郑柯 - 四川大学 - 化学学院

个人简介

学习经历 2007 ～ 2012 四川大学有机化学专业理学博士学位，师从冯小明教授从事不对称催化的研究 2003 ～ 2007 四川大学应用化学专业理学学士学位，保送四川大学化学学院有机化学专业攻读博士研究生研究及工作经历 2016 ～至今四川大学化学学院教授博士生导师 2014 ～ 2016 密西根大学安娜堡分校癌症中心研究员，合作导师 : Dr. Shaomeng Wang 2012 ～ 2014 The Scripps Research Institute 研究助理，合作导师 : Dr. Philip LoGrasso & Dr. Yangbo Feng

研究领域

1. 绿色有机合成方法学（可见光催化或电化学产生的可控自由基反应及其合成应用） 2. 发展小分子催化的高选择性、高效性的自由基（光化学或电化学）参与的不对称合成方法学 3. 手性药物及靶向抗癌药物的理性设计合成及相关应用

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Xiang Sun, Ke Zheng* “Electrochemical halogen-atom transfer alkylation via α-aminoalkyl radical activation of alkyl iodides” Nat. Commun. 2023, accepted. Yujun Li1, Shaopeng Guo2, Qing-Han Li2 and Ke Zheng1* “Metal-free Photoinduced C(sp3)–H/C(sp3)–H Cross-Coupling to access α‑Tertiary Amino Acids Derivatives” Nat. Commun. 2023, ASAP Cong Lu, Rui Chen, Rui Wang, Dong Jing and Ke Zheng* “Synthesis of sulfur-containing oxindoles by photoinduced alkene difunctionalization via sulfur 1,2-relocation” Org. Lett. 2023, 25, 5, 750–755 Jia-jing Luo, Dong Jing, Cong Lu, Ke Zheng* “Photoinduced Metal-Free Decarboxylative Transformations: Rapid Access to Amines, Alkyl Halides, and Olefins”, Eur. J. Org. Chem. 2023, e202300167 Pan Tao,# Yujun Li,# and Ke Zheng* “Electrochemical direct C-H halogenation of N-heteroarenes and naphthols” Eur. J. Org. Chem. 2023, e202300622 Yujun Li, Jie Yang, Xinxin Geng, Pan Tao, Yanling Shen, Zhishan Su, and Ke Zheng* “Modular Construction of Unnatural α-Tertiary Amino Acid Derivatives by Multicomponent Radical Cross-Couplings” Angew. Chem. Int. Ed. 2022, 61, e202210755 Cong Lu, Dong Jing, Yanling Shen, Jiajing Luo and Ke Zheng* “Redox-neutral access to 3,3’-disubstituted oxindoles via radical coupling reactions” Org. Chem. Front., 2022, 9, 4164–4170 Dailin Xi, Cong Lu, Dong Jing, and Ke Zheng* “Carbothiolation of Styrenes by Visible-Light-Induced Thiyl Radicals: C3-Functionalization of Benzofuran-2(3H)-ones“ Eur. J. Org. Chem. 2022, e202200688 Yanling Shen, Ning Lei, Cong Lu, Dailin Xi, Xinxin Geng, Pan Tao Zhishan Su, and Ke Zheng* “Construction of sterically congested oxindole derivatives via visible-light-induced radical-coupling” Chem. Sci., 2021, 12, 15399–15406. Songyang Jin, # Xinxin Geng, # Yujun Li and Ke Zheng* “Phosphoric Acid Mediated Light-Induced Minisci C–H Alkylation of N-Heteroarenes” Eur. J. Org. Chem. 2021, 969–972. Ning Lei, Yanling Shen, Yujun Li, Pan Tao, Liquan Yang, Zhishan Su and Ke Zheng*“Electrochemical Iodoamination of Indoles using Unactivated Amines” Org. Lett. 2023, 22, 9184–9189 Liquan Yang, Zhaoran Liu, Yujun Li, Ning Lei, Yanling Shen, and Ke Zheng* “Electrochemically Enabled C3-Formylation and -Acylation of Indoles with Aldehydes” Org. Lett. 2019, 21, 7702−7707. Dong Jing,# Cong Lu,# Zhuo Chen, Songyang Jin, Lijuan Xie, Ziyi Meng, Zhishan Su, Ke Zheng* “Light-Driven Intramolecular C-N Cross-Coupling via a Long-Lived Photoactive Photoisomer Complex” Angew. Chem. Int. Ed. 2019, 58, 14666 –14672. Cong Lu# Zhishan Su,# Dong Jing, Songyang Jin, Lijuan Xie, Liangrui, Li and Ke Zheng* “Intramolecular Reductive Cyclization of o-Nitroarenes via Biradical Recombination” Org. Lett. 2019, 21, 1438−1443. Yujun Li, Qi Yang, Liquan Yang, Ning Lei and Ke Zheng* “A scalable electrochemical dehydrogenative cross-coupling of P(O)H compounds with RSH/ROH” Chem. Commun., 2019, 55, 4981-4984. Angelo Aguilar, # Ke Zheng, # et al. and Shaomeng Wang * “Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction” J. Med. Chem. 2019, 62, 6015−6034. Lijuan Xie, Cong Lu, Dong Jing, Xinrui Ou, and Ke Zheng* “Metal-Free Synthesis of Polycyclic Quinazolinones Enabled by a (NH4)2S2O8-Promoted Intramolecular Oxidative Cyclization” Eur. J. Org. Chem. 2019, 3649−3653. Ke Zheng, Xiaohua Liu, and Xiaoming Feng* “Recent Advances in Metal-Catalyzed Asymmetric 1,4-Conjugate Addition (ACA) of Nonorganometallic Nucleophiles” Chem. Rev. 2018, 118, 7586−7656. Shilin Xu#, Angelo Aguilar#, Tianfeng Xu#, Ke Zheng#, et al. and Shaomeng Wang * “Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein–Protein Interaction” Angew. Chem. Int. Ed. 2018, 57, 1601−1605. Ke Zheng, Chul Min Park, Sarah Iqbal, Pamela Hernandez, HaJeung Park, Philip V. LoGrasso,* and Yangbo Feng* “Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors” ACS Med. Chem. Lett., 2015, 6, 413-418. Yan Yin, Ke Zheng, Nibal Eid, et al, Philip V. LoGrasso,* and Yangbo Feng*“Bis-aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors” J. Med. Chem. 2015, 58(4), 1846-1861.