Stewart, Martin - University of Technology Sydney

个人简介

My current research interests are in cell manipulation and analysis, specifically in the areas of intracellular delivery and cell biophysics. Intracellular delivery is a foundational technology for cell engineering applications such as gene and cell-based therapy. Prior to joining UTS in 2018, I competed postdoctoral fellowships with the Swiss National Science Foundation (Switzerland) and the Life Sciences Research Foundation (USA). Grants from the American Australian Association and the Broad Institute of Harvard and MIT gave me the opportunity to pursue my interest in cell response to membrane-based intracellular delivery methods, such as microfluidic cell squeezing and electroporation. In my previous research, I have been mentored by Bob Langer (MIT), Klavs Jensen (MIT), Tony Hyman (Max Planck Institute) and Daniel Muller (ETH Zurich). Currently, I am a research Group Leader and Lecturer in the Faculty of Science, School of Life Sciences.

研究领域

Intracellular Delivery Cell Engineering Cell Biophysics Cell Mechanics Low-Cost Low-Toxicity Cancer Treatments

近期论文

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Stewart, MP, Langer, R & Jensen, KF 2018, 'Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts', CHEMICAL REVIEWS, vol. 118, no. 16, pp. 7409-7531.View/Download from: UTS OPUS or Publisher's site Toyoda, Y, Cattin, CJ, Stewart, MP, Poser, I, Theis, M, Kurzchalia, TV, Buchholz, F, Hyman, AA & Müller, DJ 2017, 'Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding.', Nature Communications, vol. 8, no. 1, pp. 1-11.View/Download from: UTS OPUS or Publisher's site Ding, X, Stewart, MP, Sharei, A, Weaver, JC, Langer, RS & Jensen, KF 2017, 'High-throughput nuclear delivery and rapid expression of DNA via mechanical and electrical cell-membrane disruption', NATURE BIOMEDICAL ENGINEERING, vol. 1, no. 3.View/Download from: UTS OPUS or Publisher's site Stewart, MP, Sharei, A, Ding, X, Sahay, G, Langer, R & Jensen, KF 2016, 'In vitro and ex vivo strategies for intracellular delivery', NATURE, vol. 538, no. 7624, pp. 183-192.View/Download from: Publisher's site Stewart, MP, Lorenz, A, Dahlman, J & Sahay, G 2016, 'Challenges in carrier-mediated intracellular delivery: moving beyond endosomal barriers', WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, vol. 8, no. 3, pp. 465-478.View/Download from: Publisher's site Sorce, B, Escobedo, C, Toyoda, Y, Stewart, MP, Cattin, CJ, Newton, R, Banerjee, I, Stettler, A, Roska, B, Eaton, S, Hyman, AA, Hierlemann, A & Mueller, DJ 2015, 'Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement', NATURE COMMUNICATIONS, vol. 6.View/Download from: Publisher's site Cattin, CJ, Dueggelin, M, Martinez-Martin, D, Gerber, C, Mueller, DJ & Stewart, MP 2015, 'Mechanical control of mitotic progression in single animal cells', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 112, no. 36, pp. 11258-11263.View/Download from: Publisher's site Ramanathan, SP, Helenius, J, Stewart, MP, Catlin, CJ, Hyman, AA & Muller, DJ 2015, 'Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement', NATURE CELL BIOLOGY, vol. 17, no. 2, pp. 148-+.View/Download from: Publisher's site Toyoda, Y, Erkut, C, Pan-Montojo, F, Boland, S, Stewart, MP, Mueller, DJ, Wurst, W, Hyman, AA & Kurzchalia, TV 2014, 'Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival', BIOLOGY OPEN, vol. 3, no. 8, pp. 777-784.View/Download from: Publisher's site Stewart, MP, Hodel, AW, Spielhofer, A, Cattin, CJ, Mueller, DJ & Helenius, J 2013, 'Wedged AFM-cantilevers for parallel plate cell mechanics', METHODS, vol. 60, no. 2, pp. 186-194.View/Download from: Publisher's site Stewart, MP, Toyoda, Y, Hyman, AA & Mueller, DJ 2012, 'Tracking mechanics and volume of globular cells with atomic force microscopy using a constant-height clamp', NATURE PROTOCOLS, vol. 7, no. 1, pp. 143-154.View/Download from: Publisher's site Stewart, MP, Toyoda, Y, Hyman, AA & Muller, DJ 2011, 'Force probing cell shape changes to molecular resolution', TRENDS IN BIOCHEMICAL SCIENCES, vol. 36, no. 8, pp. 444-450.View/Download from: Publisher's site Stewart, MP, Helenius, J, Toyoda, Y, Ramanathan, SP, Muller, DJ & Hyman, AA 2011, 'Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding', NATURE, vol. 469, no. 7329, pp. 226-230.View/Download from: Publisher's site