Sedger, Lisa - University of Technology Sydney

个人简介

Dr. Lisa Sedger heads the Viruses and Cytokine Immunology group in the School of LIfe Science at UTS. Lisa gained her B.App.Science degree with First Class Honours in immunology in Prof Raison’s laboratory at UTS. She completed a PhD (1995) in viral immunology and virus host-interactions at the John Curtin School of Medical Research (ANU). Dr Sedger undertook post-doctoral training in two internationally renowned laboratories in Canada and the US. She was awarded an Alberta Heritage Foundation Post-Doctoral Fellowship to work in Prof. McFadden's Viral Pathogenesis Laboratory in the Dept. Biochemistry at the University of Alberta, Edmonton, Canada (1995-1997). She was then undertook a Post-doctoral Fellowship in Molecular Immunology at Immunex Corporation (now Amgen) in Seattle, USA (1997-2000). Her post-doctoral research focused on viral modulators of Tumour Necrosis Factor (TNF) (University of Alberta), and immunobiology of the TNF-family cytokine TRAIL (Immunex Corporation). Dr Sedger joined the USyd as a U2000 Fellow based primarily at the Westmead Millennium Institute. She is now Senior Lecturer (Virology) in the Faculty of Science, UTS, where she lectures in Virology, Immunology and Flow Cytometry. Her research is focused on the virus-host interactions and cytokines, including basic biology, immunopathology, and immune profiling in infection and immune-based disease conditions.

研究领域

Viruses and Cytokine Immunology group are interested in elucidating the mechanisms by which cytokines (especially Tumour Necrosis Factor-family cytokines) control leukocyte biology including cell survival / cell death and inflammation. The three main themes of Dr Sedger's research are: (1) Cytokine mediated immuobiology & immunopathology (2) Virus-host interactions involving death-inducing cytokines / receptors, (3) "Immune signatures" in normal biology, infection and in immune system diseases.

近期论文

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Scully, T, Scott, CD, Firth, SM, Sedger, LM, Pintar, JE, Twigg, SM & Baxter, RC 2018, 'Enhancement of mammary tumour growth by IGFBP-3 involves impaired T cell accumulation.', Endocrine-Related Cancer, vol. 25, no. 2, pp. 111-122.View/Download from: UTS OPUS or Publisher's site Sedger, LM, Tull, DL, McConville, MJ, De Souza, DP, Rupasinghe, TWT, Williams, SJ, Dayalan, S, Lanzer, D, Mackie, H, Lam, TC & Boyages, J 2016, 'Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema.', PLoS ONE, vol. 11, no. 5, pp. 1-22.View/Download from: UTS OPUS or Publisher's site Zhao, Z, Johnson, MS, Chen, B, Grace, M, Ukath, J, Lee, VS, McRobb, LS, Sedger, LM & Stoodley, MA 2016, 'Live-cell imaging to detect phosphatidylserine externalization in brain endothelial cells exposed to ionizing radiation: implications for the treatment of brain arteriovenous malformations', Journal of Neurosurgery, pp. 1-8.View/Download from: UTS OPUS or Publisher's site Sedger, LM & McDermott, MF 2014, 'TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future', CYTOKINE & GROWTH FACTOR REVIEWS, vol. 25, no. 4, pp. 453-472.View/Download from: UTS OPUS or Publisher's site Sedger, LM, Seddiki, N & Ranasinghe, C 2014, 'Cytokines and cytokine receptors as immunotherapeutics: humble beginnings and exciting futures', CYTOKINE & GROWTH FACTOR REVIEWS, vol. 25, no. 4, pp. 351-353.View/Download from: UTS OPUS or Publisher's site Sedger, LM 2013, 'microRNA control of interferons and interferon induced anti-viral activity', MOLECULAR IMMUNOLOGY, vol. 56, no. 4, pp. 781-793.View/Download from: UTS OPUS or Publisher's site Winkler, I, Bendall, LJ, Forristal, C, Helwani, F, Nowlan, B, Barbier, V, Shen, Y, Cisterne, A, Sedger, LM & Levesque, J 2013, 'B-lymphopoiesis Is Stopped By Mobilizing Doses Of G-CSF And Is Rescued By Overexpression Of The Anti-apoptotic Protein Bcl2', Haematologica, vol. 98, no. 3, pp. 325-333.View/Download from: UTS OPUS or Publisher's site McGowan, EM, Tran, NT, Alling, N, Yagoub, D, Sedger, LM & Martiniello-Wilks, R 2012, 'P14ARF Post-transcriptional Regulation Of Nuclear Cyclin D1 In Mcf-7 Breast Cancer Cells: Discrimination Between A Good And Bad Prognosis?', Plos One, vol. 7, no. 7, pp. 1-16.View/Download from: UTS OPUS or Publisher's site Sedger, LM, Katewa, A, Pettersen, AK, Osvath, SO, Farrell, G, Stewart, G, Bendall, LJ & Alexander, SI 2010, 'Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL and TRAIL double-deficient mice.', Blood, vol. 115, no. 16, pp. 3258-3268.View/Download from: UTS OPUS or Publisher's site Tamanini, E, Katewa, A, Sedger, LM, Todd, M & Watkinson, M 2009, 'A Synthetically Simple, Click-Generated Cyclam-Based Zinc(II) Sensor', Inorganic Chemistry, vol. 48, no. 1, pp. 319-324.View/Download from: UTS OPUS or Publisher's site Farrell, G, Larter, C, Hou, JY, Zhang, RH, Yeh, MM, Williams, J, Pena, A, Francisco, R, Osvath, SR, Brooling, J, Teoh, N & Sedger, LM 2009, 'Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression.', Journal of Gastroenterology and Hepatology, vol. 24, no. 3, pp. 443-452.View/Download from: UTS OPUS or Publisher's site Wiede, F, Vana, K, Sedger, LM, Lechner, A & KÃ¶rner, H 2007, 'TNF-dependent overexpression of CCL21 is an underlying cause of progressive lymphoaccumulation in generalized lymphoproliferative disorder.', European Journal of Immunology, vol. 37, no. 2, pp. 351-357.View/Download from: UTS OPUS or Publisher's site Sedger, LM, Osvath, SR, Xu, X-M, Li, G, Chan, FK-M, Barrett, JW & McFadden, G 2006, 'Poxvirus tumor necrosis factor receptor (TNFR)-like T2 proteins contain a conserved preligand assembly domain that inhibits cellular TNFR1-induced cell death', JOURNAL OF VIROLOGY, vol. 80, no. 18, pp. 9300-9309.View/Download from: Publisher's site Sedger, LM, Osvath, SO, Xu, M, Li, G, Chan, FK, Barrett, JW & McFadden, GD 2006, 'Poxvirus Tumor Necrosis Factor Receptor (TNFR)-Like T2 Proteins Contain a Conserved Preligand Assembly Domain That Inhibits Cellular TNFR1-Induced Cell Death', Journal of Virology, vol. 71, no. 3, pp. 9300-9309.View/Download from: UTS OPUS Sedger, LM 2005, 'Viral inhibition of tumour necrosis factor-α (TNFα) and TNF-receptor induced apoptosis and inflammation', Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents, vol. 4, no. 6, pp. 597-615.View/Download from: Publisher's site Arnold, S, Osvath, SR, Hall, R, King, N & Sedger, LM 2004, 'Regulation of antigen processing and presentation molecules in West Nile virus-infected human skin fibroblasts.', Virology, vol. 225, no. 2, pp. 286-296.View/Download from: UTS OPUS Sedger, LM, Glaccum, MB, Schuh, JACL, Kanaly, ST, Williamson, E, Kayagaki, N, Yun, T, Smolak, P, Le, T, Goodwin, R & Gliniak, B 2002, 'Characterization of the in vivo function of TNF-α-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice', European Journal of Immunology, vol. 32, no. 8, pp. 2246-2254.View/Download from: 3.0.CO;2-6">Publisher's site Sedger, LM, Hou, S, Osvath, SR, Glaccum, MB, Peschon, JJ, van Rooije, N & Hyland, L 2002, 'Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha.', Journal of Immunology, vol. 169, no. 11, pp. 6193-6201.View/Download from: UTS OPUS or Publisher's site Sedger, LM, Glaccum, MB, Schuh, JC, Kanaly, ST, Williamson, E, Kayagaki, N, Yun, T, Smolak, S, Le, T, Goodwin, R & Gliniak, B 2002, 'Characterization of the in vivo function of TNF-alpha-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice.', European Journal Of Immunology, vol. 32, no. 8, pp. 2246-2254.View/Download from: UTS OPUS or 3.0.CO;2-6">Publisher's site Cretney, E, Takeda, K, Wiltrout, RH, Sedger, LM, Kayagaki, N, Yagita, H & Okumura, K 2001, 'Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis', Journal Of Experimental Medicine, vol. 193, no. 6, pp. 661-670.View/Download from: UTS OPUS or Publisher's site Kennedy, MK, Glaccum, M, Brown, SN, Butz, EA, Viney, JL, Embers, M, Matsuki, N, Charrier, K, Sedger, LM, Willis, CR, Brasel, K, Morrissey, PJ, Stocking, K, Schuh, JC, Joyce, S & Peschon, JJ 2000, 'Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice', Journal Of Experimental Medicine, vol. 191, no. 5, pp. 771-780.View/Download from: UTS OPUS or Publisher's site Sedger, LM, Shows, DM, Blanton, RA, Peschon, JJ, Goodwin, RG, Cosman, D & Wiley, SR 1999, 'IFN-γ mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression', Journal of Immunology, vol. 163, no. 2, pp. 920-926. Sedger, LM, Shows, DM, Blanton, RA, Peschon, JJ, Goodwin, R, Cosman, D & Wiley, SR 1999, 'IFN-gamma mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression', Journal of Immunology, vol. 163, no. 2, pp. 920-926.View/Download from: UTS OPUS Griffin, TS, Wiley, SR, Kubin, MZ, Sedger, LM, Mailszewski, CR & Fanger, NA 1999, 'Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine, TRAIL', Journal Of Experimental Medicine, vol. 189, no. 8, pp. 1343-1353.View/Download from: UTS OPUS or Publisher's site Schreiber, M, Sedger, LM & McFadden, GD 1997, 'Distinct domains of M-T2, the myxoma virus tumor necrosis factor (TNF) receptor homolog, mediate extracellular TNF binding and intracellular apoptosis inhibition', Journal of Virology, vol. 71, no. 3, pp. 2171-2181.View/Download from: UTS OPUS McFadden, GI, Schreiber, M & Sedger, LM 1997, 'Myxoma T2 protein as a model for poxvirus TNF receptor homologs', Journal of Neuroimmunology, vol. 72, pp. 2-119.View/Download from: UTS OPUS Sedger, LM, Ramshaw, I, Condie, A, Medveczky, J, Braithwaite, A & Ruby, J 1996, 'Vaccinia virus replication is independent of cellular HSP72 expression which is induced during virus infection', Virology, vol. 225, no. 2, pp. 423-427.View/Download from: UTS OPUS or Publisher's site Sedger, LM & McFadden, G 1996, 'M-T2: A poxvirus TNF receptor homologue with dual activities', Immunology And Cell Biology, vol. 74, no. 6, pp. 538-545.View/Download from: UTS OPUS or Publisher's site SEDGER, L & RUBY, J 1994, 'HEAT-SHOCK RESPONSE TO VACCINIA VIRUS-INFECTION', JOURNAL OF VIROLOGY, vol. 68, no. 7, pp. 4685-4689. Ruby, J, Sedger, L & Ramshaw, I 1993, 'Cytokine production in virus-infected mice: A single cell analysis', Viral Immunology, vol. 6, no. 2, pp. 125-134.View/Download from: Publisher's site