Faiz, Alen - University of Technology Sydney

个人简介

Dr Alen Faiz is a molecular biologist and geneticist who competed his PhD at The Woolcock Institute of Medical Research in 2014. He then traveled on a RESPIRE2 fellowship from ERS as a postdoctoral researcher at the Experimental Pulmonology and Inflammation Research (EXPIRE) laboratory, Department of Pathology & Medical Biology, University Medical Center Groningen, the Netherlands (2014-18). In 2015 Dr Faiz was also a visiting postdoctoral fellow at the Respiratory Medicine Queen Mary’s Medical Centre, University of Nottingham, United Kingdom and in 2018 he was a visiting postdoctoral fellow at Imperial College, London. Dr Faiz has maintained his primary research interest of understanding the biology of respiratory systems at the genetic and epigenetic levels, including under conditions of exposure to cigarette smoke and the microbiome, throughout his career thus far. Dr Faiz’s multidisciplinary skills in high level integrative bioinformatics and advanced cell culture allows him to move beyond simple associations to identify causal pathways and mechanisms. Recently, Dr Faiz has moved back from Europe and started a new position at University of Technology Sydney (UTS).

近期论文

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Christenson, SA, van den Berge, M, Faiz, A, Inkamp, K, Bhakta, N, Bonser, LR, Zlock, LT, Barjaktarevic, IZ, Barr, RG, Bleecker, ER, Boucher, RC, Bowler, RP, Comellas, AP, Curtis, JL, Han, MK, Hansel, NN, Hiemstra, PS, Kaner, RJ, Krishnanm, JA, Martinez, FJ, O'Neal, WK, Paine, R, Timens, W, Wells, JM, Spira, A, Erle, DJ & Woodruff, PG 2019, 'An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup', JOURNAL OF CLINICAL INVESTIGATION, vol. 129, no. 1, pp. 169-181.View/Download from: Publisher's site Zeng, X, Vonk, JM, van der Plaat, DA, Faiz, A, Pare, PD, Joubert, P, Nickle, D, Brandsma, C-A, Kromhout, H, Vermeulen, R, Xu, X, Huo, X, de Jong, K & Boezen, HM 2019, 'Genome-wide interaction study of gene-by-occupational exposures on respiratory symptoms', ENVIRONMENT INTERNATIONAL, vol. 122, pp. 263-269.View/Download from: Publisher's site Rathnayake, SNH, Van den Berge, M & Faiz, A 2019, 'Genetic profiling for disease stratification in chronic obstructive pulmonary disease and asthma', CURRENT OPINION IN PULMONARY MEDICINE, vol. 25, no. 3, pp. 317-322.View/Download from: Publisher's site Faiz, A, Steiling, K, Roffel, MP, Postma, DS, Spira, A, Lenburg, ME, Borggrewe, M, Eijgenraam, TR, Jonker, MR, Koppelman, GH, Pouwels, SD, Liu, G, Alekseyev, YO, Lam, S, Hiemstra, PS, Sterk, PJ, Timens, W, Brandsma, C-A, Heijink, IH & van den Berge, M 2019, 'Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD', EUROPEAN RESPIRATORY JOURNAL, vol. 53, no. 4.View/Download from: Publisher's site van der Plaat, DA, Vonk, JM, Lahousse, L, de Jong, K, Faiz, A, Nedeljkovic, I, Amin, N, van Diemen, CC, Brusselle, GG, Bosse, Y, Brandsma, C-A, Hao, K, Pare, PD, van Duijn, CM, Postma, DS & Boezen, HM 2019, 'Limited overlap in significant hits between genome-wide association studies on two airflow obstruction definitions in the same population', BMC PULMONARY MEDICINE, vol. 19.View/Download from: Publisher's site Faiz, A, van den Berge, M, Vermeulen, CJ, ten Hacken, NHT, Guryev, V & Pouwels, SD 2019, 'AGER expression and alternative splicing in bronchial biopsies of smokers and never smokers', RESPIRATORY RESEARCH, vol. 20.View/Download from: Publisher's site van den Berge, M, Brandsma, C-A, Faiz, A, de Vries, M, Rathnayake, SNH, Paré, PD, Sin, DD, Bossé, Y, Laviolette, M, Nickle, DC, Hao, K, Obeidat, M, Dragani, TA, Colombo, F, Timens, W & Postma, DS 2019, 'Differential lung tissue gene expression in males and females: implications for the susceptibility to develop COPD.', Eur Respir J.View/Download from: Publisher's site Pouwels, SD, Klont, F, Kwiatkowski, M, Wiersma, VR, Faiz, A, van den Berge, M, Horvatovich, P, Bischoff, R & Ten Hacken, NHT 2018, 'Reply to: Acute and Chronic Effects of Cigarette Smoking on sRAGE.', American Journal of Respiratory and Critical Care Medicine.View/Download from: Publisher's site Pouwels, SD, Faiz, A, Heijink, IH, Vermeulen, CJ, Guryev, V, Van den Berge, M & Nawijn, MC 2018, 'Cigarette smoke exposure decreases CFLAR expression in bronchial epithelium, augmenting susceptibility for cell death and DAMP release', EUROPEAN RESPIRATORY JOURNAL, vol. 52.View/Download from: UTS OPUS or Publisher's site Burgess, JK, Ketheson, A, Faiz, A, Limbert Rempel, KA, Oliver, BG, Ward, JPT & Halayko, AJ 2018, 'Phenotype and Functional Features of Human Telomerase Reverse Transcriptase Immortalized Human Airway Smooth Muscle Cells from Asthmatic and Non-Asthmatic Donors.', Scientific Reports, vol. 8, no. 1, pp. 805-805.View/Download from: UTS OPUS or Publisher's site Wang, J, Faiz, A, Ge, Q, Vermeulen, CJ, Van der Velden, J, Snibson, KJ, van de Velde, R, Sawant, S, Xenaki, D, Oliver, B, Timens, W, Ten Hacken, N, van den Berge, M, James, A, Elliot, JG, Dong, L, Burgess, JK & Ashton, AW 2018, 'Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: Relationship with airway remodelling.', Journal of Cellular and Molecular Medicine, vol. 22, no. 5, pp. 2826-2837.View/Download from: UTS OPUS or Publisher's site Faiz, A, Weckmann, M, Tasena, H, Vermeulen, CJ, Van den Berge, M, Ten Hacken, NHT, Halayko, AJ, Ward, JPT, Lee, TH, Tjin, G, Black, JL, Haghi, M, Xu, C-J, King, GG, Farah, CS, Oliver, BG, Heijink, IH & Burgess, JK 2018, 'Profiling of healthy and asthmatic airway smooth muscle cells following interleukin-1β treatment: a novel role for CCL20 in chronic mucus hypersecretion.', European Respiratory Journal, vol. 52, no. 2, pp. 1-12.View/Download from: UTS OPUS or Publisher's site Jaffar, J, Yang, S-H, Kim, SY, Kim, H-W, Faiz, A, Chrzanowski, W & Burgess, JK 2018, 'Greater cellular stiffness in fibroblasts from patients with idiopathic pulmonary fibrosis.', American journal of physiology. Lung cellular and molecular physiology, vol. 315, no. 1, pp. L59-L65.View/Download from: UTS OPUS or Publisher's site Hartjes, FJ, Vonk, JM, Faiz, A, Hiemstra, PS, Lapperre, TS, Kerstjens, HAM, Postma, DS, van den Berge, M & and the Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) Study Group 2018, 'Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD.', Respirology, vol. 23, no. 11, pp. 1023-1031.View/Download from: UTS OPUS or Publisher's site Imkamp, K, Berg, M, Vermeulen, CJ, Heijink, IH, Guryev, V, Kerstjens, HAM, Koppelman, GH, van den Berge, M & Faiz, A 2018, 'Nasal epithelium as a proxy for bronchial epithelium for smoking-induced gene expression and expression Quantitative Trait Loci.', Journal of Allergy and Clinical Immunology, vol. 142, no. 1, pp. 314-317.e15.View/Download from: Publisher's site Nedeljkovic, I, Lahousse, L, Carnero-Montoro, E, Faiz, A, Vonk, JM, de Jong, K, van der Plaat, DA, van Diemen, CC, van den Berge, M, Obeidat, M, Bossé, Y, Nickle, DC, Consortium, BIOS, Uitterlinden, AG, van Meurs, JBJ, Stricker, BHC, Brusselle, GG, Postma, DS, Boezen, HM, van Duijn, CM & Amin, N 2018, 'COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression.', Human molecular genetics, vol. 27, no. 2, pp. 396-405.View/Download from: UTS OPUS or Publisher's site Nedeljkovic, I, Carnero-Montoro, E, Lahousse, L, van der Plaat, DA, de Jong, K, Vonk, JM, van Diemen, CC, Faiz, A, van den Berge, M, Obeidat, M, Bossé, Y, Nickle, DC, Consortium, B, Uitterlinden, AG, van Meurs, JJB, Stricker, BCH, Brusselle, GG, Postma, DS, Boezen, HM, van Duijn, CM & Amin, N 2018, 'Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics.', European Journal of Human Genetics, vol. 26, no. 5, pp. 709-722.View/Download from: UTS OPUS or Publisher's site Pouwels, SD, Klont, F, Kwiatkowski, M, Wiersma, VR, Faiz, A, van den Berge, M, Horvatovich, P, Bischoff, R & ten Hacken, NHT 2018, 'Cigarette Smoking Acutely Decreases Serum Levels of the Chronic Obstructive Pulmonary Disease Biomarker sRAGE', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 198, no. 11, pp. 1456-1458.View/Download from: Publisher's site Billatos, E, Faiz, A, Gesthalter, Y, LeClerc, A, Alekseyev, YO, Xiao, X, Liu, G, Ten Hacken, NHT, Heijink, IH, Timens, W, Brandsma, CA, Postma, DS, van den Berge, M, Spira, A & Lenburg, ME 2018, 'Impact of acute exposure to cigarette smoke on airway gene expression.', Physiological genomics, vol. 50, no. 9, pp. 705-713.View/Download from: UTS OPUS or Publisher's site Vonk, JM, Nieuwenhuis, MAE, Dijk, FN, Boudier, A, Siroux, V, Bouzigon, E, Probst-Hensch, N, Imboden, M, Keidel, D, Sin, D, Bossé, Y, Hao, K, van den Berge, M, Faiz, A, Koppelman, GH & Postma, DS 2018, 'Novel genes and insights in complete asthma remission: A genome-wide association study on clinical and complete asthma remission.', Clinical and Experimental Allergy, vol. 48, no. 10, pp. 1286-1296.View/Download from: UTS OPUS or Publisher's site Tasena, H, Faiz, A, Timens, W, Noordhoek, J, Hylkema, MN, Gosens, R, Hiemstra, PS, Spira, A, Postma, DS, Tew, GW, Grimbaldeston, MA, van den Berge, M, Heijink, IH & Brandsma, C-A 2018, 'microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD.', European Respiratory Journal, vol. 52, no. 3.View/Download from: Publisher's site Faiz, A, Heijink, IH, Vermeulen, CJ, Guryev, V, van den Berge, M, Nawijn, MC & Pouwels, SD 2018, 'Cigarette smoke exposure decreases CFLAR expression in the bronchial epithelium, augmenting susceptibility for lung epithelial cell death and DAMP release.', Scientific reports, vol. 8, pp. 12426-12426.View/Download from: UTS OPUS or Publisher's site Faiz, A, Donovan, C, Nieuwenhuis, MAE, van den Berge, M, Postma, DS, Yao, S, Park, CY, Hirsch, R, Fredberg, JJ, Tjin, G, Halayko, AJ, Rempel, KL, Ward, JPT, Lee, T, Bossé, Y, Nickle, DC, Obeidat, M, Vonk, JM, Black, JL, Oliver, BG, Krishnan, R, McParland, B, Bourke, JE & Burgess, JK 2017, 'Latrophilin receptors: Novel bronchodilator targets in asthma', Thorax, vol. 72, pp. 74-82.View/Download from: UTS OPUS or Publisher's site de Vries, M, Faiz, A, Woldhuis, RR, Postma, DS, de Jong, TV, Sin, DD, Bossé, Y, Nickle, DC, Guryev, V, Timens, W, van den Berge, M & Brandsma, C-A 2017, 'Lung tissue gene-expression signature for the ageing lung in COPD.', Thorax, vol. 73, pp. 609-617.View/Download from: UTS OPUS or Publisher's site Osei, ET, Florez-Sampedro, L, Tasena, H, Faiz, A, Noordhoek, JA, Timens, W, Postma, DS, Hackett, TL, Heijink, IH & Brandsma, CA 2017, 'miR-146a-5p plays an essential role in the aberrant epithelial-fibroblast cross-talk in COPD', The European respiratory journal, vol. 49, no. 5.View/Download from: Publisher's site