Simpson, Ann - University of Technology Sydney

个人简介

Professor Simpson has a BSc (Hons) and a PhD (Veterinary Science) from the University of Sydney. Professor Simpson joined the staff at UTS in 1994 and since 2002 has held the position of Professor of Biochemistry in the Department of Medical & Molecular Biosciences and since July 2009 has been Head of that Department. She has also been Director of the Research Centre for Health Technologies since 2006. Prior to coming to UTS she was a Postdoctoral Fellow at both the University of Sydney and the University of New South Wales. At UTS Prof. Simpson is involved in teaching final year Science students Biochemistry and Molecular Biology. Her current research interest is the gene therapy of diabetes mellitus. Specifically, her research is concerned with investigating the possibility of engineering an artificial insulin-producing cell to replace the insulin-secreting beta cells that have been destroyed by the autoimmune process in Type I diabetics. The principle behind this approach is that non-pancreatic cells can be genetically altered to produce, store and secrete insulin to physiological stimuli such as glucose. Her laboratory has a Research Fellow, a Research Assistant and Postgraduate students. Since joining UTS she has received research funding from organizations such as the NHMRC, ARC, Juvenile Diabetes Research Foundation, Australian Diabetes Research Trust, Roche Organ Transplant Research Foundation, Rebecca Cooper Foundation, Ramiciotti Research Foundation and commercial sources. She has collaborations with Dr. Bronwyn O'Brien and Najah Nassif in MMB, Dr. Wayne Hawthorne at Westmead Hospital, Dr. Ian Alexander at Westmead Children's Hospital and Dr. John Feller at the Royal Hospital, Randwick. International collaborations include Sir Roy Calne and Prof. Andrew Lever, Cambridge University, Prof. Dick White, Nottingham University, Prof. Lee Kok Onn and Dr. Shu Vin Gan, National University of Singapore and a commercial relationship with Austrianova Singapore.

研究领域

Specifically, Prof. Simpson's research is concerned with investigating the possibility of engineering an liver cells to replace the beta cells that have been destroyed by the autoimmune process in Type I diabetics. The group is approaching this problem from 2 main directions: 1. The use of human liver cell lines that store and secrete insulin to glucose, which could be used to correct diabetes via transplantation of the encapsulated cells into patients, and 2. Direct delivery of the insulin gene and other components directly to the liver of patients to induce them to store mature insulin and secrete it in a physiological manner. Recently the group has engineered a liver cell line derived that secretes insulin in the physiological range: Melligen cells. Her research with Dr. Binhai Ren and Dr. Bronwyn O'Brien has also led to reversal of diabetes in streptozotocin-diabetic immunocompetant rats and NOD mice by the direct delivery of the insulin gene directly through the portal circulation of the animal. The animals have maintained normo-glycaemia for over 500 days with normal glucose tolerance and liver function tests. The group is moving to large animal studies.

近期论文

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Gerace, D, Martiniello-Wilks, R, Habib, R, Ren, B, Nassif, NT, O'Brien, BA & Simpson, AM 2019, 'Ex Vivo Expansion of Murine MSC Impairs Transcription Factor-Induced Differentiation into Pancreatic -Cells', STEM CELLS INTERNATIONAL.View/Download from: UTS OPUS or Publisher's site Shad, KF, Luqman, N, Simpson, AM & Lal, S 2018, 'Peripheral Biomarker for Vascular Disorders.', Biomarker insights, vol. 13.View/Download from: UTS OPUS or Publisher's site Haddadi, N, Lin, Y, Travis, G, Simpson, AM, Nassif, NT & McGowan, EM 2018, 'PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy.', Molecular cancer, vol. 17, no. 1.View/Download from: UTS OPUS or Publisher's site Lees, T, Fatima-Shad, K, Simpson, A, Nassif, N, Lin, Y & Lal, S 2018, 'Heart Rate Variability as a Biomarker for Predicting Stroke, Post-stroke Complications and Functionality', Biomarker Insights, vol. 13, pp. 1-13.View/Download from: UTS OPUS or Publisher's site Ren, B, La, QT, O'Brien, BA, Nassif, NT, Tan, Y, Gerace, D, Martiniello-Wilks, R, Torpy, F, Dane, AP, Alexander, IE & Simpson, AM 2018, 'Partial pancreatic transdifferentiation of primary human hepatocytes in the livers of a humanised mouse model.', The journal of gene medicine, vol. 20, no. 5.View/Download from: UTS OPUS or Publisher's site Lees, T, Nassif, N, Simpson, A, Shad-Kaneez, F, Martiniello-Wilks, R, Lin, Y, Jones, A, Qu, X & Lal, S 2017, 'Recent advances in molecular biomarkers for diabetes mellitus: a systematic review.', Biomarkers, vol. 22, no. 7, pp. 604-613.View/Download from: UTS OPUS or Publisher's site Gerace, D, Martiniello-Wilks, R, Nassif, NT, Lal, S, Steptoe, R & Simpson, AM 2017, 'CRISPR-targeted genome editing of mesenchymal stem cell-derived therapies for type 1 diabetes: a path to clinical success?', STEM CELL RESEARCH & THERAPY, vol. 8.View/Download from: UTS OPUS or Publisher's site Haddadi, N, Lin, Y, Simpson, AM, Nassif, NT & McGowan, EM 2017, ''Dicing and Splicing' Sphingosine Kinase and Relevance to Cancer', International Journal of Molecular Sciences, vol. 18, no. 9, pp. 1-25.View/Download from: UTS OPUS or Publisher's site Powell, KL, Stevens, V, Upton, DH, McCracken, SA, Simpson, AM, Cheng, Y, Tasevski, V, Morris, JM & Ashton, AW 2016, 'Role for the thromboxane A2 receptor β-isoform in the pathogenesis of intrauterine growth restriction.', Scientific Reports, vol. 6, pp. 1-15.View/Download from: UTS OPUS or Publisher's site Lund, ME, Greer, J, Dixit, A, Alvarado, R, McCauley-Winter, P, To, J, Tanaka, A, Hutchinson, AT, Robinson, MW, Simpson, AM, O'Brien, BA, Dalton, JP & Donnelly, S 2016, 'A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis.', Scientific Reports, vol. 6, pp. 1-11.View/Download from: UTS OPUS or Publisher's site Ren, B, Tao, C, Swan, MA, Joachim, N, Martiniello-Wilks, R, Nassif, NT, O'Brien, BA & Simpson, AM 2016, 'Pancreatic Transdifferentiation and Glucose-Regulated Production of Human Insulin in the H4IIE Rat Liver Cell Line', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 17, no. 4.View/Download from: UTS OPUS or Publisher's site McGowan, EM, Simpson, A, McManaman, J, Boonyaratanakornkit, V & Hardikar, AA 2015, 'Hijacking of Endocrine and Metabolic Regulation in Cancer and Diabetes', BioMed Research International, vol. 2015.View/Download from: UTS OPUS or Publisher's site Gerace, D, Martiniello-Wilks, R & Simpson, AM 2015, 'Diabetes reversal via gene transfer: building on successes in animal models', Research and Reports in Endocrine Disorders, vol. 5, pp. 15-29.View/Download from: UTS OPUS or Publisher's site Gerace, D, Martiniello-Wilks, R, O'Brien, BA & Simpson, AM 2015, 'The use of beta-cell transcription factors in engineering artificial beta cells from non-pancreatic tissue', GENE THERAPY, vol. 22, no. 1, pp. 1-8.View/Download from: UTS OPUS or Publisher's site Lawandi, J, Tao, C, Ren, B, Williams, P, Ling, D, Swan, MA, Nassif, NT, Torpy, FR, O'Brien, BA & Simpson, AM 2015, 'Reversal of diabetes following transplantation of an insulin-secreting human liver cell line: Melligen cells', MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, vol. 2.View/Download from: UTS OPUS or Publisher's site Nield, BS, Guzowski, R, Nassif, N, Simpson, AM & Martiniello-Wilks, R 2014, 'First use of Re: View: A tool to combine assessment tasks, marking criteria and graduate attributes for biochemistry students', International Journal of Innovation in Science and Mathematics Education, vol. 22, no. 7, pp. 49-64.View/Download from: UTS OPUS Lund, ME, O'Brien, B, Hutchinson, AT, Robinson, MW, Simpson, AM, Dalton, JP & Donnelly, SM 2014, 'Secreted proteins from the helminth Fasciola hepatica inhibit the initiation of autoreactive T cell responses and prevent diabetes in the NOD mouse', PLoS One, vol. 9, no. 1, p. e86289.View/Download from: UTS OPUS or Publisher's site Gerace, D, Ren, B, Hawthorne, W, Byrne, M, Phillips, P, O'Brien, B, Nassif, N, Alexander, I & Simpson, AM 2013, 'Pancreatic transdifferentiation in porcine liver following lentiviral delivery of human furin-cleavable insulin', Transplantation Proceedings, vol. 45, no. 5, pp. 1869-1874.View/Download from: UTS OPUS or Publisher's site Ren, B, O'Brien, B, Byrne, M, Ch'ng, E, Gatt, PN, Swan, MA, Nassif, N, Wei, M, Gijsbers, R, Debyser, Z & Simpson, AM 2013, 'Long-term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy.', The Journal of gene Medicine, vol. 15, no. 1, pp. 28-41.View/Download from: UTS OPUS or Publisher's site Simpson, AM, Ren, B, O'Brien, BA & Nassif, NT 2013, 'Response to the letter to the editor by M. Elsner et al: "Comment on Binhai Ren et al (2013;15:28-41). Long term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy"', Journal of Gene Medicine, vol. 15, no. 8-9, pp. 309-310.View/Download from: UTS OPUS or Publisher's site Tohidi-Esfahani, D, Graham, L, Hannan, G, Simpson, AM & Hill, R 2011, 'An Ecdysone Receptor From The Pentatomomorphan, Nezara Viridula, Shows Similar Affinities For Moulting Hormones Makisterone A And 20-Hydroxyecdysone', Insect Biochemistry and Molecular Biology, vol. 41, no. 2, pp. 77-89.View/Download from: UTS OPUS or Publisher's site Tohidi-Esfahani, D, Lawrence, M, Graham, L, Hannan, G, Simpson, AM & Hill, R 2011, 'Isoforms Of The Heteropteran Nezara Viridula Ecdysone Receptor: Protein Characterisation, Rh5992 Insecticide Binding And Homology Modelling', Pest Management Science, vol. 67, no. 11, pp. 1457-1467.View/Download from: UTS OPUS or Publisher's site Lutherborrow, M, Appavoo, M, Simpson, AM & Tuch, BE 2009, 'Gene expression profiling of HUH7-ins Lack of a granulogenic function for Chromogranin A', Islets, vol. 1, no. 1, pp. 60-72.View/Download from: UTS OPUS or Publisher's site Lutherborrow, MA, Appavoo, M, Simpson, AM & Tuch, BE 2009, 'Gene expression profiling of HUH7-ins: lack of a granulogenic function for chromogranin A.', Islets, vol. 1, no. 1, pp. 62-74.View/Download from: Publisher's site Simpson, A.M. 2008, 'Gene Therapy Reverse Diabetes', Australasian Science, vol. April, pp. 23-25. Feller, JM, Simpson, AM, Nelson, M, Swan, MA, O'Connell, PJ, Hawthorne, WJ, Tao, CZ & O'Brien, B 2008, 'Growth-promoting effect of Rh(D) antibody on human pancreatic islet cells', Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 9, pp. 3560-3567.View/Download from: UTS OPUS or Publisher's site O'Brien, B, Archer, NS, Simpson, AM, Torpy, FR & Nassif, N 2008, 'Association of SLC11A1 promoter polymorphisms with the incidence of autoimmune and inflammatory diseases: A meta-analysis', Journal Of Autoimmunity, vol. 31, no. 1, pp. 42-51.View/Download from: UTS OPUS or Publisher's site Simpson, AM & O'Brien, B 2008, 'Diabetes therapy by lentiviral hepatic insulin gene expression without transofrmation of liver. Reply to Elsner M, Jorns A, Lenzen S (letter)', Diabetologia, vol. 51, pp. 696-696. Mccann, L, Haywood, M, Ren, B, Simpson, AM, Guilhaus, M, Wasinger, V, Raftery, MJ & Davey, RA 2007, 'Identification Of Vascular Surface Proteins By In Vivo Biotinylation: A Method Sufficiently Sensitive To Detect Changes In Rat Liver 2 Weeks After Partial Hepatectomy', Journal Of Proteome Research, vol. 6, no. 8, pp. 3108-3113.View/Download from: UTS OPUS or Publisher's site Lawandi, J., O'Brien, B. & Simpson, A.M. 2007, 'An Insulin Secreting Liver Cell Line, Tao, Is Resistant To The Cytotoxic Effects Of Pro-inflammatory Cytokines Via Nf-kb-dependent Pathways', Journal Of Gene Medicine, vol. 9, no. 6, pp. 527-527.