Smith, Nick - University of Technology Sydney

个人简介

My career has been devoted to studying how parasites and their hosts interact, with particular emphasis on immune responses to parasites and developing vaccines to fight parasitic disease. I received a PhD in Parasitology from the Australian National University in 1988 and from 1988 to 1990 was a National Research Fellow, also at the ANU. I was then the Head of Coccidiosis Research in the Institute of Parasitology at the University of Zurich, Switzerland, until 1994, when I returned to Australia as a Queensland Institute of Medical Research Fellow. I joined UTS as a Lecturer in 1996, was Acting Director of the Institute for the Biotechnology of Infectious Diseases in 2002 and its Deputy Director from 2003-2005. In 2005, I was appointed National Convenor of the ARC/NHMRC Research Network for Parasitology, an organisation charged with focusing and enhancing Australia's parasitological research effort. I was appointed Professor of Parasitology at UTS in 2009, Tropical Leader and Professor of Cell Molecular Biology at James Cook University in 2011, Deputy Dean of Science and Health at Western Sydney University in 2017 and Discipline Leader of Biology and Biotechn0logy at UTS in 2018. I was elected a Fellow of the Australian Society for Parasitology in 2008 in recognition of my service to parasitology research and education.

研究领域

My research revolves around understanding how hosts and parasites interact with each other; this includes an interest in the immune response of hosts to parasites as well as adaptations of parasites that facilitate their survival, growth, reproduction, virulence and transmission. Ultimately, my research is directed at discovery of innovative ways to control parasitic diseases. My research team applies a variety of techniques in biochemistry and proteomics, molecular biology and recombinant protein expression, cell culture, immunofluorescence microscopy, immunology and vaccinology. I have been privileged to receive funding for my research from the National Health and Medical Research Council, the Australian Research Council, the Swiss Commission for Technology aand Innovation, the National Institutes of Health (USA), the Bellberry Foundation, the Swiss National Fund, the World Health Organisation and the Rural Industries Research and Development Corporation, funding that has been used to support numerous Honours, Masters and PhD students, as well as Postdoctoral Research Fellows.

近期论文

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Ramakrishnan, C, Maier, S, Walker, RA, Rehrauer, H, Joekel, DE, Winiger, RR, Basso, WU, Grigg, ME, Hehl, AB, Deplazes, P & Smith, NC 2019, 'An experimental genetically attenuated live vaccine to prevent transmission of Toxoplasma gondii by cats', SCIENTIFIC REPORTS, vol. 9.View/Download from: Publisher's site Alhallaf, R, Agha, Z, Miller, CM, Robertson, AAB, Sotillo, J, Croese, J, Cooper, MA, Masters, SL, Kupz, A, Smith, NC, Loukas, A & Giacomin, PR 2018, 'The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection.', Cell reports, vol. 23, no. 4, pp. 1085-1098.View/Download from: UTS OPUS or Publisher's site Lippuner, C, Ramakrishnan, C, Basso, WU, Schmid, MW, Okoniewski, M, Smith, NC, Hässig, M, Deplazes, P & Hehl, AB 2018, 'RNA-Seq analysis during the life cycle of Cryptosporidium parvum reveals significant differential gene expression between proliferating stages in the intestine and infectious sporozoites.', International journal for parasitology, vol. 48, no. 6, pp. 413-422.View/Download from: Publisher's site Bussière, FI, Niepceron, A, Sausset, A, Esnault, E, Silvestre, A, Walker, RA, Smith, NC, Quéré, P & Laurent, F 2018, 'Establishment of an in vitro chicken epithelial cell line model to investigate Eimeria tenella gamete development.', Parasites & Vectors, vol. 11, no. 1, pp. 44-44.View/Download from: UTS OPUS or Publisher's site Ramakrishnan, C, Walker, RA, Eichenberger, RM, Hehl, AB & Smith, NC 2017, 'The merozoite-specific protein, TgGRA11B, identified as a component of the Toxoplasma gondii parasitophorous vacuole in a tachyzoite expression model.', International Journal for Parasitology, vol. 47, no. 10-11, pp. 597-600.View/Download from: UTS OPUS or Publisher's site Rajendran, E, Hapuarachchi, SV, Miller, CM, Fairweather, SJ, Cai, Y, Smith, NC, Cockburn, IA, Broer, S, Kirk, K & van Dooren, GG 2017, 'Cationic amino acid transporters play key roles in the survival and transmission of apicomplexan parasites', NATURE COMMUNICATIONS, vol. 8.View/Download from: UTS OPUS or Publisher's site Walker, RA, Niepceron, A, Ramakrishnan, C, Sedano, L, Hehl, AB, Brossier, F & Smith, NC 2016, 'Discovery of a tyrosine-rich sporocyst wall protein in Eimeria tenella', PARASITES & VECTORS, vol. 9.View/Download from: Publisher's site Miller, CM, Zakrzewski, AM, Robinson, DP, Fuller, SJ, Walker, RA, Ikin, RJ, Bao, SJ, Grigg, ME, Wiley, JS & Smith, NC 2015, 'Lack of a Functioning P2X7 Receptor Leads to Increased Susceptibility to Toxoplasmic Ileitis', PLOS ONE, vol. 10, no. 6.View/Download from: Publisher's site Walker, RA, Sharman, PA, Miller, CM, Lippuner, C, Okoniewski, M, Eichenberger, RM, Ramakrishnan, C, Brossier, F, Deplazes, P, Hehl, AB & Smith, NC 2015, 'RNA Seq analysis of the Eimeria tenella gametocyte transcriptome reveals clues about the molecular basis for sexual reproduction and oocyst biogenesis', BMC GENOMICS, vol. 16.View/Download from: Publisher's site Hehl, AB, Basso, WU, Lippuner, C, Ramakrishnan, C, Okoniewski, M, Walker, RA, Grigg, ME, Smith, NC & Deplazes, P 2015, 'Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes', BMC GENOMICS, vol. 16.View/Download from: Publisher's site Witcombe, DM & Smith, NC 2014, 'Strategies for anti-coccidial prophylaxis', Parasitology, vol. 141, no. 11, pp. 1379-1389.View/Download from: Publisher's site Chapman, HD, Barta, JR, Blake, D, Gruber, A, Jenkins, M, Smith, NC, Suo, X & Tomley, FM 2013, 'A Selective Review of Advances in Coccidiosis Research', ADVANCES IN PARASITOLOGY, VOL 83, vol. 83, pp. 93-171.View/Download from: Publisher's site Walker, RA, Ferguson, DJP, Miller, CMD & Smith, NC 2013, 'Sex and Eimeria: a molecular perspective', PARASITOLOGY, vol. 140, no. 14, pp. 1701-1717.View/Download from: Publisher's site Rieux, A, Gras, S, Lecaille, F, Niepceron, A, Katrib, M, Smith, NC, Lalmanach, G & Brossier, F 2012, 'Eimeripain, a Cathepsin B-Like Cysteine Protease, Expressed throughout Sporulation of the Apicomplexan Parasite Eimeria tenella', PLoS One, vol. 7, no. 3, pp. 1-11.View/Download from: UTS OPUS or Publisher's site Katrib, M, Ikin, RJ, Brossier, F, Robinson, M, Slapetova, I, Sharman, PA, Walker, RA, Belli, SI, Tomley, FM & Smith, NC 2012, 'Stage-specific expression of protease genes in the apicomplexan parasite, Eimeria tenella', BMC GENOMICS, vol. 13.View/Download from: UTS OPUS or Publisher's site Mai, K, Smith, NC, Feng, Z, Katrib, M, Slapeta, J, Slapetova, I, Wallach, M, Luxford, C, Davies, MJ, Zhang, X, Norton, RS & Belli, SI 2011, 'Peroxidase catalysed cross-linking of an intrinsically unstructured protein via dityrosine bonds in the oocyst wall of the apicomplexan parasite, Eimeria maxima', International Journal For Parasitology, vol. 41, no. 11, pp. 1157-1164.View/Download from: UTS OPUS or Publisher's site Miller, CM, Zakrzewski, AM, Ikin, RJ, Boulter, N, Katrib, M, Lees, MP, Fuller, S, Wiley, JS & Smith, NF 2011, 'Dysregulation of the inflammatory response to the parasite, Toxoplasma gondii, in P2X7 receptor-deficient mice', International Journal For Parasitology, vol. 41, no. 3-4, pp. 301-308.View/Download from: UTS OPUS or Publisher's site Lees, MP, Fuller, S, McLeod, R, Boulter, N, Miller, CM, Zakrzewski, AM, Mui, E, Witola, WH, Coyne, J, Hargrave, A, Jamieson, S, Blackwell, J, Wiley, JS & Smith, NC 2011, 'P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages', Journal of Immunology, vol. 184, no. 12, pp. 7040-7046.View/Download from: UTS OPUS or Publisher's site Miller, CM, Boulter, NR, Fuller, SJ, Zakrzewski, AM, Lees, MP, Saunders, BM, Wiley, JS & Smith, NC 2011, 'The Role of the P2X(7) Receptor in Infectious Diseases', PLOS PATHOGENS, vol. 7, no. 11.View/Download from: UTS OPUS or Publisher's site Parameswaran, N, Thompson, RS, Sundar, N, Pan, S, Johnson, MS, Smith, NC & Grigg, M 2010, 'Non-Archetypal Type Ii-Like And Atypical Strains Of Toxoplasma Gondii Infecting Marsupials Of Australia', International Journal For Parasitology, vol. 40, no. 6, pp. 635-640.View/Download from: UTS OPUS or Publisher's site Walker, RA, Slapetova, I, Slapeta, J, Miller, CM & Smith, NC 2010, 'The Glycosylation Pathway Of Eimeria Tenella Is Upregulated During Gametocyte Development And May Play A Role In Oocyst Wall Formation', Eukaryotic Cell, vol. 9, no. 1, pp. 127-135.View/Download from: UTS OPUS or Publisher's site Jamieson, S, Peixoto-rangel, A, Hargrave, A, De Roubaix, L, Mui, E, Boulter, N, Miller, E, Fuller, S, Wiley, JS, Castellucci, L, Boyer, K, Peixe, R, Kirisits, M, Elias, L, Coyne, J, Correa-oliveira, R, Sautter, M, Smith, NF, Lees, MP, Swisher, C, Heydemann, P, Noble, AG, Patel, D, Bardo, D, Burrowes, D, McLone, D, Roizen, N, Withers, S, Bahia-Oliveira, L, McLeod, R & Blackwell, J 2010, 'Evidence For Associations Between The Purinergic Receptor P2X(7) (P2Rx7) And Toxoplasmosis', Genes And Immunity, vol. 11, no. 5, pp. 374-383.View/Download from: UTS OPUS or Publisher's site Sharman, PA, Smith, NC, Wallach, M & Katrib, M 2010, 'Chasing the golden egg: Vaccination against poultry coccidiosis', Parasite Immunology, vol. 32, no. 8, pp. 590-598.View/Download from: UTS OPUS or Publisher's site Miller, CM, Smith, NC, Ikin, RJ, Boulter, N, Dalton, JP & Donnelly, SM 2009, 'Immunological interactions between 2common pathogens, the Th1-inducing protozoan Toxoplasma gondii and the Th2-inducing helminth Fasciola hepatica', PLoS ONE, vol. 4, no. 5, pp. 1-10.View/Download from: UTS OPUS Belli, SI, Ferguson, DJ, Katrib, M, Slapetova, I, Mai, K, Slapeta, J, Flowers, SA, Miska, KB, Tomley, FM, Shirley, M, Wallach, M & Smith, NC 2009, 'Conservation of proteins involved in oocyst wall formation in Eimeria maxima, Eimeria tenella and Eimeria acervulina', International Journal For Parasitology, vol. 39, no. 10, pp. 1063-1070.View/Download from: UTS OPUS or 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