田雷蕾 - 南方科技大学 - 材料科学与工程系

个人简介

教育背景 2003年–2008年，吉林大学化学学院高分子化学与物理博士 1999年–2003年，吉林大学化学学院化学工程与工艺本科工作经历 2015年– 至今，副教授，材料科学与工程系，南方科技大学 2014年–2014年，研究员，美国芝加哥大学 2011年–2014年，博士后，美国芝加哥大学 2009年–2010年，博士后，美国克莱姆森大学 2008年–2009年，博士后，美国南卡莱罗纳大学

研究领域

基于生物大分子的复合、杂化智能材料：我们的项目致力于开发新型核酸纳米生物技术，利用核酸大分子的智能识别、基因治疗、酶催化等功能，通过同其它功能材料复合或者共价杂化发展可应用于生物检测、化学传感、生物医药、疾病诊疗等领域的新型生物智能材料有机光电功能材料的化学、生物传感应用：通过对分子间作用力的设计和调控，实现对小分子或者生物标记物的高灵敏检测利用信号放大策略的高灵敏癌症标记物检测方法的设计开发

近期论文

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Fan, G. L.; Hou, S. X.; Zhang, W. K.; Jiang, H. F.; Xiao, F.; Yu, J. T.; Tian, L. L.;* “Polymer-DNA Carriers Co-Deliver Photosensitizer and siRNA for Light-Promoted Gene Transfection and Hypoxia-Relieved Photodynamic Therapy” Angew.Chem. Int. Ed. 2024, In Press. Zhu, Y. L.; Lai, H. J.; Gu, Y.; Wei, Z. X.; Chen, L.; Lai, X.; Han, L.; Tan, P.; Pu, M. R.; Xiao, F.; He, F.;*, Tian, L. L.;* “The Balance Effect of π–π Electronic Coupling on NIR‐II Emission and Photodynamic Properties of Highly Hydrophobic Conjugated Photosensitizers”Adv. Sci. 2024, 11, 2307569. Yu, J. T.; Tang, M.; Zhou, Z. D.; Wei, Z. X.; Wan, F. Y.; Hou, S. X.; Li, Q.; Li, Y.;*, Tian, L. L.;* “Biologically Produced and Metal-Organic Framework Delivered Dual-Cut CRISPR/Cas9 System for Efficient Gene Editing and Sensitized Cancer Therapy” Acta Biomater. 2024, 178, 296-306. Li, H.; Qing Li, Q.; Gu, Y.; Wang, M. Y.; Tan, P.; Wang, H. T.; Han, L.; Zhu, Y. L.; He, F.; Tian, L. L.;* “Dimerization Extends π-Conjugation of Electron Donor-Acceptor Structures Leading to Phototheranostic Properties Beyond the Sum of Two Monomers” Aggregate 2024, e528. Wan, F. Y.; Wang, H.; Gu, Y.; Fan, G. L.; Hou, S. X.; Wang, M. Y.; He, F.; Tian, L. L.;* “Bromine Substitution Improves the Photothermal Performance of π‐Conjugated Phototheranostic Molecules” Chem.Eur. J. 2024, 30, e202303502. Li, M. P.; Tian, L. L.;*, He, F.;* “How can We Improve the Stability of Organic Solar Cells from Materials Design to Device Engineering” Aggregate 2024, e567. Pu, M. R.; Lai, X.; Chen, H.; Cao, C. C.; Wei, Z. X.; Zhu, Y. L.;Tian, L. L.;*, He, F.;* “Superior Aggregation, Morphology and Photovoltaic Performance Enabled by Fine Tuning of Fused Electron-Deficient Units in Polymer Donors” Energy Chem. 2023, 19-26. Yu, J. T.; Li, Q.; Wei, Z. X.; Fan, G. L.; Wan, F. Y.; Tian, L. L.;∗"Ultra-stable MOF@MOF nanoplatform for photodynamic therapy sensitized by relieved hypoxia due to mitochondrial respiration inhibition" Acta Biomaterialia, 2023.170, 330-343. Han, L.; Liu, J. H.; Wei, Z. X.; Gu, Y.; Zhu, Y. L.;Chen, L.; Zhang, X. D.;Wu, W. T.;He, F.;* and Tian, L. L.;*"Structural Morphology Changes the Fate of Semiconducting Polymers in Afterglow Luminescence Imaging"Chem. Mater. 2023, 35, 6920−6931. Pu, M. R.; Lai, X.; Li, Y.; Zhu, Y. L.; Wei, Z. X.;Zhu, Y. W.; Chen, H.;Tian, L. L.;* and He, F.;*"Backbone Tuning Enhances the Solution Aggregation to Refine Fibrillization Network Morphology for Efficient All-Chlorinated Polymer Donor"ACS Materials Lett. 2023, 5, 2369−2376. Gu, Y.; Lai, H. J.; Chen, Z. Y.; Zhu, Y. L.; Sun, Z. Z.; Lai, X.; Wang, H. T.; Wei, Z. X.; Chen, L.; Huang, L. M.; Zhang, Y. Z.; He, F.;* and Tian, L. L.;*"Chlorination-Mediated π–π Stacking Enhances the Photodynamic Properties of a NIR-II Emitting Photosensitizer with Extended Conjugation"Angew. Chem. Int. Ed. 2023, e202303476 (1 of 10). Li, Q.; Yu, J. T.; Lin, L.; Zhu, Y. L.; Wei, Z. X.; Wan, F. Y.; Zhang, X. D.; He, F.; and Tian, L. L.;*"One-Pot Rapid Synthesis of Cu2+-Doped GOD@MOF to Amplify the Antitumor Efficacy of Chemodynamic Therapy"ACS Appl. Mater. Inter, 2023, 15, 16482–16491. Wei, Z. X.;Chao, Z. C.;Zhang, X. D.; Yu, J. X.;Xiao, F.; Zhang, X. J.;* and Tian, L. L.;*"NIR-II Luminescent and Multi-Responsive Rare Earth Nanocrystals for Improved Chemodynamic Therapy"ACS Appl. Mater. Inter, 2023, 15, 11575-11585. Sun, C. Z.; Lai, X.; Rehman, T.; Lai, H. J.; Ke, C. X.; Shen, X. Y.; Zhu, Y. L.; Tian, L. L.;*, He, F.;* “Benzonitrile-Functionalized Non-Fullerene Acceptors for Organic Solar Cells with Low Non-Radiative Loss” Mater. Chem. C 2022, 17174–17181. Lu, H. W.; Chen, A.; Zhang, X. D.; Wei, Z. X.; Cao, R.; Zhu, Y.; Lu, J. X.; Wang, Z. L.; Tian, L. L.;*"A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging"Nat. Commun. 2022, 13:7948. Chen, Z.; Wei, Z. X.; Xiao, F.; Chao, Z. C.; Lu, J. X.; Wang, Z. M.; Tian, L. L.;*"The Hydrophobicity of AIE Dye Facilitates DNA Condensation for Carrier-Free Gene Therapy"Adv. Funct. Mater. 2022, 2207845. Zhang, X. D.; Lu, H. W.; Tang, N.; Chen, A.; Wei, Z. X.; Cao, R.; Zhu, Y.; Lin, L.; Li, Q.; Wang, Z. L.;* and Tian, L. L.;*"Low-Power Magnetic Resonance-Guided Focused Ultrasound Tumor Ablation upon Controlled Accumulation of Magnetic Nanoparticles by Cascade-Activated DNA Cross-Linkers"ACS. Appl. Mater. Inter. 2022, 14, 31677-31688. Zhu, Y, L,; Lai, H, J,; Guo, H,; Peng, D, L,; Han, L,; Gu, Y,; Wei, Z, X,; Zhao, D, K,; Zheng, N,; Hu, D, H,; Xi, L,; He, F,;*,and Tian, L. L.;* "Side-Chain-Tuned Molecular Packing Allows Concurrently Boosted Photoacoustic Imaging and NIR-II Fluorescence" Angew. Chem. Int. Ed. 2022, 202117433. Xiao, F.; Fang, X, F,; Li, H, Y,; Xue, H, B,; Wei, Z, X,; Zhang, W, K,; Zhu, Y, L,; Lin, L,; Zhao, Y,; Wu, C, F,; Tian, L. L.*"Light-Harvesting Fluorescent Spherical Nucleic Acids Self-Assembled from a DNA-Grafted Conjugated Polymer for Amplified Detection of Nucleic Acids"Angew. Chem. Int. Ed. 2022, 202115812. Li, H,; Han, L,; Li, Q,; Lai, H, J,;Paco Fernández-Trillo, Tian, L. L.;and He, F,;*"Hierarchical Chiral Supramolecular Nanoarchitectonics with Molecular Detection: Helical Structure Controls upon Self-Assembly and Coassembly" Adv. Sci. 2021, 2100690. Yu, J. T.; Wei, Z. X.; Li, Q.; Wan, F. Y,; Chao, Z. C.; Zhang, X. D.; Li, L,; Meng, H,; Tian, L. L.*"Advanced Cancer Starvation Therapy by Simultaneous Deprivation of Lactate and Glucose Using a MOF Nanoplatform"Adv. Sci. 2021, 2101467． Lin, L.; Yu, J. T.; Lu, H. W.; Wei, Z. X.; Chao, Z. C.; Wang, Z. L.; Wu, W. T.; Jiang, H. F.; Tian, L. L.*"Mn–DNA coordination of nanoparticles for efficient chemodynamic therapy†" Chem. Commun. 2021, 57, 1734-1737(Front Cover). Lu, J. X.; Hu, P. C.; Lingyan Cao, L. Y.; Wei, Z. X.; Xiao, F.; Chen, Z.; Li, Y.; Tian, L. L.*"Genetically Encoded and Biologically Produced All‐DNA Nanomedicine Based on One‐Pot Assembly of DNA Dendrimers for Targeted Gene Regulation" Angew. Chem. Int. Ed. 2021, 60, 5377-5385 (Hot Paper). Li, L. Q.; Shao, C.; Liu, T.; Chao, Z. C.; Chen, H. L.; Xiao, F.; He, H. M.; Wei, Z. X.; Zhu, Y. L.; Wang, H.; Zhang, X. D.; Wen, Y. T.; Yang, B.; He, F.; Tian, L. L.* "An NIR‐II‐Emissive Photosensitizer for Hypoxia‐Tolerant Photodynamic Theranostics"Adv. Mater. 2020, 2003471． Xiao, F.; Chen, Z.; Wei, Z. X.; Tian, L. L.* "Hydrophobic Interaction: A Promising Driving Force for theBiomedical Applications of Nucleic Acids" Adv. Sci. 2020, 2001048. Chao, Z. C.; Lu, H. W.; Xiao, F.; Shao, C.; Wei, Z. X.; Yu, J. T.; Zhang, X. D.; Li, L.; Tian, L. L.* “Robust and Tumor-Environment-Activated DNA Crosslinker Driving Nanoparticle Accumulation for Enhanced Therapeutics” CCS Chemistry 2020, 2, 349–361. Xiao, F.; Li, L.; Chao, Z. C.; Shao, C.; Chen, Z.; Wei, Z. X.; Lu, J. X.; Huang, Y. S.; Li, L. Q.; Liu, Q.; Liang, Y. Y.; Tian, L. L.* “Organic Spherical Nucleic Acids for the Transport of a NIR‐II‐Emitting Dye Across the Blood–Brain Barrier” Angew. Chem. Int. Ed. 2020, 59, 9702–9710. Xiao, F.; Wei, Z. X.; Wang, M.; Hoff, A.; Bao, Y.*; Tian, L. L.* “Oligonucleotide-Polymer Conjugates: From Molecular Basics to Practical Application” Top. Curr. Chem. 2020, 378: 24. Chen, Z.; Lu, J. X.; Xiao, F.; Huang, Y. S.; Zhang, X. J.*; Tian, L. L.* “A Self-Delivery DNA Nanoprobe for Reliable MicroRNA Imaging in Live Cells by Aggregation Induced Red-Shift-Emission” Chem. Commun. 2020, 56, 1501-1504. Wang, M. J.; Han, L.; Zhu, Y. L.; Qi, R.; Tian, L. L.*; He, F.* “Formation of Hierarchical Architectures with Dimensional and Morphological Control in the Self-Assembly of Conjugated Block Copolymers” Small Methods 2020, 4, 1900470. Shao, C.; Xiao, F.; Guo, H.; Yu, J. T.; Jin, D.; Wu, C. F.; Xi, L.*; Tian, L. L.* “Utilizing Polymer Micelle to Control Dye J-aggregation and Enhance Its Theranostic Capability” iScience 2019, 22, 229–239. Yu, J. T.; Li, J.; Zhai, S. Y.; Li, L.; Wang, K.; Tang, B.; Meng, H.; Tian, L. L.* “Enzymatically Synthesized DNA Polymer as Co-carrier for Enhanced RNA Interference” ACS Appl. Bio Mater. 2019, 2, 5204−5215. He, S. H.a; Yu, J. T.a; Wang, F. F.*; Tian, L. L.* “Well-Optimized Conjugated GO-DNA Nanosystem for Sensitive Ratiometric pH Detection in Live Cells” Langmuir. 2019, 35, 13745−13752. Li, J.; Li, L.; Yu, J. T.; Zhai, S. Y.; Liu, G. Y.; Tian, L. L.* “Fabrication and Biomedical Applications of “Polymer-Like” Nucleic Acids Enzymatically Produced by Rolling Circle Amplification” ACS Appl. Bio Mater. 2019, 2, 4106−4120. Mo, D. Z.; Chen, Z.; Han, L.; Lai, H. J.; Chao, P. J.; Zhang, Q. W.*; Tian, L. L.*; He, F.* “Highly Stable and Bright Fluorescent Chlorinated Polymer Dots for Cellular Imaging” New J. Chem. 2019, 43, 2540-2549. Li, P.a; Chen, Z.a; Huang, Y. S.; Li, J.; Xiao, F.; Zhai, S. Y.; Wang, Z. M.*; Zhang, X. J.*; Tian, L. L.* “A pH Responsive Fluorescent Probe Based on Dye Modified i-motif Nucleic Acids” Organic & Biomolecular Chemistry. 2018, 16, 9402-9408. Yuan, X. X.a; Xiao, F.a; Zhao, H. R.; Huang, Y. S.; Shao, C.; Weizmann, Y.*; Tian, L. L.* “High-Yield Method To Fabricate and Functionalize DNA Nanoparticles from the Products of Rolling Circle Amplification” ACS Appl. Bio Mater. 2018, 1, 511−519.