Reyk, David Van - University of Technology Sydney

个人简介

After completing a Biomedical Science degree here at UTS, I undertook a PhD in free radical biology with Professor Nicholas Hunt in the Department of Pathology, University of Sydney. Towards the end of that time and then after graduation, I worked in Roger Dean and Wendy Jessup’s group at the Heart Research Institute with a focus on low-density lipoprotein (LDL) oxidation and foam cell macrophages. I have been a lecturer in pathophysiology at UTS since 2000. As Director of Student Mobility and Engagement I (i) oversee global exchange and short term mobility with regard to Faculty of Science students; and (ii) I am one of the subject coordinators for the Faculty’s internship subjects. Faculty of Science students with mobility or internship inquiries can lodge them via this mailbox: science.mobility@uts.edu.au I continue to research in the area of free radical biology and I am currently working with Brian Oliver and Hui Chen with regard to inflammatory respiratory diseases. I also research my teaching practice. My foci being the teaching of students of the health professions and student transitioning to university. I am member of a cross institutional team which created and now manages an open access website BioScience Essentials 2BRN (www.bioscienceessentials2brn.com) designed to provide support for students entering health profession programs with regard to basic sciences, anatomy and physiology subjects.

研究领域

BIOSCIENCE TEACHING "Bioscience" is the catch all phrase commonly used to describe the science taught to students studying to qualify as a health professional such as a nurse, midwife or paramedic. Commonly these students find bioscience a challenge and this can have impacts upon broader academic achievements and also retention. For a number of years I have collaborated with other Bioscience educators in other Australian institutions investigating this problem with a particular interest in developing resources to support and engage these students OXIDATIVE DAMAGE/MODIFICATIONS TO PLASMA PROTEINS, CELLS AND TISSUES How such changes to plasma proteins, cell and tissue components can contribute to disease development remained to my research. This has included in vivo studies examing the potential of "anti-oxidants" to prevent this changes and thus block disease progression as well as in vitro studies looking at modulation of cell function upon exposure to oxidising inflammatory agents and oxidised extracellular proteins.

近期论文

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Pan, GJ, Rayner, BS, Zhang, Y, van Reyk, DM & Hawkins, CL 2018, 'A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid.', Archives of biochemistry and biophysics, vol. 642, pp. 23-30.View/Download from: UTS OPUS or Publisher's site Chen, H, Li, G, Chan, YL, Nguyen, T, van Reyk, D, Saad, S & Oliver, BG 2018, 'Modulation of neural regulators of energy homeostasis, and of inflammation, in the pups of mice exposed to e-cigarettes.', Neuroscience letters, vol. 684, pp. 61-66.View/Download from: UTS OPUS or Publisher's site Abdo, AI, Rayner, BS, van Reyk, DM & Hawkins, CL 2017, 'Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction.', Redox biology, vol. 13, pp. 623-632.View/Download from: UTS OPUS or Publisher's site Capistrano, SJ, van Reyk, D, Chen, H & Oliver, BG 2017, 'Evidence of Biomass Smoke Exposure as a Causative Factor for the Development of COPD.', Toxics, vol. 5, no. 4, pp. 1-16.View/Download from: UTS OPUS or Publisher's site Bennett, D, Knight, E, Divan, A, Kuchel, L, Horn, J, van Reyk, D & Burke da Silva, K 2017, 'How do research-intensive universities portray employability strategies? A review of their websites', Australian Journal of Career Development, vol. 26, no. 2, pp. 52-61.View/Download from: UTS OPUS or Publisher's site Chen, H, Kelly, M, Hayes, C, van Reyk, D & Herok, G 2016, 'The use of simulation as a novel experiential learning module in undergraduate science pathophysiology education', ADVANCES IN PHYSIOLOGY EDUCATION, vol. 40, no. 3, pp. 335-341.View/Download from: UTS OPUS or Publisher's site Ismael, FO, Proudfoot, JM, Brown, BE, van Reyk, DM, Croft, KD, Davies, MJ & Hawkins, CL 2015, 'Comparative reactivity of the myeloperoxidase-derived oxidants HOCl and HOSCN with low-density lipoprotein (LDL): Implications for foam cell formation in atherosclerosis', ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 573, pp. 40-51.View/Download from: UTS OPUS or Publisher's site Kim, CHJ, Mitchell, JB, Bursill, CA, Sowers, AL, Thetford, A, Cook, JA, van Reyk, DM & Davies, MJ 2015, 'The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE(-/-) mice', ATHEROSCLEROSIS, vol. 240, no. 1, pp. 234-241.View/Download from: UTS OPUS or Publisher's site Chan, YL, Saad, S, Simar, D, Oliver, B, McGrath, K, Reyk, DV, Bertrand, PP, Gorrie, C, Pollock, C & Chen, H 2015, 'Short term exendin-4 treatment reduces markers of metabolic disorders in female offspring of obese rat dams', International Journal of Developmental Neuroscience, vol. 46, pp. 67-75.View/Download from: UTS OPUS or Publisher's site Brown, BE, Kim, CH, Torpy, FR, Bursill, CA, Mcrobb, L, Heather, AK, Davies, MJ & Van Reyk, DM 2014, 'Supplementation with carnosine decreases plasma triglycerides and modulates atherosclerotic plaque composition in diabetic apo E -/- mice.', Atherosclerosis, vol. 232, pp. 403-409.View/Download from: UTS OPUS or Publisher's site Rathner, JA, van Reyk, D & Crane, JW 2013, 'Editorial-volume 21, numbers 2 & 3', International Journal of Innovation in Science and Mathematics Education, vol. 21, no. 2. Rathner, JA, van Reyk, D & Crane, JW 2013, 'Editorial', International Journal of Innovation in Science and Mathematics Education, vol. 21, no. 3. Ang, K & Van Reyk, DM 2013, ''Teach Me Chemistry Like a Ladder and Make it Real' - Barriers and Motivations Students Face in Learning Chemistry for Bioscience', International Journal of Innovation in Science and Mathematics Education, vol. 21, no. 2, pp. 1-12.View/Download from: UTS OPUS Moheimani, F, Kim, CH, Suryo Rahmanto, A, Van Reyk, DM & Davies, MJ 2012, 'Inhibition of lysosomal function in macrophages incubated with elevated glucose concentrations: A potential contributory factor in diabetes-associated atherosclerosis', Atherosclerosis, vol. 223, no. 1, pp. 144-151.View/Download from: UTS OPUS or Publisher's site Moheimani, F, Tan, JT, Brown, BE, Heather, AK, Van Reyk, DM & Davies, MJ 2011, 'Effect of exposure of human monocyte-derived macrophages to high, versus normal, glucose on subsequent lipid accumulation from glycated and acetylated low-density lipoproteins', Experimental Diabetes Research, vol. 2011, no. 851280, pp. 1-10.View/Download from: UTS OPUS or Publisher's site Moheimani, F, Morgan, PE, Van Reyk, DM & Davies, MJ 2010, 'Deleterious effects of reactive aldehydes and glycated proteins on macrophage proteosomal function: Possible links between diabetes and atherosclerosis', Biochimica et Biophysica acta, vol. 1802, no. 6, pp. 561-571.View/Download from: UTS OPUS Lloyd, MM, Van Reyk, DM, Davies, MJ & Hawkins, CL 2008, 'Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid', Biochemical Journal, vol. 414, pp. 271-280.View/Download from: UTS OPUS or Publisher's site Rashid, I, Van Reyk, DM & Davies, MJ 2007, 'Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro', FEBS Letters, vol. 581, no. 5, pp. 1067-1070.View/Download from: UTS OPUS or Publisher's site Brown, B, Rashid, I, Van Reyk, DM & Davies, MJ 2007, 'Glycation of low-density lipoprotein results in the time- dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages', FEBS Journal, vol. 274, no. 6, pp. 1530-1540.View/Download from: UTS OPUS or Publisher's site Van Reyk, DM, Brown, A, Hults'en, LM, Dean, R & Jessup, W 2006, 'Oxysterols in biological systems: sources, metabolism and pathophysiological relevances', Redox Report, vol. 11, no. 6, pp. 255-262.View/Download from: UTS OPUS or Publisher's site Brown, B, Mahroof, F, Cook, N, Van Reyk, DM & Davies, MJ 2006, 'Hydrazine compounds inhibit glycation of low-density lipoproteins and prevent the in vitro formation of model foam cells from glycolaldehyde-modified low-density lipoproteins', Diabetologia, vol. 49, no. 4, pp. 775-783.View/Download from: UTS OPUS or Publisher's site