Nassif, Najah - University of Technology Sydney

个人简介

Najah started at UTS in 2003 and her primary research interests are in the investigation of the genetic and molecular basis of human disease with the aim of developing diagnostic/prognostic biomarkers and future novel therapies. Her current research is focussed on understanding how dysregulation of gene expression leads to disease, with a particular focus on cancer and diabetes. Her current research topics include examining the role of gene/pseudogene interactions in gene expression regulation and the role(s) of tumour suppressor gene mutations in the regulation of cancer development and progression. In addition to her research, Najah is committed to student learning and teaching and coordinates and teaches subjects from second year undergraduate level to Honours. She is also a supervisor/co-supervisor of a number of research students at the Honours, Masters and PhD level.

近期论文

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Gerace, D, Martiniello-Wilks, R, Habib, R, Ren, B, Nassif, NT, O'Brien, BA & Simpson, AM 2019, 'Ex Vivo Expansion of Murine MSC Impairs Transcription Factor-Induced Differentiation into Pancreatic -Cells', STEM CELLS INTERNATIONAL.View/Download from: UTS OPUS or Publisher's site Haddadi, N, Lin, Y, Travis, G, Simpson, AM, Nassif, NT & McGowan, EM 2018, 'PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy.', Molecular cancer, vol. 17, no. 1.View/Download from: UTS OPUS or Publisher's site Ren, B, La, QT, O'Brien, BA, Nassif, NT, Tan, Y, Gerace, D, Martiniello-Wilks, R, Torpy, F, Dane, AP, Alexander, IE & Simpson, AM 2018, 'Partial pancreatic transdifferentiation of primary human hepatocytes in the livers of a humanised mouse model.', The journal of gene medicine, vol. 20, no. 5.View/Download from: UTS OPUS or Publisher's site Chen, H, McGowan, E, Ren, N, Nassif, N, Lal, S, Qu, X & Lin, Y 2018, 'Nattokinase: A Promising Alternative in Prevention andTreatment of Cardiovascular Diseases', Biomarker Insights, vol. 13.View/Download from: UTS OPUS or Publisher's site Lees, T, Fatima-Shad, K, Simpson, A, Nassif, N, Lin, Y & Lal, S 2018, 'Heart Rate Variability as a Biomarker for Predicting Stroke, Post-stroke Complications and Functionality', Biomarker Insights, vol. 13, pp. 1-13.View/Download from: UTS OPUS or Publisher's site Lees, T, Nassif, N, Simpson, A, Shad-Kaneez, F, Martiniello-Wilks, R, Lin, Y, Jones, A, Qu, X & Lal, S 2017, 'Recent advances in molecular biomarkers for diabetes mellitus: a systematic review.', Biomarkers, vol. 22, no. 7, pp. 604-613.View/Download from: UTS OPUS or Publisher's site Hatoum, D, Yagoub, D, Ahadi, A, Nassif, NT & McGowan, EM 2017, 'Annexin/S100A protein family regulation through p14ARF-p53 activation: A role in cell survival and predicting treatment outcomes in breast cancer', PLoS ONE, vol. 12, no. 1.View/Download from: UTS OPUS or Publisher's site Gerace, D, Martiniello-Wilks, R, Nassif, NT, Lal, S, Steptoe, R & Simpson, AM 2017, 'CRISPR-targeted genome editing of mesenchymal stem cell-derived therapies for type 1 diabetes: a path to clinical success?', STEM CELL RESEARCH & THERAPY, vol. 8.View/Download from: UTS OPUS or Publisher's site Hatoum, D, Haddadi, N, Lin, Y, Nassif, NT & McGowan, EM 2017, 'Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.', Oncotarget, vol. 8, no. 22, pp. 36898-36929.View/Download from: UTS OPUS or Publisher's site Haddadi, N, Lin, Y, Simpson, AM, Nassif, NT & McGowan, EM 2017, ''Dicing and Splicing' Sphingosine Kinase and Relevance to Cancer', International Journal of Molecular Sciences, vol. 18, no. 9, pp. 1-25.View/Download from: UTS OPUS or Publisher's site Winata, P, Williams, M, McGowan, E, Nassif, N, Van Zandwijk, N & Reid, G 2017, 'The analysis of novel microRNA mimic sequences in cancer cells reveals lack of specificity in stem-loop RT-qPCR-based microRNA detection', BMC Research Notes, vol. 10, no. 1, pp. 1-7.View/Download from: UTS OPUS or Publisher's site Ren, B, Tao, C, Swan, MA, Joachim, N, Martiniello-Wilks, R, Nassif, NT, O'Brien, BA & Simpson, AM 2016, 'Pancreatic Transdifferentiation and Glucose-Regulated Production of Human Insulin in the H4IIE Rat Liver Cell Line', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 17, no. 4.View/Download from: UTS OPUS or Publisher's site Suen, H, Brown, R, Yang, S, Weatherburn, C, Ho, PJ, Woodland, N, Nassif, N, Barbaro, P, Bryant, C, Hart, D, Gibson, J & Joshua, D 2016, 'Multiple myeloma causes clonal T-cell immunosenescence: identification of potential novel targets for promoting tumour immunity and implications for checkpoint blockade', LEUKEMIA, vol. 30, no. 8, pp. 1716-1724.View/Download from: UTS OPUS or Publisher's site Archer, NS, Nassif, NT & O'Brien, BA 2015, 'Genetic variants of SLC11A1 are associated with both autoimmune and infectious diseases: systematic review and meta-analysis', GENES AND IMMUNITY, vol. 16, no. 4, pp. 275-283.View/Download from: UTS OPUS or Publisher's site Haass, NK, Nassif, N & McGowan, EM 2015, 'Switching the Sphingolipid Rheostat in the Treatment of Diabetes and Cancer Comorbidity from a Problem to an Advantage', BIOMED RESEARCH INTERNATIONAL.View/Download from: UTS OPUS or Publisher's site Lawandi, J, Tao, C, Ren, B, Williams, P, Ling, D, Swan, MA, Nassif, NT, Torpy, FR, O'Brien, BA & Simpson, AM 2015, 'Reversal of diabetes following transplantation of an insulin-secreting human liver cell line: Melligen cells', MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, vol. 2.View/Download from: UTS OPUS or Publisher's site McAuliffe, S, Brown, R, Catalano, A, Ho, PJ, Nassif, N, Woodland, N, Hart, D, Weatherburn, C, Yang, S, Suen, H, Paul, C, Joshua, D & Gibson, J 2015, 'Using digital polymerase chain reaction to detect minimal residual disease in myeloma by identifying FGFR3 up-regulation', LEUKEMIA & LYMPHOMA, vol. 56, no. 9, pp. 2714-2716.View/Download from: UTS OPUS or Publisher's site Favaloro, J, Liyadipitiya, T, Brown, R, Yang, S, Suen, H, Woodland, N, Nassif, N, Hart, D, Fromm, P, Weatherburn, C, Gibson, J, Ho, PJ & Joshua, D 2014, 'Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma', LEUKEMIA & LYMPHOMA, vol. 55, no. 12, pp. 2893-2900.View/Download from: UTS OPUS or Publisher's site Nield, BS, Guzowski, R, Nassif, N, Simpson, AM & Martiniello-Wilks, R 2014, 'First use of Re: View: A tool to combine assessment tasks, marking criteria and graduate attributes for biochemistry students', International Journal of Innovation in Science and Mathematics Education, vol. 22, no. 7, pp. 49-64.View/Download from: UTS OPUS Simpson, AM, Ren, B, O'Brien, BA & Nassif, NT 2013, 'Response to the letter to the editor by M. Elsner et al: "Comment on Binhai Ren et al (2013;15:28-41). Long term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy"', Journal of Gene Medicine, vol. 15, no. 8-9, pp. 309-310.View/Download from: UTS OPUS or Publisher's site Bryant, C, Suen, H, Brown, R, Yang, S, Favaloro, J, Aklilu, E, Gibson, J, Ho, PJ, Iland, H, Fromm, P, Woodland, N, Nassif, N, Hart, D & Joshua, DE 2013, 'Long-term survival in multiple myeloma is associated with a distinct immunological profile, which includes proliferative cytotoxic T-cell clones and a favourable Treg/Th17 balance', Blood Cancer Journal, vol. 3, pp. 1-7.View/Download from: UTS OPUS or Publisher's site Ren, B, O'Brien, B, Byrne, M, Ch'ng, E, Gatt, PN, Swan, MA, Nassif, N, Wei, M, Gijsbers, R, Debyser, Z & Simpson, AM 2013, 'Long-term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy.', The Journal of gene Medicine, vol. 15, no. 1, pp. 28-41.View/Download from: UTS OPUS or Publisher's site Gerace, D, Ren, B, Hawthorne, W, Byrne, M, Phillips, P, O'Brien, B, Nassif, N, Alexander, I & Simpson, AM 2013, 'Pancreatic transdifferentiation in porcine liver following lentiviral delivery of human furin-cleavable insulin', Transplantation Proceedings, vol. 45, no. 5, pp. 1869-1874.View/Download from: UTS OPUS or Publisher's site Brown, R, Kabani, K, Favaloro, J, Yang, S, Ho, PJ, Gibson, J, Fromm, P, Suen, H, Woodland, NB, Nassif, N, Hart, D & Joshua, D 2012, 'CD86+ or HLA-G+ can be transferred via trogocytosis from myeloma cells to T cells and are associated with poor prognosis', Blood, vol. 120, pp. 2055-2063.View/Download from: UTS OPUS or Publisher's site