李超 - 北京生命科学研究所 -

个人简介

Professional Experience 2017.11-Current Assistant Investigator, National Institute of Biological Sciences, Beijing 2014.10-2017.10 Post-doctoral Fellow, The Scripps Research Institute, La Jolla, San Diego, CA, USA.Advisor: Prof. Phil S. Baran 2013.7-2014.9 Post-doctoral Fellow, National Institute of Biological Science (NIBS), Beijing, China.Advisor: Prof. Xiaoguang Lei Education 2008-2013 Ph.D. in Organic Synthesis, National Institute of Biological Science (NIBS), Beijing, China. & Tianjin University, Tianjin, China.Advisor: Prof. Xiaoguang Lei 2004-2008 B.S. in Pharmaceutical Engineering, Qingdao University of Science and Technology, Qingdao, China.Advisor: Prof. Fengke Yang Honors 2022 Wuxi AppTec Life Science and Chemistry Award 2021 Chinese Chemical Society Young Chemist Award 2020 Thieme Chemistry Journals Award 2013 Storm International Diversity (CSID) Fellowship for Gordon Research Conference 2012 National Scholarship for Excellence in Scientific Research 2012 Graduate Student Award Sponsored by Baoshan Iron and Steel Company

研究领域

Research in our group focus on the discovery of novel chemical reactions, and their applications in the syntheses of natural products and bioactive molecules

近期论文

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Ying, X.; Li, Y.; Li, L.; Li, C. “Nickel-Catalyzed C–I-Selective C(sp2)–C(sp3) Cross-Electrophile Coupling of Bromo(iodo)arenes with Alkyl Bromides” Angew. Chem. Int. Ed. 2023, 62, Accepted Articles Zhuo, J.; Zhu, C.; Wu, J.; Li, Z.; Li, C. “Reductive Radical Annulation Strategy toward Bicyclo[3.2.1]octanes: Synthesis of ent-Kaurane and Beyerane Diterpenoids” J. Am. Chem. Soc. 2022,144, 99-105. Li, Y.; Wang, Z.; Li, L.; Tian, X.; Shao, F.; Li, C. “Chemoselective and Diastereoselective Synthesis of C-Aryl-Nucleoside Analogues by Nickel-Catalyzed Cross-Coupling of Furanosyl Acetates with Aryl Iodides” Angew. Chem. Int. Ed. 2022, 61, e202110391. Yang, S.;# Chen, C.;# Chen, J.#; Li, C. “Total Synthesis of the Potent and Broad-Spectrum Antibiotics Amycolamicin and Kibdelomycin” J. Am. Chem. Soc. 2021, 143, 21258–21263. Zhang, Y.; Sun, W.; Li, C. “Nickel-Catalyzed Paired Electrochemical Cross-Coupling of Aryl Halides with Nucleophiles” Synthesis, 2022, 54, 281-294. Li, Z.; Sun, W.; Wang, X.; Li, L; Zhang, Y.; Li, C. “Electrochemically Enabled, Nickel-Catalyzed Dehydroxylative Cross-Coupling of Alcohols with Aryl Halides” J. Am. Chem. Soc. 2021, 143, 3536-3543. Xu, G.;# Wu, J.;# Li, L.; Lu, Y.; Li, C. “Total Synthesis of (-)-Daphnezomines A and B” J. Am. Chem. Soc. 2020, 142, 15240–15245. Zhuo, J.;# Zhang, Y.; # Li, Z.; Li, C. “Nickel-Catalyzed Direct Acylation of Aryl and Alkyl Bromides with Acylimidazoles” ACS Catal. 2020, 10, 3895-3903. Zhang, J.;# Li, Z.;# Zhuo, J.; Cui, Y.; Han, T.; Li, C. “Tandem Decarboxylative Cyclization/Alkenylation Strategy for Total Syntheses of (+)-Longirabdiol, (-)-Longirabdolactone, and (-)-Effusin” J. Am. Chem. Soc. 2019, 141, 8372-8380. Takahira, Y.; Chen, M.; Kawamata, Y.; Mykhailiuk, P.; Nakamura, H. Peters, B. K.; Reisberg, S. H.; Li, C.; Chen, L.; Hoshikawa, T.; Shibuguchi, T.; Baran, P. S. Electrochemical C(sp3)-H Fluorination. Synlett. 2019, 30, 1178. Kawamata, Y.; Vantourout, J. C.; Hickey, D. P.; Bai, P.; Chen, L.; Hou, Q.; Qiao, W.; Barman, K.; Edwards, M. A.; Garrido-Castro, A. F.; deGruyter, J. N.; Nakamura, H.; Knouse, K.; Qin, C.; Clay, K. J.; Bao, D.; Li, C.; Starr, J. T.; Garcia-Irizarry, C.; Sach, N.; White, H. S.; Neurock, M.; Minteer, S. D.; Baran, P. S. Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications. J. Am. Chem. Soc. 2019, 141, 6392. Li, C.#; Kawamata, Y.#; Nakamura, H.; Vantourout, J. C.; Liu, Z.; Hou, Q.; Bao, D.; Star, J. T.; Chen, J.; Yan, M.; Baran, P. S.* “Electrochemically Enabled, Ni-Catalyzed Amination” Angew. Chem. Int. Ed. 2017, 56, 13088. Li, C.#; Wang, J.#; Barton, L. M.; Yu, S.; Tian, M.; Peters, D. S.; Kumar, M.; Yu, A. W.; Johnson, K. A.; Chatterjee, A. K.; Yan, M.; Baran, P. S.* “Decarboxylative Borylation” Science, 2017, eaam7355. (Article). Qin, T.#; Cornella, J.#; Li, C.#; Malins, L. R.; Edwards, J. T.; Kawamura, S.; Maxwell, B. D.;Eastgate, M. D.; Baran, P. S.* “A General Alkyl-Alkyl Cross-Coupling Enabled by Redox-Active Esters and Alkylzinc Reagents” Science, 2016, 352, 801-805.(Highlighted in Angew. Chem. Int. Ed. 2016, 55, 11340; Synfacts 2016, 12, 0723) Li, C.; Jones, A. X.; Lei, X.* “Synthesis and mode of action of oligomeric sesquiterpene lactones”Nat. Prod. Rep. 2016, 33, 602-611. Li, D.#; Li, C.#; Li, L.; Chen, S.; Wang, L.; Li, Q.; Wang, X.; Lei, X.*; Shen, Z.* “Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis” Cell Chemical Biology, 2016, 23, 257-266. (Featured Article) Hong, B.#; Li, C.#; Wang, Z.; Chen, J.; Li, H.*; Lei, X.* “Enantioselective Total Synthesis of (−)-Incarviatone A” J. Am. Chem. Soc. 2015, 137, 11946-11949.(News story describing this work was highlighted in Chem. & Eng. News 2015, 93, 35) Dao, H. T.; Li, C.; Michaudel, Q.; Maxwell, B. D.; Baran, P. S.* “Hydromethylation of Unactivated Olefins” J. Am. Chem. Soc. 2015, 137, 8046-8049. Dong, T.#; Li, C.#; Wang, X.; Dian, L.; Zhang, X.; Li, L.; Chen, S.; Cao, R.; Li, L.; Huang, N.; He, S.;* Lei, X.* “Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine” Nature Commun. 2015, 6, 6522. Li, C.#; Dong, T.#; Li, Q.; Lei, X.* “Probing the Anticancer Mechanism of (−)-Ainsliatrimer A through Diverted Total Synthesis and Bioorthogonal Ligation” Angew. Chem. Int. Ed. 2014, 53, 12111-12115. Li, C.; Lei, X.* “Strategies toward the Biomimetic Syntheses of Oligomeric Sesquiterpenoids” J. Org. Chem. 2014, 79, 3289-3295. Li, C.; Dong, T.; Dian, L.; Zhang, W.; and Lei, X.* “Biomimetic Syntheses and Structural Elucidation of the Apoptosis-Inducing Sesquiterpenoid Trimers: (-)-Ainsliatrimers A and B” Chem. Sci. 2013, 4, 1163-1167. Li, C.; Li, X.; Wang, X.; Lei, X.* “Diversity-oriented Synthesis of Bicyclic Ring Systems via a Conjugate Addition/aldol/RCM Process” Sci. China. Chem. 2013, 56, 337-341. Li, C.; Dian, L.; Zhang, W.; Lei, X.* “Biomimetic Syntheses of (-)-Gochnatiolides A-C and (-)-Ainsliadimer B” J. Am. Chem. Soc. 2012, 134, 12414-12417. Li, C.; Tu, S.; Wen, S.; Li, S.; Chang, J.; Shao, F, Lei, X.* “Total Synthesis of the G2/M DNA Damage Checkpoint Inhibitor Psilostachyin C” J. Org. Chem. 2011, 76, 3566-3570. Li, C.; Yu, X.; Lei, X.* “A Biomimetic Total Synthesis of (+)-Ainsliadimer A” Org. Lett. 2010, 12, 4284-4287.