林爱福 - 浙江大学 - 生命科学学院

个人简介

研究工作经历 2016-研究员浙江大学生命科学学院 2015-2016 讲师M.D.安德森癌症研究中心(美国)，非编码 RNA与肿瘤信号转导 2012-2015 博士后M.D.安德森癌症研究中心(美国)，肿瘤代谢与非编码RNA调控 2010-2012 博士后美国国家健康科学院国家癌症研究所癌症研究中心，肿瘤与炎症 2005-2007 硕士中国科学院上海生化细胞所，胚胎干细胞分化与发育教育经历 2007-2010 博士浙江大学生命科学学院，研究方向是细胞与免疫 2004-2007 硕士华东师范大学生命科学学院，研究方向是细胞分化与发育 2000-2004 本科海南大学

研究领域

研究集中在肿瘤与干细胞生物学领域，致力于包括非编码RNA在内的肿瘤信号转导、干细胞分化发育调控机理机制，以及肿瘤免疫治疗和干细胞转化医学应用研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

L Sang, H Ju,G Liu, T Tian, G Ma,Y Lu, Z Liu, R Pan, R Li, H Piao, J R.Marks, L Yang, Q Yan, W Wang, J Shao,Y Zhou, T Zhou, and A Lin*. LncRNA Regulates Ca2+ Signaling-Mediated Tumor Microenvironment Remodeling. Molecular Cell. 2018. In press. Yanxiu Ma, Junmei Zhang, Lixia Wen, Aifu Lin*. Membrane-Lipid Associated LncRNA: A New Regulator in Cancer Signaling. Cancer Letters. 2018 Apr; 419, 27-29 Xin Zheng, Han Han, Guang-ping Liu, Yan-Xiu Ma, Ruo-Lang Pan, Ling-Jie Sang, Rui-Hua Li, Luo-Jia Yang, Jeffrey R. Marks, Wenqi Wang & Aifu Lin*. LncRNA Wires up Hippo and Hedgehog Signaling to Reprogram Glucose Metabolism. The EMBO Journal. 2017. Sep; 36, 3325-3335. C Li , S Wang , Z Xing , A Lin , K Liang , J Song , Q Hu , J Yao , Z Chen , P Park , D Hawke , J Zhou , Y Zhou , S Zhang , H Liang , M Hung , G Gallick , L Han , C Lin, & L Yang. A ROR1–HER3–lncRNA signalling axis modulates the Hippo–YAP pathway to regulate bone metastasis. Nature Cell Biology. 2017 Jan. 19, 106–119. A Lin, Q Hu , C Li, Z Xing , G Ma, C Wang, J Li , J Yao, K Liang , S Wang, P Park, J Marks, Y Zhou, J Zhou, M Hung , H Liang, Z Hu, H Shen, D Hawke, L Han, Y Zhou, C Lin& L Yang. The LINK-A lncRNA interacts with PI(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT Inhibitors. Nature Cell Biology. 2017 Feb; 19, 238-251(Highlighted in Nature Reviews Molecular Cell Biology) A Lin, C Li, Z Xing, K Liang, J Yao, S Wang, L Han, P Park, M Hung, H Liang, C Lin, & L Yang. LncRNA Activates Normoxic HIF1α Signaling in Triple-negative Breast Cancer. Nature Cell Biology. 2016 Feb; 18(2):213-24（Editors' choice in Science Signaling, and an MD Anderson news release） Z Xing#, A Lin#, C Li#, K Liang#, S Wang, Y Liu, P Park, L Qin, Y Wei, D Hawke, M Hung, C Lin& L Yang. LncRNA directs cooperative epigenetic regulation downstream of chemokine signals. Cell. 2014, 159 (5), 1110-1125 (Highlighted in Nature Structural & Molecular Biology and Cancer Research, and an MD Anderson news release) (#Co-first author, equal contribution) A Lin, H Piao, L Zhuang, DD Sarbassov, L Ma, B Gan. FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway. Cancer Research. 2014 Mar 15; 74(6):1682-93 A Lin, J Yao, L Zhuang, D Wang, J Han, EWF Lam, B Gan. The FoxO–BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress.Oncogene. 2014 Jun 12; 33(24):3183-94 L Zhu, A Lin, T Shao, L Nie, W Dong, L Xiang, J Shao. B cells in teleost fish act as pivotal initiating APCs in priming adaptive immunity: an evolutionary perspective on the origin of the B-1 cell subset and B7 molecules. The Journal of Immunology. 2014 Mar 15; 192(6):2699-714 A Lin, L Xiang, Q Wang, W Dong, Y Gong, J Shao. The DC-SIGN of zebrafish: insights into the existence of a CD209 homologue in a lower vertebrate and its involvement in adaptive immunity. The Journal of Immunology. 2009 Dec 1; 183(11):7398-410