Donnelly, Sheila - University of Technology Sydney

个人简介

A Senior lecturer within the University of Technology, Sydney (UTS) Faculty of Science, Sheila is course co-ordinator of Biotechnology and a member of the ithree institute (previously the Institute for the Biotechnology of Infectious Diseases (IBID). Dr Donnelly has a degree in Microbiology from Trinity College Dublin, Ireland and a PhD in Virology from the same university. Her early postdoctoral work at the National University of Ireland Maynooth, focused primarily on the neuro-immunological response to vaccination. During this time, she developed and published the details of a murine model, which reported a definitive link between administration of whole cell vaccines and the induction of seizure behaviour. In 2001, she moved to Dublin City University, Ireland to work with Prof Dalton on the isolation and characterization of immune modulating proteins secreted by helminth parasites. Research here led to the discovery of a protein secreted by helminth parasites that modulates cells of the innate immune system, specifically, activating macrophages towards an alternative phenotype which has downstream effects on the host T cell response. This was the first paper to describe the alternative activation of macrophages by an individual parasite-secreted protein independently of IL-4 and IL-13 signalling. In 2004, Dr Donnelly moved to UTS and since then has continued to investigate host-parasite interactions. This research has two streams: understanding the mechanisms by which helminth parasites successfully manipulate their host’s immune system; and using this knowledge to develop novel therapeutics for the treatment of autoimmune disease. During her scientific career Dr Donnelly has published widely in high-impact scientific journals and more recently has been involved in commercialisation of her research findings in the areas of human health.

研究领域

Host-Pathogen interactions Therapeutic potential of novel immunomodulators secreted by pathogens Role of macrophages in the regulation of immune responses

近期论文

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Cwiklinski, K, Jewhurst, H, McVeigh, P, Barbour, T, Maule, AG, Tort, J, O'Neill, SM, Robinson, MW, Donnelly, S & Dalton, JP 2018, 'Infection by the Helminth Parasite Fasciola hepatica Requires Rapid Regulation of Metabolic, Virulence, and Invasive Factors to Adjust to Its Mammalian Host.', Molecular & cellular proteomics : MCP, vol. 17, no. 4, pp. 792-809.View/Download from: UTS OPUS or Publisher's site Tanaka, A, Allam, VSRR, Simpson, J, Tiberti, N, Shiels, J, To, J, Lund, M, Combes, V, Weldon, S, Taggart, C, Dalton, JP, Phipps, S, Sukkar, MB & Donnelly, S 2018, 'The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 141, no. 6, pp. 2316-2319.View/Download from: UTS OPUS or Publisher's site Wong, SL, To, J, Santos, J, Allam, VSRR, Dalton, JP, Djordjevic, SP, Donnelly, S, Padula, MP & Sukkar, MB 2018, 'Proteomic Analysis of Extracellular HMGB1 Identifies Binding Partners and Exposes Its Potential Role in Airway Epithelial Cell Homeostasis.', Journal of Proteome Research, vol. 17, no. 1, pp. 33-45.View/Download from: UTS OPUS or Publisher's site Ruiz-Campillo, MT, Molina-Hernandez, V, Escamilla, A, Stevenson, M, Perez, J, Martinez-Moreno, A, Donnelly, S, Dalton, JP & Cwiklinski, K 2017, 'Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica', Scientific Reports, vol. 7, no. 1, pp. 1-14.View/Download from: UTS OPUS or Publisher's site Dixit, A, Tanaka, A, Greer, JM & Donnelly, S 2017, 'Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms.', International Journal of Molecular Sciences, vol. 18, no. 10, pp. 1-17.View/Download from: UTS OPUS or Publisher's site Donnelly, S, Huston, WM, Johnson, M, Tiberti, N, Saunders, B, O'Brien, B, Burke, C, Labbate, M & Combes, V 2017, 'Targeting the master regulator mTOR: a new approach to prevent the neurological of consequences of parasitic infections?', Parasites & Vectors, vol. 10, no. 1, pp. 1-6.View/Download from: UTS OPUS or Publisher's site Alvarado, R, To, J, Lund, ME, Pinar, A, Mansell, A, Robinson, MW, O'Brien, BA, Dalton, JP & Donnelly, S 2017, 'The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages.', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 31, no. 1, pp. 85-95.View/Download from: UTS OPUS or Publisher's site Tanaka, A, To, J, O'Brien, B, Donnelly, S & Lund, M 2017, 'Selection of reliable reference genes for the normalisation of gene expression levels following time course LPS stimulation of murine bone marrow derived macrophages.', BMC Immunology, vol. 18, no. 1, pp. 1-12.View/Download from: UTS OPUS or Publisher's site Cwiklinski, K, O'Neill, SM, Donnelly, S & Dalton, JP 2016, 'A prospective view of animal and human Fasciolosis', PARASITE IMMUNOLOGY, vol. 38, no. 9, pp. 558-568.View/Download from: UTS OPUS or Publisher's site Lund, ME, Greer, J, Dixit, A, Alvarado, R, McCauley-Winter, P, To, J, Tanaka, A, Hutchinson, AT, Robinson, MW, Simpson, AM, O'Brien, BA, Dalton, JP & Donnelly, S 2016, 'A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis.', Scientific Reports, vol. 6, pp. 1-11.View/Download from: UTS OPUS or Publisher's site Lund, ME, To, J, O'Brien, BA & Donnelly, S 2016, 'The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus', JOURNAL OF IMMUNOLOGICAL METHODS, vol. 430, pp. 64-70.View/Download from: UTS OPUS or Publisher's site Alvarado, R, O'Brien, B, Tanaka, A, Dalton, JP & Donnelly, S 2015, 'A parasitic helminth-derived peptide that targets the macrophage lysosome is a novel therapeutic option for autoimmune disease', IMMUNOBIOLOGY, vol. 220, no. 2, pp. 262-269.View/Download from: UTS OPUS or Publisher's site Molina-Hernandez, V, Mulcahy, G, Perez, J, Martinez-Moreno, A, Donnelly, S, O'Neill, SM, Dalton, JP & Cwiklinski, K 2015, 'Fasciola hepatica vaccine: We may not be there yet but we're on the right road', VETERINARY PARASITOLOGY, vol. 208, no. 1-2, pp. 101-111.View/Download from: UTS OPUS or Publisher's site El Ridi, R, Tallima, H, Selim, S, Donnelly, S, Cotton, S, Santana, BG & Dalton, JP 2014, 'Cysteine Peptidases as Schistosomiasis Vaccines with Inbuilt Adjuvanticity', PLOS ONE, vol. 9, no. 1.View/Download from: UTS OPUS or Publisher's site Adams, PN, Aldridge, A, Vukman, KV, Donnelly, S & O'Neill, SM 2014, 'Fasciola hepatica tegumental antigens indirectly induce an M2 macrophage-like phenotype in vivo.', Parasite immunology, vol. 36, no. 10, pp. 531-539.View/Download from: UTS OPUS or Publisher's site El Ridi, R, Tallima, H, Dalton, JP & Donnelly, S 2014, 'Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases', FRONTIERS IN GENETICS, vol. 5.View/Download from: UTS OPUS or Publisher's site Lund, ME, O'Brien, B, Hutchinson, AT, Robinson, MW, Simpson, AM, Dalton, JP & Donnelly, SM 2014, 'Secreted proteins from the helminth Fasciola hepatica inhibit the initiation of autoreactive T cell responses and prevent diabetes in the NOD mouse', PLoS One, vol. 9, no. 1, p. e86289.View/Download from: UTS OPUS or Publisher's site Robinson, MW, Donnelly, S & Dalton, JP 2013, 'Helminth defence molecules-immunomodulators designed by parasites!', FRONTIERS IN MICROBIOLOGY, vol. 4.View/Download from: UTS OPUS or Publisher's site Robinson, MW, Dalton, JP, O'Brien, B & Donnelly, SM 2013, 'Fasciola hepatica: The therapeutic potential of a worm secretome', International Journal For Parasitology, vol. 43, no. 3-4, pp. 283-291.View/Download from: UTS OPUS or Publisher's site Dalton, JP, Robinson, MW, Mulcahy, G, O'neill, S & Donnelly, SM 2013, 'Immunomodulatory molecules of Fasciola hepatica:Candidates for both vaccine and immunotherapeuticdevelopment', Veterinary Parasitology, vol. 195, no. 3-4, pp. 272-285.View/Download from: UTS OPUS or Publisher's site Thivierge, K, Cotton, S, Schaefer, D, Riggs, M, To, JH, Lund, ME, Robinson, MW, Dalton, JP & Donnelly, SM 2013, 'Cathelicidin-like Helminth Defence Molecules (HDMs): Absence of Cytotoxic, Anti-microbial and Anti-protozoan Activities Imply a Specific Adaptation to Immune Modulation', Plos Neglected Tropical Diseases, vol. 7, no. 7, pp. 1-14.View/Download from: UTS OPUS or Publisher's site Cotton, S, Donnelly, SM, Robinson, MW, Dalton, JP & Thivierge, K 2012, 'Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules?', Frontiers in Immunology, vol. 3, pp. 1-7.View/Download from: UTS OPUS or Publisher's site Robinson, MW, Hutchinson, AT & Donnelly, SM 2012, 'Antimicrobial peptides: utility players in innate immunity', Frontiers in Immunology, vol. 3, no. 325.View/Download from: UTS OPUS or Publisher's site Robinson, MW, Alvarado, R, To, J, Hutchinson, AT, Dowdell, SN, Lund, ME, Turnbull, L, Whitchurch, CB, O'Brien, B, Dalton, JP & Donnelly, SM 2012, 'A helminth cathelicidin-like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase', Faseb Journal, vol. 26, no. 11, pp. 4614-4627.View/Download from: UTS OPUS or Publisher's site Donnelly, SM, Dalton, JP & Robinson, MW 2011, 'How pathogen-derived cysteine proteases modulate host immune responses', Advances in Experimental Medicine and Biology, vol. 712, pp. 192-207.View/Download from: UTS OPUS or Publisher's site Robinson, MW, Donnelly, SM, Hutchinson, AT, To, J, Taylor, NL, Norton, RS, Perugini, M & Dalton, JP 2011, 'A Family of Helminth Molecules that Modulate Innate Cell Responses via Molecular Mimicry of Host Antimicrobial Peptides', Plos Pathogens, vol. 7, no. 5, pp. 1-15.View/Download from: UTS OPUS or Publisher's site Robinson, MW, Hutchinson, AT, Donnelly, SM & Dalton, JP 2010, 'Worm secretory molecules are causing alarm', Trends in Parasitology, vol. 26, no. 8, pp. 371-372.View/Download from: Publisher's site Robinson, MW, Hutchinson, AT, Donnelly, SM & Dalton, JP 2010, 'Peroxiredoxin: a central player in immune modulation.', Parasite Immunology, vol. 32, no. 5, pp. 305-313.View/Download from: UTS OPUS or Publisher's site Golden, O, Flynn, RY, Read, C, Sekiya, M, Donnelly, SM, Stack, CM, Dalton, JP & Mulcahy, G 2010, 'Protection Of Cattle Against A Natural Infection Of Fasciola Hepatica By Vaccination With Recombinant Cathepsin L1 (Rfhcl1)', Vaccine, vol. 28, no. 34, pp. 5551-5557.View/Download from: UTS OPUS or Publisher's site Dowling, D, Hamilton, C, Donnelly, SM, La Course, J, Brophy, P, Dalton, JP & O'neill, S 2010, 'Major Secretory Antigens Of The Helminth Fasciola Hepatica Activate A Suppressive Dendritic Cell Phenotype That Attenuates Th17 Cells But Fails To Activate Th2 Immune Responses', Infection And Immunity, vol. 78, no. 2, pp. 793-801.View/Download from: UTS OPUS or Publisher's site Donnelly, SM, O'Neill, S, Stack, CM, Robinson, MW, Turnbull, L, Whitchurch, CB & Dalton, JP 2010, 'Helminth cysteine proteases inhibit TRIF - dependent activation of macrophages via degradation of TLR3.', Journal Of Biological Chemistry, vol. 285, no. 5, pp. 3383-3392.View/Download from: UTS OPUS or Publisher's site Trenholme, K, Brown, CL, Skinner-Adams, TS, Stack, CM, Lowther, J, To, J, Robinson, MW, Donnelly, SM, Dalton, JP & Gardiner, D 2010, 'Aminopeptidases of malaria parasites: New targets for chemotherapy.', Infectious Disorders Drug Targets, vol. 10, no. 3, pp. 217-225.View/Download from: UTS OPUS or Publisher's site Miller, CM, Smith, NC, Ikin, RJ, Boulter, N, Dalton, JP & Donnelly, SM 2009, 'Immunological interactions between 2common pathogens, the Th1-inducing protozoan Toxoplasma gondii and the Th2-inducing helminth Fasciola hepatica', PLoS ONE, vol. 4, no. 5, pp. 1-10.View/Download from: UTS OPUS Robinson, MW, Menon, R, Donnelly, SM, Dalton, JP & Ranganathan, S 2009, 'An Integrated Transcriptomics And Proteomics Analysis Of The Secretome Of The Helminth Pathogen Fasciola Hepatica Proteins Associated With Invasion And Infection Of The Mammalian Host', Molecular & Cellular Proteomics, vol. 8, no. 8, pp. 1891-1907.View/Download from: UTS OPUS or Publisher's site