Campiglia, Andres - University of Central Florida

研究领域

Our research focuses on the development of novel analytical approaches based on multidimensional luminescence spectroscopy. We take advantage of fluorescence and phosphorescence phenomena to directly determine target compounds in complex samples, to study mechanisms of interaction between chemical species in the liquid phase, and to elucidate solid-liquid interfacial phenomena. Our efforts directly impact areas of chemical sensing, environmental chemistry, liquid chromatography and capillary electrophoresis, and biological, forensic and pharmaceutical analysis. Current efforts are divided in four projects. First, we are developing new experimental methodologies and instruments for absorption, excitation, and multidimensional luminescence analysis at liquid nitrogen (77°K) and liquid helium (4.2° K) temperatures. This approach is based on the use of cryogenic fiber optic probes, making it possible to perform low-temperature measurements in a matter of seconds. We have developed the only existing method that provides unambiguous determination of dibenzo[a, l]pyrene in contaminated samples. This compound is the most carcinogenic polycyclic aromatic hydrocarbon known. Our second project deals with new strategies for targeting specific proteins in complex physiological fluids. Protein recognition is achieved via luminescence probes consisting of lanthanide ions incorporated into polymerized liposomes. The two remaining projects target specific needs in forensic science and nanotechnology. The forensic science project investigates ways to identify textile fibers encountered as physical evidence in criminal investigations. The nanotechnology project focuses on the development of new separation methodology with potential impact on biotechnical, biochemical, and biological research.

近期论文

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S. Yu and A. D. Campiglia*, 2005. Direct Determination of Dibenzo[a,l]pyrene and its Four Dibenzopyrene Isomers in Water Samples by Solid-Liquid Extraction and Laser-Excited Time-Resolved Shpol’skii Spectrometry. Analytical Chemistry, in press. S. Yu and A. D. Campiglia*, 2005. Laser-Excited Time-Resolved Shpol’skii Spectroscopy for the Direct Analysis of Dibenzopyrene Isomers in Liquid Chromatography Fractions. Applied Spectroscopy, in press. H. C. Goicoechea, B. C. Roy, M. Santos, A. D. Campiglia* and S. Mallik, 2005. Evaluation of Two Lanthanide Complexes for Qualitative and Quantitative Analysis of Target Proteins via Partial Least Squares Analysis. Analytical Biochemistry 336, 64-74. M. Santos, B. C. Roy, H. C. Goicoechea, A. D. Campiglia* and S. Mallik, 2004. An Investigation on the Analytical Potential of Polymerized Liposomes bound to Lanthanide Ions for Protein Analysis. Journal of the American Chemical Society 126 (34), 10738-10745. A. J. Bystol and A. D. Campiglia*, 2003. Fluorescence Line Narrowing Spectroscopy of Polycyclic Aromatic Hydrocarbons on Solid-Liquid Extraction Membranes. Applied Spectroscopy 57(6), 697-702. A. F. Arruda, H. C. Coicoechea, M. Santos, A. D. Campiglia* and A. C. Olivieri, 2003. Solid-liquid extraction room temperature phosphorimetry and pattern recognition for screening polycyclic aromatic hydrocarbons and polychlorinated biphenyls in water samples. Environmental Science and Technology 37, 1385-1391. A. J. Bystol, T. Thorstenson, A. D. Campiglia*, 2002. Laser-Induced Multidimensional Fluorescence Spectroscopy in Shpol’skii Matrices for the Analysis of Polycyclic Aromatic Hydrocarbons in HPLC Fractions and Complex Environmental Extracts. Environmental Science and Technology 36, 4424-4429. T. L. Martin, A. F. Arruda, A. D. Campiglia*, 2002. Time-resolved laser excited phosphorimetry at liquid helium temperature for the direct analysis of 2,3,7,8-tetrachlorodibenzo-para-dioxin in complex mixtures. Applied Spectroscopy 56 (10) 1354-1360. A. J. Bystol, J. L. Whitcomb and A. D. Campiglia*, 2001. Solid-Liquid Extraction Laser Excited Time-Resolved Shpol’skii Spectrometry: A Facile Method for the Direct Identification of Fifteen Priority Pollutants in Water Samples. Environmental Science and Technology, 35, 2566-2571. A. J. Bystol, A. D. Campiglia*, G. D. Gillispie, 2001. Laser-Induced Multidimensional Fluorescence Spectroscopy in Shpol’skii Matrices with a Fiber Optic Probe at Liquid Helium Temperature. Analytical Chemistry, 73, 5762-5770.