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个人简介

Ph.D., University of Kansas (2009) with Jeffrey Aubé Postdoctoral, Princeton University (2010) with David MacMillan Postdoctoral, University of Manchester (2011-2014) with David Procter

研究领域

The central theme of our research is synthetic organic and organometallic chemistry with a focus on the development of new synthetic methods based on transition metal catalysis and various aspects of transition metal mediated free radical chemistry and their application to the synthesis of biologically active molecules.

近期论文

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Zhang, J.; Zhang, P.; Shao, L.; Wang, R.; Ma, Y.; Szostak, M. “Mechanochemical Solvent-Free Suzuki–Miyaura Cross-Coupling of Amides via Highly Chemoselective N–C Cleavage,” Angew. Chem. Int. Ed. 2022, 61, DOI: 10.1002/anie.202114146. Liu, C.; Szostak, M. “Decarbonylative Sonogashira Cross-Coupling: Fruitful Marriage of Alkynes with Carboxylic Acid Electrophiles,” Org. Chem. Front. 2022, 9, DOI: 10.1039/D1QO01539G. Li, D. H.; Lan, X. B.; Song, A. X.; Rahman, M.; Xu, C.; Huang, F. D.; Szostak, R.; Szostak, M.; Liu, F. S. “Buchwald-Hartwig Amination of Coordinating Heterocycles Enabled by Large-but-Flexible Pd–BIAN–NHC Catalysts,” Chem. Eur. J. 2022, 28, DOI: 10.1002/chem.202103341. Lei, P.; Wang, Y.; Mu, Y.; Wang, Y.; Ma, Z.; Feng, J.; Liu, X.; Szostak, M. “Green-Solvent Selection for Acyl Buchwald–Hartwig Cross-Coupling of Amides (Transamidation),” ACS Sustainable Chem. Eng. 2021, 9, 14937-14945. Zhang, W.; Bie, F.; Ma, J.; Zhou, F.; Szostak, M.; Liu, C. “Palladium-Catalyzed Decarbonylative Borylation of Aryl Anhydrides,” J. Org. Chem. 2021, 86, 17445-17452. Xia, Q.; Shi, S.; Gao, P.; Lalancette, R.; Szostak, R.; Szostak, M. “[(NHC)PdCl2(Aniline)] Complexes: Easily Synthesized, Highly Active Pd(II)–NHC Precatalysts for Cross-Coupling Reactions,” J. Org. Chem. 2021, 86, 15648-15657. Liu, C.; Szostak, M. “Forging C–S Bonds Through Decarbonylation,” ChemCatChem 2021, 13, 4878-4881. (Hot Topic: C-C Coupling) Bie, F.; Liu, X.; Cao, H.; Shi, Y.; Zhou, T.; Szostak, M.; Liu, C. “Pd-Catalyzed Double-Decarbonylative Aryl Sulfide Synthesis through Aryl Exchange between Amides and Thioesters,” Org. Lett. 2021, 23, 8098-8103. Durand, C.; Szostak, M. “Recent Advances in the Synthesis of Piperazines: Focus on C–H Functionalization,” Organics 2021, 2, 337-347. (Special Issue: Featured Papers; open access: https://doi.org/10.3390/org2040018) Bisz, E.; Koston, M.; Szostak, M. “N-Butylpyrrolidone (NBP) as a Non-Toxic Substitute for NMP in Iron-Catalyzed C(sp2)–C(sp3) Cross-Coupling of Aryl Chlorides,” Green Chem. 2021, 23, 7515-7521. (Selected as a Hot Article). Meng, G.; Zhang, J.; Szostak, M. “Acyclic Twisted Amides,” Chem. Rev. 2021, 121, 12746-12783. Zhao, Q.; Meng, G.; Li, G.; Flach, C.; Mendelsohn, R.; Lalancette, R.; Szostak, R.; Szostak, M. “IPr# – Highly Hindered, Broadly Applicable N-Heterocyclic Carbenes,” Chem. Sci. 2021, 12, 10583-10589. Rahman, M.; Pyle, D. J.; Bisz, E.; Dziuk, B.; Ejsmont, K.; Lalancette, R.; Wang, Q.; Chen, H.; Szostak, R.; Szostak, M. “Evaluation of Cyclic Amides as Activating Groups in N–C Bond Cross-Coupling: Discovery of N–Acyl-d-valerolactams as Effective Twisted Amide Precursors for Cross-Coupling Reactions,” J. Org. Chem. 2021, 86, 10455-10466. Cao, H.; Liu, X.; Bie, F.; Shi, Y.; Han, Y.; Yan, P.; Szostak, M.; Liu, C. “Rh(I)-Catalyzed Intramolecular Decarbonylation of Thioesters,” J. Org. Chem. 2021, 86, 10829-10837. Liu, C.; Szostak, M. “Decarbonylative Sulfide Synthesis from Carboxylic Acids and Thioesters via Cross-Over C–S Activation and Acyl Capture,” Org. Chem. Front. 2021, 8, 4805-4813. Rahman, M.; Szostak, M. “Synthesis of Sulfoxonium Ylides from Amides by Selective N–C(O) Activation,” Org. Lett. 2021, 23, 4818-4822. Liu, C.; Szostak, M. “Decarbonylative Sonogashira Cross-Coupling of Carboxylic Acids,” Org. Lett. 2021, 23, 4726-4730. Li, H.; Peng, M,; Lai, Z,; Ning, L.; Chen, X.; Zhang, X.; Wang, P.; Szostak, R.; Szostak, M.; An, J. “Acyl Fluorides as Direct Precursors to Fluoride Ketyl Radicals: Reductive Deuteration Using SmI2 and D2O,” Chem. Commun. 2021, 57, 5195-5198. Urbina, K.; Tresp, D.; Sips, K.; Szostak, M. “Recent Advances in Metal-Catalyzed Functionalization of Indoles,” Adv. Synth. Catal. 2021, 363, 2723-2739. Mughal; H.; Szostak, M. “Recent Advances in the Synthesis and Reactivity of Azetidines: Strain-Driven Character of the Four-Membered Heterocycle,” Org. Biomol. Chem. 2021, 19, 3274-3286.

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