Rodgers, Ken - University of Technology Sydney

个人简介

Ken Rodgers trained as a pharmacist in the United Kingdom and had ten years experience in the pharmaceutical industry before embarking on an academic research career. After completing his Ph.D. studies in the Faculty of Medicine at the University of Sydney he was awarded a Pfizer postdoctoral fellowship and spent two years in the United Kingdom working with Dr Chris Jackson in the plaque rupture group at the Bristol Heart Institute and with Pfizer drug development in Kent. In 1999 Ken returned to Australia to take up a Senior Research Officer position at the Heart Research Institute in Sydney with Professor Roger Dean. This resulted some seminal work on the cellular handling of oxidised proteins, made possible by the development of a novel experimental approach to generate oxidised proteins in cells. Ken was the head of the Cell Biology Research Group at the Heart Research Institute in Sydney from 2005 to 2011 where he published on the protein oxidation, incorporation of non-native amino acids into proteins, atherosclerosis and plaque rupture. In February 2011 he joined the University of Technology Sydney as a senior lecturer in pharmacology. His research laboratory is now located in the School of Medical and Molecular Biosciences at UTS, which is a well-equipped research collective. He also holds a visiting scientist position at the Heart Research Institute. His main research interests are on how incorporation of non-protein amino acids into proteins could be an environmental trigger for neurodegeneration.

研究领域

Cyanobacterial and algal toxins Environmental risk factors for neurodegenerative diseases Atherosclerosis and plaque rupture Neurodegeneration Protein synthesis Ageing Lysosomes

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Violi, JP, Mitrovic, SM, Colville, A, Main, BJ & Rodgers, KJ 2019, 'Prevalence of beta-methylamino-L-alanine (BMAA) and its isomers in freshwater cyanobacteria isolated from eastern Australia', ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, vol. 172, pp. 72-81.View/Download from: Publisher's site Samardzic, K & Rodgers, KJ 2019, 'Cytotoxicity and mitochondrial dysfunction caused by the dietary supplement l-norvaline', TOXICOLOGY IN VITRO, vol. 56, pp. 163-171.View/Download from: Publisher's site Rodgers, KJ, Main, BJ & Samardzic, K 2018, 'Cyanobacterial Neurotoxins: Their Occurrence and Mechanisms of Toxicity.', Neurotoxicity research, vol. 33, no. 1, pp. 168-177.View/Download from: UTS OPUS or Publisher's site Main, BJ & Rodgers, KJ 2018, 'Assessing the Combined Toxicity of BMAA and Its Isomers 2,4-DAB and AEG In Vitro Using Human Neuroblastoma Cells.', Neurotoxicity Research, vol. Volume 33, no. 1, pp. 33-42.View/Download from: UTS OPUS or Publisher's site Main, BJ, Italiano, CJ & Rodgers, KJ 2018, 'Investigation of the interaction of β-methylamino-L-alanine with eukaryotic and prokaryotic proteins.', Amino Acids, vol. 50, no. 3-4, pp. 397-407.View/Download from: UTS OPUS or Publisher's site Main, BJ, Bowling, LC, Padula, MP, Bishop, DP, Mitrovic, SM, Guillemin, GJ & Rodgers, KJ 2018, 'Detection of the suspected neurotoxin β-methylamino-l-alanine (BMAA) in cyanobacterial blooms from multiple water bodies in Eastern Australia.', Harmful algae, vol. 74, pp. 10-18.View/Download from: UTS OPUS or Publisher's site Samardzic, K & Rodgers, KJ 2017, 'Oxidised protein metabolism: recent insights.', Biological chemistry, vol. 398, no. 11, pp. 1165-1175.View/Download from: UTS OPUS or Publisher's site Main, BJ, Dunlop, RA & Rodgers, KJ 2016, 'The use of L-serine to prevent beta-methylamino-L-alanine (BMAA)-induced proteotoxic stress in vitro', TOXICON, vol. 109, pp. 7-12.View/Download from: UTS OPUS or Publisher's site Geronimo, FRB, Barter, PJ, Rye, KA, Heather, AK, Shearston, KD & Rodgers, KJ 2016, 'Plaque stabilizing effects of apolipoprotein A-IV', ATHEROSCLEROSIS, vol. 251, pp. 39-46.View/Download from: Publisher's site Reyna Zeballos, JL, Meier, P, Geronimo, F & Rodgers, K 2016, 'Implementing Digital Media Presentations as Assessment Tools for Pharmacology Students', American Journal of Educational Research, vol. 4, no. 14, pp. 983-991.View/Download from: UTS OPUS or Publisher's site Dunlop, RA, Main, BJ & Rodgers, K 2015, 'The deleterious effects of non-protein amino acids from desert plants on human and animal health', Journal of Arid Environments, vol. 112B, pp. 152-158.View/Download from: Publisher's site Shiozawa-West, N, Dunlop, RA & Rodgers, KJ 2015, 'Using an in vitro model to study oxidised protein accumulation in ageing fibroblasts.', Biochimica et biophysica acta, vol. 1850, no. 11, pp. 2177-2184.View/Download from: UTS OPUS or Publisher's site Rodgers, KJ 2014, 'Non-protein amino acids and neurodegeneration: the enemy within.', Experimental Neurology, vol. 253, pp. 192-196.View/Download from: UTS OPUS or Publisher's site Dunlop, RA, Cox, P, Banack, S & Rodgers, K 2013, 'The Non-Protein Amino Acid BMAA Is Misincorporated into Human Proteins in Place of L-Serine Causing Protein Misfolding and Aggregation', Plos One, vol. 8, no. 9, pp. 1-8.View/Download from: UTS OPUS or Publisher's site Chan, S, Dunlop, RA, Rowe, A, Double, KL & Rodgers, K 2012, 'L-DOPA is incorporated into brain proteins of patients treated for Parkinson's disease, inducing toxicity in human neuroblastoma cells in vitro', Experimental Neurology, vol. 238, no. 1, pp. 29-37.View/Download from: UTS OPUS or Publisher's site Rodgers, KJ & Jackson, CL 2012, 'Aneurysm prevention: keep the cat out of the bag', CARDIOVASCULAR RESEARCH, vol. 96, no. 3, pp. 350-351.View/Download from: Publisher's site Dunlop, RA, Brunk, UT & Rodgers, K 2011, 'Proteins containing oxidized amino acids induce apoptosis in human monocytes', Biochemical Journal, vol. 435, pp. 207-216.View/Download from: UTS OPUS or Publisher's site Gracanin, M, Lam, MA, Morgan, PE, Rodgers, K, Hawkins, CL & Davies, MJ 2011, 'Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome', Free Radical Biology & Medicine, vol. 50, no. 2, pp. 389-399.View/Download from: UTS OPUS or Publisher's site Reimers, GJ, Jackson, CL, Rickards, J, Chan, PY, Cohn, JS, Rye, K, Barter, PJ & Rodgers, K 2011, 'Inhibition of Rupture of Established Atherosclerotic Plaques by Treatment with Apolipoprotein A-I', Cardiovascular Research, vol. 91, no. 1, pp. 37-44.View/Download from: UTS OPUS or Publisher's site Tang, J, Dunlop, RA, Rowe, A, Rodgers, K & Ramzan, I 2011, 'Kavalactones yangonin and methysticin induce apoptosis in human hepatocytes (HepG2) in vitro', Phytotherapy Research, vol. 25, no. 3, pp. 417-423.View/Download from: UTS OPUS or Publisher's site Dunlop, RA, Brunk, U & Rodgers, K 2009, 'Oxidized proteins: Mechanisms of removal and consequences of accumulation', IUBMB Life, vol. 61, no. 5, pp. 522-527.View/Download from: UTS OPUS or Publisher's site Rodgers, K, Ford, J & Brunk, U 2009, 'Heat shock proteins: Keys to healthy ageing?', Redox Report, vol. 14, no. 4, pp. 147-153.View/Download from: UTS OPUS or Publisher's site Thompson, AM, Dunlop, RA, Dean, R & Rodgers, K 2009, 'Evidence that DOPA-derivatives are generated after L-DOPA incorporation into proteins by mammalian cells', Journal Of Adhesion, vol. 85, no. 9, pp. 561-575.View/Download from: UTS OPUS or Publisher's site Dunlop, RA, Dean, R & Rodgers, K 2008, 'The impact of specific oxidized amino acids on protein turnover in J774 cells', Biochemical Journal, vol. 410, no. 1, pp. 131-140.View/Download from: UTS OPUS or Publisher's site Rodgers, K & Shiozawa, N 2008, 'Misincorporation of amino acid analogues into proteins by biosynthesis', International Journal of Biochemistry & Cell Biology, vol. 40, no. 8, pp. 1452-1466.View/Download from: UTS OPUS or Publisher's site Headlam, H, Gracanin, M, Rodgers, K & Davies, MJ 2006, 'Inhibition of cathepsins and related proteases by amino acid, peptide, and protein hydroperoxides', Free Radical Biology & Medicine, vol. 40, no. 9, pp. 1539-1548.View/Download from: UTS OPUS or Publisher's site Rodgers, K, Hume, P, Morris, J & Dean, R 2006, 'Evidence for L-dopa incorporation into cell proteins in patients treated with levodopa', Journal of Neurochemistry, vol. 98, no. 4, pp. 1061-1067.View/Download from: UTS OPUS or Publisher's site Rodgers, K, Watkins, D, Miller, A, Chan, P, Karanam, S, Brissette, W, Long, C & Jackson, C 2006, 'Destabilizing role of cathepsin S in murine atherosclerotic plaques', Arteriosclerosis Thrombosis And Vascular Biology, vol. 26, no. 4, pp. 851-856.View/Download from: UTS OPUS or Publisher's site Zeng, J, Dunlop, RA, Rodgers, K & Davies, MJ 2006, 'Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols', Biochemical Journal, vol. 398, no. 2, pp. 197-206.View/Download from: UTS OPUS Ozawa, K, Headlam, M, Mouradov, D, Watt, S, Beck, J, Rodgers, K, Dean, R, Huber, T, Otting, G & Dixon, N 2005, 'Translational incorporation of L-3,4-dihydroxyphenylalanine into proteins', FEBS Journal, vol. 272, no. 12, pp. 3162-3171.View/Download from: UTS OPUS or Publisher's site Rodgers, K, Hume, P, Dunlop, RA & Dean, R 2004, 'Biosynthesis and turnover of DOPA-containing proteins by human cells', Free Radical Biology & Medicine, vol. 37, no. 11, pp. 1756-1764.View/Download from: UTS OPUS or Publisher's site Dean, R, Dunlop, RA, Hume, P & Rodgers, K 2003, 'Proteolytic 'defences' and the accumulation of oxidized polypeptides in cataractogenesis and atherogenesis', Biochemical Society Symposium, vol. 70, no. 1, pp. 135-146.View/Download from: UTS OPUS Rodgers, K & Dean, R 2003, 'Assessment of proteasome activity in cell lysates and tissue homogenates using peptide substrates', International Journal of Biochemistry & Cell Biology, vol. 35, no. 5, pp. 716-727.View/Download from: UTS OPUS or Publisher's site