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个人简介

学习经历 2007 ~ 2012 四川大学 有机化学专业 理学博士学位,师从冯小明教授从事不对称催化的研究 2003 ~ 2007 四川大学 应用化学专业 理学学士学位,保送四川大学化学学院有机化学专业攻读博士研究生 研究及工作经历 2016 ~至今 四川大学化学学院 教授 博士生导师 2014 ~ 2016 密西根大学安娜堡分校癌症中心 研究员,合作导师 : Dr. Shaomeng Wang 2012 ~ 2014 The Scripps Research Institute 研究助理,合作导师 : Dr. Philip LoGrasso & Dr. Yangbo Feng

研究领域

1. 绿色有机合成方法学(可见光催化或电化学产生的可控自由基反应及其合成应用) 2. 发展小分子催化的高选择性、高效性的自由基(光化学或电化学)参与的不对称合成方法学 3. 手性药物及靶向抗癌药物的理性设计合成及相关应用

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Xiang Sun, Ke Zheng* “Electrochemical halogen-atom transfer alkylation via α-aminoalkyl radical activation of alkyl iodides” Nat. Commun. 2023, accepted. Yujun Li1, Shaopeng Guo2, Qing-Han Li2 and Ke Zheng1* “Metal-free Photoinduced C(sp3)–H/C(sp3)–H Cross-Coupling to access α‑Tertiary Amino Acids Derivatives” Nat. Commun. 2023, ASAP Cong Lu, Rui Chen, Rui Wang, Dong Jing and Ke Zheng* “Synthesis of sulfur-containing oxindoles by photoinduced alkene difunctionalization via sulfur 1,2-relocation” Org. Lett. 2023, 25, 5, 750–755 Jia-jing Luo, Dong Jing, Cong Lu, Ke Zheng* “Photoinduced Metal-Free Decarboxylative Transformations: Rapid Access to Amines, Alkyl Halides, and Olefins”, Eur. J. Org. Chem. 2023, e202300167 Pan Tao,# Yujun Li,# and Ke Zheng* “Electrochemical direct C-H halogenation of N-heteroarenes and naphthols” Eur. J. Org. Chem. 2023, e202300622 Yujun Li, Jie Yang, Xinxin Geng, Pan Tao, Yanling Shen, Zhishan Su, and Ke Zheng* “Modular Construction of Unnatural α-Tertiary Amino Acid Derivatives by Multicomponent Radical Cross-Couplings” Angew. Chem. Int. Ed. 2022, 61, e202210755 Cong Lu, Dong Jing, Yanling Shen, Jiajing Luo and Ke Zheng* “Redox-neutral access to 3,3’-disubstituted oxindoles via radical coupling reactions” Org. Chem. Front., 2022, 9, 4164–4170 Dailin Xi, Cong Lu, Dong Jing, and Ke Zheng* “Carbothiolation of Styrenes by Visible-Light-Induced Thiyl Radicals: C3-Functionalization of Benzofuran-2(3H)-ones“ Eur. J. Org. Chem. 2022, e202200688 Yanling Shen, Ning Lei, Cong Lu, Dailin Xi, Xinxin Geng, Pan Tao Zhishan Su, and Ke Zheng* “Construction of sterically congested oxindole derivatives via visible-light-induced radical-coupling” Chem. Sci., 2021, 12, 15399–15406. Songyang Jin, # Xinxin Geng, # Yujun Li and Ke Zheng* “Phosphoric Acid Mediated Light-Induced Minisci C–H Alkylation of N-Heteroarenes” Eur. J. Org. Chem. 2021, 969–972. Ning Lei, Yanling Shen, Yujun Li, Pan Tao, Liquan Yang, Zhishan Su and Ke Zheng*“Electrochemical Iodoamination of Indoles using Unactivated Amines” Org. Lett. 2023, 22, 9184–9189 Liquan Yang, Zhaoran Liu, Yujun Li, Ning Lei, Yanling Shen, and Ke Zheng* “Electrochemically Enabled C3-Formylation and -Acylation of Indoles with Aldehydes” Org. Lett. 2019, 21, 7702−7707. Dong Jing,# Cong Lu,# Zhuo Chen, Songyang Jin, Lijuan Xie, Ziyi Meng, Zhishan Su, Ke Zheng* “Light-Driven Intramolecular C-N Cross-Coupling via a Long-Lived Photoactive Photoisomer Complex” Angew. Chem. Int. Ed. 2019, 58, 14666 –14672. Cong Lu# Zhishan Su,# Dong Jing, Songyang Jin, Lijuan Xie, Liangrui, Li and Ke Zheng* “Intramolecular Reductive Cyclization of o-Nitroarenes via Biradical Recombination” Org. Lett. 2019, 21, 1438−1443. Yujun Li, Qi Yang, Liquan Yang, Ning Lei and Ke Zheng* “A scalable electrochemical dehydrogenative cross-coupling of P(O)H compounds with RSH/ROH” Chem. Commun., 2019, 55, 4981-4984. Angelo Aguilar, # Ke Zheng, # et al. and Shaomeng Wang * “Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction” J. Med. Chem. 2019, 62, 6015−6034. Lijuan Xie, Cong Lu, Dong Jing, Xinrui Ou, and Ke Zheng* “Metal-Free Synthesis of Polycyclic Quinazolinones Enabled by a (NH4)2S2O8-Promoted Intramolecular Oxidative Cyclization” Eur. J. Org. Chem. 2019, 3649−3653. Ke Zheng, Xiaohua Liu, and Xiaoming Feng* “Recent Advances in Metal-Catalyzed Asymmetric 1,4-Conjugate Addition (ACA) of Nonorganometallic Nucleophiles” Chem. Rev. 2018, 118, 7586−7656. Shilin Xu#, Angelo Aguilar#, Tianfeng Xu#, Ke Zheng#, et al. and Shaomeng Wang * “Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein–Protein Interaction” Angew. Chem. Int. Ed. 2018, 57, 1601−1605. Ke Zheng, Chul Min Park, Sarah Iqbal, Pamela Hernandez, HaJeung Park, Philip V. LoGrasso,* and Yangbo Feng* “Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors” ACS Med. Chem. Lett., 2015, 6, 413-418. Yan Yin, Ke Zheng, Nibal Eid, et al, Philip V. LoGrasso,* and Yangbo Feng*“Bis-aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors” J. Med. Chem. 2015, 58(4), 1846-1861.

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