Cranfield, Charles - University of Technology Sydney

个人简介

Since obtaining his Science degree with Honours in Pharmacology from Monash University in 1996, Dr Cranfield completed his PhD in Biophysics at Swinburne University of Technology in 2002 where he investigated the effects of mobile phone radiation on calcium levels in T lymphocytes. His first post-doctoral position saw him travel to Keele University in England under the mentorship of Prof Jon Dobson to investigate how biogenic magnetic nanoparticles might interact with mobile phone radiation. Dr Cranfield then returned to his native Melbourne where, under the auspices of Prof Min Gu at the Centre for Micro-Photonics at Swinburne University of Technology, he assisted in the development of the world’s first non-linear endoscope. Dr Cranfield was then the beneficiary of 2 Marie Curie Transfer of Knowledge Fellowships. The first was at the Tyndall National Institute in Cork, Ireland, to assist in the development of fluorescence based point-of care diagnostic devices. The second was to work with biomolecular photonics expert Prof Christoph Biskup at University Hospital Jena, Germany, where he helped develop novel fluorescent ion nanosensors. From 2010 - 2013 he then worked in the laboratory of Prof Boris Martinac at the Victor Chang Cardiac Research Institute researching the lipid protein interactions of mechanosensitive ion channels. In 2014 he was appointed as Senior Lecturer at University of Technology Sydney and in 2015 he was appointed Team Leader of the Molecular Biosciences Team within the newly formed School of Life Sciences. In 2018 he became Deputy Leader of the Biology and Biotechnology Discipline.

研究领域

Research Topics Dr Cranfield's current research interests are in using the tethered lipid bilayer membranes (tBLMs) in conjunction with electrical impedance spectroscopy to investigate the insertion and function of membrane proteins, ion carriers, ion channels and antimicrobial peptides. In the past Dr Cranfield has published in diverse areas of biophysics including: mechanosensitive ion channels advanced fluorescence imaging techniques, fluorescent ion nanosensors, the possible effects of mobile phone radiation on immune cells

近期论文

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Alghalayini, A, Garcia, A, Berry, T & Cranfield, CG 2019, 'The Use of Tethered Bilayer Lipid Membranes to Identify the Mechanisms of Antimicrobial Peptide Interactions with Lipid Bilayers', ANTIBIOTICS-BASEL, vol. 8, no. 1.View/Download from: UTS OPUS or Publisher's site Huston, WM, Cranfield, CG, Forbes, SL & Leigh, A 2019, 'A sponsorship action plan for increasing diversity in STEMM.', Ecology and Evolution, vol. 9, no. 5, pp. 2340-2345.View/Download from: UTS OPUS or Publisher's site Cranfield, CG 2019, 'ABA/ASB Membrane Biophysics session II 2018', Biophysical Reviews.View/Download from: Publisher's site Deplazes, E, White, J, Murphy, C, Cranfield, CG & Garcia, A 2019, 'Competing for the same space: protons and alkali ions at the interface of phospholipid bilayers.', Biophysical reviews.View/Download from: UTS OPUS or Publisher's site Facey, JA, Steele, JR, Violi, JP, Mitrovic, SM & Cranfield, C 2019, 'An examination of microcystin-LR accumulation and toxicity using tethered bilayer lipid membranes (tBLMs).', Toxicon, vol. 158, pp. 51-56.View/Download from: Publisher's site Kuppusamy, R, Yasir, M, Berry, T, Cranfield, CG, Nizalapur, S, Yee, E, Kimyon, O, Taunk, A, Ho, KKK, Cornell, B, Manefield, M, Willcox, M, Black, DS & Kumar, N 2018, 'Design and synthesis of short amphiphilic cationic peptidomimetics based on biphenyl backbone as antibacterial agents.', European journal of medicinal chemistry, vol. 143, pp. 1702-1722.View/Download from: UTS OPUS or Publisher's site Deplazes, E, Poger, D, Cornell, B & Cranfield, CG 2018, 'The effect of hydronium ions on the structure of phospholipid membranes.', Physical Chemistry Chemical Physics, vol. 20, no. 1, pp. 357-366.View/Download from: UTS OPUS or Publisher's site Nguyen, T, Li, GE, Chen, H, Cranfield, CG, McGrath, KC & Gorrie, CA 2018, 'Maternal E-Cigarette Exposure Results in Cognitive and Epigenetic Alterations in Offspring in a Mouse Model.', Chemical research in toxicology, vol. 31, no. 7, pp. 601-611.View/Download from: UTS OPUS or Publisher's site Berry, T, Dutta, D, Chen, R, Leong, A, Wang, H, Donald, WA, Parviz, M, Cornell, B, Willcox, M, Kumar, N & Cranfield, CG 2018, 'Lipid Membrane Interactions of the Cationic Antimicrobial Peptide Chimeras Melimine and Cys-Melimine.', Langmuir : the ACS journal of surfaces and colloids, vol. 34, no. 38, pp. 11586-11592.View/Download from: UTS OPUS or Publisher's site Deplazes, E, Poger, D, Cornell, B & Cranfield, CG 2018, 'The effect of H3O+ on the membrane morphology and hydrogen bonding of a phospholipid bilayer', Biophysical Reviews, vol. 10, no. 5, pp. 1371-1376.View/Download from: Publisher's site Nizalapur, S, Kimyon, O, Yee, E, Ho, K, Berry, T, Manefield, M, Cranfield, CG, Willcox, M, Black, DS & Kumar, N 2017, 'Amphipathic guanidine-embedded glyoxamide-based peptidomimetics as novel antibacterial agents and biofilm disruptors.', Organic and Biomolecular Chemistry, vol. 15, no. 9, pp. 2033-2051.View/Download from: UTS OPUS or Publisher's site Tsz, TU, Nizalapur, S, Ho, KKK, Yee, E, Berry, T, Cranfield, CG, Willcox, M, Black, DS & Kumar, N 2017, 'Design, Synthesis and Biological Evaluation of N-Sulfonylphenyl glyoxamide-Based Antimicrobial Peptide Mimics as Novel Antimicrobial Agents', Chemistry Select, vol. 2, no. 12, pp. 3452-3461.View/Download from: UTS OPUS or Publisher's site Cranfield, CG, Henriques, ST, Martinac, B, Duckworth, P, Craik, DJ & Cornell, B 2017, 'Kalata B1 and Kalata B2 Have a Surfactant-Like Activity in Phosphatidylethanolomine-Containing Lipid Membranes.', Langmuir: the ACS journal of surfaces and colloids, vol. 33, no. 26, pp. 6630-6637.View/Download from: UTS OPUS or Publisher's site Hoiles, W, Gupta, R, Cornell, B, Cranfield, C & Krishnamurthy, V 2016, 'The Effect of Tethers on Artificial Cell Membranes: A Coarse-Grained Molecular Dynamics Study', PLOS ONE, vol. 11, no. 10.View/Download from: UTS OPUS or Publisher's site Constantine, M, Liew, CK, Lo, V, Macmillan, A, Cranfield, CG, Sunde, M, Whan, R, Graham, RM & Martinac, B 2016, 'Heterologously-expressed and Liposome-reconstituted Human Transient Receptor Potential Melastatin 4 Channel (TRPM4) is a Functional Tetramer', SCIENTIFIC REPORTS, vol. 6.View/Download from: UTS OPUS or Publisher's site Nizalapur, S, Ho, KKK, Kimyon, O, Yee, E, Berry, T, Manefield, M, Cranfield, CG, Willcox, M, Black, DS & Kumar, N 2016, 'Synthesis and biological evaluation of N-naphthoyl-phenylglyoxamide-based small molecular antimicrobial peptide mimics as novel antimicrobial agents and biofilm inhibitors', ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 14, no. 14, pp. 3623-3637.View/Download from: UTS OPUS or Publisher's site Cranfield, CG, Berry, T, Holt, SA, Hossain, KR, Le Brun, AP, Carne, S, Al Khamici, H, Coster, H, Valenzuela, SM & Cornell, B 2016, 'Evidence of the Key Role of H3O+ in Phospholipid Membrane Morphology', LANGMUIR, vol. 32, no. 41, pp. 10725-10734.View/Download from: UTS OPUS or Publisher's site Cranfield, CG, Bettler, T & Cornell, B 2015, 'Nanoscale Ion Sequestration To Determine the Polarity Selectivity of Ion Conductance in Carriers and Channels', LANGMUIR, vol. 31, no. 1, pp. 292-298.View/Download from: UTS OPUS or Publisher's site Hoiles, W, Krishnamurthy, V, Cranfield, CG & Cornell, B 2014, 'An Engineered Membrane to Measure Electroporation: Effect of Tethers and Bioelectronic Interface', BIOPHYSICAL JOURNAL, vol. 107, no. 6, pp. 1339-1351.View/Download from: UTS OPUS or Publisher's site Cranfield, CG, Cornell, BA, Grage, SL, Duckworth, P, Carne, S, Ulrich, AS & Martinac, B 2014, 'Transient potential gradients and impedance measures of tethered bilayer lipid membranes: pore-forming peptide insertion and the effect of electroporation.', Biophysical Journal, vol. 106, no. 1, pp. 182-189.View/Download from: UTS OPUS or Publisher's site Martinac, B, Nomura, T, Chi, G, Petrov, E, Rohde, PR, Battle, AR, Foo, A, Constantine, M, Rothnagel, R, Carne, S, Deplazes, E, Cornell, B, Cranfield, CG, Hankamer, B & Landsberg, MJ 2014, 'Bacterial mechanosensitive channels: models for studying mechanosensory transduction.', Antioxidants and Redox Signaling, vol. 20, no. 6, pp. 952-969.View/Download from: UTS OPUS or Publisher's site Martinac, B. & Cranfield, C.G. 2012, 'Shining a light on the structural dynamics of ion channels using Förster resonance energy transfer (FRET).', IPSI BgD Transactions on Advanced Research, vol. 8, pp. 19-24. Nomura, T, Cranfield, CG, Deplazes, E, Owen, DM, Macmillan, A, Battle, AR, Constantine, M, Sokabe, M & Martinac, B 2012, 'Differential effects of lipids and lyso-lipids on the mechanosensitivity of MscL and MscS', Proceedings of The National Academy of Sciences of the United States of America, vol. 109, no. 22, pp. 8770-8775.View/Download from: UTS OPUS or Publisher's site Idzik, KR, Cywinski, PJ, Cranfield, CG, Mohr, GJ & Beckert, R 2011, 'Molecular Recognition of the Antiretroviral Drug Abacavir: Towards the Development of a Novel Carbazole-Based Fluorosensor', Journal of Fluorescence, vol. 21, no. 3, pp. 1195-1204.View/Download from: UTS OPUS or Publisher's site Stanca, SE, Nietzsche, S, Fritzsche, W, Cranfield, CG & Biskup, C 2010, 'Intracellular ion monitoring using a gold core-polymer shell nanosensor architecture', Nanotechnology, vol. 21, no. 5.View/Download from: UTS OPUS or Publisher's site Cranfield, CG 2010, 'Synthesis and sensing properties of a new carbazole fluorosensor for detection of abacavir', Supramolecular chemistry, vol. 22.View/Download from: UTS OPUS or Publisher's site Fu, L, Jain, A, Cranfield, C, Xie, H & Gu, M 2007, 'Three-dimensional nonlinear optical endoscopy', JOURNAL OF BIOMEDICAL OPTICS, vol. 12, no. 4.View/Download from: Publisher's site Day, D, Cranfield, CG & Gu, M 2006, 'High-speed fluorescence imaging and intensity profiling of femtosecond-induced calcium transients.', International journal of biomedical imaging, vol. 2006, p. 93438.View/Download from: UTS OPUS or Publisher's site Fu, L, Jain, A, Xie, HK, Cranfield, C & Gu, M 2006, 'Nonlinear optical endoscopy based on a double-clad photonic crystal fiber and a MEMS mirror', OPTICS EXPRESS, vol. 14, no. 3, pp. 1027-1032.View/Download from: Publisher's site Cranfield, C, Bomzon, Z, Day, D, Gu, M & Cartmell, S 2006, 'Mechanical strains induced in osteoblasts by use of point femtosecond laser targeting.', International journal of biomedical imaging, vol. 2006, p. 10427.View/Download from: UTS OPUS or Publisher's site Cranfield, CG, Dawe, A, Karloukovski, V, Dunin-Borkowski, RE, De Pomerai, D & Dobson, J 2004, 'Biogenic magnetite in the nematode Caenorhabditis elegans', Proceedings of the Royal Society B: Biological Sciences, vol. 271, no. SUPPL. 6.View/Download from: Publisher's site Cranfield, CG, Dawe, A, Karloukovski, V, Dunin-Borkowski, RE, de Pomerai, D & Dobson, J 2004, 'Biogenic magnetite in the nematode Caenorhabditis elegans', PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, vol. 271, pp. S436-S439.View/Download from: Publisher's site Cranfield, CG, Weiser, HG & Dobson, J 2003, 'Exposure of magnetic bacteria to simulated mobile phone-type RF radiation has no impact on mortality', IEEE TRANSACTIONS ON NANOBIOSCIENCE, vol. 2, no. 3, pp. 146-149.View/Download from: Publisher's site Cranfield, C, Wieser, HG, Al Madan, J & Dobson, J 2003, 'Preliminary evaluation of nanoscale biogenic magnetite-based ferromagnetic transduction mechanisms for mobile phone bioeffects', IEEE TRANSACTIONS ON NANOBIOSCIENCE, vol. 2, no. 1, pp. 40-43.View/Download from: Publisher's site Cranfield, CG, Wood, AW, Anderson, V & Menezes, KG 2001, 'Effects of mobile phone type signals on calcium levels within human leukaemic T-cells (Jurkat cells)', INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, vol. 77, no. 12, pp. 1207-1217.View/Download from: Publisher's site