陆晓杰 - 中国科学院上海药物研究所 -

个人简介

陆晓杰，2005年毕业于南京大学化学系获得化学学士学位，随后到美国Brandeis University 在邓力老师的指导下从事有机小分子催化的不对称反应研究。在2007和2011年先后获得了有机化学的硕士和博士学位。2010年底加入美国葛兰素史克（GSK）任研究员,专门从事核酸编码化合物库的技术开发研究，2016年入选了葛兰素史克Associate Fellow。 2017年加入中国科学院上海药物研究所任研究员，课题组长。教育经历 2007.9-2011.5 Brandeis University, 有机化学博士 2005.9-2007.8 Brandeis University, 有机化学硕士 2001.9-2005.6南京大学，化学本科工作经历 2017.7-至今上海药物研究所，课题组长，研究员 2016.5-2017.6葛兰素史克, 美国波士顿， Associate Fellow 2010.11-2016.5葛兰素史克, 美国波士顿, 研究员

研究领域

将核酸编码化合库筛选技术和其他药物开发技术（计算机辅助药物设计，天然产物药物开发等）结合起来设计和合成针对特定靶点的核酸编码集中库来加快小分子药物的开发。 1. 针对特定靶点的核酸编码集中库的设计，合成和筛选 2. 和核酸相容能用于核酸编码化合物库合成的化学反应开发 3. 多功能小分子药物的设计和合成 4. 大分子的选择性化学修饰

近期论文

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Ke Li, Xiaohong Liu, Sixiu Liu, Yulong An, Yanfang Shen, Qingxia Sun, Xiaodong Shi, Wenji Su, Weiren Cui, Zhiqiang Duan, Letian Kuai, Hongfang Yang, Alexander L. Satz, Kaixian Chen, Hualiang Jiang, Mingyue Zheng,* Xuanjia Peng,* Xiaojie Lu*，“Solution Phase DNA-Compatible Pictet-Spengler Reaction Aided By Machine Learning Building Block Filtering”，iScience 2020, DOI: 10.1016/j.isci.2020.101142. Yi Qu, Sixiu Liu，Huanan Wen, Yanfen Xu, Yulong An, Ke Li, Mengyuan Ni, Yanfang Shen, Xiaodong Shi, Wenji Su, Weiren Cui, Letian Kuai, Alexander L. Satz, Hongfang Yang, Xiaojie Lu*, Xuanjia Peng*，“Palladium-Mediated Suzuki-Miyaura Cross-Coupling Reaction of Potassium Boc-protected Aminomethyltrifluoroborate with DNA-Conjugated Aryl Bromides for DNA-Encoded Chemical Library Synthesis”，Biochem. Biophys. Res. Commun，2020，DOI: 10.1016/j.bbrc.2020.04.027. (invited article for special issue: DNA encoded chemistry) Xuan Wang, Hui Sun, Jiaxiang Liu, Wenge Zhong, Mingqiang Zhang, Hu Zhou, Dongcheng Dai*, and Xiaojie Lu* “Palladium-Promoted DNA-Compatible Heck Reaction” Org. Lett., 2019, 21, 719. Dong-Yu Wang, Xin Wen, Chao-Dong Xiong, Jian-Nan Zhao, Chun-Yong Ding, Qian Meng, Hu Zhou, Chao Wang, Masanobu Uchiyama, Xiao-Jie Lu*，Ao Zhang * "Non-Transition Metal-Mediated Diverse Aryl–Heteroatom Bond Formation of Arylammonium Salts" iScience, 2019,15, 307. Gang Yao*, Xiaojie Lu, Christopher B. Phelps, Ghotas Evindar, Chapter 7, DNA encoded library technology, page 153-183. “Chemical and Biological Synthesis: Enabling Approaches for Understanding Biology”, Royal Society Chemistry, 2018. Xuan Wang, Hui Sun, Jiaxiang Liu, Dongcheng Dai, Mingqiang Zhang, Hu Zhou, Wenge Zhong*, Xiaojie Lu* “Ruthenium Promoted C-H Activation Reactions between DNA-conjugated Acryl amide and Aromatic Acids” Org. Lett., 2018, 20, 4764. Xiaojie Lu*, Sarah Roberts, George J. Frankline and Christopher P. Davie, “On-DNA Pd and Cu promoted C-N Cross-Coupling Reactions”, MedChemComm, 2017, 8, 1614. 8.Xiaojie Lu*, Lijun Fan*, Christopher B. Phelps, Christopher P. Davie, and Christine P. Donahue, “Ruthenium Promoted On-DNA Ring-Closing Metathesis and Cross-Metathesis”, Bioconjugate Chem., 2017, 28, 1625 (This article was highlighted by C&EN, “Making macrocyclic compounds for DNA-encoded libraries”, C&EN online July 6, 2017). Baptiste Thomas, Xiaojie Lu*, William Birmingham, Kun Huang, Peter Both, Juana Reyes Martinez, Robert Young*, Christopher Davie, Sabine Flitsch*, “Application of Biocatalysis to on-DNA Carbohydrate Library Synthesis”, ChemBioChem, 2017, 18, 858-863. (This article was selected as the cover picture for special issue: DNA encoded chemistry, ChemBioChem, 2017, 18, 825.)