研究领域

Biological & Medicinal Chemistry; Catalytic Processes; Chemical Synthesis; Nuclear and Radiochemistry; Organic Chemistry

CATALYSIS AND MOLECULAR RECOGNITION APPLIED TO BIOLOGY RESEARCH THEME: My research uses the tools of synthetic chemistry to address questions of molecular recognition and catalysis within a biological setting, all the while maintaining medically relevant goals. I provide a comprehensive research program at the interface of chemistry and biology, and preliminary data for these projects have already appeared in first-rate peer reviewed journals. KEY WORDS: Radiopharmaceuticals, natural product libraries, chemical biology, DNA recognition, self-assembly, synthetic DNAzymes, enzyme mimics, Protein Evolution.

近期论文

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"Perrin, D. M. ; Ting, R. ; Harwig, C. ; Li, Y. Arylboronic Acids As Captors Of Aqueous 18F-Fluoride For The One Step Labeling Of Biomolecules Suitable For Pet Imaging. In; American Chemical Society, 2010; p. ORGN-430.BibTex Perrin, D. M. ; May, J. P. Internal Savige-Fontana Tryptathionylation In The Synthesis Of Bicyclic Peptide Toxins And An Unexpected Chemical Entree From Hpi-Containing Phakellistatin/omphalotin-Like Macrolactams. In; American Chemical Society, 2010; p. ORGN-476.BibTex Lam, C. H. ; Perrin, D. M. Introduction Of Guanidinium-Modified Deoxyuridine Into The Substrate Binding Regions Of Dnazyme 10-23 To Enhance Target Affinity: Implications For Dnazyme Design. Bioorganic & Medicinal Chemistry Letters 2010, 20, 5119 - 5122.BibTex Keller, Uauf dem; Bellac, C. L. ; Li, Y. ; Lou, Y. ; Lange, P. F. ; Ting, R. ; Harwig, C. ; Kappelhoff, R. ; Dedhar, S. ; Adam, M. J. ; Ruth, T. J. ; Benard, F. ; Perrin, D. M. ; Overall, C. M. Novel Matrix Metalloproteinase Inhibitor [18F]Marimastat-Aryltrifluoroborate As A Probe For In Vivo Positron Emission Tomography Imaging In Cancer. Cancer Research 2010, 70, 7562 - 7569.BibTex Perrin, D. M. ; Hollenstein, M. ; Lam, C. H. ; Hipolito, C. J. Synthetic Rna-Cleaving Dnazymes With Three Protein Side Chains: Amines, Imidazoles, And Guanidines. In; American Chemical Society, 2010; p. BIOT-303.BibTex Keller, U. A. D. ; Lou, Y. M. ; Ting, R. ; Harwig, C. ; Prudova, A. ; Dedhar, S. ; Perrin, D. M. ; Overall, C. M. Substrate Degradomics And Activity Imaging Of Matrix Metalloproteinases In Breast Carcinogenesis. Clinical & Experimental Metastasis 2009, 26, 866-866.BibTex Thomas, J. M. ; Perrin, D. M. Probing General Acid Catalysis In The Hammerhead Ribozyme. Journal of the American Chemical Society 2009, 131, 1135-1143.BibTex Hollenstein, M. ; Hipolito, C. J. ; Lam, C. H. ; Perrin, D. M. A Dnazyme With Three Protein-Like Functional Groups: Enhancing Catalytic Efficiency Of M2+-Independent Rna Cleavage. Chembiochem 2009, 10, 1988-1992.BibTex Li, Y. ; Asadi, A. ; Perrin, D. M. Hydrolytic Stability Of Nitrogenous-Heteroaryltrifluoroborates Under Aqueous Conditions At Near Neutral Ph. Journal of Fluorine Chemistry 2009, 130, 377-382.BibTex Thomas, J. M. ; Yoon, J. K. ; Perrin, D. M. Investigation Of The Catalytic Mechanism Of A Synthetic Dnazyme With Protein-Like Functionality: An Rnasea Mimic?. Journal of the American Chemical Society 2009, 131, 5648-5658.BibTex Hollenstein, M. ; Hipolito, C. J. ; Lam, C. H. ; Perrin, D. M. A Self-Cleaving Dna Enzyme Modified With Amines, Guanidines And Imidazoles Operates Independently Of Divalent Metal Cations (M2+). Nucleic acids research 2009, 37, 1638-49.BibTex Lam, C. ; Hipolito, C. ; Perrin, D. M. Synthesis And Enzymatic Incorporation Of Modified Deoxyadenosine Triphosphates. European Journal of Organic Chemistry 2008, 4915-4923.BibTex Thomas, J. M. ; Perrin, D. M. Probing General Base Catalysis In The Hammerhead Ribozyme. Journal of the American Chemical Society 2008, 130, 15467-15475.BibTex Ting, R. ; Lo, J. ; Adam, M. J. ; Ruth, T. J. ; Perrin, D. M. Capturing Aqueous [F-18]-Fluoride With An Arylboronic Ester For Pet: Synthesis And Aqueous Stability Of A Fluorescent [F-18]-Labeled Aryltrifluoroborate. Journal of Fluorine Chemistry 2008, 129, 349-358.BibTex Harwig, C. W. ; Ting, R. ; Adam, M. J. ; Ruth, T. J. ; Perrin, D. M. Synthesis And Characterization Of 2,6-Difluoro-4-Carboxyphenylboronic Acid And A Biotin Derivative Thereof As Captors Of Anionic Aqueous [F-18]-Fluoride For The Preparation Of [F-18/f-19]-Labeled Aryltrifluoroborates With High Kinetic Stability. Tetrahedron Letters 2008, 49, 3152-3156.BibTex Ting, R. ; Harwig, C. W. ; Lo, J. ; Li, Y. ; Adam, M. J. ; Ruth, T. J. ; Perrin, D. M. Substituent Effects On Aryltrifluoroborate Solvolysis In Water: Implications For Suzuki-Miyaura Coupling And The Design Of Stable F-18-Labeled Aryltrifluoroborates For Use In Pet Imaging. Journal of Organic Chemistry 2008, 73, 4662-4670.BibTex Hollenstein, M. ; Hipolito, C. ; Lam, C. ; Dietrich, D. ; Perrin, D. M. A Highly Selective Dnazyme Sensor For Mercuric Ions. Angewandte Chemie-International Edition 2008, 47, 4346-4350.BibTex May, J. P. ; Perrin, D. M. Intraannular Savige-Fontana Reaction: One-Step Conversion Of One Class Of Monocyclic Peptides Into Another Class Of Bicyclic Peptides. Chemistry-a European Journal 2008, 14, 3404-3409.BibTex May, J. P. ; Fournier, P. ; Patrick, B. O. ; Perrin, D. M. Synthesis, Characterisation, And In Vitro Evaluation Of Pro(2)-Ile(3)-S-Deoxo-Amaninamide And Pro(2)-D-Allo-Ile(3)-S-Deoxo-Amaninamide: Implications For Structure-Activity Relationships In Amanitin Conformation And Toxicity. Chemistry-a European Journal 2008, 14, 3410-3417.BibTex Ting, R. ; Harwig, C. ; U. Keller, aufdem; McCormick, S. ; Austin, P. ; Overall, C. M. ; Adam, M. J. ; Ruth, T. J. ; Perrin, D. M. Toward [F-18]-Labeled Aryltrifluoroborate Radiotracers: In Vivo Positron Emission Tomography Imaging Of Stable Aryltrifluoroborate Clearance In Mice. Journal of the American Chemical Society 2008, 130, 12045-12055.BibTex"