Huston, Willa - University of Technology Sydney

个人简介

I am a Molecular Microbiologist (PhD awarded 2004) with an interest in chlamydia and chlamydial diseases. My work has mainly focussed on understadning the chlamydial mechanisms of disease, persistence, and how the disease causes infertility in women. I am also interested in the role proteases have in pathogenesis and biology. I have strong expertise in intracellular infection models and human dsease models. My team has research project on-going in chamydial biology, human disease pathology, diagnosis and treatment. We welcome enquiries from interested students or collaborators.

研究领域

My group is focussed on understanding how chlamydial causes infertility in women and how this intracellular bacterial pathogen interacts with human cells. We are also interested in pelvic inflammatory disease. We are focussed on understanding the bacterial pathogenic factors in order to develop future improved diagnostics and therapeutics for humans. We are also interested in chlamydia and Koalas and the development of new drugs to treat this devastating disease.

近期论文

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Christensen, S, McMahon, RM, Martin, JL & Huston, WM 2019, 'Life inside and out: making and breaking protein disulfide bonds in Chlamydia', CRITICAL REVIEWS IN MICROBIOLOGY, vol. 45, no. 1, pp. 33-50.View/Download from: UTS OPUS or Publisher's site Huston, WM, Cranfield, CG, Forbes, SL & Leigh, A 2019, 'A sponsorship action plan for increasing diversity in STEMM.', Ecology and Evolution, vol. 9, no. 5, pp. 2340-2345.View/Download from: UTS OPUS or Publisher's site Ziklo, N, Huston, WM, Taing, K & Timms, P 2019, 'High expression of IDO1 and TGF-β1 during recurrence and post infection clearance with Chlamydia trachomatis, are independent of host IFN-γ response 11 Medical and Health Sciences 1107 Immunology', BMC Infectious Diseases, vol. 19, no. 1.View/Download from: UTS OPUS or Publisher's site Lau, A, Kong, FYS, Huston, W, Chow, EPF, Fairley, CK & Hocking, JS 2019, 'Factors associated with anorectal Chlamydia trachomatis or Neisseria gonorrhoeae test positivity in women: a systematic review and meta-analysis.', Sexually transmitted infections.View/Download from: UTS OPUS or Publisher's site Dawson, A, Poulsen, A, Huston, W & Bengtson Nash, S 2018, 'Expression of common biomarkers in Antarctic krill (Euphausia superba) exposed to an organochlorine contaminant', Polar Biology, vol. 41, no. 3, pp. 505-513.View/Download from: UTS OPUS or Publisher's site Agbowuro, AA, Mazraani, R, McCaughey, LC, Huston, WM, Gamble, AB & Tyndall, JDA 2018, 'Stereochemical basis for the anti-chlamydial activity of the phosphonate protease inhibitor JO146', Tetrahedron, vol. 74, no. 12, pp. 1184-1190.View/Download from: UTS OPUS or Publisher's site Agbowuro, AA, Huston, WM, Gamble, AB & Tyndall, JDA 2018, 'Proteases and protease inhibitors in infectious diseases.', Medicinal Research Reviews, vol. 38, no. 4, pp. 1295-1331.View/Download from: UTS OPUS or Publisher's site Wee, BA, Thomas, M, Sweeney, EL, Frentiu, FD, Samios, M, Ravel, J, Gajer, P, Myers, G, Timms, P, Allan, JA & Huston, WM 2018, 'A retrospective pilot study to determine whether the reproductive tract microbiota differs between women with a history of infertility and fertile women.', The Australian and New Zealand Journal of Obstetrics and Gynaecology (ANZJOG), vol. 58.View/Download from: UTS OPUS or Publisher's site Islam, MM, Jelocnik, M, Huston, WM, Timms, P & Polkinghorne, A 2018, 'Characterization of the In Vitro Chlamydia pecorum Response to Gamma Interferon.', Infection and immunity, vol. 86, no. 4.View/Download from: UTS OPUS or Publisher's site Dawson, A, Huston, W, Kawaguchi, S, King, C, Cropp, R, Wild, S, Eisenmann, P, Townsend, K & Nash, SB 2018, 'Uptake and Depuration Kinetics Influence Microplastic Bioaccumulation and Toxicity in Antarctic KriII (Euphausia superba)', ENVIRONMENTAL SCIENCE & TECHNOLOGY, vol. 52, no. 5, pp. 3195-3201.View/Download from: UTS OPUS or Publisher's site Dawson, AL, Kawaguchi, S, King, CK, Townsend, KA, King, R, Huston, WM & Nash, SMB 2018, 'Turning microplastics into nanoplastics through digestive fragmentation by Antarctic krill', NATURE COMMUNICATIONS, vol. 9.View/Download from: UTS OPUS or Publisher's site Giffard, PM, Andersson, P, Wilson, J, Buckley, C, Lilliebridge, R, Harris, TM, Kleinecke, M, O Grady, KAF, Huston, WM, Lambert, SB, Whiley, DM & Holt, DC 2018, 'CtGEM typing: Discrimination of Chlamydia trachomatis ocular and urogenital strains and major evolutionary lineages by high resolution melting analysis of two amplified DNA fragments', PLoS ONE, vol. 13, no. 4.View/Download from: UTS OPUS or Publisher's site Ziklo, N, Vidgen, ME, Taing, K, Huston, WM & Timms, P 2018, 'Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association with Chlamydia trachomatis Genital Infections.', Frontiers in cellular and infection microbiology, vol. 8.View/Download from: UTS OPUS or Publisher's site Woodhall, SC, Gorwitz, RJ, Migchelsen, SJ, Gottlieb, SL, Horner, PJ, Geisler, WM, Winstanley, C, Hufnagel, K, Waterboer, T, Martin, DL, Huston, WM, Gaydos, CA, Deal, C, Unemo, M, Dunbar, JK & Bernstein, K 2018, 'Advancing the public health applications of Chlamydia trachomatis serology', The Lancet Infectious Diseases, vol. 18, no. 12, pp. e399-e407.View/Download from: UTS OPUS or Publisher's site Burke, C, Burnard, D, Polkinghorne, A, Webb, J & Huston, WM 2018, 'Cloacal and Ocular Microbiota of the Endangered Australian Northern Quoll.', Microorganisms, vol. 6, no. 3.View/Download from: UTS OPUS or Publisher's site Phillips, S, Vodstrcil, LA, Huston, WM, Lawerence, A, Timms, P, Chen, MY, Worthington, K, McIver, R, Bradshaw, CS, Garland, SM, Tabrizi, SN & Hocking, JS 2018, 'Detection of Chlamydia trachomatis mRNA using digital PCR as a more accurate marker of viable organism.', European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, vol. 37, no. 11, pp. 2117-2122.View/Download from: UTS OPUS or Publisher's site Kroon, SJ, Ravel, J & Huston, WM 2018, 'Cervicovaginal microbiota, women's health, and reproductive outcomes.', Fertility and sterility, vol. 110, no. 3, pp. 327-336.View/Download from: UTS OPUS or Publisher's site Wang, JTH, Huston, WM, Johanesen, P, Lloyd, M & Waller, KL 2018, '"A Laboratory Competency Examination in Microbiology".', FEMS Microbiology Letters, vol. 365, no. 20.View/Download from: UTS OPUS or Publisher's site Paul, B, Kim, HS, Kerr, MC, Huston, WM, Teasdale, RD & Collins, BM 2017, 'Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis.', eLife, vol. 6, pp. 1-23.View/Download from: UTS OPUS or Publisher's site Kerr, MC, Gomez, GA, Ferguson, C, Tanzer, MC, Murphy, JM, Yap, AS, Parton, RG, Huston, WM & Teasdale, RD 2017, 'Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis.', Nature Communications, vol. 8, pp. 1-12.View/Download from: UTS OPUS or Publisher's site Vodstrcil, LA, Rupasinghe, TWT, Kong, FYS, Tull, D, Worthington, K, Chen, MY, Huston, WM, Timms, P, McConville, MJ, Fairley, CK, Bradshaw, CS, Tabrizi, SN & Hocking, JS 2017, 'Measurement of tissue azithromycin levels in self-collected vaginal swabs post treatment using liquid chromatography and tandem mass spectrometry (LC-MS/MS).', PLoS ONE, vol. 12, no. 5, pp. 1-13.View/Download from: UTS OPUS or Publisher's site Marsh, JW, Ong, VA, Lott, WB, Timms, P, Tyndall, JDA & Huston, WM 2017, 'CtHtrA: the lynchpin of the chlamydial surface and a promising therapeutic target.', Future Microbiology, vol. 12, no. 9, pp. 817-829.View/Download from: UTS OPUS or Publisher's site Marsh, JW, Djoko, KY, McEwan, AG & Huston, WM 2017, 'Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents', Pathogens and Disease, vol. 75, no. 7, pp. 1-4.View/Download from: UTS OPUS or Publisher's site Castrillon, J, Huston, W & Bengtson Nash, S 2017, 'The blubber adipocyte index: A nondestructive biomarker of adiposity in humpback whales (Megaptera novaeangliae).', Ecology and Evolution, vol. 7, no. 14, pp. 5131-5139.View/Download from: UTS OPUS or Publisher's site Burnard, D, Huston, WM, Webb, JK, Jelocnik, M, Reiss, A, Gillett, A, Fitzgibbon, S, Carver, S, Carrucan, J, Flanagan, C, Timms, P & Polkinghorne, A 2017, 'Molecular evidence of Chlamydia pecorum and arthropod-associated Chlamydiae in an expanded range of marsupials.', Scientific Reports, vol. 7, no. 1, pp. 1-9.View/Download from: UTS OPUS or Publisher's site Gupta, VK, Waugh, CA, Ziklo, N, Huston, WM, Hocking, JS & Timms, P 2017, 'Systemic antibody response to Chlamydia Trachomatis infection in patients either infected or reinfected with different Chlamydia serovars.', Indian Journal of Medical Microbiology, vol. 35, no. 3, pp. 394-401.View/Download from: UTS OPUS or Publisher's site