个人简介

1、学历背景 1998.09～2002.07 浙江大学药学院药学专业理学学士 2002.09～2007.07 浙江大学药学院药物化学专业医学博士 2、国外学习经历 2007.09～2008.08 德国Johannes Gutenberg University of Mainz访问学者 3、工作经历 2007.07～2009.06 浙江大学师资博士后 2009.07～2011.12 浙江大学药学院助理研究员、浙江省”钱江人才”、浙江大学“求是青年学者” 2012.01～至今 浙江大学副教授、硕士生导师

研究领域

酶化学与酶结构生物学类药生物碱库的仿生构建及应用基础研究靶向抗肿瘤药物研究

药物化学 酶催化

近期论文

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1、Fangrui Wu, Huajian Zhu, Lianli Sun, Chitra Rajendran, Meitian Wang, Xin Ren, Santosh Panjikar, Artem Cherkasov, Hongbin Zou*, Joachim Stöckigt*. Scaffold Tailoring by a Newly Detected Pictet-Spenglerase Activity of Strictosidine Synthase: From the Common Tryptoline Skeleton to the Rare Piperazino-indole Framework. Journal of American Chemical Society, 2012, 134, 1498-1500. （IF=9.91） 2、Hongbin Zou, Liang Zhang, Jingfeng Ouyang, Marc A. Giulianotti,Yongping Yu*.Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents.European Journal of Medicinal Chemistry, 2011, 46, 5970-5977. （IF=3.19） 3、Hongbin Zou, Huajian Zhu, Jiaan Shao, Jianwei Wu, Wenteng Chen, Marc A. Giulianotti, Yongping Yu*.A Facile Approach To Polysubstituted Pyrazoles From Hydrazonyl Chlorides And Vinyl Azides.Tetrahedron, 2011, 67, 4887-4891.（IF=3.22） 4、Huajian Zhu, Joachim Stöckigt, Yongping Yu, Hongbin Zou*. “One-Pot” Multicomponent Approach to Indolizines and Pyrido[1,2-a]indoles. Organic Letters, 2011, 13, 2792-2794.（IF=5.42） 5、Hongbin Zou, Huajian Zhu, Liang Zhang, Liuqing Yang, Yongping Yu*and Joachim Stöckigt*. A Facile Chemoenzymatic Approach: One-Step Syntheses of Monoterpenoid Indole Alkaloids. Chemistry–an Asian Journal, 2010, 5, 2400–2404.（IF=4.37） 6、Hongbin Zou, Hao Wu, Xiangnan Zhang, Yu Zhao, Joachim Stöckigt, Yijia Lou*, Yongping Yu*. Synthesis, biological evaluation, and structure–activity relationship study of novel cytotoxic aza-caffeic acid derivatives. Bioorgannic & Medicinal Chemistry, 2010, 18, 6351–6359.（IF=2.82） 7、Liuqing Yangξ, Hongbin Zou*ξ, Huajian Zhu, Martin Ruppert, Jingxu Gong, Joachim Stöckigt*. Improved expression of His6-tagged strictosidine synthase cDNA for chemo-enzymatic alkaloid diversification.Chemistry and Biodiversity, 2010, 7, 860-870. (ξ These authors contributed equally to this work, highlighted by Wiley database company) （IF=1.93） 8、Wenteng Chen, Miao Hu, Jianwei Wu, Hongbin Zou*, Yongping Yu*. Domino Approach for the Synthesis of Pyrrolo[1,2-]pyrazine from Vinyl Azides. Organic Letters, 2010, 12(17), 3863–3865.（Highlighted by Synfacts 2010, 11, 1234-1234）（IF=5.42） 9、Jianwei Wu, Wenteng Chen, Miao Hu, Hongbin Zou, Yongping Yu*. Synthesis of polysubstituted 5–aminooxazoles from diazocarbonyl esters and isocyanoacetamides. Organic Letters, 2010, 12(3), 616–618.（IF=5.42） 10、Hongbin Zou, Shengyi Dong, Changxin Zhou, Li Hong Hu, Yihang Wu, Haibo Li, Jingxu Gong, Lianli Sun, Xiumei Wu, Hua Bai, Botao Fan, Xiaojiang Hao, Joachim Stöckigt, Yu Zhao. Design, Synthesis and SAR Analysis of Cytotoxic Sinapyl Alcohol Derivatives. Bioorganic & Medicinal Chemistry, 2006, 14, 2060–2071. （IF=2.82）