Huang, Meilan - Queen's University - School of Chemistry and Chemical Engineering

个人简介

I have achieved PGCHET. Since I took the post, I have been building up my teaching load, delivering lectures to various levels of students, and have received good student feedback on my teaching. I have been coordinating three modules. In addition, developed the new MSci Medicinal chemistry course. I have been taken the duty of the school Examination Officier.

研究领域

I have established a computational chemistry and biology group in the areas of computer-aided drug/material design and rational engineering enzymes as biocatalysts, having been engaged in developing and applying structure-based approaches to identify lead compounds or new biocatalysts. I have been supervising interdisciplinary research in collaboration with molecular biologists, biochemists and medicinal chemists from international renowned institutions such as Zhejiang Univ, Shanghai Jiaotong Univ, Beijing Univ of Chemical Technology, University of Malaya and industry such as Almac. My group has developed novel statistical methods to design peptide inhibitors targeting protein-protein interactions as potential anti-virus therapy. Another research area is rationally engineering enzymes guided by theoretical modeling, where I have been the academic leader of the academia-industry collaborative project funded by Invest NI “Development of a computational and molecular biology platform for QUB and Almac”. Recently, I have developed research interest in rational design of new solar cell materials. The research has been published on international peer-reviewed high-impact journals such as ACS Catalysis, J Phys Chem, Biochemistry, Bioorg Med Chem Lett, Proteins, PLOS One, etc.

近期论文

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Artificial Cysteine-Lipases with High Activity and Altered Catalytic Mechanism Created by Laboratory Evolution Cen, Y., Singh, W., Arkin, M., Moody, T., Huang, M., Zhou, J., Wu, Q. & Reetz, M., 24 Jun 2019, (Accepted) In : Nature Communications. Research output: Contribution to journal › Article An Efficient, Full Spectrum-Driven H2 Evolution Z-Scheme Co2P/CdS Photocatalyst with Co-S Bonds Li, N., Ding, Y., Wu, J., Zhao, Z., Li, X., Zheng, Y-Z., Huang, M. & Tao, X., 04 Jun 2019, In : ACS Applied Materials and Interfaces. Research output: Contribution to journal › Article Stereodivergent Protein Engineering of a Lipase to Access All Possible Stereoisomers of Chiral Esters with Two Stereo-centers Wu, J., Cen, Y., Singh, W., Fan, J., Wu, L., Lin, X., Zhou, J., Huang, M., Reetz, M. & Wu, Q., 26 Apr 2019, (Accepted) In : Journal of the American Chemical Society. Research output: Contribution to journal › Article Phosphorylation Mechanism of N-acetyl-L-Glutamate Kinase, a QM/MM Study McClory, J., Hu, G-X., Zou, J., Timson, D. J. & Huang, M., 08 Mar 2019, In : The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical. Research output: Contribution to journal › Article Catalytic Mechanism of Mevalonate Kinase Revisited, a QM/MM Study McClory, J., Lin, J., Timson, D., Zhang, J. & Huang, M., Feb 2019, (Accepted) In : Organic and Biomolecular Chemistry. Research output: Contribution to journal › Article “Top” or “Bottom” Switches of a Cyclohexanone Monooxygenase Controlling the Enantioselectivity of the Sandwiched Substrate Hu, Y., Wang, J., Cen, Y., Zhang, H., Huang, M. & Wu, Q., 25 Jan 2019, In : Chemical Communications. Research output: Contribution to journal › Article Are the Apo Proteins Suitable for the Rational Discovery of Allosteric Drugs An, X., Lu, S., Song, K., Shen, Q., Huang, M., Yao, X., Liu, H. & Zhang, J., 07 Dec 2018, In : JOURNAL OF CHEMICAL INFORMATION AND MODELING. p. 1-30 Research output: Contribution to journal › Article Modulation of the mobility of a key region in human galactokinase: impacts on catalysis and stability McAuley, M., Huang, M. & Timson, D., Dec 2018, In : Bioorganic Chemistry. 81 Research output: Contribution to journal › Article Water-mediated network in the resistance mechanism of fosfomycin McClory, J., Lin, J. T., Timson, D. J., Zhang, J. & Huang, M., 02 Aug 2018, In : Physical Chemistry Chemical Physics. 20, 33, p. 21660-21667 8 p. Research output: Contribution to journal › Article Improving the activity and stability of human galactokinase for therapeutic and biotechnological applications McAuley, M., Mesa-Torres, N., McFall, A., Morris, S., Huang, M., Pey, A. L. & Timson, D. J., 18 May 2018, In : ChemBioChem. 19, 10, p. 1088-1095 Research output: Contribution to journal › Article Hexamethylenetetramine-mediated growth of grain-boundary-passivation CH3NH3PbI3 for highly reproducible and stable perovskite solar cells Zheng, Y-Z., Li, X-T., Zhao, E-F., Lv, X-D., Meng, F-L., Peng, C., Lai, X-S., Huang, M., Cao, G., Tao, X. & Chen, J-F., 15 Feb 2018, In : Journal of Power Sources. 377, p. 103-109 Research output: Contribution to journal › Article Spatial requirement for phenylacetone monooxygenases for transformation of non-native linear substrates Carvalho, A., Dourado, D., Skvortsov, T., Miguel, D. A., Ferguson, L., Quinn, D., Moody, T. & Huang, M., 03 Jan 2018, In : Physical Chemistry Chemical Physics. p. 1-32 Research output: Contribution to journal › Article The Reaction Mechanism of Isopentenyl Phosphate Kinase: A QM/MM Study McClory, J., Timson, D., Singh, W., Zhang, J. & Huang, M., 20 Nov 2017, In : Journal of Physical Chemistry B. p. 1-29 Research output: Contribution to journal › Article High-efficiency near-infrared enabled planar perovskite solar cells by embedding upconversion nanocrystals Fan-Li Meng, Wu, JI-J., Zhao, E-F., Zheng, Y-Z., Huang, M-L., Dai, L-M., Tao, X. & Chen, J-F., 06 Nov 2017, In : Nanoscale. 9, 46, p. 18535-18545 Research output: Contribution to journal › Article New Insights into PI3K Inhibitor Design using X-ray Structures of PI3Kα Complexed with a Potent Lead Compound Yang, X., Zhang, X., Huang, M., Song, K., Li, X., Huang, M., Meng, L. & Zhang, J., 06 Nov 2017, In : Scientific Reports. 7, p. 1-7 14572., 14572 Research output: Contribution to journal › Article Catalytic mechanism of Phenylacetone monooxygenases for non-native linear substrates: implications on rational engineering of BVMOs to expand the substrate specificity Carvalho, A. T. P., Dourado, D. F. A. R., Skvortsov, T., de Abreu, M., Ferguson, L., Quinn, D. J., Moody, T. S. & Huang, M., 07 Sep 2017, In : Physical Chemistry Chemical Physics. 19, 39, p. 26851-26861 11 p. Research output: Contribution to journal › Article Conformational and Energy Evaluations of Novel Peptides Binding to Dengue Virus Envelope Protein Amir-Hassan, A., Sanghiran Lee, V., Baharuddin, A., Othman, S., Xu, Y., Huang, M., Yusof, R., Rahman, N. A. & Othman, R., Jun 2017, In : Journal of Molecular Graphics and Modelling. 74, p. 273–287 Research output: Contribution to journal › Article Toward a uniform description of hydrogen bond and halogen bond: correlations of interaction energies with various geometric, electronic and topological parameters Zou, J-W., Huang, M., Hu, G-X. & Jiang, Y-J., 07 Feb 2017, In : RSC Advances. 7, p. 10295-10305 11 p. Research output: Contribution to journal › Article Insight into the mechanism of galactokinase: role of a critical glutamate residue and helix/coil transitions McAuley, M., Huang, M. & Timson, D. J., 24 Oct 2016, In : Biochimica et Biophysica Acta - Proteins and Proeomics. Research output: Contribution to journal › Article