Marsh, Deborah - University of Technology Sydney

个人简介

Professor Deborah Marsh is a cell and molecular biologist who, since August 2018 has led the Translational Oncology Group at UTS in the School of Life Sciences (SoLS), Faculty of Science. She is also the Discipline Leader for Medical Science in SoLS and holds an honorary appointment at the University of Sydney as a Professor of Molecular Oncology. She was awarded her PhD from the University of Sydney on the RET proto-oncogene and undertook postdoctoral studies at the Dana Farber Cancer Institute associated with Harvard Medical School, Boston, USA (1996-1999). Here, she was involved in implicating the tumour suppressor gene PTEN in a range of familial and sporadic cancers, with a number of seminal, highly cited papers including in Nature Genetics. Today, PTEN is well recognised as the second most frequently mutated gene in human malignancy. After returning to Australia she established her research group at the Kolling Institute, a medical research institute associated with the University of Sydney (1999-2018). At the Kolling she worked on a number of familial cancer syndromes, including Hyperparathyroidism Jaw Tumour Syndrome, led bio-banking initiatives and established her research program on ovarian cancer. She has a broader research interest in all malignancies that affect women, including breast and endometrial cancer. Over a 15 year period at the Kolling Institute she held a number of competitive fellowships, including an RD Wright Fellowship (NHMRC), Cancer Institute Career Development Fellowships, an ARC Future Fellowship and a NHMRC Senior Research Fellowship. She has also attracted research funding from numerous sources including the NHMRC, ARC, Cancer Institute NSW and the Ovarian Cancer Research Foundation. She also serves on the executive of the Australian Breast Cancer Tissue Bank. Professor Marsh has published around 125 papers, attracting >9,800 citations and an h-index of 45 (Scopus).

研究领域

Professor Marsh’s major research interests include: Genetics of cancer Epigenetics / epigenomics, including histone modifications and malignancy Ovarian cancer Women’s cancers including ovarian, endometrial and breast cancer Familial cancer syndromes, including Cowden syndrome and Hyperparathyroidism Jaw Tumour syndrome Cancer associated signalling pathways Bio-banking (tumour banking) Non-coding RNA

近期论文

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Gill, A, Lim, G, Cheung, V, Andrici, J, Perry-Keene, J, Paik, J, Sioson, L, Clarkson, A, Sheen, A, Luxford, C, Elston, M, Meyer-Rochow, G, Nano, T, Kruiff, S, Engelsman, A, Sywak, M, Sidhu, S, Delbridge, L, Robinson, B, Marsh, D, Toon, C, Chou, A & Clifton-Bligh, R 2019, 'Parafibromin-deficient (HPT-JT Type, CDC73 Mutated) Parathyroid Tumors Demonstrate Distinctive Morphologic Features', American Journal of Surgical Pathology, vol. 43, no. 1, pp. 35-46.View/Download from: Publisher's site Marsh, DJ & Dickson, K-A 2019, 'Writing Histone Monoubiquitination in Human Malignancy-The Role of RING Finger E3 Ubiquitin Ligases', GENES, vol. 10, no. 1.View/Download from: UTS OPUS or Publisher's site Shah, JS, Gard, GB, Yang, J, Maidens, J, Valmadre, S, Soon, PS & Marsh, DJ 2018, 'Combining serum microRNA and CA-125 as prognostic indicators of preoperative surgical outcome in women with high-grade serous ovarian cancer.', Gynecologic oncology, vol. 148, no. 1, pp. 181-188.View/Download from: UTS OPUS or Publisher's site Cole, AJ, Zhu, Y, Dwight, T, Yu, B, Dickson, K-A, Gard, GB, Maidens, J, Valmadre, S, Gill, AJ, Clifton-Bligh, R & Marsh, DJ 2017, 'Comprehensive analyses of somatic TP53 mutation in tumors with variable mutant allele frequency', Scientific data, vol. 4, pp. 170120-170120.View/Download from: UTS OPUS or Publisher's site Cole, AJ, Dwight, T, Gill, AJ, Dickson, K-A, Zhu, Y, Clarkson, A, Gard, GB, Maidens, J, Valmadre, S, Clifton-Bligh, R & Marsh, DJ 2016, 'Assessing mutant p53 in primary high-grade serous ovarian cancer using immunohistochemistry and massively parallel sequencing', SCIENTIFIC REPORTS, vol. 6.View/Download from: UTS OPUS or Publisher's site Shah, JS, Soon, PS & Marsh, DJ 2016, 'Comparison of Methodologies to Detect Low Levels of Hemolysis in Serum for Accurate Assessment of Serum microRNAs', PLOS ONE, vol. 11, no. 4.View/Download from: UTS OPUS or Publisher's site Marsh, DJ & Eng, C 2016, 'Lessons learnt from outstanding mid-career women in endocrine cancer research.', Endocrine-related cancer, vol. 23, no. 11, pp. E5-E7.View/Download from: Publisher's site Dickson, K-A, Cole, AJ, Gill, AJ, Clarkson, A, Gard, GB, Chou, A, Kennedy, CJ, Henderson, BR, Fereday, S, Traficante, N, Alsop, K, Bowtell, DD, deFazio, A, Clifton-Bligh, R & Marsh, DJ 2016, 'The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer', HUMAN MOLECULAR GENETICS, vol. 25, no. 24, pp. 5460-5471.View/Download from: Publisher's site Wheate, NJ, Dickson, K-A, Kim, RR, Nematollahi, A, Macquart, RB, Kayser, V, Yu, G, Church, WB & Marsh, DJ 2016, 'Host-Guest Complexes of Carboxylated Pillar[n]arenes With Drugs', JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 105, no. 12, pp. 3615-3625.View/Download from: Publisher's site Chung, L, Phillips, L, Lin, MZ, Moore, K, Marsh, DJ, Boyle, FM & Baxter, RC 2015, 'A novel truncated form of S100P predicts disease-free survival in patients with lymph node positive breast cancer', CANCER LETTERS, vol. 368, no. 1, pp. 64-70.View/Download from: Publisher's site Marsh, DJ 2015, 'Networks regulating ubiquitin and ubiquitin-like proteins promise new therapeutic targets.', Endocrine-related cancer, vol. 22, no. 1, pp. E1-E3.View/Download from: Publisher's site Cole, AJ, Clifton-Bligh, R & Marsh, DJ 2015, 'Histone H2B monoubiquitination: roles to play in human malignancy', ENDOCRINE-RELATED CANCER, vol. 22, no. 1, pp. T19-T33.View/Download from: Publisher's site Kan, CWS, Howell, VM, Hahn, MA & Marsh, DJ 2015, 'Genomic Alterations as Mediators of miRNA Dysregulation in Ovarian Cancer', GENES CHROMOSOMES & CANCER, vol. 54, no. 1, pp. 1-19.View/Download from: Publisher's site Pillai, U, Phillips, K, Wilkins, G, Baxter, RC, Benn, DE, Parker, NR, Smith, RC & Marsh, DJ 2014, 'Factors that May Influence the Willingness of Cancer Patients to Consent for Biobanking', BIOPRESERVATION AND BIOBANKING, vol. 12, no. 6, pp. 409-414.View/Download from: Publisher's site Marsh, DJ, Shah, JS & Cole, AJ 2014, 'Histones and their modifications in ovarian cancer - drivers of disease and therapeutic targets', Frontiers in Oncology, vol. 4 JUN.View/Download from: Publisher's site Chung, L, Moore, K, Phillips, L, Boyle, FM, Marsh, DJ & Baxter, RC 2014, 'Novel serum protein biomarker panel revealed by mass spectrometry and its prognostic value in breast cancer', BREAST CANCER RESEARCH, vol. 16, no. 3.View/Download from: UTS OPUS or Publisher's site Chung, L, Shibli, S, Moore, K, Elder, EE, Boyle, FM, Marsh, DJ & Baxter, RC 2013, 'Tissue biomarkers of breast cancer and their association with conventional pathologic features', BRITISH JOURNAL OF CANCER, vol. 108, no. 2, pp. 351-360.View/Download from: UTS OPUS or Publisher's site Paul, RG, Elston, MS, Gill, AJ, Marsh, D, Beer, I, Wolmarans, L, Conaglen, JV & Meyer-Rochow, GY 2012, 'Hypercalcaemia due to parathyroid carcinoma presenting in the third trimester of pregnancy', AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, vol. 52, no. 2, pp. 204-207.View/Download from: Publisher's site Kan, CWS, Hahn, MA, Gard, GB, Maidens, J, Huh, JY, Marsh, DJ & Howell, VM 2012, 'Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer', BMC CANCER, vol. 12.View/Download from: UTS OPUS or Publisher's site Mertens-Walker, I, Baxter, RC & Marsh, DJ 2012, 'Gonadotropin signalling in epithelial ovarian cancer', CANCER LETTERS, vol. 324, no. 2, pp. 152-159.View/Download from: Publisher's site Gribben, L, Baxter, RC & Marsh, DJ 2012, 'Insulin-like growth factor binding protein-3 inhibits migration of endometrial cancer cells.', Cancer letters, vol. 317, no. 1, pp. 41-48.View/Download from: Publisher's site Hahn, MA, Dickson, K-A, Jackson, S, Clarkson, A, Gill, AJ & Marsh, DJ 2012, 'The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination', HUMAN MOLECULAR GENETICS, vol. 21, no. 3, pp. 559-568.View/Download from: Publisher's site Lim, S, Elston, MS, Gill, AJ, Marsh, DJ & Conaglen, JV 2011, 'Metastatic parathyroid carcinoma initially misdiagnosed as parathyroid adenoma: the role of parafibromin in increasing diagnostic accuracy', INTERNAL MEDICINE JOURNAL, vol. 41, no. 9, pp. 695-699.View/Download from: Publisher's site Marsh, DJ, Trahair, TN & Kirk, EP 2011, 'Mutant AKT1 in Proteus Syndrome', NEW ENGLAND JOURNAL OF MEDICINE, vol. 365, no. 22, pp. 2141-2142. Marsh, DJ & Gimm, O 2011, 'Multiple endocrine neoplasia: types 1 and 2.', Advances in oto-rhino-laryngology, vol. 70, pp. 84-90.View/Download from: Publisher's site Lin, WH, Martin, JL, Marsh, DJ, Jack, MM & Baxter, RC 2011, 'Involvement of Insulin-like Growth Factor-binding Protein-3 in the Effects of Histone Deacetylase Inhibitor MS-275 in Hepatoma Cells', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 34, pp. 29540-29547.View/Download from: Publisher's site Marsh, DJ & Howell, VM 2010, 'The use of denaturing high performance liquid chromatography (DHPLC) for mutation scanning of hereditary cancer genes.', Methods in molecular biology (Clifton, N.J.), vol. 653, pp. 133-145. Hahn, MA, Howell, VM, Gill, AJ, Clarkson, A, Weaire-Buchanan, G, Robinson, BG, Delbridge, L, Gimm, O, Schmitt, WD, Teh, BT & Marsh, DJ 2010, 'CDC73/HRPT2 CpG island hypermethylation and mutation of 5'-untranslated sequence are uncommon mechanisms of silencing parafibromin in parathyroid tumors.', Endocrine-related cancer, vol. 17, no. 1, pp. 273-282.View/Download from: Publisher's site Mertens-Walker, I, Bolitho, C, Baxter, RC & Marsh, DJ 2010, 'Gonadotropin-induced ovarian cancer cell migration and proliferation require extracellular signal-regulated kinase 1/2 activation regulated by calcium and protein kinase C delta', ENDOCRINE-RELATED CANCER, vol. 17, no. 2, pp. 335-349.View/Download from: Publisher's site Bolitho, C, Hahn, MA, Baxter, RC & Marsh, DJ 2010, 'The chemokine CXCL1 induces proliferation in epithelial ovarian cancer cells by transactivation of the epidermal growth factor receptor', ENDOCRINE-RELATED CANCER, vol. 17, no. 4, pp. 929-940.View/Download from: Publisher's site Meyer-Rochow, GY, Smith, JM, Richardson, A-L, Marsh, DJ, Sidhu, SB, Robinson, BG & Benn, DE 2009, 'Denaturing High Performance Liquid Chromatography Detection of SDHB, SDHD, and VHL Germline Mutations in Pheochromocytoma', JOURNAL OF SURGICAL RESEARCH, vol. 157, no. 1, pp. 55-62.View/Download from: Publisher's site Howell, VM, Gill, A, Clarkson, A, Nelson, AE, Dunne, R, Delbridge, LW, Robinson, BG, Teh, BT, Gimm, O & Marsh, DJ 2009, 'Accuracy of Combined Protein Gene Product 9.5 and Parafibromin Markers for Immunohistochemical Diagnosis of Parathyroid Carcinoma', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 94, no. 2, pp. 434-441.View/Download from: Publisher's site Hahn, MA, McDonnell, J & Marsh, DJ 2009, 'The effect of disease-associated HRPT2 mutations on splicing.', The Journal of endocrinology, vol. 201, no. 3, pp. 387-396.View/Download from: Publisher's site Marsh, DJ, Trahair, TN, Martin, JL, Chee, WY, Walker, J, Kirk, EP, Baxter, RC & Marshall, GM 2008, 'Rapamycin treatment for a child with germline PTEN mutation', NATURE CLINICAL PRACTICE ONCOLOGY, vol. 5, no. 6, pp. 357-361.View/Download from: Publisher's site Hahn, MA & Marsh, DJ 2007, 'Nucleolar localization of parafibromin is mediated by three nucleolar localization signals', FEBS LETTERS, vol. 581, no. 26, pp. 5070-5074.View/Download from: Publisher's site Hahn, MA & Marsh, DJ 2007, 'Erratum: Identification of a functional bipartite nuclear localization signal in the tumor suppressor parafibromin (Oncogene (2005) 24, (6241-6248) DOI: 10.1038/sj.onc.1208778)', Oncogene, vol. 26, no. 5, p. 788.View/Download from: Publisher's site Marsh, DJ, Hahn, MA, Howell, VM & Gill, AJ 2007, 'Molecular diagnosis of primary hyperparathyroidism in familial cancer syndromes', Expert Opinion on Medical Diagnostics, vol. 1, no. 3, pp. 377-392.View/Download from: Publisher's site Moscova, M, Marsh, DJ & Baxter, RC 2006, 'Protein chip discovery of secreted proteins regulated by the phosphatidylinositol 3-kinase pathway in ovarian cancer cell lines', CANCER RESEARCH, vol. 66, no. 3, pp. 1376-1383.View/Download from: Publisher's site Benn, DE, Gimenez-Roqueplo, AP, Reilly, JR, Bertherat, J, Burgess, J, Byth, K, Croxson, M, Dahia, PLM, Elston, M, Gimm, O, Henley, D, Herman, P, Murday, V, Niccoli-Sire, P, Pasieka, JL, Rohmer, V, Tucker, K, Jeunemaitre, X, Marsh, DJ, Plouin, PF & Robinson, BG 2006, 'Clinical presentation and penetrance of pheochromocytoma/paraganglioma syndromes', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 91, no. 3, pp. 827-836.View/Download from: Publisher's site Gill, AJ, Clarkson, A, Gimm, O, Keil, J, Dralle, H, Howell, VM & Marsh, DJ 2006, 'Loss of nuclear expression of parafibromin distinguishes parathyroid carcinomas and hyperparathyroidism-jaw tumor (HPT-JT) syndrome-related adenomas from sporadic parathyroid adenomas and hyperplasias', AMERICAN JOURNAL OF SURGICAL PATHOLOGY, vol. 30, no. 9, pp. 1140-1149. Howell, VM, Cardinal, JW, Richardson, A-L, Gimm, O, Robinson, BG & Marsh, DJ 2006, 'Rapid mutation screening for HRPT2 and MEN1 mutations associated with familial and sporadic primary hyperparathyroidism.', The Journal of molecular diagnostics : JMD, vol. 8, no. 5, pp. 559-566.View/Download from: Publisher's site Gimm, O, Lorenz, K, Thanh, PN, Schneyer, U, Bloching, M, Howell, VM, Marsh, DJ, Teh, BT, Krause, U & Dralle, H 2006, 'Prophylactic parathyroidectomy for familial parathyroid carcinoma', CHIRURG, vol. 77, no. 1, pp. 15-24.View/Download from: Publisher's site Hahn, MA & Marsh, DJ 2005, 'Identification of a functional bipartite nuclear localization signal in the tumor suppressor parafibromin.', Oncogene, vol. 24, no. 41, pp. 6241-6248.View/Download from: Publisher's site Dahia, PLM, Ross, KN, Wright, ME, Hayashida, CY, Santagata, S, Barontini, M, Kung, AL, Sanso, G, Powers, JF, Tischler, AS, Hodin, R, Heitritter, S, Moore, F, Dluhy, R, Sosa, JA, Ocal, IT, Benn, DE, Marsh, DJ, Robinson, BG, Schneider, K, Garber, J, Arum, SM, Korbonits, M, Grossman, A, Pigny, P, Toledo, SPA, Nose, V, Li, C & Stiles, CD 2005, 'A HIF1 alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas', PLOS GENETICS, vol. 1, no. 1, pp. 72-80.View/Download from: Publisher's site Howell, WM, Zori, RT, Stalker, HJ, Nelson, AE, Robinson, BG & Marsh, DJ 2004, 'A molecular diagnosis of hyperparathyroidism-jaw tumor syndrome in an adolescent with recurrent kidney stones', JOURNAL OF PEDIATRICS, vol. 145, no. 4, pp. 567-567.View/Download from: Publisher's site