Valenzuela, Stella - University of Technology Sydney

个人简介

Stella Valenzuela undertook her PhD studies in cell and molecular biology [identifying novel genes – CLIC1 and MIC-1 - from activated macrophage cells] at the Centre for Immunology (CFI), St Vincent’s Hospital Sydney, obtaining her PhD from the University of NSW in 1998. Prior to this she had worked in the commercial sector, in the biotechnology companies Australian Monoclonal Development Pty Ltd and Cellabs Pty Ltd in research and development of monoclonal antibody technologies for research and diagnostic purposes. Following her PhD studies she was a Research Scientist at the CFI [functional studies of intracellular ion channel proteins – CLICs], later moving to the University of NSW to take up a position as an NHMRC Research Fellow [knockout mouse studies of S100 inflammatory proteins]. In 2001 she joined the University of Technology, Key Centre for Health Technologies [cellular responses to mobile phone frequencies]. She then took up an academic position at UTS in 2004. She is currently the Associate Head of School (Research) in the School of Life Sciences, UTS. Prof Valenzuela is a member of both the Centre for Health Technologies and previously also a member of the Institute of Nanoscale Technologies, UTS. She has been instrumental in establishing Bionanotechnology research at UTS and is currently working with her industry partner Surgical Diagnostics Pty Ltd, within the IDEAL HUB, an ARC Industry transformation hub, developing devices that use ion channel proteins and tethered membrane technologies.

研究领域

Stella Valenzuela was awarded her PhD in 1998, and has extensive research experience in the field of cell biology, ion channels and membrane-associated proteins. She was the first to identify and characterise the protein NCC27 (now referred to as CLIC1) following the screening of a subtraction cDNA library for novel genes involved in macrophage activation. Her work demonstrated that CLIC1 was a novel nuclear chloride ion channel protein, published in the Journal of Biological Chemistry (1997). Her project also resulted in identification of a novel cytokine, MIC-1, published in PNAS, 1997. Since then she has demonstrated that CLIC1 was ubiquitously expressed in humans and involved in regulation of the cell cycle (J Physiol, 2000). This was followed by determination of the crystal structure of the soluble form of CLIC1 at 1.4 Å resolution, in collaboration with Prof Paul Curmi's team (JBC, 2001). Most recently, her research team have demonstrated for the first time that members of the CLIC family have oxidoreductase enzymatic activity, in addition to being ion channels (PLOS ONE 2015 & Nature Communications 2017). Her group are also leading studies into the regulation of CLIC proteins by sterols. This work is applying tethered membrane technologies in collaboration with her industry partner, Surgical Diagnostics P/L along with neutron and X-ray reflectometry studies in collaboration with Dr Holt, at the BRAGG Institute, ANSTO. Prof Valenzuela is currently a member of the IDEAL Research Hub, funded by the Australian Research Council. The IDEAL Hub brings together academic researchers and industry partners to focus on improving the sensitivity, selectivity, speed and cost-effectiveness of detecting at low levels in order to develop the next generation of diagnostic and testing devices. Prof Valenzuela is recognized as one of the University’s leading Nanobiotechnology researchers. Her work with gold nanoparticles has potential application in the treatment of chronic inflammatory diseases by targeting and regulating macrophage cells. Working with Professor Cortie from the Institute of Nanoscale Technologies at UTS, they successfully demonstrated the first selective targeting and killing of disease-causing protozoans by photothermal treatment with antibody conjugated gold nanoparticles. Her more recent work with Dr Hui Chen has demonstrated a role for gold nanoparticles in the regulation of obesity and metabolic disorders (PLOS ONE, 2013 and Journal of Nanobiotechnology, 2018) .

近期论文

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Hossain, KR, Turkewitz, DR, Holt, SA, Herson, L, Brown, LJ, Cornell, BA, Curmi, PMG & Valenzuela, SM 2019, 'A conserved GXXXG motif in the transmembrane domain of CLIC proteins is essential for their cholesterol-dependant membrane interaction', Biochimica et Biophysica Acta - General Subjects, vol. 1863, no. 8, pp. 1243-1253.View/Download from: Publisher's site Chen, Y, Duong, HTT, Wen, S, Mi, C, Zhou, Y, Shimoni, O, Valenzuela, SM & Jin, D 2018, 'Exonuclease III-Assisted Upconversion Resonance Energy Transfer in a Wash-Free Suspension DNA Assay.', Analytical Chemistry, vol. 90, no. 1, pp. 663-668.View/Download from: UTS OPUS or Publisher's site Bray, K, Cheung, L, Hossain, KR, Aharonovich, I, Valenzuela, SM & Shimoni, O 2018, 'Versatile multicolor nanodiamond probes for intracellular imaging and targeted labeling', JOURNAL OF MATERIALS CHEMISTRY B, vol. 6, no. 19, pp. 3078-3084.View/Download from: UTS OPUS or Publisher's site Chen, H, Ng, JPM, Bishop, DP, Milthorpe, BK & Valenzuela, SM 2018, 'Gold nanoparticles as cell regulators: beneficial effects of gold nanoparticles on the metabolic profile of mice with pre-existing obesity', JOURNAL OF NANOBIOTECHNOLOGY, vol. 16.View/Download from: UTS OPUS or Publisher's site Hernandez-Fernaud, JR, Ruengeler, E, Casazza, A, Neilson, LJ, Pulleine, E, Santi, A, Ismail, S, Lilla, S, Dhayade, S, MacPherson, IR, McNeish, I, Ennis, D, Ali, H, Kugeratski, FG, Al Khamici, H, van den Biggelaar, M, van den Berghe, PVE, Cloix, C, McDonald, L, Millan, D, Hoyle, A, Kuchnio, A, Carmeliet, P, Valenzuela, SM, Blyth, K, Yin, H, Mazzone, M, Norman, JC & Zanivan, S 2017, 'Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.', Nature Communications, vol. 8, pp. 1-17.View/Download from: UTS OPUS or Publisher's site Hossain, KR, Holt, SA, Le Brun, AP, Al Khamici, H & Valenzuela, SM 2017, 'X-ray and Neutron Reflectivity Study Shows That CLIC1 Undergoes Cholesterol-Dependent Structural Reorganization in Lipid Monolayers.', Langmuir, vol. 33, no. 43, pp. 12497-12509.View/Download from: UTS OPUS or Publisher's site Yeoh, GH, Gu, X, Timchenko, V, Valenzuela, SM & Cornell, BA 2016, 'High order accurate dual-phase-lag numerical model for microscopic heating in multiple domains', INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER, vol. 78, pp. 21-28.View/Download from: Publisher's site Cranfield, CG, Berry, T, Holt, SA, Hossain, KR, Le Brun, AP, Carne, S, Al Khamici, H, Coster, H, Valenzuela, SM & Cornell, B 2016, 'Evidence of the Key Role of H3O+ in Phospholipid Membrane Morphology', LANGMUIR, vol. 32, no. 41, pp. 10725-10734.View/Download from: UTS OPUS or Publisher's site Al Khamici, H, Hossain, KR, Cornell, BA & Valenzuela, SM 2016, 'Investigating Sterol and Redox Regulation of the Ion Channel Activity of CLIC1 Using Tethered Bilayer Membranes.', Membranes, vol. 6, no. 4, pp. 1-13.View/Download from: UTS OPUS or Publisher's site Hossain, KR, Al Khamici, H, Holt, SA & Valenzuela, SM 2016, 'Cholesterol Promotes Interaction of the Protein CLIC1 with Phospholipid Monolayers at the Air-Water Interface.', Membranes, vol. 6, no. 1, pp. 1-13.View/Download from: UTS OPUS or Publisher's site Al Khamici, H, Brown, LJ, Hossain, KR, Hudson, AL, Sinclair-Burton, AA, Jane, PMN, Daniel, EL, Hare, JE, Cornell, BA, Curmi, PMG, Davey, MW & Valenzuela, SM 2015, 'Members of the Chloride Intracellular Ion Channel Protein Family Demonstrate Glutaredoxin-Like Enzymatic Activity', PLOS ONE, vol. 10, no. 1.View/Download from: UTS OPUS or Publisher's site Yepuri, NR, Holt, SA, Moraes, G, Holden, PJ, Hossain, KR, Valenzuela, SM, James, M & Darwish, TA 2014, 'Stereoselective synthesis of perdeuterated phytanic acid, its phospholipid derivatives and their formation into lipid model membranes for neutron reflectivity studies', CHEMISTRY AND PHYSICS OF LIPIDS, vol. 183, pp. 22-33.View/Download from: Publisher's site Chou, J, Valenzuela, SM, Santos, J, Bishop, D, Milthorpe, B, Green, DW, Otsuka, M & Ben-Nissan, B 2014, 'Strontium- and magnesium-enriched biomimetic beta-TCP macrospheres with potential for bone tissue morphogenesis', JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 8, no. 10, pp. 771-778.View/Download from: Publisher's site Valenzuela, SM, Jiang, L, Curmi, PMG, Phang, JM, Yu, J, Harrop, SJ, Sokolova, AV, Duff, AP, Wilk, KE, Alkhamici, H, Breit, SN & Brown, LJ 2014, 'CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: A smoking gun?', Biochimica et Biophysica Acta - Biomembranes, vol. 1838, no. 2, pp. 643-657.View/Download from: Publisher's site Chou, J, Valenzuela, S, Green, DW, Kohan, L, Milthorpe, B, Otsuka, M & Ben-Nissan, B 2014, 'Antibiotic delivery potential of nano and micro porous marine structures derived ß-TCP spheres for medical applications', Nanomedicine, vol. 1, pp. 1-9.View/Download from: UTS OPUS or Publisher's site Jones, PM, Curmi, PMG, Valenzuela, SM & George, AM 2013, 'Computational Analysis of the Soluble Form of the Intracellular Chloride Ion Channel Protein CLIC1', BIOMED RESEARCH INTERNATIONAL.View/Download from: UTS OPUS or Publisher's site Chen, H, Dorrigan, A, Saad, S, Hare, DJ, Cortie, MB & Valenzuela, S 2013, 'In Vivo Study of Spherical Gold Nanoparticles: Inflammatory Effects and Distribution in Mice', PLoS One, vol. 8, no. 2, pp. 1-8.View/Download from: UTS OPUS or Publisher's site Valenzuela, S, Alkhamici, H, Brown, LJ, Almond, OC, Goodchild, SC, Carne, S, Curmi, PM, Holt, S & Cornell, BA 2013, 'Regulation Of The Membrane Insertion And Conductance Activity Of The Metamorphic Chloride Intracellular Channel Protein CLIC1 By Cholesterol', Plos One, vol. 8, no. 2, pp. 1-8.View/Download from: UTS OPUS or Publisher's site Cortie, MB, Al Hafed, E, Chen, H, Valenzuela, S, Ting, S, Sonvico, F & Milthorpe, BK 2013, 'Nanomedical research in Australia and New Zealand', Nanomedicine, vol. 8, no. 12, pp. 1999-2006.View/Download from: UTS OPUS or Publisher's site Chou, J, Ben-Nissan, B, Green, DD, Valenzuela, S & Kohan, L 2011, 'Targeting And Dissolution Characteristics Of Bone Forming And Antibacterial Drugs By Harnessing The Structure Of Microspherical Shells From Coral Beach Sand', Advanced Engineering Materials, vol. 13, no. 1-2, pp. 93-99.View/Download from: UTS OPUS or Publisher's site Windley, MJ, Escoubas, P, Valenzuela, S & Nicholson, GM 2011, 'A Novel Family of Insect-Selective Peptide Neurotoxins Targeting Insect Large-Conductance Calcium-Activated K(+) Channels Isolated from the Venom of the Theraphosid Spider Eucratoscelus constrictus', Molecular Pharmacology, vol. 80, no. 1, pp. 1-13.View/Download from: UTS OPUS or Publisher's site Valenzuela, S, Berkahn, MB, Porkovich, A, Huynh, TG, Goyette, J, Martin, DK & Geczy, CL 2011, 'Soluble structure of CLIC and S100 proteins investigated by atomic force microscopy', Journal of Biomaterials and Nanobiotechnology, vol. 2, pp. 8-17.View/Download from: UTS OPUS or Publisher's site Ting, HJ, Haas, MR, Valenzuela, S & Martin, DK 2010, 'Terminating polyelectrolyte in multilayer films influences growth and morphology of adhering cells', Iet Nanobiotechnology, vol. 4, no. 3, pp. 77-90.View/Download from: UTS OPUS or Publisher's site Qiu, MR, Jiang, L, Matthaei, KI, Schoenwaelder, SM, Kuffner, T, Mangin, P, Joseph, JE, Low, J, Connor, D, Valenzuela, SM, Curmi, PMG, Brown, LJ, Mahaut-Smith, M, Jackson, SP & Breit, SN 2010, 'Generation and Characterization of Mice With Null Mutation of the Chloride Intracellular Channel 1 Gene', GENESIS, vol. 48, no. 2, pp. 127-136.View/Download from: Publisher's site Pissuwan, D, Cortie, CH, Valenzuela, S & Cortie, MB 2010, 'Functionalised gold nanoparticles for controlling pathogenic bacteria', Trends In Biotechnology, vol. 28, no. 4, pp. 207-213.View/Download from: Publisher's site Qiu, M, Jiang, L, Matthaei, K, Schoenwaelder, S, Kuffner, T, Mangin, P, Joseph, J, Low, JA, Connor, DI, Valenzuela, S, Curmi, PM, Brown, L, Mahaut-smith, M, Jackson, S & Breit, SN 2010, 'Generation And Characterization Of Mice With Null Mutation Of The Chloride Intracellular Channel 1 Gene', Genesis, vol. 48, no. 2, pp. 127-136.View/Download from: UTS OPUS or Publisher's site Littler, DR, Harrop, SJ, Goodchild, SC, Phang, JM, Mynott, AV, Jiang, L, Valenzuela, S, Mazzanti, M, Brown, LJ, Breit, S & Curmi, PM 2010, 'The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?', FEB Letters, vol. 584, no. 10, pp. 2093-2101.View/Download from: UTS OPUS Lewis, KC, Wuhrer, R, Ben-Nissan, B, Valenzuela, S & Moran, K 2010, 'X-Ray mapping of mineral phases incorporated into liposomes', Microscopy Today, vol. 18, pp. 30-32. Pissuwan, D, Valenzuela, S & Cortie, MB 2009, 'Prospects for Gold Nanorod Particles in Diagnostic and Therapeutic Applications', Biotechnology & Genetic Engineering Reviews, vol. 25, pp. 93-112.View/Download from: UTS OPUS Battle, AR, Valenzuela, S, Mechler, A, Nichols, R, Praporski, S, Di Maio, I, Islam, H, Girard-Egrot, AP, Cornell, BA, Prashar, J, Caruso, F, Martin, LL & Martin, DK 2009, 'Novel engineered ion channel provides controllable ion permability for polyelectrolyte microcapsules coated with a lipid membrane', Advanced Functional Materials, vol. 19, pp. 201-208.View/Download from: UTS OPUS or Publisher's site Pissuwan, D, Valenzuela, S, Miller, CM, Killingsworth, MC & Cortie, MB 2009, 'Destruction and Control of Toxoplasma gondii Tachyzoites Using Gold Nanosphere / Antibody Conjugates', Small, vol. 5, no. 9, pp. 1030-1034.View/Download from: UTS OPUS or Publisher's site