Saunders, Bernadette - University of Technology Sydney

个人简介

I am a cellular immunologist specialising in infectious diseases. I trained at the University of Melbourne, before post-doctoral studies at Colorado State University, USA and the Centenary Institute where I established my own research group before taking up position at UTS in 2015. My current research projects are focused on identifying new biomarkers to aid the diagnosis of active TB disease and in dissecting the mechanisms by which macrophages control infection and regulate inflammation. TB is still a major human pathogen despite the availability of antibiotics TB still kills around 1.5 million people a year, and growing drug resistance in TB strains is an increasing problem. New diagnostic tests to help identify TB patients and to monitor their progress during treatment to rapidly identify treatment non-responders are urgently required. I have projects examining the response of macrophages, the natural host for TB. This work is focused on determining how TB infection modulates microRNA and microparticle expression and the biomarker potential of these molecules. I have active collaborations with colleagues in India, China and Australia collecting samples from TB patients and matched controls for analysis. I also have ongoing project looking at human macrophages and in vivo models of TB infection to dissect the mechanisms that regulate inflammation and granuloma formation.

研究领域

Development of new biomarkers to aid diagnosis of TB Examination of the role of microRNA in regulation of immunity to TB infection Inflammation and Granuloma Formation during TB infection Role of TNF family members in regulating immunity to TB infection

近期论文

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Barry, SE, Ellis, M, Yang, Y, Guan, G, Wang, X, Britton, WJ & Saunders, BM 2018, 'Identification of a plasma microRNA profile in untreated pulmonary tuberculosis patients that is modulated by anti-mycobacterial therapy.', The Journal of infection, vol. 77, no. 4, pp. 341-348.View/Download from: UTS OPUS or Publisher's site Saunders, BM, Rudnicka, C, Filipovska, A, Davies, S, Ward, N, Hricova, J, Schlaich, MP & Matthews, VB 2018, 'Shining LIGHT on the metabolic role of the cytokine TNFSF14 and the implications on hepatic IL-6 production.', Immunology and cell biology, vol. 96, no. 1, pp. 41-53.View/Download from: UTS OPUS or Publisher's site Hare, NJ, Lee, LY, Loke, I, Britton, WJ, Saunders, BM & Thaysen-Andersen, M 2017, 'Mycobacterium tuberculosis Infection Manipulates the Glycosylation Machinery and the N-Glycoproteome of Human Macrophages and Their Microparticles.', Journal of Proteome Research, vol. 16, no. 1, pp. 247-263.View/Download from: UTS OPUS or Publisher's site Nagalingam, G, Vinuesa, CG, Britton, WJ & Saunders, BM 2017, 'Modulation of Roquin Function in Myeloid Cells Reduces Mycobacterium tuberculosis-Induced Inflammation.', Journal of immunology (Baltimore, Md. : 1950), vol. 199, no. 5, pp. 1796-1804.View/Download from: UTS OPUS or Publisher's site Sierro, F, Evrard, M, Rizzetto, S, Melino, M, Mitchell, AJ, Florido, M, Beattie, L, Walters, SB, Tay, SS, Lu, B, Holz, LE, Roediger, B, Wong, YC, Warren, A, Ritchie, W, McGuffog, C, Weninger, W, Le Couteur, DG, Ginhoux, F, Britton, WJ, Heath, WR, Saunders, BM, McCaughan, GW, Luciani, F, MacDonald, KPA, Ng, LG, Bowen, DG & Bertolino, P 2017, 'A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment', IMMUNITY, vol. 47, no. 2, pp. 374-+.View/Download from: UTS OPUS or Publisher's site Donnelly, S, Huston, WM, Johnson, M, Tiberti, N, Saunders, B, O'Brien, B, Burke, C, Labbate, M & Combes, V 2017, 'Targeting the master regulator mTOR: a new approach to prevent the neurological of consequences of parasitic infections?', Parasites & Vectors, vol. 10, no. 1, pp. 1-6.View/Download from: UTS OPUS or Publisher's site Kapetanovic, R, Bokil, NJ, Achard, ME, Ong, CL, Peters, KM, Stocks, CJ, Phan, MD, Monteleone, M, Schroder, K, Irvine, KM, Saunders, BM, Walker, MJ, Stacey, KJ, McEwan, AG, Schembri, MA & Sweet, MJ 2016, 'Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages.', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 30, no. 5, pp. 1901-1912.View/Download from: UTS OPUS or Publisher's site Barry, SE, Chan, B, Ellis, M, Yang, Y, Plit, ML, Guan, G, Wang, X, Britton, WJ & Saunders, BM 2015, 'Identification of miR-93 as a suitable miR for normalizing miRNA in plasma of tuberculosis patients', JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 19, no. 7, pp. 1606-1613.View/Download from: UTS OPUS or Publisher's site Hare, NJ, Chan, B, Chan, E, Kaufman, KL, Britton, WJ & Saunders, BM 2015, 'Microparticles released from Mycobacterium tuberculosis-infected human macrophages contain increased levels of the type I interferon inducible proteins including ISG15', PROTEOMICS, vol. 15, no. 17, pp. 3020-3029.View/Download from: UTS OPUS or Publisher's site Fox, GJ, Sy, DN, Nhung, NV, Yu, B, Ellis, MK, Van Hung, N, Cuong, NK, Thi Lien, L, Marks, GB, Saunders, BM & Britton, WJ 2014, 'Polymorphisms of SP110 are associated with both pulmonary and extra-pulmonary tuberculosis among the Vietnamese.', PLoS ONE, vol. 9, no. 7, pp. 1-9.View/Download from: UTS OPUS or Publisher's site Walters, SB, Kieckbusch, J, Nagalingam, G, Swain, A, Latham, SL, Grau, GER, Britton, WJ, Combes, V & Saunders, BM 2013, 'Microparticles from Mycobacteria-Infected Macrophages Promote Inflammation and Cellular Migration', JOURNAL OF IMMUNOLOGY, vol. 190, no. 2, pp. 669-677.View/Download from: UTS OPUS or Publisher's site Blumenthal, A, Nagalingam, G, Huch, JH, Walker, L, Guillemin, GJ, Smythe, GA, Ehrt, S, Britton, WJ & Saunders, BM 2012, 'M-tuberculosis Induces Potent Activation of IDO-1, but This Is Not Essential for the Immunological Control of Infection', PLOS ONE, vol. 7, no. 5.View/Download from: UTS OPUS or Publisher's site Stanley, AC, Rivera, FDL, Haque, A, Sheel, M, Zhou, Y, Amante, FH, Bunn, PT, Randall, LM, Pfeffer, K, Scheu, S, Hickey, MJ, Saunders, BM, Ware, C, Hill, GR, Tamada, K, Kaye, PM & Engwerda, CR 2011, 'Critical Roles for LIGHT and Its Receptors in Generating T Cell-Mediated Immunity during Leishmania donovani Infection', PLOS PATHOGENS, vol. 7, no. 10.View/Download from: UTS OPUS or Publisher's site Miller, CM, Boulter, NR, Fuller, SJ, Zakrzewski, AM, Lees, MP, Saunders, BM, Wiley, JS & Smith, NC 2011, 'The Role of the P2X(7) Receptor in Infectious Diseases', PLOS PATHOGENS, vol. 7, no. 11.View/Download from: UTS OPUS or Publisher's site Bokil, NJ, Totsika, M, Carey, AJ, Stacey, KJ, Hancock, V, Saunders, BM, Ravasi, T, Ulett, GC, Schembri, MA & Sweet, MJ 2011, 'Intramacrophage survival of uropathogenic Escherichia coli: Differences between diverse clinical isolates and between mouse and human macrophages', IMMUNOBIOLOGY, vol. 216, no. 11, pp. 1164-1171.View/Download from: UTS OPUS or Publisher's site Beham, AW, Puellmann, K, Laird, R, Fuchs, T, Streich, R, Breysach, C, Raddatz, D, Oniga, S, Peccerella, T, Findeisen, P, Kzhyshkowska, J, Gratchev, A, Schweyer, S, Saunders, B, Wessels, JT, Moebius, W, Keane, J, Becker, H, Ganser, A, Neumaier, M & Kaminski, WE 2011, 'A TNF-Regulated Recombinatorial Macrophage Immune Receptor Implicated in Granuloma Formation in Tuberculosis', PLOS PATHOGENS, vol. 7, no. 11.View/Download from: UTS OPUS or Publisher's site Gu, BJ, Saunders, BM, Petrou, S & Wiley, JS 2011, 'P2X(7) Is a Scavenger Receptor for Apoptotic Cells in the Absence of Its Ligand, Extracellular ATP', JOURNAL OF IMMUNOLOGY, vol. 187, no. 5, pp. 2365-2375.View/Download from: UTS OPUS or Publisher's site Wozniak, TM, Saunders, BM, Ryan, AA & Britton, WJ 2010, 'Mycobacterium bovis BCG-Specific Th17 Cells Confer Partial Protection against Mycobacterium tuberculosis Infection in the Absence of Gamma Interferon', INFECTION AND IMMUNITY, vol. 78, no. 10, pp. 4187-4194.View/Download from: Publisher's site Musicki, K, Briscoe, H, Britton, WJ & Saunders, BM 2010, 'LIGHT contributes to early but not late control of Mycobacterium tuberculosis infection', INTERNATIONAL IMMUNOLOGY, vol. 22, no. 5, pp. 353-358.View/Download from: Publisher's site Kuang, Z, Lewis, RS, Curtis, JM, Zhan, Y, Saunders, BM, Babon, JJ, Kolesnik, TB, Low, A, Masters, SL, Willson, TA, Kedzierski, L, Yao, S, Handman, E, Norton, RS & Nicholson, SE 2010, 'The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation', JOURNAL OF CELL BIOLOGY, vol. 190, no. 1, pp. 129-141.View/Download from: Publisher's site Gu, BJ, Saunders, BM, Jursik, C & Wiley, JS 2010, 'The P2X(7)-nonmuscle myosin membrane complex regulates phagocytosis of nonopsonized particles and bacteria by a pathway attenuated by extracellular ATP', BLOOD, vol. 115, no. 8, pp. 1621-1631.View/Download from: Publisher's site Hagge, DA, Saunders, BM, Ebenezer, GJ, Ray, NA, Marks, VT, Britton, WJ, Krahenbuhl, JL & Adams, LB 2009, 'Lymphotoxin-alpha and TNF Have Essential but Independent Roles in the Evolution of the Granulomatous Response in Experimental Leprosy', AMERICAN JOURNAL OF PATHOLOGY, vol. 174, no. 4, pp. 1379-1389.View/Download from: Publisher's site Miu, J, Mitchell, AJ, Müller, M, Carter, SL, Manders, PM, McQuillan, JA, Saunders, BM, Ball, HJ, Lu, B, Campbell, IL & Hunt, NH 2008, 'Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency', Journal of Immunology, vol. 180, no. 2, pp. 1217-1230.View/Download from: Publisher's site Britton, WJ, Fernando, SL, Saunders, BM, Sluyter, R & Wiley, JS 2007, 'The genetic control of susceptibility to Mycobacterium tuberculosis.', Novartis Foundation symposium, vol. 281, pp. 79-209. Saunders, BM & Britton, WJ 2007, 'Life and death in the granuloma: immunopathology of tuberculosis', IMMUNOLOGY AND CELL BIOLOGY, vol. 85, no. 2, pp. 103-111.View/Download from: Publisher's site Fernando, SL, Saunders, BM, Sluyter, R, Skarratt, KK, Goldberg, H, Marks, GB, Wiley, JS & Britton, WJ 2007, 'A polymorphism in the P2X(7) gene increases susceptibility to extrapulmonary tuberculosis', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 175, no. 4, pp. 360-366.View/Download from: Publisher's site Musicki, K, Briscoe, H, Tran, S, Britton, WJ & Saunders, BM 2006, 'Differential requirements for soluble and transmembrane tumor necrosis factor in the immunological control of primary and secondary Listeria monocytogenes infection.', Infection and immunity, vol. 74, no. 6, pp. 3180-3189.View/Download from: Publisher's site Shemon, AN, Sluyter, R, Fernando, SL, Clarke, AL, Dao-Ung, LP, Skarratt, KK, Saunders, BM, Khai, ST, Gu, BJ, Fuller, SJ, Britton, WJ, Petrou, S & Wiley, JS 2006, 'A Thr357to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7function and impairs ATP-induced mycobacterial killing by macrophages', Journal of Biological Chemistry, vol. 281, no. 4, pp. 2079-2086.View/Download from: Publisher's site Roach, DR, Briscoe, H, Saunders, BA & Britton, WJ 2005, 'Independent protective effects for tumor necrosis factor and lymphotoxin alpha in the host response to Listeria monocytogenes infection', INFECTION AND IMMUNITY, vol. 73, no. 8, pp. 4787-4792.View/Download from: Publisher's site Fernando, SL, Saunders, BM, Sluyter, R, Skarratt, KK, Wiley, JS & Britton, WJ 2005, 'Gene dosage determines the negative effects of polymorphic alleles of the P2X7 receptor on adenosine triphosphate-mediated killing of mycobacteria by human macrophages', Journal of Infectious Diseases, vol. 192, no. 1, pp. 149-155.View/Download from: Publisher's site Saunders, BM, Tran, S, Ruuls, S, Sedgwick, JD, Britton, H & Warwick, BJ 2005, 'Transmembrane TNF is sufficient to initiate cell migration and granuloma formation and provide acute, but not long-term, control of Mycobacterium tuberculosis infection', Journal of Immunology, vol. 174, no. 8, pp. 4852-4859.View/Download from: Publisher's site Pinto, R, Saunders, BM, Camacho, LR, Britton, WJ, Gicquel, B & Triccas, JA 2004, 'Mycobacterium tuberculosis Defective in Phthiocerol Dimycocerosate Translocation Provides Greater Protective Immunity against Tuberculosis than the Existing Bacille Calmette-Guérin Vaccine', Journal of Infectious Diseases, vol. 189, no. 1, pp. 105-112.View/Download from: Publisher's site