个人简介

B.A., Haverford College (1983); Ph.D., University of California, Los Angeles (D.J. Cram, 1988); Research Associate, The Rockefeller University (E.T. Kaiser, 1988-89); NIH Postdoctoral Fellow, New York University (N.R. Kallenbach, 1989-91).

研究领域

Organic Chemistry

Professor Sherman is interested in the design and synthesis of organic and biological molecules that have well-defined structure. These compounds are designed to explore molecular recognition and to probe the factors governing protein folding. One project involves the creation of a new system of hybrid cavitand-proteins or 'caviteins' (pictured). These de novo proteins are composed of four alpha-helical peptide chains that are organized into a bundle by a rigid bowl-shaped organic macrocyclic cavitand molecule. This cavitand moiety creates an enforced cavity suitable for complexation of guest molecules while the helices form a super-secondary protein structure atop the hydrophobic cavity. The caviteins are designed to selectively bind guest molecules such as amino acids, to catalyze reactions such as amide hydrolysis, and to help elucidate some of the interactions that are important in promoting super-secondary structure in proteins. A second research area explores the reaction mechanism and templation effects responsible for the formation of carceplexes. Carceplexes are closed-surface organic molecules that permenantly entrap smaller molecules within their confines. The wate r solubilization of carceplexes will unleash entirely new areas of study including applications such as drug delivery. Another project entails the creation of a new family of self-assembling structures (SAS's). SAS's are ubiquitous in nature (e.g., DNA double helix, cell membranes, etc.) and are receiving great attention in materials science (e.g., monolayers, liquid crystals, etc.). We are covalently linking bowl-shaped molecules and studying their aggregation to form 1-D rods and 2-D bilayers. Techniques employed in this lab include organic synthesis, peptide synthesis, operation of and analysis by HPLC, NMR and circular dichroism.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

"Freeman, J. O. ; Lee, W. C. ; Murphy, M. E. P. ; Sherman, J. C. X-Ray Crystal Analysis Of A Tasp: Structural Insights Of A Cavitein Dimer. Journal of the American Chemical Society 2009, 131, 7421-7429.BibTex Nikan, M. ; Sherman, J. C. Cation-Complexation Behavior Of Template-Assembled Synthetic G-Quartets. Journal of Organic Chemistry 2009, 74, 5211-5218.BibTex Sun, J. Y. ; Patrick, B. O. ; Sherman, J. C. A New [4]Carceplex, And A Crystal Structure And Dynamic Combinatorial Chemistry Of A [5]Carceplex. Tetrahedron 2009, 65, 7296-7302.BibTex Huttunen-Hennelly, H. E. K. ; Sherman, J. C. An Investigation Into The Native-Like Properties Of De Novo Designed Cavitand-Based Four-Helix Bundle Proteins. Biopolymers 2008, 90, 37-50.BibTex Nikan, M. ; Sherman, J. C. Template-Assembled Synthetic G-Quartets (Tasqs). Angewandte Chemie-International Edition 2008, 47, 4900-4902.BibTex Seo, E. S. ; Scott, W. R. P. ; Straus, S. K. ; Sherman, J. C. Optimal Attachment Position And Linker Length Promote Native-Like Character Of Cavitand-Based Template-Assembled Synthetic Proteins (Tasps). Chemistry-a European Journal 2007, 13, 3596-3605.BibTex Huttunen-Hennelly, H. E. K. ; Sherman, J. C. The Design, Synthesis, And Characterization Of The First Cavitand-Based De Novo Hetero-Template-Assembled Synthetic Proteins (Hetero-Tasps). Organic & Biomolecular Chemistry 2007, 5, 3637-3650.BibTex Sherman, J. C. Donald J. Cram. Chemical Society Reviews 2007, 36, 148-150.BibTex Freeman, J. O. ; Wallhorn, D. ; Sherman, J. C. Four-Helix Bundle Cavitein Reveals Middle Leucine As Linchpin. Biopolymers 2007, 88, 725-732.BibTex Scott, W. R. P. ; Seo, E. ; Huttunen, H. ; Wallhorn, D. ; Sherman, J. C. ; Straus, S. K. Characterization Of De Novo Four-Helix Bundles By Molecular Dynamics Simulations. Proteins-Structure Function and Bioinformatics 2006, 64, 719-729.BibTex Makeiff, D. A. ; Sherman, J. C. A Six-Bowl Carceplex That Entraps Seven Guest Molecules. Journal of the American Chemical Society 2005, 127, 12363-12367.BibTex Scott, W. R. ; Seo, E. ; Huttunen, H. ; Wallhorn, D. ; Sherman, J. C. ; Straus, S. K. Characterization Of De Novo Four-Helix Bundles By Molecular Dynamics Simulations. Protein Science 2004, 13, 343.BibTex Seo, E. S. ; Sherman, J. C. Cavitand Based Four-Helix Bundles. In Peptide Revolution: Genomics, Proteomics & Therapeutics; Chorev, M. ; Sawyer, T. K. ; Peptide Revolution: Genomics, Proteomics & Therapeutics; Amer Chemical Soc: Washington, 2004; pp. 246-247.BibTex Huttunen, H. K. ; Sherman, J. C. De Novo Four-Helix Bundle Proteins. In Peptide Revolution: Genomics, Proteomics & Therapeutics; Chorev, M. ; Sawyer, T. K. ; Peptide Revolution: Genomics, Proteomics & Therapeutics; Amer Chemical Soc: Washington, 2004; pp. 244-245.BibTex Makeiff, D. A. ; Sherman, J. C. Template Effect Where 1-3 Molecules Drive Formation Of A Trimer Carceplex. Chemistry-a European Journal 2003, 9, 3253-3262.BibTex Makeiff, D. A. ; Vishnumurthy, K. ; Sherman, J. C. Ketonization Of Incarcerated Acetophenone Enol. Journal of the American Chemical Society 2003, 125, 9558-9559.BibTex Seo, E. S. ; Sherman, J. C. Cavitand Based Four-Helix Bundles. Biopolymers 2003, 71, P062.BibTex Huttunen, H. K. ; Sherman, J. C. De Novo Four-Helix Bundle Proteins. Biopolymers 2003, 71, P067.BibTex Sherman, J. Molecules That Can’T Resist Templation. Chemical Communications 2003, 1617-1623.BibTex Causton, A. S. ; Sherman, J. C. A Comparison Of Three- And Four-Helix Bundle Tasp Molecules. Journal of Peptide Science 2002, 8, 275-282.BibTex