王平 - 上海交通大学 - 化学化工学院

个人简介

教育背景 2000年本科毕业于南京大学 2005年毕业于上海有机化学研究所，获博士学位（导师：俞飚院士）曾获得国家杰出青年基金、国家海外高层次青年人才等荣誉工作经历 2005-2008：美国伯纳姆医学研究所，博士后 2008-2013：纪念斯隆凯特琳癌症中心，博士后、资深研究科学家 2013-2016.4：波士顿WARP DRIVE BIO 生物技术公司，研究科学家 2016.5- ：上海交通大学化学化工学院，研究员

研究领域

1）化学合成具有重要生理活性的糖蛋白、糖肽 2）糖类分子合成及其方法学研究 3）多肽合成方法学研究

近期论文

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Zhao, J.; Wang, P., et. al. Semi-synthesis of interleukin-1a via expressed threonine ligation and native chemical ligation-desulfurization. Tetrahedron Letters 104 (2022) 154024. Zheng, M.; Yin, H.; Wang S.; Wang, P., Stereoselective Synthesis of β-thiolated Aryl Amino Acids. Synthesis 2022. doi: 10.1055/a-1874-4829. Chen, X.; Luo, X.; Wang, P., Electrochemical-induced Radical Allylation via the Fragmentation of Alkyl 1,4-Dihydropyridines. Tetrahedron Letters 2022, doi.org/10.1016/j.tetlet.2022.153646. Luo, X.; Feng, Q.; Wang, P., Radical Addition of Hydroxy Quinazolines and Alkylation of Quinones via the Electro-induced Homolysis of 4-Alkyl-1,4-dihydropyridines. Synthesis. 2022, DOI: 10.1055/a-1737-2765. Wang, S.; Zhou, Q.; Li, Y.; Wei, B.; Liu, X.; Zhao, J.; Ye, F.; Zhou, Z.; Ding, B.; Wang, P. Quinoline-based photolabile protection strategy facilitates efficient protein assembly. J. Am. Chem. Soc. 2022, 144, 1232-1242. Zhao, J.; Wang, P., et. al. Revealing functional significance of interleukin-2 glycoproteoforms enabled by expressed serine ligation. Chin. J. Chem. 2022, 40, 787-793. Wang, S.; Zhou, Q.; Zhang, X.; Wang, P., Site-Selective Itaconation of Complex Peptides by Photoredox Catalysis. Angew. Chem. Int. Ed. 2022, 61, e202111388. Chen, X.; Wang, P., Facile Access to C-Glycosyl Amino Acids and Peptides via Ni-Catalyzed Reductive Hydroglycosylation of Alkynes. Chin. J. Org. Chem. 2021, 41, 4517-4518. Luo, X.; Wang, P., Ynonylation of Acyl Radicals by Electroinduced Homolysis of 4‑Acyl1,4-dihydropyridine. Org. Lett. 2021, 23, 4960-4965. Wang, S.; Zhou, Q.; Chen, X.; Luo, R.-H.; Li, Y.; Liu, X.; Yang, L.-M.; Zheng, Y.-T.; Wang, P., Modification of N-Terminal α-Amine of Proteins via Biomimetic ortho-quinone-mediated Oxidation. Nat. Commun. 2021, 12:2257. Ye, F.; Zhao, J.; Xu, P.; Liu, X.; Yu, J.; Shangguan, W.; Liu, J.; Luo, X.; Li, C.; Ying, T.; Wang, J.; Yu, B.; Wang, P., Synthetic Homogeneous Glycoforms of the SARS-CoV-2 Spike Receptor-Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies. Angew. Chem. Int. Ed. 2021, 60, 12904-12910. Li, Y.; Liu, J.; Zhou, Q.; Zhao, J.; Wang, P., The preparation of peptide selenoesters from their corresponding acyl hydrazides. Chin. J. Chem. 2021, 39, 1861-1866. Chen, X.; Luo, X.; Wang, K.; Liang, F.; Wang, P., Late-Stage Alkylation of N-Containing Heteroarenes Enabled by Homolysis of Alkyl-1,4-dihydropyridines under Blue LED Irradiation. Synlett 2021, 32, 733–737. Yin, H.; Zheng, M.; Chen, H.; Wang, S.; Zhou, Q.; Zhang, Q.; Wang, P., Stereoselective and Divergent Construction of β-Thiolated/Selenolated Amino Acids via Photoredox-Catalyzed Asymmetric Giese Reaction. J. Am. Chem. Soc. 2020, 142, 14201-14209. Chen, X.; Luo, X.; Peng, X.; Guo, J.; Zai, J.; Wang, P., Catalyst-Free Decarboxylation of Carboxylic Acids and Deoxygenation of Alcohols by Electro-Induced Radical Formation. Chem. Eur. J. 2020, 26, 3226- 3230. Lu, D.; Wang, S.; Yin, H.; Chu, F.; Wei, Q.; Wang, P., Rapid Assembly of Oligosaccharides by Using a Hydrophobic Tag-Assisted Liquid-Phase Method. Synlett 2020, 31, 1163-1166. Lu, D.; Yin, H.; Wang, S.; Tang, F.; Huang, W.; Wang, P., Chemical Synthesis of the Homogeneous Granulocyte-Macrophage Colony-Stimulating Factor Through Se-Auxiliary-Mediated Ligation. J. Org. Chem. 2020, 85, 1652-1660. Chen, X.; Ye, F.; Luo, X.; Liu, X.; Zhao, J.; Wang, S.; Zhou, Q.; Chen, G.; Wang, P., Histidine-Specific Peptide Modification via Visible-Light-Promoted C–H Alkylation. J. Am. Chem. Soc. 2019, 141, 18230-18237. Liu, X.; Liu, J.; Wu, Z.; Chen, L.; Wang, S.; Wang, P., Photo-cleavable purification/protection handle assisted synthesis of giant modified proteins with tandem repeats. Chem. Sci. 2019, 10, 8694-8700. Wang, K.; Chen, X.; Peng, X.; Wang, P.; Liang, F., A highly selective H/D exchange reaction of 1,4-dihydropyridines. Org. Biomol. Chem. 2019, 17, 3845-3852. Wang, S.; Thopate, Y. A.; Zhou, Q.; Wang, P., Chemical Protein Synthesis by Native Chemical Ligation and Variations Thereof. Chin. J. Chem. 2019, 37, 1181-1193. Ye, J.; Xia, H.; Sun, N.; Liu, C.-C.; Sheng, A.; Chi, L.; Liu, X.-W.; Gu, G.; Wang, S.-Q.; Zhao, J.; Wang, P.; Xiao, M.; Wang, F.; Cao, H., Reprogramming the enzymatic assembly line for site-specific fucosylation. Nat. Catal. 2019, 2, 514-522. Yin, H.; Lu, D.; Wang, S.; Wang, P., Development of Powerful Auxiliary-Mediated Ligation To Facilitate Rapid Protein Assembly. Org. Lett. 2019, 21, 5138-5142. Luo, H.; Yin, H.; Tang, C.; Wang, P.; Liang, F., Synthesis of cyclic peptide reniochalistatin E and conformational isomers. Chin. Chem. Lett. 2018, 29, 1143-1146.