.-J.; Lan, L.; Gao, Y.-T.; Liu, Q.; Cheng, L.*; Wang, D.; Liu, L.* "Visible-Light-Mediated Stereoselective 1,2-Iodoalkylation of Alkynes", Adv. Synth. Catal. 2019, 361, 1283-1288. Li, X.-D.; Liu, L.; Cheng, L.* "Identification of Thienopyridine Carboxamides as Selective Binders of HIV-1 Trans Activation Response (TAR) and Rev Response Element (RRE) RNAs", Org. Biomol. Chem. 2018, 16, 9191-9196. Gao, Y.-T.; Jin, X.-Y.; Liu, Q.; Liu, A.-D.; Cheng, L.*; Wang, D.; Liu, L.* "Iodide/H2O2 Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2'-Pyrrolidinyl Spirooxindoles", Molecules, 2018, 23, 2265. Liu, Q.; Liu, J.-J.; Cheng, L.*, Wang, D.; Liu, L.* "TEMPO Promoted Direct Multi-functionalization of Terminal Alkynes with 2-Oxindoles/Benzofuran-2(3H)-one", Org. Biomol. Chem. 2018, 16, 5228-5231. Zhong, N.-J.; Wang, Y.-Z.; Cheng, L.*; Wang, D.; Liu, L.* "Recent advances in the annulation of Morita-Baylis-Hillman adducts", Org. Biomol. Chem. 2018, 16, 5214-5227. Li, X.-D.; Chen, B.; Lan, L.; Wang, R.-L.; Luo, D.-Q.; Liu, L.; Cheng, L.* "Selective Recognition of HIV RNA by Dinuclear Metallic Ligands", Chin. Chem. Lett. 2018, 29, 1637-1640. Jin, X.-Y.; Xie, L.-J.; Cheng, H.-P.; Liu, A.-D.; Li, X.-D.; Wang, D.; Cheng, L.*; Liu, L.* "Ruthenium-Catalyzed Decarboxylative C-H Alkenylation in Aqueous Media: A Synthesis of Tetrahydropyridoindoles", J. Org. Chem. 2018, 83, 7514-7522. Liu, J.-J.#; Huang, H.-Y.#; Cheng, L.*; Liu, Q.; Wang, D.; Liu, L.* "Catalyst-Free Intermolecular trans-Iodoalkylation of Alkynes", Org. Biomol. Chem. 2018, 16, 899-903. Gu, C.-L.*; Li, Y.-X.; Xiao, L.; Fu, H.-B.; Wang, D.; Cheng, L.; Liu, L.* "Tunable Heck-Mizoroki Reaction of Dibromo Naphthalene Diimide with Aryl ethylenes: Design, Synthesis and Characterization of Coplanar NDI-based Conjugated Molecules", J. Org. Chem. 2017, 82, 12806-12812. Xie, L.-J.; Wang, R.-L.; Wang, D.; Liu, L.; Cheng, L.* "Visible-Light-Mediated Oxidative Demethylation of N6-Methyl Adenines", Chem. Commun. 2017, 53, 10734-10737. Liu, J.-J.; Cheng, L.*; Huang, H.-Y.; Wei, F.; Wang, D.; Liu, L.* "Unprecedented Formation of 3-(Tetrahydrofuran-2-yl)-4H-chromen-4-one in the Reaction between 3,3a-Dihydro-9H-furo[3,4-b]chromen-9-one with Malononitrile", Org. Biomol. Chem. 2017, 15, 5078-5088. Huang, H.-Y.; Cheng, L.*; Liu, J.-J.; Wang, D.; Liu, L.*; Li, C.-J.* "Transition-Metal-Free Alkynylation of 2-Oxindoles through Radical-Radical Coupling", J. Org. Chem. 2017, 82, 2656-2663. Wei, F.; Cheng, L.*; Huang, H.-Y.; Liu, J.-J.; Wang, D.; Liu, L.* "Intermolecular Dearomative Oxidative Coupling of Indoles with Ketones and Sulfonylhydrazines Catalyzed by I2 for the Synthesis of [2,3]-Fused Indoline Tetrahydropyridazines", Sci. China Chem. 2016, 59, 1311-1316. Kong, D.-L.; Cheng, L.*; Yue, T.; Wu, H.-R.; Feng, W.-C.; Wang, D.; Liu, L.* "Cobalt-Catalyzed Peroxidation of 2-Oxindoles with Hydroperoxides", J. Org. Chem. 2016, 81, 5337-5344. Wu, H.-R.; Cheng, L.; Kong, D.-L.; Huang, H.-Y.; Gu, C.-L.; Liu, L.*; Wang, D.; Li, C.-J.* "FeCl3-Mediated Radical Tandem Reactions of 3-Benzyl-2-oxindoles with Styrene Derivatives for the Stereoselective Synthesis of Spirocyclohexene Oxindoles", Org. Lett. 2016, 18, 1382-1385. Li, X.-D.; Xie, L.-J.; Kong, D.-L.; Liu, L.; Cheng, L.* "Metal-free Allylation of Electron-rich Heteroaryl Boronic Acids with Allylic Alcohols", Tetrahedron 2016, 72, 1873-1880. Kong, D.-L.; Cheng, L.; Wu, H.; Li, Y.; Wang, D.; Liu, L.* "Metal-free Yne-addition/1,4-aryl migration/decarboxylation Cascade Reaction of Alkynoates with Csp3-H Centers", Org. Biomol. Chem. 2016, 14, 2210-2217.