彭文杰 - 上海交通大学 - 系统生物医学研究院

个人简介

学习经历 2001-2006 理学博士中科院大连化学物理研究所、中科院上海有机化学研究所（联合培养） 1997-2001 理学学士南开大学化学系工作经历 2018.04 起上海交通大学系统生物医学研究院研究员、博士生导师、课题组组长 2015.11-2017.11 美国Scripps研究所分子医学系 Staff Scientist 2010.01-2015.10 美国Scripps研究所化学生理系 Research Associate 2006.11-2010.01 加拿大Alberta大学化学系、加拿大国家糖组学中心博士后 2013.09-2014.08 美国Cassia LLC生物技术公司课题负责人 2010.01-2011.10 美国功能糖组学协会（CFG）糖芯片组负责人

研究领域

本实验室结合化学生物学、细胞生物学和分子生物学等技术手段，研究糖链在免疫调节和人类疾病中的生物学功能意义，致力于糖链在转化医学和精准治疗等方面的药物开发。主要研究方向为： 1．基于化学酶法精准合成技术构建复杂糖链化合物库及糖芯片 2．病毒感染及变异机制 3．抗肿瘤药物靶向输送

近期论文

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de Toro B#, Peng W#, Thompson A, Domínguez G, Cañada J, Pérez-Castells J, Paulson J*, Jiménez-Barbero J*, Canales Á*. New NMR Avenues to Characterize the Interactions of Extended N-glycans with Proteins: The Influenza Hemagglutinin Case. Angew Chem Int Engl Ed 2018, 15051-15055. Imai H, Dinis J, Zhong G, Moncla L, Lopes T, Mcbride R, Thompson A, Peng W, Le M, Hanson A, Lauck M, Sakai-Tagawa Y, Yamada S, Eggenberger J, O’Connor D, Suzuki Y, Hatta M, Paulson J, Neumann G, Friedrich T, Kawaoka Y. Diversity of Influenza A(H5N1) Viruses in Infected humans, Northern Vietnam, 2004-2010. Emerging Infectious Diseases 2018，1128-1238. Peng W, Bouwman KM, McBride R, Grant OC, Woods RJ, Verheije MH, Paulson JC, de Vries RP. Enhanced human-type receptor binding by ferret transmissible H5N1 with a K193T mutation. J Virol. 2018, 92(10):e02016-17 Peng W, Paulson JC. CD22 Ligands on a Natural N-Glycan Scaffold Efficiently Delivers Toxins to B-Lymphoma Cells. J Am Chem Soc. 2017, 139(36):12450-12458. Peng W#, de Vries RP#, Grant OC, Thompson A, McBride R, Tsogtbaatar B, Lee PS, Razi N, Wilson IA, Woods RJ, Paulson JC. Recent H3N2 Viruses Have Evolved for Extended Branched Human-type Receptors Conferring Potential for Increased Avidity. Cell Host & Microbe 2017, 21, 23-34. de Vries RP#, Peng W#, Grant OC, Thompson AJ, Zhu XY, Bouwman KM, de la Pena ATT, van Breemen MJ, Ambepitiya Wichramasinghe IN, de Haan CAM, Yu W, McBride R, Sanders RW, Woods RJ, Verheije MH, Wilson IA, Paulson JC. Three Mutations Switch H7N9 Influenza to Human-type Receptor Specificty. Plos Pathogens 2017, 13(6): e1006390. Li W, Hulswit RJG, Widjaja I, Raj VS, McBride R, Peng W, Widagdo W, Tortorici MA, van Dieren B, Lang Y, van Lent JWM, Paulson JC, de Haan CAM, de Groot RJ, van Kuppeveld FJM, Haagmans BL, Bosch BJ. Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein. Proc Natl Acad Sci U S A. 2017,114(40):E8508-E8517. de Vries RP#, Tzarum N#, Peng W#, Thompson AJ#, Ambepitiya Wickramasinghe IN, de la Pena ATT, van Breemen MJ, Bouwman KM, Zhu X, McBride R, Yu W, Sanders RW, Verheije MH, Wilson IA, Paulson JC. A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors. EMBO Mol Med. 2017, 9(9):1314-1325. Tzarum N, McBride R, Nycholat CM, Peng W, Paulson JC, Wilson IA. Unique Structural Features of Influenza H15 HA. J Virol 2017, e00046-17. Tzarum N, de Vries RP, Peng W, Thompson A, Bouwman K, McBride R, Yu W, Zhu X, Verheije M, Paulson J, Wilson I. The 150-loop Restricts the Host Specificity of Human H10N8 Influenza Virus. Cell Reports 2017, 235-245. Dai MD, Mcbride R, Dortmans J, Peng W, Bakkers M, van Kuppeveld F, Paulson J, de Vries E, de Haan C. Mutation of the 2nd Sialic Acid-Binding Site Resulting in Reduced Neuraminidase Activity Preceded Emergence of H7N9 Influenza A Virus. J. Virol. 2017, e00049-17. Guo H, de Vries E, Mcbride R, Dekkers J, Peng W, Bouwman K, Nycholat C, Verheije H, Paulson J, van Kuppeveld F, de Haan C. Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity. Emerg Infect Dis 2017, 23, 220-231. Hiono T, Okamatsu M, Igarashi M, McBride R, de Vries RP, Peng W, Paulson JC, Sakoda Y, Kida H. (2015) Amino acid residues at positions 222 and 227 of the hemagglutinin together with the neuraminidase determine binding of H5 avian influenza viruses to sialyl Lewis X. J Arch Virol. 2015, 161(2):307-316. Macauley MS, Kawasaki N, Peng W, Wang SH, He Y, Arlian BM, McBride R, Kanagi R, Khoo KH, Paulson JC. Unmasking of CD22 on germinal center B-cells occurs by alternative mechanisms in mouse and man. J Biol Chem. 2015;290(50):30066-77. Ambepitiya WI, de Vries RP, Weerts EA. van Beruden SJ, Peng W, McBride R, Ducatez M, Guy J, Brown P, Eterradossi N, Grone A, Paulson JC, Verheije MH. Novel receptor specificity of avian gammacoronaviruses That Cause Enteritis. J Virol. 2015, 89, 8783. Blattner C, Lee JH, Sliepen K, Derking R, Falkowska E, de la Peña AT, Cupo A, Julien JP, van Gils M, Lee PS, Peng W, Paulson JC, Poignard P, Burton DR, Moore JP, Sanders RW, Wilson IA, Ward AB. Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers. Immunity 2014; 40:669-680. Nycholat C#, Peng W#, McBride R, Antonopoulos A, de Vries RP, Polonskaya Z, Finn MG, Dell A, Haslam SM, Paulson JC. Synthesis of biologically active N- and O-linked glycans with multi-sialylated poly-N-acetyllactosamine extensions using P. damsela alpha 2,6-sialyltransferase. J Am Chem Soc 2013;135: 18280-18283. Wang Z, Chinoy Z, Ambere S, Peng W, McBride R, de Vries RP, Glushka J, Paulson JC, Boons G. A general strategy for the chemoenzymatic synthesis of asymmetrically branched N-glycans. Science 2013; 341(6144):379-83. Peng W, Zou L, Bhamidi S, McNeil MR, Lowary TL. The galactosamine residue in mycobacterial arabinogalactan is alpha-linked. J Org Chem. 2012;77(21):9826-32. Peng W, Pranskevich J, Nycholat C, Gilbert M, Wakarchuk W, Paulson JC, Razi N. Helicobacter pylori beta1,3-N-acetylglucosaminyltransferase for versatile synthesis of type 1 and type 2 poly-LacNAcs on N-linked, O-linked and I-antigen glycans. Glycobiology. 2012;22(11):1453-64.