McGrath, Kristine - University of Technology Sydney

个人简介

Kristine is a lecturer within the University of Technology Sydney, Faculty of Science. She is currently coordinating the first year core Science Subject – Cell Biology and Genetics. Kristine has completed a Bachelor of Science (Hons) majoring in Biochemistry at the University of Western Australia. She then moved to Sydney and completed a PhD study (“Molecular pathways of androgen action in the male cardiovascular system) under the supervision of Prof Alison Heather, Prof David Celermajer and Prof David Handelsman, at the University of Sydney. Kristine presented her PhD results at the Cardiac Society of Australia and New Zealand (CSANZ) and was awarded the prestigious CSANZ Ralph Reader Prize. Her early postdoctoral work in Prof Kerry-Anne Rye research laboratory at the Heart Research Institute (Sydney) focused on characterizing the anti-inflammatory properties of high density lipoprotein (HDL). In 2011, she received a UTS Chancellor’s Postdoctoral Research Fellowship where she evaluated the anti-inflammatory effects of HDL in suppressing inflammation that underlies diet-induced insulin resistance. Kristine current interest is to find targets/compounds to treat and/or reduce chronic inflammation that underlies insulin resistance, type 2 diabetes and atherosclerosis. Experimental approaches are based on molecular, cellular and animal models.

研究领域

Therapeutic potential of anti-inflammatory and/or antioxidant compounds in NAFLD, type 2 diabetes and atherosclerosis Therapeutic potential of complementary and alternative medicines in NAFLD, type 2 diabetes and atherosclerosis

近期论文

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Cooper, ER, McGrath, KCY, Li, X & Heather, AK 2018, 'Androgen Bioassay for the Detection of Nonlabeled Androgenic Compounds in Nutritional Supplements.', International journal of sport nutrition and exercise metabolism, vol. 28, no. 1, pp. 10-18.View/Download from: UTS OPUS or Publisher's site Chen, H, Li, G, Chan, YL, Chapman, DG, Sukjamnong, S, Nguyen, T, Annissa, T, McGrath, KC, Sharma, P & Oliver, BG 2018, 'Maternal E-Cigarette Exposure in Mice Alters DNA Methylation and Lung Cytokine Expression in Offspring.', American Journal of Respiratory Cell and Molecular Biology, vol. 58, no. 3, pp. 366-377.View/Download from: UTS OPUS or Publisher's site Saad, S, Al-Odat, I, Chan, YL, McGrath, KC, Pollock, CA, Oliver, BG & Chen, H 2018, 'Maternal L-carnitine supplementation improves glucose and lipid profiles in female offspring of dams exposed to cigarette smoke.', Clinical and experimental pharmacology & physiology, vol. 45, no. 7, pp. 694-703.View/Download from: UTS OPUS or Publisher's site Nguyen, T, Li, GE, Chen, H, Cranfield, CG, McGrath, KC & Gorrie, CA 2018, 'Maternal E-Cigarette Exposure Results in Cognitive and Epigenetic Alterations in Offspring in a Mouse Model.', Chemical research in toxicology, vol. 31, no. 7, pp. 601-611.View/Download from: UTS OPUS or Publisher's site Dowse, R, Melvold, J & McGrath, K 2018, 'Students guiding students: Implementing student peer review into a large first year science subject. A Practice Report', Student Success, vol. 9, no. 3, pp. 79-86.View/Download from: UTS OPUS or Publisher's site McGrath, KCY, Gangoda, SVS, Li, X-H, McRobb, LS & Heather, AK 2018, 'Inhibitory Effect of a French Maritime Pine Bark Extract-Based Nutritional Supplement on TNF-alpha-Induced Inflammation and Oxidative Stress in Human Coronary Artery Endothelial Cells (vol 2015, 260530, 2015)', EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.View/Download from: Publisher's site Cooper, ER, McGrath, KC, Li, X, Akram, O, Kasz, R, Kazlauskas, R, McLeod, MD, Handelsman, DJ & Heather, AK 2017, 'The use of tandem yeast and mammalian cell in vitro androgen bioassays to detect androgens in internet-sourced sport supplements.', Drug Testing and Analysis, vol. 9, no. 4, pp. 545-552.View/Download from: UTS OPUS or Publisher's site McRobb, LS, McGrath, KCY, Tsatralis, T, Liong, EC, Tan, JTM, Hughes, G, Handelsman, DJ & Heather, AK 2017, 'Estrogen Receptor Control of Atherosclerotic Calcification and Smooth Muscle Cell Osteogenic Differentiation.', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 37, no. 6, pp. 1127-1137.View/Download from: UTS OPUS or Publisher's site Cawley, AT, Blakey, K, Waller, CC, Mcleod, MD, Boyd, S, Heather, A, Mcgrath, KC, Handelsman, DJ & Willis, AC 2016, 'Detection and metabolic investigations of a novel designer steroid: 3-chloro-17α-methyl-5α-androstan-17β-ol', Drug Testing and Analysis.View/Download from: Publisher's site Chan, YL, Saad, S, Simar, D, Oliver, B, McGrath, K, Reyk, DV, Bertrand, PP, Gorrie, C, Pollock, C & Chen, H 2015, 'Short term exendin-4 treatment reduces markers of metabolic disorders in female offspring of obese rat dams', International Journal of Developmental Neuroscience, vol. 46, pp. 67-75.View/Download from: UTS OPUS or Publisher's site McGrath, KCY, Li, X-H, McRobb, LS & Heather, AK 2015, 'Inhibitory Effect of a French Maritime Pine Bark Extract-Based Nutritional Supplement on TNF-alpha-Induced Inflammation and Oxidative Stress in Human Coronary Artery Endothelial Cells', EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.View/Download from: UTS OPUS or Publisher's site McGrath, KC, Li, XH, Whitworth, PT, Kasz, R, Tan, JT, McLennan, SV, Celermajer, DS, Barter, PJ, Rye, K-A & Heather, AK 2014, 'High density lipoproteins improve insulin sensitivity in high-fat diet-fed mice by suppressing hepatic inflammation', JOURNAL OF LIPID RESEARCH, vol. 55, no. 3, pp. 421-430.View/Download from: UTS OPUS or Publisher's site Li, X-H, McGrath, KCY, Tran, VH, Li, Y-M, Mandadi, S, Duke, CC, Heather, AK & Roufogalis, BD 2013, 'Identification of a Calcium Signalling Pathway of S-[6]-Gingerol in HuH-7 Cells', EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.View/Download from: UTS OPUS or Publisher's site Li, X, McGrath, KC, Tran, VH, Li, Y, Duke, C, Roufogalis, BD & Heather, AK 2013, 'Attenuation of proinflammatory responses by S -[6]-Gingerol via inhibition of ROS/NF-Kappa B/COX2 activation in HuH7 cells', Evidenced based Complementary and Alternative Medicine, vol. 2013, pp. 1-8.View/Download from: UTS OPUS or Publisher's site Cooper, ER, McGrath, KC & Heather, AK 2013, 'In Vitro Androgen Bioassays As A Detection Method For Designer Androgens', Sensors, vol. 13, no. 2, pp. 2148-2163.View/Download from: UTS OPUS or Publisher's site Lim, H, Thiam, C, Yeo, K, Bisoendial, R, Hii, C, McGrath, KC, Tan, K, Heather, AK, Alexander, JR & Angeli, V 2013, 'Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-Mediated transport of HDL', Cell Metabolism, vol. 17, no. 5, pp. 671-684.View/Download from: UTS OPUS or Publisher's site Li, X, McGrath, KC, Nammi, S, Heather, AK & Roufogalis, BD 2012, 'Attenuation Of Liver Pro-Inflammatory Responses By Zingiber Officinale Via Inhibition Of Nf-Kappa B Activation In High-Fat Diet-Fed Rats', Basic & Clinical Pharmacology & Toxicology, vol. 110, no. 3, pp. 238-244.View/Download from: UTS OPUS or Publisher's site McGrath, KC & Heather, AK 2012, 'Endoplasmic reticulum stress in inflammatory disease', Endocrinology, vol. 153, no. 7, pp. 2949-2952.View/Download from: Publisher's site McGrath, KC, Li, XH, Gaus, K, Williams, P, Celermajer, DS, Handelsman, DJ & Heather, AK 2012, 'Androgens rapidly activate nuclear factor-kappa B via intracellular Ca2+ signalling in human vascular endothelial cells', Journal of Steroids & Hormonal Science, vol. S2, pp. 1-6.View/Download from: UTS OPUS Sieveking, DP, Lim, P, Chow, RW, Dunn, LL, Bao, S, McGrath, KC, Heather, AK, Handelsman, D, Celermajer, DS & Ng, MK 2010, 'A sex-specific role for androgens in angiogenesis', Journal Of Experimental Medicine, vol. 207, no. 2, pp. 345-352.View/Download from: UTS OPUS or Publisher's site McGrath, KC, Hill, MD, Mcrobb, L & Heather, AK 2010, 'The androgen receptor drives the sex-specific expression of vascular cell adhesion molecule-1 in endothelial cells but not lipid metabolism genes in monocyte-derived macrophages', Hormone Molecular Biology and Clinical Investigation, vol. 2, no. 1, pp. 203-209.View/Download from: UTS OPUS McGrath, KC, Li, X, Puranik, R, Liong, E, Tan, J, Dy, V, Dibartolo, B, Barter, P, Rye, K & Heather, AK 2009, 'Role of 3 beta-hydroxysteroid-delta 24 reductase in mediating antiinflammatory effects of high-density lipoproteins in endothelial cells', Arteriosclerosis Thrombosis And Vascular Biology, vol. 29, no. 6, pp. 877-882.View/Download from: UTS OPUS or Publisher's site McGrath, KCY, McRobb, LS & Heather, AK 2008, 'Androgen therapy and atherosclerotic cardiovascular disease', Vascular Health and Risk Management, vol. 4, no. 1, pp. 11-21.View/Download from: Publisher's site McGrath, KC, Mcrobb, L & Heather, AK 2008, 'Androgen therapy and atherosclerotic cardiovascular disease', Vascular Health and Risk Management, vol. 4, no. 1, pp. 11-21.View/Download from: UTS OPUS or Publisher's site Skropeta, D, Settasatian, C, McMahon, MR, Shearston, K, Caiazza, D, McGrath, KC, Jin, W, Rader, DJ, Barter, PJ & Rye, K 2007, 'N-Glycosylation regulates endothelial lipase-mediated phospholipid hydrolysis in apoE- and apoA-I-containing high density lipoproteins', Journal of Lipid Research, vol. 48, no. 9, pp. 2047-2057.View/Download from: UTS OPUS or Publisher's site Heather, AK, McGrath, KC & Handelsman, D 2005, 'Valproate is an anti-androgen and anti-progestin', Steroids, vol. 70, no. 14, pp. 946-953.View/Download from: UTS OPUS or Publisher's site Sader, M, McGrath, KC, Hill, M, Bradstock, K, Jimenez, M, Handelsman, D, Celermajer, DS & Heather, AK 2005, 'Androgen receptor gene expression in leucocytes is hormonally regulated: implications for gender differences in disease pathogenesis', Clinical Endocrinology, vol. 62, no. 1, pp. 56-63.View/Download from: UTS OPUS or Publisher's site Wu, T, McGrath, KC & Heather, AK 2005, 'Cardiovascular disease in diabetic nephropathy patients: cell adhesion molecules as potential markers?', Vascular Health and Risk Management, vol. 1, no. 4, pp. 309-316.View/Download from: UTS OPUS Death, AK, McGrath, KC, Sader, MA, Nakhla, S, Jessup, W, Handelsman, DJ & Celermajer, DS 2004, 'Dihydrotestosterone promotes vascular cell adhesion molecule-1 expression in male human endothelial cells via a nuclear factor-kB-dependent pathway', Endocrinology, vol. 145, no. 4, pp. 1889-1897.View/Download from: Publisher's site Heather, AK, McGrath, KC, Kazlauskas, R & Handelsman, D 2004, 'Tetrahydrogestrinone is a potent androgen and progestin', Journal Of Clinical Endocrinology & Metabolism, vol. 89, no. 5, pp. 2498-2500.View/Download from: Publisher's site Sunde, M, McGrath, KC, Young, L, Matthews, J, Chua, E, Mackay, J & Heather, AK 2004, 'TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer', Cancer Research, vol. 64, no. 8, pp. 2766-2773.View/Download from: Publisher's site Heather, AK, McGrath, KC, Sader, M, Nakhla, S, Jessup, W, Handelsman, D & Celermajer, DS 2004, 'Dihydrotestosterone promotes vascular cell adhesion molecule-1 expression in male human endothelial cells via a nuclear factor-kappa B-dependent pathway', Endocrinology, vol. 145, no. 4, pp. 1889-1897.View/Download from: Publisher's site Heather, AK, Fisher, E, McGrath, KC & Yue, D 2003, 'High glucose alters matrix metalloproteinase expression in two key vascular cells: potential impact on atherosclerosis in diabetes', Atherosclerosis, vol. 168, no. 2, pp. 263-269.View/Download from: Publisher's site Heather, AK, Nakhla, S, McGrath, KC, Martell, S, Yue, D, Jessup, W & Celermajer, DS 2002, 'Nitroglycerin upregulates matrix metalloproteinase expression by human macrophages', Journal Of The American College Of Cardiology, vol. 39, no. 12, pp. 1943-1950.View/Download from: Publisher's site