个人简介

Royal Society Dorothy Hodgkin Research Fellow, University of Oxford, UK (2000-2002); Postdoctoral Fellow, University of Pennsylvania, USA (NSERC PDF - 1998-2000); PhD, ETH Zurich, Switzerland (NSERC PGS A and B - 1993-1998); BSc (Honours), McGill University, Canada (1993);

研究领域

Biological & Medicinal Chemistry; Physical & Theoretical Chemistry

Membrane proteins play a very important role in many cellular processes, and account for 20-40% of the products of open reading frames of known genomes. Their association with a number of diseases [1,2] has stimulated great interest in these proteins, in particular, in understanding how they function in their native lipid environments. Because membrane proteins are embedded in a lipid matrix, the application of routine structure determination methods, namely solution state nuclear magnetic resonance (NMR) and x-ray crystallography, is precluded. The limited number of structures of membrane proteins reported to date is evidence of the difficulty in applying these methods to such systems [3,4]. In recent years, developments in the field of solid state NMR have led to an emergence of biomolecular studies using this technique. One significant advantage of using solid state NMR to study membrane proteins is that these can be studied in native-like phospholipid environments directly [5]. A further advantage of solid state NMR is that it also allows the study of membrane protein/peptide dynamics. Information on peptide mobility can provide insight into the conformational rearrangements which are linked to the peptide's biologal activity in the membrane. Research in my laboratory focuses on the application and development of solid state NMR methods to characterise the structure and dynamics of membrane proteins. To gain insight into membrane peptide/protein, a number of relevant systems will be studied. Specifically, studies on membrane protein/lipid and membrane protein/ligand interactions will be undertaken.

近期论文

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"Cheng, J. T. J. ; Hale, J. D. ; Kindrachuk, J. ; Jessen, H. ; Elliott, M. ; Hancock, R. E. W. ; Straus, S. K. Importance Of Residue 13 And The C-Terminus For The Structure And Activity Of The Antimicrobial Peptide Aurein 2.2. Biophysical Journal 2010, 99, 2926 - 2935.BibTex Wieczorek, M. ; Jenssen, H. ; Kindrachuk, J. ; Scott, W. R. P. ; Elliott, M. ; Hilpert, K. ; Cheng, J. T. J. ; Hancock, R. E. W. ; Straus, S. K. Structural Studies Of A Peptide With Immune Modulating And Direct Antimicrobial Activity. Chemistry & Biology (Cambridge, MA, United States) 2010, 17, 970 - 980.BibTex Pan, J. ; C. Lai, B. ; Scott, W. R. P. ; Straus, S. K. Synthetic Fusion Peptides Of Tick-Borne Encephalitis Virus As Models For Membrane Fusion. Biochemistry 2010, 49, 287 - 296.BibTex Cheng, J. T. J. ; Hale, J. D. ; Elliot, M. ; Hancock, R. E. W. ; Straus, S. K. Effect Of Membrane Composition On Antimicrobial Peptides Aurein 2.2 And 2.3 From Australian Southern Bell Frogs. Biophysical Journal 2009, 96, 552-565.BibTex Beasley, C. L. ; Dwork, A. J. ; Rosoklija, G. ; Mann, J. J. ; Mancevski, B. ; Jakovski, Z. ; Davceva, N. ; Tait, A. R. ; Straus, S. K. ; Honer, W. G. Metabolic Abnormalities In Fronto-Striatal-Thalamic White Matter Tracts In Schizophrenia. Schizophrenia Research 2009, 109, 159-166.BibTex Straus, S. K. ; Scott, W. R. P. ; Symmons, M. F. ; Marvin, D. A. On The Structures Of Filamentous Bacteriophage Ff (Fd, F1, M13). European Biophysics Journal with Biophysics Letters 2008, 37, 521-527.BibTex Straus, S. K. ; Scott, W. R. P. ; Marvin, D. A. The Hand Of The Filamentous Bacteriophage Helix. European Biophysics Journal with Biophysics Letters 2008, 37, 1077-1082.BibTex Jung, D. ; Powers, J. P. ; Straus, S. K. ; Hancock, R. E. W. Lipid-Specific Binding Of The Calcium-Dependent Antibiotic Daptomycin Leads To Changes In Lipid Polymorphism Of Model Membranes. Chemistry and Physics of Lipids 2008, 154, 120-128.BibTex Tait, A. R. ; Straus, S. K. Phosphorylation Of U24 From Human Herpes Virus Type 6 (Hhv-6) And Its Potential Role In Mimicking Myelin Basic Protein (Mbp) In Multiple Sclerosis. Febs Letters 2008, 582, 2685-2688.BibTex Ho, S. W. ; Jung, D. ; Calhoun, J. R. ; Lear, J. D. ; Okon, M. ; Scott, W. R. P. ; Hancock, R. E. W. ; Straus, S. K. Effect Of Divalent Cations On The Structure Of The Antibiotic Daptomycin. European Biophysics Journal with Biophysics Letters 2008, 37, 421-433.BibTex Scott, W. R. P. ; Baek, S. B. ; Jung, D. ; Hancock, R. E. W. ; Straus, S. K. Nmr Structural Studies Of The Antibiotic Lipopeptide Daptomycin In Dhpc Micelles. Biochimica Et Biophysica Acta-Biomembranes 2007, 1768, 3116-3126.BibTex Pan, Y. L. ; Cheng, J. T. J. ; Hale, J. ; Pan, J. H. ; Hancock, R. E. W. ; Straus, S. K. Characterization Of The Structure And Membrane Interaction Of The Antimicrobial Peptides Aurein 2.2 And 2.3 From Australian Southern Bell Frogs. Biophysical Journal 2007, 92, 2854-2864.BibTex Straus, S. K. ; Hancock, R. E. W. Mode Of Action Of The New Antibiotic For Gram-Positive Pathogens Daptomycin: Comparison With Cationic Antimicrobial Peptides And Lipopeptides. Biochimica Et Biophysica Acta-Biomembranes 2006, 1758, 1215-1223.BibTex Marvin, D. A. ; Welsh, L. C. ; Symmons, M. F. ; Scott, W. R. P. ; Straus, S. K. Molecular Structure Of Fd (F1, M13) Filamentous Bacteriophage Refined With Respect To X-Ray Fibre Diffraction And Solid-State Nmr Data Supports Specific Models Of Phage Assembly At The Bacterial Membrane. Journal of Molecular Biology 2006, 355, 294-309.BibTex Beasley, C. L. ; Tait, A. ; Straus, S. ; Dwork, A. J. ; Honer, W. G. Metabolomic And Proteomic Investigation Of The Anterior Limb Of The Internal Capsule In Schizophrenia - Evidence For Metabolic Changes?. Biological Psychiatry 2006, 59, 113.BibTex Dave, P. C. ; Billington, E. ; Pan, Y. L. ; Straus, S. K. Interaction Of Alamethicin With Ether-Linked Phospholipid Bilayers: Oriented Circular Dichroism, P-31 Solid-State Nmr, And Differential Scanning Calorimetry Studies. Biophysical Journal 2005, 89, 2434-2442.BibTex Bleile, D. W. ; Scott, W. R. P. ; Straus, S. K. Can Pisema Experiments Be Used To Extract Structural Parameters For Mobile Beta-Barrels?. Journal of Biomolecular Nmr 2005, 32, 101-111.BibTex Vaccaro, L. ; Cross, K. J. ; Kleinjung, J. ; Straus, S. K. ; Thomas, D. J. ; Wharton, S. A. ; Skehel, J. J. ; Fraternali, F. Plasticity Of Influenza Haemagglutinin Fusion Peptides And Their Interaction With Lipid Bilayers. Biophysical Journal 2005, 88, 25-36.BibTex"